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Aliases for OR2T11 Gene

Aliases for OR2T11 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 11 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 2, Subfamily T, Member 11 2 3
  • Olfactory Receptor OR1-65 3 4
  • Olfactory Receptor, Family 2, Subfamily T, Member 11 (Gene/Pseudogene) 2
  • Olfactory Receptor 2T11 3
  • OR2T11Q 3

External Ids for OR2T11 Gene

Previous GeneCards Identifiers for OR2T11 Gene

  • GC00U903042
  • GC01U901023
  • GC01M245116
  • GC01M246856
  • GC01M248789

Summaries for OR2T11 Gene

Entrez Gene Summary for OR2T11 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR2T11 Gene

OR2T11 (Olfactory Receptor Family 2 Subfamily T Member 11 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T35.

UniProtKB/Swiss-Prot for OR2T11 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T11 Gene

Genomics for OR2T11 Gene

Regulatory Elements for OR2T11 Gene

Enhancers for OR2T11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G248471 0.6 FANTOM5 3.5 +155.4 155438 0.4 HDGF TARDBP MAFG ZNF207 OR14I1 OR2T1 OR2M2 OR2M7 OR2M5 OR2M4 OR2T33 OR2T6 OR2M3 OR2T10
GH01G248631 0.7 ENCODE 0.7 -4.6 -4625 0.2 GATAD2A JUN HLF CEBPB MAX CEBPG JUND ATF3 CEBPA FOS LOC101928226 OR2T11 OR2T35
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2T11 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2T11 Gene

Chromosome:
1
Start:
248,626,119 bp from pter
End:
248,627,190 bp from pter
Size:
1,072 bases
Orientation:
Minus strand

Genomic View for OR2T11 Gene

Genes around OR2T11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T11 Gene

Proteins for OR2T11 Gene

  • Protein details for OR2T11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH01-O2T11_HUMAN
    Recommended name:
    Olfactory receptor 2T11
    Protein Accession:
    Q8NH01
    Secondary Accessions:
    • Q6IEY6

    Protein attributes for OR2T11 Gene

    Size:
    316 amino acids
    Molecular mass:
    34797 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T11 Gene

Post-translational modifications for OR2T11 Gene

Other Protein References for OR2T11 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T11 Gene

Domains & Families for OR2T11 Gene

Gene Families for OR2T11 Gene

Protein Domains for OR2T11 Gene

Suggested Antigen Peptide Sequences for OR2T11 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NH01

UniProtKB/Swiss-Prot:

O2T11_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T11: view

Function for OR2T11 Gene

Molecular function for OR2T11 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T11: view
genes like me logo Genes that share phenotypes with OR2T11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T11 Gene

Localization for OR2T11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2T11 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T11: view

Pathways & Interactions for OR2T11 Gene

genes like me logo Genes that share pathways with OR2T11: view

Pathways by source for OR2T11 Gene

Interacting Proteins for OR2T11 Gene

Gene Ontology (GO) - Biological Process for OR2T11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA,IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T11: view

No data available for SIGNOR curated interactions for OR2T11 Gene

Drugs & Compounds for OR2T11 Gene

No Compound Related Data Available

Transcripts for OR2T11 Gene

mRNA/cDNA for OR2T11 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T11 Gene

No ASD Table

Relevant External Links for OR2T11 Gene

GeneLoc Exon Structure for
OR2T11
ECgene alternative splicing isoforms for
OR2T11

Expression for OR2T11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2T11 Gene

Protein differential expression in normal tissues from HIPED for OR2T11 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2T11 Gene



Protein tissue co-expression partners for OR2T11 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2T11 Gene:

OR2T11

SOURCE GeneReport for Unigene cluster for OR2T11 Gene:

Hs.626619
genes like me logo Genes that share expression patterns with OR2T11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2T11 Gene

Orthologs for OR2T11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469778 34
  • 98.42 (n)
dog
(Canis familiaris)
Mammalia COR2T18 34
  • 87.29 (n)
cow
(Bos Taurus)
Mammalia OR2T11 34
  • 85.29 (n)
Species where no ortholog for OR2T11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T11 Gene

ENSEMBL:
Gene Tree for OR2T11 (if available)
TreeFam:
Gene Tree for OR2T11 (if available)

Paralogs for OR2T11 Gene

(451) SIMAP similar genes for OR2T11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR2T11: view

