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Aliases for OR2T35 Gene

Aliases for OR2T35 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 35 2 3 5
  • Olfactory Receptor, Family 2, Subfamily T, Member 35 2
  • Olfactory Receptor OR1-66 4

External Ids for OR2T35 Gene

Previous GeneCards Identifiers for OR2T35 Gene

  • GC01U901016
  • GC01M245117
  • GC01M246868
  • GC01M248801

Summaries for OR2T35 Gene

Entrez Gene Summary for OR2T35 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T35 Gene

OR2T35 (Olfactory Receptor Family 2 Subfamily T Member 35) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2T35 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T35 Gene

Genomics for OR2T35 Gene

Regulatory Elements for OR2T35 Gene

Enhancers for OR2T35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR2T35 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2T35 Gene

Chromosome:
1
Start:
248,638,287 bp from pter
End:
248,642,735 bp from pter
Size:
4,449 bases
Orientation:
Minus strand

Genomic View for OR2T35 Gene

Genes around OR2T35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T35 Gene

Proteins for OR2T35 Gene

  • Protein details for OR2T35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGX2-O2T35_HUMAN
    Recommended name:
    Olfactory receptor 2T35
    Protein Accession:
    Q8NGX2
    Secondary Accessions:
    • Q6IEY7

    Protein attributes for OR2T35 Gene

    Size:
    323 amino acids
    Molecular mass:
    36101 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T35 Gene

Proteomics data for OR2T35 Gene at MOPED

Post-translational modifications for OR2T35 Gene

  • Glycosylation at Asn 9
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2T35 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for OR2T35

No data available for DME Specific Peptides for OR2T35 Gene

Domains & Families for OR2T35 Gene

Gene Families for OR2T35 Gene

Protein Domains for OR2T35 Gene

Suggested Antigen Peptide Sequences for OR2T35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGX2

UniProtKB/Swiss-Prot:

O2T35_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T35: view

Function for OR2T35 Gene

Molecular function for OR2T35 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR2T35 Gene

GenomeRNAi human phenotypes for OR2T35:
genes like me logo Genes that share phenotypes with OR2T35: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T35 Gene

Localization for OR2T35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T35 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2T35 Gene COMPARTMENTS Subcellular localization image for OR2T35 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2T35: view

Pathways & Interactions for OR2T35 Gene

genes like me logo Genes that share pathways with OR2T35: view

Pathways by source for OR2T35 Gene

Interacting Proteins for OR2T35 Gene

Gene Ontology (GO) - Biological Process for OR2T35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T35: view

No data available for SIGNOR curated interactions for OR2T35 Gene

Drugs & Compounds for OR2T35 Gene

No Compound Related Data Available

Transcripts for OR2T35 Gene

mRNA/cDNA for OR2T35 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T35 Gene

No ASD Table

Relevant External Links for OR2T35 Gene

GeneLoc Exon Structure for
OR2T35
ECgene alternative splicing isoforms for
OR2T35

Expression for OR2T35 Gene

mRNA expression in normal human tissues for OR2T35 Gene

Protein differential expression in normal tissues from HIPED for OR2T35 Gene

This gene is overexpressed in Blymphocyte (26.0), Monocytes (22.6), Neutrophil (11.8), and Tlymphocyte (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2T35 Gene



SOURCE GeneReport for Unigene cluster for OR2T35 Gene Hs.534846

genes like me logo Genes that share expression patterns with OR2T35: view

Protein tissue co-expression partners for OR2T35 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR2T35 Gene

Orthologs for OR2T35 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T35 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR2T2 35
  • 85.82 (n)
  • 86.34 (a)
-- 36
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR2T2 35
  • 83.95 (n)
  • 88.82 (a)
OR04B08 36
  • 88 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC469774 35
  • 99.27 (n)
  • 98.74 (a)
-- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1605 35
  • 82.6 (n)
  • 85.94 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr721-ps1 36
  • 83 (a)
OneToMany
Species with no ortholog for OR2T35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T35 Gene

ENSEMBL:
Gene Tree for OR2T35 (if available)
TreeFam:
Gene Tree for OR2T35 (if available)

Paralogs for OR2T35 Gene

(447) SIMAP similar genes for OR2T35 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2T35: view

Variants for OR2T35 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2T35 Gene

Variant ID Type Subtype PubMed ID
nsv515858 CNV Gain+Loss 19592680
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
nsv873462 CNV Loss 21882294
dgv20n17 CNV Loss 16327808
dgv206e1 CNV Complex 17122850
nsv428357 CNV Loss 18775914
esv2750835 CNV Gain 17911159
dgv571n71 CNV Gain 21882294
nsv7193 OTHER Inversion 18451855
dgv207e1 CNV Complex 17122850
dgv575n71 CNV Gain 21882294
dgv208e1 CNV Complex 17122850
nsv483043 CNV Complex 15286789
nsv469750 CNV Loss 16826518
dgv577n71 CNV Loss 21882294
esv29940 CNV Loss 18421352
dgv578n71 CNV Gain 21882294
dgv579n71 CNV Loss 21882294
nsv873510 CNV Gain 21882294
nsv433194 CNV Loss 18776910
nsv9202 CNV Gain 18304495

Variation tolerance for OR2T35 Gene

Gene Damage Index Score: 20.38; 99.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2T35 Gene

HapMap Linkage Disequilibrium report
OR2T35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for OR2T35 Gene

Disorders for OR2T35 Gene

Relevant External Links for OR2T35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2T35

No disorders were found for OR2T35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T35 Gene

Publications for OR2T35 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for OR2T35 Gene

Sources for OR2T35 Gene

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