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Aliases for OR2T3 Gene

Aliases for OR2T3 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 3 2 3 5
  • Olfactory Receptor, Family 2, Subfamily T, Member 3 2

External Ids for OR2T3 Gene

Previous GeneCards Identifiers for OR2T3 Gene

  • GC01U990371
  • GC01P245535
  • GC01P244963
  • GC01P246703
  • GC01P248636

Summaries for OR2T3 Gene

Entrez Gene Summary for OR2T3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T3 Gene

OR2T3 (Olfactory Receptor Family 2 Subfamily T Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T34.

UniProtKB/Swiss-Prot for OR2T3 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T3 Gene

Genomics for OR2T3 Gene

Regulatory Elements for OR2T3 Gene

Enhancers for OR2T3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F248471 0.5 FANTOM5 0.8 -1.6 -1599 0.4 HDGF TARDBP OR14I1 OR2T1 OR2M2 OR2M7 OR2M5 OR2M4 OR2T33 OR2T6 OR2M3 OR2T10
GH01F248448 0.5 Ensembl 0.3 -24.3 -24261 1.5 POLR2A TARDBP MLLT1 OR2T2 OR2T3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2T3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2T3 Gene

Chromosome:
1
Start:
248,473,351 bp from pter
End:
248,474,307 bp from pter
Size:
957 bases
Orientation:
Plus strand

Genomic View for OR2T3 Gene

Genes around OR2T3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T3 Gene

Proteins for OR2T3 Gene

  • Protein details for OR2T3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH03-OR2T3_HUMAN
    Recommended name:
    Olfactory receptor 2T3
    Protein Accession:
    Q8NH03
    Secondary Accessions:
    • B2RNJ1

    Protein attributes for OR2T3 Gene

    Size:
    318 amino acids
    Molecular mass:
    35598 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T3 Gene

Post-translational modifications for OR2T3 Gene

  • Glycosylation at Asn 5 and Asn 10

Other Protein References for OR2T3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T3 Gene

Domains & Families for OR2T3 Gene

Gene Families for OR2T3 Gene

Protein Domains for OR2T3 Gene

Suggested Antigen Peptide Sequences for OR2T3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH03

UniProtKB/Swiss-Prot:

OR2T3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T3: view

Function for OR2T3 Gene

Molecular function for OR2T3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T3: view

Phenotypes for OR2T3 Gene

GenomeRNAi human phenotypes for OR2T3:
genes like me logo Genes that share phenotypes with OR2T3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T3 Gene

Localization for OR2T3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2T3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T3: view

Pathways & Interactions for OR2T3 Gene

genes like me logo Genes that share pathways with OR2T3: view

Pathways by source for OR2T3 Gene

Gene Ontology (GO) - Biological Process for OR2T3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T3: view

No data available for SIGNOR curated interactions for OR2T3 Gene

Transcripts for OR2T3 Gene

mRNA/cDNA for OR2T3 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T3 Gene

No ASD Table

Relevant External Links for OR2T3 Gene

GeneLoc Exon Structure for
OR2T3
ECgene alternative splicing isoforms for
OR2T3

Expression for OR2T3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2T3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2T3 Gene:

OR2T3

SOURCE GeneReport for Unigene cluster for OR2T3 Gene:

Hs.554481
genes like me logo Genes that share expression patterns with OR2T3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR2T3 Gene

Orthologs for OR2T3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 82 (a)
ManyToMany
-- 35
  • 80 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 64 (a)
OneToMany
Species where no ortholog for OR2T3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T3 Gene

ENSEMBL:
Gene Tree for OR2T3 (if available)
TreeFam:
Gene Tree for OR2T3 (if available)

Paralogs for OR2T3 Gene

(441) SIMAP similar genes for OR2T3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2T3: view

Variants for OR2T3 Gene

Sequence variations from dbSNP and Humsavar for OR2T3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs113200129 -- 248,471,646(+) GAAAC(A/T)GACGA intron-variant, upstream-variant-2KB
rs113286914 -- 248,474,791(+) TCTCC(A/C)AAGGC intron-variant, downstream-variant-500B
rs113467668 -- 248,471,992(+) TTGTT(A/T)TTTTG intron-variant, upstream-variant-2KB
rs114641156 -- 248,472,046(+) TCCAC(A/G)TGCCT intron-variant, upstream-variant-2KB
rs116232546 -- 248,472,673(+) TGCAC(C/T)CCAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2T3 Gene

Variant ID Type Subtype PubMed ID
dgv163e212 CNV gain 25503493
dgv17e55 CNV loss 17911159
dgv20n17 CNV loss 16327808
dgv323n106 OTHER inversion 24896259
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
nsv945471 CNV duplication 23825009
nsv7193 OTHER inversion 18451855
nsv549641 CNV gain 21841781
nsv549630 CNV loss 21841781
nsv549603 CNV loss 21841781
nsv515858 CNV gain+loss 19592680
nsv428357 CNV loss 18775914
nsv1150779 OTHER inversion 26484159
nsv1079019 OTHER inversion 25765185
nsv1013273 CNV gain 25217958
nsv1009036 CNV gain+loss 25217958
nsv1007621 CNV gain 25217958
nsv1004790 CNV gain 25217958
nsv1001494 CNV gain 25217958
nsv1001474 CNV gain 25217958
esv3891415 CNV gain 25118596
esv3578547 CNV loss 25503493
esv3575950 CNV gain 25503493
esv3575894 CNV gain 25503493
esv3424893 CNV duplication 20981092
esv32670 CNV gain+loss 17666407
esv2760083 CNV gain+loss 21179565
esv2759015 CNV gain+loss 17122850
esv2750835 CNV gain 17911159
esv2750832 CNV gain 17911159
dgv906n54 CNV gain 21841781
dgv617n100 CNV gain 25217958
dgv616n100 CNV gain 25217958
dgv615n100 CNV loss 25217958
dgv613n100 CNV loss 25217958

Variation tolerance for OR2T3 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.03; 87.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2T3 Gene

Human Gene Mutation Database (HGMD)
OR2T3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2T3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T3 Gene

Disorders for OR2T3 Gene

Relevant External Links for OR2T3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2T3

No disorders were found for OR2T3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T3 Gene

Publications for OR2T3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR2T3 Gene

Sources for OR2T3 Gene

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