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Aliases for OR2T33 Gene

Aliases for OR2T33 Gene

  • Olfactory Receptor, Family 2, Subfamily T, Member 33 2 3
  • Olfactory Receptor OR1-56 3 4
  • Novel 7 Transmembrane Receptor (Rhodopsin Family) Protein 3
  • Olfactory Receptor 2T33 3
  • OR1-56 3

External Ids for OR2T33 Gene

Summaries for OR2T33 Gene

Entrez Gene Summary for OR2T33 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T33 Gene

OR2T33 (Olfactory Receptor, Family 2, Subfamily T, Member 33) is a Protein Coding gene. Diseases associated with OR2T33 include placenta accreta. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2T33 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T33 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T33 Gene

Genomics for OR2T33 Gene

Genomic Location for OR2T33 Gene

Start:
248,272,852 bp from pter
End:
248,273,814 bp from pter
Size:
963 bases
Orientation:
Minus strand

Genomic View for OR2T33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2T33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T33 Gene

Regulatory Elements for OR2T33 Gene

Proteins for OR2T33 Gene

  • Protein details for OR2T33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG76-O2T33_HUMAN
    Recommended name:
    Olfactory receptor 2T33
    Protein Accession:
    Q8NG76
    Secondary Accessions:
    • B2RNN0

    Protein attributes for OR2T33 Gene

    Size:
    320 amino acids
    Molecular mass:
    35876 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T33 Gene

Proteomics data for OR2T33 Gene at MOPED

Post-translational modifications for OR2T33 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn17

Other Protein References for OR2T33 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2T33 Gene

Domains for OR2T33 Gene

Gene Families for OR2T33 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2T33 Gene

UniProtKB/Swiss-Prot:

O2T33_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NG76
genes like me logo Genes that share domains with OR2T33: view

Function for OR2T33 Gene

Molecular function for OR2T33 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T33: view

Phenotypes for OR2T33 Gene

genes like me logo Genes that share phenotypes with OR2T33: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2T33 Gene

Localization for OR2T33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T33 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2T33 Gene COMPARTMENTS Subcellular localization image for OR2T33 gene
Compartment Confidence
plasma membrane 5
endosome 1

Gene Ontology (GO) - Cellular Components for OR2T33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T33: view

Pathways for OR2T33 Gene

genes like me logo Genes that share pathways with OR2T33: view

Pathways by source for OR2T33 Gene

Interacting Proteins for OR2T33 Gene

Gene Ontology (GO) - Biological Process for OR2T33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T33: view

Transcripts for OR2T33 Gene

mRNA/cDNA for OR2T33 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T33 Gene

No ASD Table

Relevant External Links for OR2T33 Gene

GeneLoc Exon Structure for
OR2T33
ECgene alternative splicing isoforms for
OR2T33

Expression for OR2T33 Gene

mRNA expression in normal human tissues for OR2T33 Gene

mRNA differential expression in normal tissues according to GTEx for OR2T33 Gene

This gene is overexpressed in Testis (7.3), Thyroid (5.7), and Cervix - Endocervix (4.1).

SOURCE GeneReport for Unigene cluster for OR2T33 Gene Hs.553783

genes like me logo Genes that share expressions with OR2T33: view

Orthologs for OR2T33 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T33 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 37
  • 74 (a)
ManyToMany
-- 37
  • 70 (a)
ManyToMany
-- 37
  • 73 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 78 (a)
OneToMany
LOC100685834 36
  • 81.3 (n)
  • 77.56 (a)
mouse
(Mus musculus)
Mammalia Olfr314 37
  • 70 (a)
OneToMany
Olfr315 16
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 57 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1454 36
  • 76.43 (n)
  • 71.34 (a)
Species with no ortholog for OR2T33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T33 Gene

ENSEMBL:
Gene Tree for OR2T33 (if available)
TreeFam:
Gene Tree for OR2T33 (if available)

Paralogs for OR2T33 Gene

Selected SIMAP similar genes for OR2T33 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR2T33 Gene

genes like me logo Genes that share paralogs with OR2T33: view

Variants for OR2T33 Gene

Sequence variations from dbSNP and Humsavar for OR2T33 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4586010 -- 248,274,266(+) AGATA(A/G)GTCTT upstream-variant-2KB
rs6587444 -- 248,275,150(+) TCTCA(C/T)ACACA upstream-variant-2KB
rs7521689 -- 248,272,529(+) TTTCC(G/T)TGCTG downstream-variant-500B
rs7530477 -- 248,274,713(+) AGTAA(C/G)AAAAG upstream-variant-2KB
rs7547041 -- 248,275,293(+) AAGCA(C/T)TGGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2T33 Gene

Variant ID Type Subtype PubMed ID
nsv515858 CNV Gain+Loss 19592680
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
dgv564n71 CNV Gain 21882294
dgv565n71 CNV Loss 21882294
esv2728006 CNV Deletion 23290073
nsv9103 CNV Loss 18304495
dgv566n71 CNV Gain 21882294
dgv567n71 CNV Gain 21882294
dgv568n71 CNV Loss 21882294
nsv873459 CNV Loss 21882294
nsv873461 CNV Gain 21882294
nsv873462 CNV Loss 21882294
nsv873463 CNV Loss 21882294

Relevant External Links for OR2T33 Gene

HapMap Linkage Disequilibrium report
OR2T33

Disorders for OR2T33 Gene

(1) MalaCards Diseases for OR2T33 Gene

Search for OR2T33 Gene in MalaCards »

(2) University of Copenhagen DISEASES for OR2T33 Gene

Relevant External Links for OR2T33

Genetic Association Database (GAD)
OR2T33
genes like me logo Genes that share disorders with OR2T33: view

No data available for UniProtKB/Swiss-Prot for OR2T33 Gene

Publications for OR2T33 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2T33 Gene

Sources for OR2T33 Gene

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