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Aliases for OR2T12 Gene

Aliases for OR2T12 Gene

  • Olfactory Receptor, Family 2, Subfamily T, Member 12 2 3
  • Olfactory Receptor OR1-57 3 4
  • Novel 7 Transmembrane Receptor (Rhodopsin Family) Protein 3
  • Olfactory Receptor 2T12 3
  • OR1-57 3

External Ids for OR2T12 Gene

Previous GeneCards Identifiers for OR2T12 Gene

  • GC00U903057
  • GC01M245356
  • GC01M244785
  • GC01M246524
  • GC01M248457

Summaries for OR2T12 Gene

Entrez Gene Summary for OR2T12 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T12 Gene

OR2T12 (Olfactory Receptor, Family 2, Subfamily T, Member 12) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2T12 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T12 Gene

Genomics for OR2T12 Gene

Regulatory Elements for OR2T12 Gene

Genomic Location for OR2T12 Gene

Start:
248,294,616 bp from pter
End:
248,295,578 bp from pter
Size:
963 bases
Orientation:
Minus strand

Genomic View for OR2T12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2T12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T12 Gene

Proteins for OR2T12 Gene

  • Protein details for OR2T12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG77-O2T12_HUMAN
    Recommended name:
    Olfactory receptor 2T12
    Protein Accession:
    Q8NG77
    Secondary Accessions:

    Protein attributes for OR2T12 Gene

    Size:
    320 amino acids
    Molecular mass:
    35946 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T12 Gene

Proteomics data for OR2T12 Gene at MOPED

Post-translational modifications for OR2T12 Gene

Other Protein References for OR2T12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T12 Gene

Domains for OR2T12 Gene

Gene Families for OR2T12 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2T12 Gene

Suggested Antigen Peptide Sequences for OR2T12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG77

UniProtKB/Swiss-Prot:

O2T12_HUMAN :
  • Q8NG77
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T12: view

Function for OR2T12 Gene

Molecular function for OR2T12 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T12: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2T12 Gene

Localization for OR2T12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T12 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2T12 Gene COMPARTMENTS Subcellular localization image for OR2T12 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T12: view

Pathways for OR2T12 Gene

genes like me logo Genes that share pathways with OR2T12: view

Pathways by source for OR2T12 Gene

Interacting Proteins for OR2T12 Gene

Gene Ontology (GO) - Biological Process for OR2T12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T12: view

Transcripts for OR2T12 Gene

mRNA/cDNA for OR2T12 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2T12

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR2T12
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T12 Gene

No ASD Table

Relevant External Links for OR2T12 Gene

GeneLoc Exon Structure for
OR2T12
ECgene alternative splicing isoforms for
OR2T12

Expression for OR2T12 Gene

mRNA expression in normal human tissues for OR2T12 Gene

SOURCE GeneReport for Unigene cluster for OR2T12 Gene Hs.553582

genes like me logo Genes that share expressions with OR2T12: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR2T12 Gene

Orthologs for OR2T12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
LOC469761 35
  • 97.92 (n)
  • 97.19 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
OR2T12 35
  • 79.94 (n)
  • 75.73 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr314 36
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
OneToMany
Species with no ortholog for OR2T12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T12 Gene

ENSEMBL:
Gene Tree for OR2T12 (if available)
TreeFam:
Gene Tree for OR2T12 (if available)

Paralogs for OR2T12 Gene

Selected SIMAP similar genes for OR2T12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2T12: view

Variants for OR2T12 Gene

Sequence variations from dbSNP and Humsavar for OR2T12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6667171 - 248,294,677(+) GCCAC(A/C)GTTTC reference, missense
rs6674940 -- 248,295,387(+) AGGGA(A/G)AGTTG synonymous-codon, reference
rs6678138 - 248,295,374(+) CATCA(C/T)GTCCA reference, missense
rs7543507 -- 248,297,118(+) cctct(C/T)cccat upstream-variant-2KB
rs7547808 -- 248,297,033(+) gtata(A/T)ggtgt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2T12 Gene

Variant ID Type Subtype PubMed ID
nsv515858 CNV Gain+Loss 19592680
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
nsv9103 CNV Loss 18304495
dgv566n71 CNV Gain 21882294
dgv567n71 CNV Gain 21882294
dgv568n71 CNV Loss 21882294
nsv873459 CNV Loss 21882294
nsv873461 CNV Gain 21882294
nsv873462 CNV Loss 21882294

Relevant External Links for OR2T12 Gene

HapMap Linkage Disequilibrium report
OR2T12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T12 Gene

Disorders for OR2T12 Gene

(1) University of Copenhagen DISEASES for OR2T12 Gene

genes like me logo Genes that share disorders with OR2T12: view

No data available for UniProtKB/Swiss-Prot for OR2T12 Gene

Publications for OR2T12 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for OR2T12 Gene

Sources for OR2T12 Gene

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