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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OR2T33 Gene

protein-coding GIFtS: 49
GCID: GC01M248436

olfactory receptor, family 2, subfamily T, member 33

Explore 4 diseases affiliated with
OR2T33 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Olfactory Receptor, Family 2, Subfamily T, Member 33¹ ²
Olfactory Receptor OR1-56² ³
OR1-56²
Novel 7 Transmembrane Receptor (Rhodopsin Family) Protein²
Olfactory Receptor 2T33²

External Ids:	HGNC: 31255¹	Entrez Gene: 391195²	Ensembl: ENSG00000177212⁷	UniProtKB: Q8NG76³

Export aliases for OR2T33 gene to outside databases

Previous GC identifers: GC01M245334 GC01M244762 GC01M246502

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR2T33:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors

(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many

neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of

odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the

olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: O2T33_HUMAN, Q8NG76

Function: Odorant receptor (Potential)

Gene Wiki entry for OR2T33

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OR2T33 gene promoter:
TBP AML1a CUTL1 GATA-2 HNF-4alpha1 PPAR-alpha PPAR-gamma1 TFIID COMP1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OR2T33 promoter sequence

Search SABiosciences Chromatin IP Primers for OR2T33

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2T33

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44

OR2T33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2T33 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M248436: view genomic region (about GC identifiers)

Start:	248,436,157 bp from pter	End:	248,437,116 bp from pter
Size:	960 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: O2T33_HUMAN, Q8NG76 (See protein sequence)

Recommended Name: Olfactory receptor 2T33

Size: 320 amino acids; 35876 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: B2RNN0

Explore the universe of human proteins at neXtProt for OR2T33: NX_Q8NG76

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NG76

HORDE protein sequence for OR2T33
OR2T33 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001004695.1

ENSEMBL proteins:

ENSP00000324687

Reactome Protein details: Q8NG76
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

OR2T33 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OR2T33 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000725 Olfact_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NG76

ProtoNet protein and cluster: Q8NG76

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O2T33_HUMAN, Q8NG76

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: O2T33_HUMAN, Q8NG76

Function: Odorant receptor (Potential)

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004984	olfactory receptor activity	IEA	--

OR2T33 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for OR2T33:

Decreased viability of wild-ty

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Olfactory transduction

Olfactory transduction

1.00

Olfactory Signaling Pathway

0.77

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for OR2T33

	GPCR downstream signaling
	Olfactory Signaling Pathway
	Signal Transduction
	Signaling by GPCR

1 Kegg Pathway (Kegg details for OR2T33):

Olfactory transduction

OR2T33 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR2T33

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for OR2T33 (Q8NG76³ ENSP00000324687⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATG3	Q9NT62³	I2D: score=1
ADRBK2	ENSP00000317578⁴	STRING: ENSP00000317578
ARRB2	ENSP00000269260⁴	STRING: ENSP00000269260
GNAL	ENSP00000334051⁴	STRING: ENSP00000334051

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR2T33
Search CenterWatch for drugs/clinical trials and news about OR2T33 / O2T33

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for OR2T33 gene:

NM_001004695.1

Unigene Cluster for OR2T33:

Olfactory receptor, family 2, subfamily T, member 33

Hs.553783

Unigene Representative Sequence: BC136995

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000318021(uc010pzi.2)

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Additional cDNA sequence:

BC136994.1 BC136995.1

1 AceView cDNA sequence:

NM_001004695

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR2T33 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAAGGTTGT

About this image

OR2T33 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See OR2T33 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.553783

SABiosciences Custom PCR Arrays for OR2T33

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for OR2T33 (if available)
TreeFam Gene Tree for OR2T33 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OR2T33 gene

OR2T35² OR2AK2² OR2V1² OR2M3² OR2L13² OR2T8² OR2M4² OR2T5²

OR2T27² OR2T10² OR2AJ1² OR2T11² OR2T29² OR2T6² OR2T1² OR2T3²

OR2V2² OR2M7² OR2T2² OR2L2² OR2T12² OR2L5² OR2M5² OR2AG1²

OR2Z1² OR2AE1² OR2M2² OR2T4² OR2L3² OR2T34² OR2L8² OR2AG2²

18/454 SIMAP similar genes for OR2T33 using alignment to 1 protein entry: O2T33_HUMAN(see all similar genes):

