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Aliases for OR2T27 Gene

Aliases for OR2T27 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 27 2 3 5
  • Olfactory Receptor, Family 2, Subfamily T, Member 27 2
  • Olfactory Receptor OR1-67 4

External Ids for OR2T27 Gene

Previous GeneCards Identifiers for OR2T27 Gene

  • GC01U901014
  • GC01M245139
  • GC01M246879
  • GC01M248813

Summaries for OR2T27 Gene

Entrez Gene Summary for OR2T27 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T27 Gene

OR2T27 (Olfactory Receptor Family 2 Subfamily T Member 27) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2T27 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T27 Gene

Additional gene information for OR2T27 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T27 Gene

Genomics for OR2T27 Gene

GeneHancer (GH) Regulatory Elements for OR2T27 Gene

Promoters and enhancers for OR2T27 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I248650 Promoter 0.5 EPDnew 550.8 +4.6 4599 0.1 OR2T27 OR2T35 OR14I1
GH01I248654 Enhancer 0.2 dbSUPER 550.8 -0.6 -589 3.5 OR2T27 ENSG00000229255 OR2W3 LOC101928226 OR14I1
GH01I248663 Enhancer 0.8 ENCODE dbSUPER 0.4 -8.1 -8147 0.2 ELF1 DPF2 IKZF1 TARDBP ZNF143 MLLT1 IKZF2 SPI1 OR2T27 LOC101928226 OR14I1
GH01I248686 Enhancer 0.6 ENCODE 0.3 -31.5 -31517 0.1 CTCF TRIM22 EBF1 ATF2 RAD21 ZNF143 MLLT1 ETV6 BCLAF1 SPI1 OR2T1 LOC101928226 OR14I1 OR2T27
GH01I248658 Enhancer 0.2 dbSUPER 0.8 -4.1 -4129 1.5 ENSG00000229255 LOC101928226 SH3BP5L OR2T27 OR14I1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR2T27 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2T27 gene promoter:

Genomic Locations for OR2T27 Gene

Genomic Locations for OR2T27 Gene
5,691 bases
Minus strand

Genomic View for OR2T27 Gene

Genes around OR2T27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T27 Gene

Proteins for OR2T27 Gene

  • Protein details for OR2T27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2T27
    Protein Accession:

    Protein attributes for OR2T27 Gene

    317 amino acids
    Molecular mass:
    35514 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T27 Gene

Post-translational modifications for OR2T27 Gene

Other Protein References for OR2T27 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T27 Gene

Domains & Families for OR2T27 Gene

Gene Families for OR2T27 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2T27 Gene

Suggested Antigen Peptide Sequences for OR2T27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T27: view

Function for OR2T27 Gene

Molecular function for OR2T27 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T27: view

Phenotypes for OR2T27 Gene

GenomeRNAi human phenotypes for OR2T27:
genes like me logo Genes that share phenotypes with OR2T27: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T27 Gene

Localization for OR2T27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T27 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2T27 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2T27 Gene

Pathways & Interactions for OR2T27 Gene

genes like me logo Genes that share pathways with OR2T27: view

Pathways by source for OR2T27 Gene

Interacting Proteins for OR2T27 Gene

Gene Ontology (GO) - Biological Process for OR2T27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T27: view

No data available for SIGNOR curated interactions for OR2T27 Gene

Drugs & Compounds for OR2T27 Gene

No Compound Related Data Available

Transcripts for OR2T27 Gene

mRNA/cDNA for OR2T27 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T27 Gene

No ASD Table

Relevant External Links for OR2T27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2T27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2T27 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2T27 Gene:


SOURCE GeneReport for Unigene cluster for OR2T27 Gene:

genes like me logo Genes that share expression patterns with OR2T27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2T27 Gene

Orthologs for OR2T27 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC469773 33
  • 98.42 (n)
-- 34
  • 97 (a)
(Canis familiaris)
Mammalia -- 34
  • 88 (a)
LOC482239 33
  • 85.91 (n)
(Bos Taurus)
Mammalia OR2T27 33
  • 86.37 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 83 (a)
Species where no ortholog for OR2T27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T27 Gene

Gene Tree for OR2T27 (if available)
Gene Tree for OR2T27 (if available)

Paralogs for OR2T27 Gene

(440) SIMAP similar genes for OR2T27 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2T27: view

Variants for OR2T27 Gene

Sequence variations from dbSNP and Humsavar for OR2T27 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1008535294 -- 248,651,939(-) A/G upstream_transcript_variant
rs1008566379 -- 248,650,453(-) A/G coding_sequence_variant, synonymous_variant
rs1010091872 -- 248,652,706(-) T/C upstream_transcript_variant
rs1017289144 -- 248,651,944(-) G/A upstream_transcript_variant
rs1017319712 -- 248,650,458(-) A/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2T27 Gene

Variant ID Type Subtype PubMed ID
dgv165e212 CNV gain 25503493
dgv166e212 CNV loss 25503493
dgv168e212 CNV loss 25503493
dgv17e55 CNV loss 17911159
dgv20n17 CNV loss 16327808
dgv29n111 CNV deletion 26073780
dgv323n106 OTHER inversion 24896259
dgv607n100 CNV loss 25217958
dgv622n100 CNV loss 25217958
dgv625n100 CNV gain 25217958
dgv626n100 CNV loss 25217958
dgv630n100 CNV gain+loss 25217958
dgv631n100 CNV gain 25217958
dgv635n100 CNV loss 25217958
dgv636n100 CNV gain+loss 25217958
dgv637n100 CNV loss 25217958
dgv638n100 CNV gain 25217958
dgv639n100 CNV gain 25217958
dgv642n100 CNV gain 25217958
dgv643n100 CNV gain 25217958
dgv906n54 CNV gain 21841781
dgv914n54 CNV loss 21841781
dgv920n54 CNV loss 21841781
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv2759015 CNV gain+loss 17122850
esv2760083 CNV gain+loss 21179565
esv2763780 CNV loss 21179565
esv3589561 CNV gain 21293372
esv3891415 CNV gain 25118596
esv3891426 CNV loss 25118596
nsv1003091 CNV gain 25217958
nsv1003605 CNV gain 25217958
nsv1004790 CNV gain 25217958
nsv1010059 CNV loss 25217958
nsv1013273 CNV gain 25217958
nsv1069433 CNV deletion 25765185
nsv1079019 OTHER inversion 25765185
nsv1130989 CNV deletion 24896259
nsv1160483 CNV duplication 26073780
nsv428357 CNV loss 18775914
nsv433194 CNV loss 18776910
nsv469750 CNV loss 16826518
nsv515858 CNV gain+loss 19592680
nsv549603 CNV loss 21841781
nsv549735 CNV loss 21841781
nsv7193 OTHER inversion 18451855
nsv945480 CNV duplication 23825009
nsv953348 CNV deletion 24416366

Variation tolerance for OR2T27 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.88; 95.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2T27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T27 Gene

Disorders for OR2T27 Gene

Additional Disease Information for OR2T27

No disorders were found for OR2T27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T27 Gene

Publications for OR2T27 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58

Products for OR2T27 Gene

Sources for OR2T27 Gene

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