Variants for OR2T11 Gene

Sequence variations from dbSNP and Humsavar for OR2T11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1003113350 -- 248,627,030(+) GCCCC(C/G)AAGAA intron-variant, reference, missense
rs1004888092 -- 248,625,772(+) CATTC(-/A)TTTTA intron-variant, downstream-variant-500B
rs1006419833 -- 248,627,350(+) CAGCT(C/T)CTTCT intron-variant, upstream-variant-2KB
rs1007400113 -- 248,628,836(+) TCAGG(C/T)CTCCC intron-variant, upstream-variant-2KB
rs1011866971 -- 248,626,023(+) AACAT(C/T)TTTCC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR2T11 Gene

Variant ID Type Subtype PubMed ID
dgv116n67 CNV loss 20364138
dgv165e212 CNV gain 25503493
dgv166e212 CNV loss 25503493
dgv167e212 CNV loss 25503493
dgv168e212 CNV loss 25503493
dgv17e55 CNV loss 17911159
dgv20n17 CNV loss 16327808
dgv29n111 CNV deletion 26073780
dgv323n106 OTHER inversion 24896259
dgv5n14 CNV loss 18776910
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv618n100 CNV loss 25217958
dgv620n100 CNV loss 25217958
dgv621n100 CNV gain+loss 25217958
dgv622n100 CNV loss 25217958
dgv623n100 CNV loss 25217958
dgv624n100 CNV gain+loss 25217958
dgv625n100 CNV gain 25217958
dgv626n100 CNV loss 25217958
dgv627n100 CNV loss 25217958
dgv628n100 CNV loss 25217958
dgv629n100 CNV gain+loss 25217958
dgv630n100 CNV gain+loss 25217958
dgv631n100 CNV gain 25217958
dgv632n100 CNV loss 25217958
dgv633n100 CNV gain+loss 25217958
dgv634n100 CNV loss 25217958
dgv635n100 CNV loss 25217958
dgv636n100 CNV gain+loss 25217958
dgv637n100 CNV loss 25217958
dgv638n100 CNV gain 25217958
dgv639n100 CNV gain 25217958
dgv640n100 CNV loss 25217958
dgv641n100 CNV loss 25217958
dgv7e213 CNV loss 24956385
dgv906n54 CNV gain 21841781
dgv909n54 CNV loss 21841781
dgv911n54 CNV loss 21841781
dgv913n54 CNV loss 21841781
dgv914n54 CNV loss 21841781
dgv916n54 CNV loss 21841781
dgv918n54 CNV loss 21841781
dgv919n54 CNV loss 21841781
dgv920n54 CNV loss 21841781
dgv921n54 CNV loss 21841781
dgv922n54 CNV loss 21841781
esv2421359 CNV deletion 20811451
esv2660478 CNV deletion 23128226
esv27363 CNV loss 19812545
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv2759015 CNV gain+loss 17122850
esv2760083 CNV gain+loss 21179565
esv2763780 CNV loss 21179565
esv29940 CNV loss 18421352
esv33052 CNV gain+loss 17666407
esv3589559 CNV loss 21293372
esv3589560 CNV gain 21293372
esv3891415 CNV gain 25118596
esv3891426 CNV loss 25118596
nsv1003091 CNV gain 25217958
nsv1003605 CNV gain 25217958
nsv1004790 CNV gain 25217958
nsv1010059 CNV loss 25217958
nsv1013273 CNV gain 25217958
nsv1068651 CNV deletion 25765185
nsv1079019 OTHER inversion 25765185
nsv1150779 OTHER inversion 26484159
nsv1160483 CNV duplication 26073780
nsv428357 CNV loss 18775914
nsv433194 CNV loss 18776910
nsv442637 CNV loss 18776908
nsv442999 CNV deletion 18674749
nsv469750 CNV loss 16826518
nsv471355 CNV loss 19718026
nsv471517 CNV loss 19718026
nsv514048 CNV loss 21397061
nsv515858 CNV gain+loss 19592680
nsv5365 CNV deletion 18451855
nsv549603 CNV loss 21841781
nsv549735 CNV loss 21841781
nsv549737 CNV loss 21841781
nsv7193 OTHER inversion 18451855
nsv821623 CNV loss 15273396
nsv827864 CNV loss 20364138
nsv9191 CNV gain+loss 18304495
nsv945695 OTHER complex 23825009

Variation tolerance for OR2T11 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.07; 68.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2T11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2T11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T11 Gene

Disorders for OR2T11 Gene

Relevant External Links for OR2T11

Genetic Association Database (GAD)
OR2T11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2T11

No disorders were found for OR2T11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T11 Gene

Publications for OR2T11 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3 64
  3. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 46 64
  4. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR2T11 Gene

Sources for OR2T11 Gene

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