OR2T12 OR2T8 OR2M2 OR2M3 OR2T1 OR2M4

OR2M5 OR2M7 OR2T29 OR2T5 OR2T7 OR2V1

OR2V2 OR2T11 OR2T27 OR2T35 OR2T4 OR2T2

OR2T33 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for OR2T33
PGOHUM00000244545

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77338923^1,2	F,	--	248435677(+)	`TATAAC/TATAAA`	1	--	ds500¹		1		WA	118
rs181334435^1,2		--	248435740(+)	`ATACAC/GCTATG`	1	--	ds500¹		0	--	--	--	--
rs7521689^1,2	C,F,H,	--	248435831(+)	`TTTCCT/GTGCTG`	1	--	ds500¹		24		NS EA NA WA CSA	2352
rs114301414^1,2		--	248435851(+)	`GGGAAC/TAATAT`	1	--	ds500¹		1		NA	120
rs186062356^1,2		--	248435854(+)	`AACAAC/TATTTA`	1	--	ds500¹		0	--	--	--	--
rs190966712^1,2		--	248435918(+)	`ACTTAC/TATCAT`	1	--	ds500¹		0	--	--	--	--
rs183331239^1,2		--	248436043(+)	`ATCCTA/CTTATA`	1	--	ds500¹		0	--	--	--	--
rs201935245^1,2		--	248436149(+)	`TGACAC/TTAGAT`	1	--	ds500¹		0	--	--	--	--
rs186146649^1,2	C,	--	248436165(+)	`TGACCC/TGTGGG`	2	R G	mis¹		0	--	--	--	--
rs142308940^1,2	C,F,	--	248436184(+)	`TGCTGG/CTGTTT`	2	/H /Q	mis¹		1		NA	4550

HapMap Linkage Disequilibrium report for OR2T33 ( 248436157 - 248437116 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for OR2T33
3 CNVs: 31702 8935 8354

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OR2T33 for disorders About GeneDecksing

4 diseases for OR2T33: About MalaCards

placenta praevia placenta accreta placental abruption neuronitis

2 diseases from the University of Copenhagen DISEASES database for OR2T33:

Placenta accreta Placental abruption

Export disorders for OR2T33 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OR2T33 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR2T33)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The human olfactory receptor gene family. (PubMed id 14983052)^{1, 2} Malnic B.... Buck L.B. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 391195	HGNC: 31255	AceView: OR2T33	Ensembl:ENSG00000177212	euGenes: HUgn391195
ECgene: OR2T33	Kegg: 391195	H-InvDB: OR2T33

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OR2T33	Pharmacogenomics, SNPs, Pathways
HORDE entry for OR2T33	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR2T33 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OR2T33 gene:
Search GeneIP for patents involving OR2T33

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2T33

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes OR2T33 gene at Home site.

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OR2T33 Gene

olfactory receptor, family 2, subfamily T, member 33

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OR2T33 Gene

olfactory receptor, family 2, subfamily T, member 33

Aliasesfor OR2T33 gene

Summariesfor OR2T33 gene

Genomic Viewsfor OR2T33 gene

Proteinsfor OR2T33 gene

Protein Domains /Familiesfor OR2T33 gene

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Genome Databases showing OR2T33 gene

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Specialized Databases showing OR2T33 gene

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Aliases
for OR2T33 gene

Summaries
for OR2T33 gene

Genomic Views
for OR2T33 gene

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for OR2T33 gene

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Families
for OR2T33 gene

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for OR2T33 gene

Pathways & Interactions
for OR2T33 gene

Drugs & Compounds
for OR2T33 gene

Transcripts
for OR2T33 gene

Expression
for OR2T33 gene

Orthologs
for OR2T33 gene

Paralogs
for OR2T33 gene

Genomic Variants
for OR2T33 gene

Disorders / Diseases
for OR2T33 gene

Publications
for OR2T33 gene

Intellectual Property
for OR2T33 gene

Products
for OR2T33 gene