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Aliases for OR2T11 Gene

Aliases for OR2T11 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 11 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 2, Subfamily T, Member 11 2 3
  • Olfactory Receptor OR1-65 3 4
  • Olfactory Receptor, Family 2, Subfamily T, Member 11 (Gene/Pseudogene) 2
  • OR2T11Q 3

External Ids for OR2T11 Gene

Previous GeneCards Identifiers for OR2T11 Gene

  • GC00U903042
  • GC01U901023
  • GC01M245116
  • GC01M246856
  • GC01M248789

Summaries for OR2T11 Gene

Entrez Gene Summary for OR2T11 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR2T11 Gene

OR2T11 (Olfactory Receptor Family 2 Subfamily T Member 11 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2T11 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T11 Gene

Genomics for OR2T11 Gene

Regulatory Elements for OR2T11 Gene

Genomic Location for OR2T11 Gene

Chromosome:
1
Start:
248,626,178 bp from pter
End:
248,627,128 bp from pter
Size:
951 bases
Orientation:
Minus strand

Genomic View for OR2T11 Gene

Genes around OR2T11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T11 Gene

Proteins for OR2T11 Gene

  • Protein details for OR2T11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH01-O2T11_HUMAN
    Recommended name:
    Olfactory receptor 2T11
    Protein Accession:
    Q8NH01
    Secondary Accessions:
    • Q6IEY6

    Protein attributes for OR2T11 Gene

    Size:
    316 amino acids
    Molecular mass:
    34797 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T11 Gene

Proteomics data for OR2T11 Gene at MOPED

Post-translational modifications for OR2T11 Gene

Other Protein References for OR2T11 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

No data available for DME Specific Peptides for OR2T11 Gene

Domains & Families for OR2T11 Gene

Gene Families for OR2T11 Gene

Protein Domains for OR2T11 Gene

Suggested Antigen Peptide Sequences for OR2T11 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NH01

UniProtKB/Swiss-Prot:

O2T11_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T11: view

Function for OR2T11 Gene

Molecular function for OR2T11 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR2T11 Gene

genes like me logo Genes that share phenotypes with OR2T11: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T11 Gene

Localization for OR2T11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2T11 Gene COMPARTMENTS Subcellular localization image for OR2T11 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2T11: view

Pathways & Interactions for OR2T11 Gene

genes like me logo Genes that share pathways with OR2T11: view

Pathways by source for OR2T11 Gene

Interacting Proteins for OR2T11 Gene

Gene Ontology (GO) - Biological Process for OR2T11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T11: view

No data available for SIGNOR curated interactions for OR2T11 Gene

Drugs & Compounds for OR2T11 Gene

No Compound Related Data Available

Transcripts for OR2T11 Gene

mRNA/cDNA for OR2T11 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T11 Gene

No ASD Table

Relevant External Links for OR2T11 Gene

GeneLoc Exon Structure for
OR2T11
ECgene alternative splicing isoforms for
OR2T11

Expression for OR2T11 Gene

mRNA expression in normal human tissues for OR2T11 Gene

Protein differential expression in normal tissues from HIPED for OR2T11 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2T11 Gene



SOURCE GeneReport for Unigene cluster for OR2T11 Gene Hs.626619

genes like me logo Genes that share expression patterns with OR2T11: view

Protein tissue co-expression partners for OR2T11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR2T11 Gene

Orthologs for OR2T11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR2T11 35
  • 85.29 (n)
  • 88.89 (a)
OR2T11 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COR2T18 35
  • 87.29 (n)
  • 90.06 (a)
OR2T11 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC469778 35
  • 98.42 (n)
  • 96.84 (a)
OR2T11 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR2T11 36
  • 84 (a)
OneToOne
Species with no ortholog for OR2T11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T11 Gene

ENSEMBL:
Gene Tree for OR2T11 (if available)
TreeFam:
Gene Tree for OR2T11 (if available)

Paralogs for OR2T11 Gene

(451) SIMAP similar genes for OR2T11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR2T11: view

Variants for OR2T11 Gene

Sequence variations from dbSNP and Humsavar for OR2T11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_053155 -
VAR_053156 -

Structural Variations from Database of Genomic Variants (DGV) for OR2T11 Gene

Variant ID Type Subtype PubMed ID
nsv515858 CNV Gain+Loss 19592680
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
nsv873462 CNV Loss 21882294
dgv20n17 CNV Loss 16327808
dgv206e1 CNV Complex 17122850
nsv428357 CNV Loss 18775914
esv2750835 CNV Gain 17911159
dgv571n71 CNV Gain 21882294
nsv7193 OTHER Inversion 18451855
dgv207e1 CNV Complex 17122850
dgv575n71 CNV Gain 21882294
nsv821623 CNV Loss 15273396
dgv208e1 CNV Complex 17122850
nsv483043 CNV Complex 15286789
nsv469750 CNV Loss 16826518
nsv5365 CNV Loss 18451855
dgv577n71 CNV Loss 21882294
dgv116n67 CNV Loss 20364138
esv29940 CNV Loss 18421352
esv33052 CNV Gain+Loss 17666407
esv27363 CNV Loss 19812545
dgv578n71 CNV Gain 21882294
nsv873503 CNV Gain+Loss 21882294
dgv579n71 CNV Loss 21882294
nsv873510 CNV Gain 21882294
nsv9191 CNV Gain+Loss 18304495
esv2660478 CNV Deletion 23128226
dgv5n14 CNV Loss 18776910
esv2421359 CNV Deletion 20811451
nsv433194 CNV Loss 18776910
nsv471517 CNV Deletion 19718026
dgv580n71 CNV Loss 21882294
nsv442637 CNV CNV 18776908
nsv827864 CNV Loss 20364138
nsv514048 CNV Loss 21397061
nsv442999 CNV Loss 18674749
nsv471355 CNV Deletion 19718026

Variation tolerance for OR2T11 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.07; 68.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2T11 Gene

HapMap Linkage Disequilibrium report
OR2T11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T11 Gene

Disorders for OR2T11 Gene

Relevant External Links for OR2T11

Genetic Association Database (GAD)
OR2T11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2T11

No disorders were found for OR2T11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T11 Gene

Publications for OR2T11 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3
  3. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2T11 Gene

Sources for OR2T11 Gene

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