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Aliases for OR2T3 Gene

Aliases for OR2T3 Gene

  • Olfactory Receptor, Family 2, Subfamily T, Member 3 2 3

External Ids for OR2T3 Gene

Summaries for OR2T3 Gene

Entrez Gene Summary for OR2T3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T3 Gene

OR2T3 (Olfactory Receptor, Family 2, Subfamily T, Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2T3 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T3 Gene

Genomics for OR2T3 Gene

Genomic Location for OR2T3 Gene

Start:
248,473,351 bp from pter
End:
248,474,307 bp from pter
Size:
957 bases
Orientation:
Plus strand

Genomic View for OR2T3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2T3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T3 Gene

Regulatory Elements for OR2T3 Gene

Proteins for OR2T3 Gene

  • Protein details for OR2T3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH03-OR2T3_HUMAN
    Recommended name:
    Olfactory receptor 2T3
    Protein Accession:
    Q8NH03
    Secondary Accessions:
    • B2RNJ1

    Protein attributes for OR2T3 Gene

    Size:
    318 amino acids
    Molecular mass:
    35598 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T3 Gene

Proteomics data for OR2T3 Gene at MOPED

Post-translational modifications for OR2T3 Gene

Other Protein References for OR2T3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2T3 Gene

Domains for OR2T3 Gene

Gene Families for OR2T3 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2T3 Gene

UniProtKB/Swiss-Prot:

OR2T3_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NH03
genes like me logo Genes that share domains with OR2T3: view

Function for OR2T3 Gene

Molecular function for OR2T3 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2T3 Gene

Localization for OR2T3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2T3 Gene COMPARTMENTS Subcellular localization image for OR2T3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T3: view

Pathways for OR2T3 Gene

genes like me logo Genes that share pathways with OR2T3: view

Pathways by source for OR2T3 Gene

Interacting Proteins for OR2T3 Gene

Gene Ontology (GO) - Biological Process for OR2T3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T3: view

Transcripts for OR2T3 Gene

mRNA/cDNA for OR2T3 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T3 Gene

No ASD Table

Relevant External Links for OR2T3 Gene

GeneLoc Exon Structure for
OR2T3
ECgene alternative splicing isoforms for
OR2T3

Expression for OR2T3 Gene

mRNA expression in normal human tissues for OR2T3 Gene

SOURCE GeneReport for Unigene cluster for OR2T3 Gene Hs.554481

genes like me logo Genes that share expressions with OR2T3: view

Orthologs for OR2T3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 37
  • 82 (a)
ManyToMany
-- 37
  • 80 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 64 (a)
OneToMany
Species with no ortholog for OR2T3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T3 Gene

ENSEMBL:
Gene Tree for OR2T3 (if available)
TreeFam:
Gene Tree for OR2T3 (if available)

Paralogs for OR2T3 Gene

Selected SIMAP similar genes for OR2T3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2T3: view

Variants for OR2T3 Gene

Sequence variations from dbSNP and Humsavar for OR2T3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs946768 -- 248,473,127(+) GCTCA(G/T)GAATA upstream-variant-2KB
rs946770 -- 248,473,675(+) TCTTC(C/T)ACCTG missense, reference
rs1629670 -- 248,472,288(-) CACCA(C/T)CCCCT upstream-variant-2KB
rs1630445 -- 248,472,215(-) AGTTG(A/C)ATTGT upstream-variant-2KB
rs1630462 -- 248,472,207(-) TGTTT(C/T)AATCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2T3 Gene

Variant ID Type Subtype PubMed ID
nsv515858 CNV Gain+Loss 19592680
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
dgv567n71 CNV Gain 21882294
nsv873462 CNV Loss 21882294
dgv20n17 CNV Loss 16327808
essv15752 CNV CNV 17122850
dgv206e1 CNV Complex 17122850
nsv428357 CNV Loss 18775914
esv2750835 CNV Gain 17911159
dgv569n71 CNV Gain+Loss 21882294
dgv570n71 CNV Gain 21882294
nsv873468 CNV Loss 21882294
dgv571n71 CNV Gain 21882294
nsv873474 CNV Gain 21882294
dgv572n71 CNV Gain+Loss 21882294
nsv7193 OTHER Inversion 18451855
dgv573n71 CNV Gain 21882294
dgv207e1 CNV Complex 17122850
esv32670 CNV Gain+Loss 17666407
nsv873482 CNV Gain 21882294
nsv873483 CNV Gain+Loss 21882294
nsv873484 CNV Loss 21882294
dgv574n71 CNV Gain 21882294
dgv575n71 CNV Gain 21882294
nsv873494 CNV Loss 21882294

Relevant External Links for OR2T3 Gene

HapMap Linkage Disequilibrium report
OR2T3

Disorders for OR2T3 Gene

No disorders were found for OR2T3 Gene.

No data available for UniProtKB/Swiss-Prot for OR2T3 Gene

Publications for OR2T3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2T3 Gene

Sources for OR2T3 Gene

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