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Aliases for OR2T34 Gene

Aliases for OR2T34 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 34 2 3 5
  • Olfactory Receptor, Family 2, Subfamily T, Member 34 2
  • Olfactory Receptor OR1-63 4

External Ids for OR2T34 Gene

Previous GeneCards Identifiers for OR2T34 Gene

  • GC01M245673
  • GC01M245063
  • GC01M246803
  • GC01M248737

Summaries for OR2T34 Gene

Entrez Gene Summary for OR2T34 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T34 Gene

OR2T34 (Olfactory Receptor Family 2 Subfamily T Member 34) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T3.

UniProtKB/Swiss-Prot for OR2T34 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T34 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T34 Gene

Genomics for OR2T34 Gene

Regulatory Elements for OR2T34 Gene

Enhancers for OR2T34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F248567 0.2 Ensembl 0.4 +7.0 6957 0.4 CTCF IRF2 ZNF644 ZSCAN29 ZBTB2 L3MBTL2 NRF1 NR2F1 MAFG GABPA OR2T29 OR2T34
GH01F248565 0.2 Ensembl 0.4 +8.7 8657 1.4 OR2T29 OR2T34
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR2T34 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2T34 Gene

Chromosome:
1
Start:
248,573,801 bp from pter
End:
248,574,757 bp from pter
Size:
957 bases
Orientation:
Minus strand

Genomic View for OR2T34 Gene

Genes around OR2T34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T34 Gene

Proteins for OR2T34 Gene

  • Protein details for OR2T34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGX1-O2T34_HUMAN
    Recommended name:
    Olfactory receptor 2T34
    Protein Accession:
    Q8NGX1
    Secondary Accessions:
    • B2RNJ8
    • Q6IEY5
    • Q96R31

    Protein attributes for OR2T34 Gene

    Size:
    318 amino acids
    Molecular mass:
    35681 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04875.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2T34 Gene

Post-translational modifications for OR2T34 Gene

  • Glycosylation at Asn 5 and Asn 10

Other Protein References for OR2T34 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T34 Gene

Domains & Families for OR2T34 Gene

Gene Families for OR2T34 Gene

Protein Domains for OR2T34 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NGX1

UniProtKB/Swiss-Prot:

O2T34_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T34: view

Function for OR2T34 Gene

Molecular function for OR2T34 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T34: view

Phenotypes for OR2T34 Gene

GenomeRNAi human phenotypes for OR2T34:
genes like me logo Genes that share phenotypes with OR2T34: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T34 Gene

Localization for OR2T34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T34 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2T34 Gene COMPARTMENTS Subcellular localization image for OR2T34 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T34: view

Pathways & Interactions for OR2T34 Gene

genes like me logo Genes that share pathways with OR2T34: view

Pathways by source for OR2T34 Gene

Gene Ontology (GO) - Biological Process for OR2T34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T34: view

No data available for SIGNOR curated interactions for OR2T34 Gene

Transcripts for OR2T34 Gene

mRNA/cDNA for OR2T34 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T34 Gene

No ASD Table

Relevant External Links for OR2T34 Gene

GeneLoc Exon Structure for
OR2T34
ECgene alternative splicing isoforms for
OR2T34

Expression for OR2T34 Gene

mRNA expression in normal human tissues for OR2T34 Gene

mRNA differential expression in normal tissues according to GTEx for OR2T34 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x7.2) and Cervix - Endocervix (x6.7).

Protein differential expression in normal tissues from HIPED for OR2T34 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.4) and Adipocyte (33.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2T34 Gene



Protein tissue co-expression partners for OR2T34 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2T34 Gene:

OR2T34

SOURCE GeneReport for Unigene cluster for OR2T34 Gene:

Hs.553584
genes like me logo Genes that share expression patterns with OR2T34: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR2T34 Gene

Orthologs for OR2T34 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T34 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 81 (a)
ManyToMany
-- 35
  • 80 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 63 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
OneToMany
Species where no ortholog for OR2T34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T34 Gene

ENSEMBL:
Gene Tree for OR2T34 (if available)
TreeFam:
Gene Tree for OR2T34 (if available)

Paralogs for OR2T34 Gene

(452) SIMAP similar genes for OR2T34 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR2T34: view

Variants for OR2T34 Gene

Sequence variations from dbSNP and Humsavar for OR2T34 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111639661 -- 248,575,309(+) TTTAA(A/G)TCCAC intron-variant, upstream-variant-2KB
rs111688645 -- 248,576,085(+) TACAA(C/T)GCACT intron-variant, upstream-variant-2KB
rs113818137 -- 248,575,510(+) AAATC(A/T)AAGGC intron-variant, upstream-variant-2KB
rs113921150 -- 248,576,170(+) AGACC(-/A/AA)AAAAA intron-variant, upstream-variant-2KB
rs11485848 -- 248,573,794(+) GCTTG(C/T)CCTTT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR2T34 Gene

Variant ID Type Subtype PubMed ID
dgv116n67 CNV loss 20364138
dgv165e212 CNV gain 25503493
dgv166e212 CNV loss 25503493
dgv17e55 CNV loss 17911159
dgv20n17 CNV loss 16327808
dgv29n111 CNV deletion 26073780
dgv323n106 OTHER inversion 24896259
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv616n100 CNV gain 25217958
dgv617n100 CNV gain 25217958
dgv618n100 CNV loss 25217958
dgv619n100 CNV gain 25217958
dgv620n100 CNV loss 25217958
dgv621n100 CNV gain+loss 25217958
dgv622n100 CNV loss 25217958
dgv623n100 CNV loss 25217958
dgv624n100 CNV gain+loss 25217958
dgv625n100 CNV gain 25217958
dgv626n100 CNV loss 25217958
dgv627n100 CNV loss 25217958
dgv628n100 CNV loss 25217958
dgv629n100 CNV gain+loss 25217958
dgv630n100 CNV gain+loss 25217958
dgv631n100 CNV gain 25217958
dgv7e213 CNV loss 24956385
dgv906n54 CNV gain 21841781
dgv909n54 CNV loss 21841781
dgv910n54 CNV loss 21841781
dgv911n54 CNV loss 21841781
esv27363 CNV loss 19812545
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv2759015 CNV gain+loss 17122850
esv2760083 CNV gain+loss 21179565
esv2763780 CNV loss 21179565
esv29940 CNV loss 18421352
esv33052 CNV gain+loss 17666407
esv3891415 CNV gain 25118596
nsv1003091 CNV gain 25217958
nsv1003605 CNV gain 25217958
nsv1004790 CNV gain 25217958
nsv1008002 CNV loss 25217958
nsv1010059 CNV loss 25217958
nsv1013273 CNV gain 25217958
nsv1079019 OTHER inversion 25765185
nsv1150779 OTHER inversion 26484159
nsv1160483 CNV duplication 26073780
nsv428357 CNV loss 18775914
nsv469750 CNV loss 16826518
nsv515858 CNV gain+loss 19592680
nsv5365 CNV deletion 18451855
nsv549603 CNV loss 21841781
nsv549641 CNV gain 21841781
nsv549644 CNV loss 21841781
nsv7193 OTHER inversion 18451855
nsv821623 CNV loss 15273396
nsv9191 CNV gain+loss 18304495

Variation tolerance for OR2T34 Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.92; 89.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2T34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2T34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T34 Gene

Disorders for OR2T34 Gene

Relevant External Links for OR2T34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2T34

No disorders were found for OR2T34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T34 Gene

Publications for OR2T34 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR2T34 Gene

Sources for OR2T34 Gene

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