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Aliases for OR2T27 Gene

Aliases for OR2T27 Gene

  • Olfactory Receptor, Family 2, Subfamily T, Member 27 2 3
  • Olfactory Receptor OR1-67 4

External Ids for OR2T27 Gene

Previous GeneCards Identifiers for OR2T27 Gene

  • GC01U901014
  • GC01M245139
  • GC01M246879
  • GC01M248813

Summaries for OR2T27 Gene

Entrez Gene Summary for OR2T27 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T27 Gene

OR2T27 (Olfactory Receptor, Family 2, Subfamily T, Member 27) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2T27 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T27 Gene

Genomics for OR2T27 Gene

Regulatory Elements for OR2T27 Gene

Genomic Location for OR2T27 Gene

Start:
248,649,931 bp from pter
End:
248,650,884 bp from pter
Size:
954 bases
Orientation:
Minus strand

Genomic View for OR2T27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2T27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T27 Gene

Proteins for OR2T27 Gene

  • Protein details for OR2T27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH04-O2T27_HUMAN
    Recommended name:
    Olfactory receptor 2T27
    Protein Accession:
    Q8NH04
    Secondary Accessions:

    Protein attributes for OR2T27 Gene

    Size:
    317 amino acids
    Molecular mass:
    35514 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T27 Gene

Proteomics data for OR2T27 Gene at MOPED

Post-translational modifications for OR2T27 Gene

Other Protein References for OR2T27 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T27 Gene

Domains for OR2T27 Gene

Gene Families for OR2T27 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2T27 Gene

Suggested Antigen Peptide Sequences for OR2T27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH04

UniProtKB/Swiss-Prot:

O2T27_HUMAN :
  • Q8NH04
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T27: view

Function for OR2T27 Gene

Molecular function for OR2T27 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T27: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2T27 Gene

Localization for OR2T27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T27 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2T27 Gene COMPARTMENTS Subcellular localization image for OR2T27 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T27: view

Pathways for OR2T27 Gene

genes like me logo Genes that share pathways with OR2T27: view

Pathways by source for OR2T27 Gene

Interacting Proteins for OR2T27 Gene

Gene Ontology (GO) - Biological Process for OR2T27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T27: view

Transcripts for OR2T27 Gene

mRNA/cDNA for OR2T27 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2T27

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR2T27
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T27 Gene

No ASD Table

Relevant External Links for OR2T27 Gene

GeneLoc Exon Structure for
OR2T27
ECgene alternative splicing isoforms for
OR2T27

Expression for OR2T27 Gene

mRNA expression in normal human tissues for OR2T27 Gene

SOURCE GeneReport for Unigene cluster for OR2T27 Gene Hs.553814

genes like me logo Genes that share expressions with OR2T27: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR2T27 Gene

Orthologs for OR2T27 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
LOC469773 35
  • 98.42 (n)
  • 97.16 (a)
cow
(Bos Taurus)
Mammalia OR2T27 35
  • 86.37 (n)
  • 90.42 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
OneToMany
LOC482239 35
  • 85.91 (n)
  • 87.7 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
Species with no ortholog for OR2T27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T27 Gene

ENSEMBL:
Gene Tree for OR2T27 (if available)
TreeFam:
Gene Tree for OR2T27 (if available)

Paralogs for OR2T27 Gene

Selected SIMAP similar genes for OR2T27 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR2T27 Gene

genes like me logo Genes that share paralogs with OR2T27: view

Variants for OR2T27 Gene

Sequence variations from dbSNP and Humsavar for OR2T27 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs954307 -- 248,651,921(+) AACAC(A/G)TCTCC upstream-variant-2KB
rs1632651 -- 248,651,687(+) TCTCA(A/T)ACTTG upstream-variant-2KB
rs1782236 -- 248,649,616(+) TTTTG(C/T)CATGA downstream-variant-500B
rs1782237 -- 248,649,646(+) GGCTA(C/G)TCCAT downstream-variant-500B
rs1782238 -- 248,649,825(+) AGTTG(C/G)TGGCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR2T27 Gene

Variant ID Type Subtype PubMed ID
nsv515858 CNV Gain+Loss 19592680
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
nsv873462 CNV Loss 21882294
dgv20n17 CNV Loss 16327808
dgv206e1 CNV Complex 17122850
nsv428357 CNV Loss 18775914
esv2750835 CNV Gain 17911159
dgv571n71 CNV Gain 21882294
nsv7193 OTHER Inversion 18451855
dgv207e1 CNV Complex 17122850
dgv575n71 CNV Gain 21882294
dgv208e1 CNV Complex 17122850
nsv483043 CNV Complex 15286789
nsv469750 CNV Loss 16826518
dgv579n71 CNV Loss 21882294
nsv873510 CNV Gain 21882294
nsv433194 CNV Loss 18776910

Relevant External Links for OR2T27 Gene

HapMap Linkage Disequilibrium report
OR2T27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T27 Gene

Disorders for OR2T27 Gene

No disorders were found for OR2T27 Gene.

No data available for UniProtKB/Swiss-Prot for OR2T27 Gene

Publications for OR2T27 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for OR2T27 Gene

Sources for OR2T27 Gene

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