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Aliases for OR2T12 Gene

Aliases for OR2T12 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 12 2 3 5
  • Olfactory Receptor OR1-57 3 4
  • Novel 7 Transmembrane Receptor (Rhodopsin Family) Protein 3
  • Olfactory Receptor, Family 2, Subfamily T, Member 12 2
  • Olfactory Receptor 2T12 3
  • OR1-57 3

External Ids for OR2T12 Gene

Previous GeneCards Identifiers for OR2T12 Gene

  • GC00U903057
  • GC01M245356
  • GC01M244785
  • GC01M246524
  • GC01M248457

Summaries for OR2T12 Gene

Entrez Gene Summary for OR2T12 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T12 Gene

OR2T12 (Olfactory Receptor Family 2 Subfamily T Member 12) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T33.

UniProtKB/Swiss-Prot for OR2T12 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T12 Gene

Genomics for OR2T12 Gene

Regulatory Elements for OR2T12 Gene

Enhancers for OR2T12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G247905 1.2 Ensembl ENCODE 5.2 +388.7 388735 1.9 HDAC1 PKNOX1 ZBTB40 TCF12 FOS U2AF2 ZBTB2 CEBPB ELF4 ELF1 OR2AJ1 TRIM58 OR2T8 OR2T12 OR2W3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2T12 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2T12 Gene

Chromosome:
1
Start:
248,294,616 bp from pter
End:
248,295,578 bp from pter
Size:
963 bases
Orientation:
Minus strand

Genomic View for OR2T12 Gene

Genes around OR2T12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T12 Gene

Proteins for OR2T12 Gene

  • Protein details for OR2T12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG77-O2T12_HUMAN
    Recommended name:
    Olfactory receptor 2T12
    Protein Accession:
    Q8NG77

    Protein attributes for OR2T12 Gene

    Size:
    320 amino acids
    Molecular mass:
    35946 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T12 Gene

Post-translational modifications for OR2T12 Gene

Other Protein References for OR2T12 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T12 Gene

Domains & Families for OR2T12 Gene

Gene Families for OR2T12 Gene

Protein Domains for OR2T12 Gene

Suggested Antigen Peptide Sequences for OR2T12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG77

UniProtKB/Swiss-Prot:

O2T12_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T12: view

Function for OR2T12 Gene

Molecular function for OR2T12 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T12: view
genes like me logo Genes that share phenotypes with OR2T12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T12 Gene

Localization for OR2T12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T12 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2T12 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T12: view

Pathways & Interactions for OR2T12 Gene

genes like me logo Genes that share pathways with OR2T12: view

Pathways by source for OR2T12 Gene

Interacting Proteins for OR2T12 Gene

Gene Ontology (GO) - Biological Process for OR2T12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T12: view

No data available for SIGNOR curated interactions for OR2T12 Gene

Transcripts for OR2T12 Gene

mRNA/cDNA for OR2T12 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T12 Gene

No ASD Table

Relevant External Links for OR2T12 Gene

GeneLoc Exon Structure for
OR2T12
ECgene alternative splicing isoforms for
OR2T12

Expression for OR2T12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2T12 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2T12 Gene:

OR2T12

SOURCE GeneReport for Unigene cluster for OR2T12 Gene:

Hs.553582
genes like me logo Genes that share expression patterns with OR2T12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2T12 Gene

Orthologs for OR2T12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469761 34
  • 97.92 (n)
-- 35
  • 97 (a)
OneToMany
-- 35
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia OR2T12 34
  • 79.94 (n)
-- 35
  • 75 (a)
ManyToMany
-- 35
  • 74 (a)
ManyToMany
-- 35
  • 71 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr314 35
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 57 (a)
OneToMany
Species where no ortholog for OR2T12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T12 Gene

ENSEMBL:
Gene Tree for OR2T12 (if available)
TreeFam:
Gene Tree for OR2T12 (if available)

Paralogs for OR2T12 Gene

(449) SIMAP similar genes for OR2T12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2T12: view

Variants for OR2T12 Gene

Sequence variations from dbSNP and Humsavar for OR2T12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000198409 -- 248,296,104(+) CCGGT(A/G)TTTGG upstream-variant-2KB
rs1000547542 -- 248,296,919(+) ATGAA(A/G)TCCTT upstream-variant-2KB
rs1000875848 -- 248,296,112(+) TGGTT(C/T)TTTGT upstream-variant-2KB
rs1001483185 -- 248,296,533(+) CTTTT(G/T)AATGA upstream-variant-2KB
rs1001867501 -- 248,297,338(+) GTGGG(C/T)TCTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2T12 Gene

Variant ID Type Subtype PubMed ID
dgv17e55 CNV loss 17911159
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv613n100 CNV loss 25217958
dgv905n54 CNV gain 21841781
esv2750832 CNV gain 17911159
esv3891415 CNV gain 25118596
nsv1001474 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv515858 CNV gain+loss 19592680
nsv549597 CNV gain 21841781
nsv549603 CNV loss 21841781
nsv549604 CNV gain 21841781
nsv549626 CNV loss 21841781
nsv549630 CNV loss 21841781
nsv9103 CNV loss 18304495
nsv945464 CNV duplication 23825009

Variation tolerance for OR2T12 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.30; 88.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2T12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2T12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T12 Gene

Disorders for OR2T12 Gene

Relevant External Links for OR2T12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2T12

No disorders were found for OR2T12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T12 Gene

Publications for OR2T12 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64

Products for OR2T12 Gene

Sources for OR2T12 Gene

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