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Aliases for OR2T10 Gene

Aliases for OR2T10 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 10 2 3 5
  • Olfactory Receptor OR1-64 3 4
  • Olfactory Receptor, Family 2, Subfamily T, Member 10 2
  • Olfactory Receptor 2T10 3
  • OR1-64 3

External Ids for OR2T10 Gene

Previous GeneCards Identifiers for OR2T10 Gene

  • GC00U903041
  • GC01M245692
  • GC01M245082
  • GC01M246822
  • GC01M248756

Summaries for OR2T10 Gene

Entrez Gene Summary for OR2T10 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T10 Gene

OR2T10 (Olfactory Receptor Family 2 Subfamily T Member 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T4.

UniProtKB/Swiss-Prot for OR2T10 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T10 Gene

Genomics for OR2T10 Gene

Regulatory Elements for OR2T10 Gene

Enhancers for OR2T10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around OR2T10 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2T10 Gene

Chromosome:
1
Start:
248,592,830 bp from pter
End:
248,593,768 bp from pter
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR2T10 Gene

Genes around OR2T10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T10 Gene

Proteins for OR2T10 Gene

  • Protein details for OR2T10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGZ9-O2T10_HUMAN
    Recommended name:
    Olfactory receptor 2T10
    Protein Accession:
    Q8NGZ9
    Secondary Accessions:
    • B2RNK7

    Protein attributes for OR2T10 Gene

    Size:
    312 amino acids
    Molecular mass:
    35403 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T10 Gene

Post-translational modifications for OR2T10 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2T10 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T10 Gene

Domains & Families for OR2T10 Gene

Gene Families for OR2T10 Gene

Protein Domains for OR2T10 Gene

Suggested Antigen Peptide Sequences for OR2T10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGZ9

UniProtKB/Swiss-Prot:

O2T10_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T10: view

Function for OR2T10 Gene

Molecular function for OR2T10 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T10: view
genes like me logo Genes that share phenotypes with OR2T10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T10 Gene

Localization for OR2T10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2T10 Gene COMPARTMENTS Subcellular localization image for OR2T10 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T10: view

Pathways & Interactions for OR2T10 Gene

genes like me logo Genes that share pathways with OR2T10: view

Pathways by source for OR2T10 Gene

Interacting Proteins for OR2T10 Gene

Gene Ontology (GO) - Biological Process for OR2T10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T10: view

No data available for SIGNOR curated interactions for OR2T10 Gene

Drugs & Compounds for OR2T10 Gene

No Compound Related Data Available

Transcripts for OR2T10 Gene

mRNA/cDNA for OR2T10 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T10 Gene

No ASD Table

Relevant External Links for OR2T10 Gene

GeneLoc Exon Structure for
OR2T10
ECgene alternative splicing isoforms for
OR2T10

Expression for OR2T10 Gene

mRNA expression in normal human tissues for OR2T10 Gene

mRNA differential expression in normal tissues according to GTEx for OR2T10 Gene

This gene is overexpressed in Kidney - Cortex (x31.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2T10 Gene



NURSA nuclear receptor signaling pathways regulating expression of OR2T10 Gene:

OR2T10

SOURCE GeneReport for Unigene cluster for OR2T10 Gene:

Hs.553585
genes like me logo Genes that share expression patterns with OR2T10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR2T10 Gene

Orthologs for OR2T10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 69 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 68 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 69 (a)
ManyToMany
Species where no ortholog for OR2T10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T10 Gene

ENSEMBL:
Gene Tree for OR2T10 (if available)
TreeFam:
Gene Tree for OR2T10 (if available)

Paralogs for OR2T10 Gene

(449) SIMAP similar genes for OR2T10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2T10: view

Variants for OR2T10 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2T10 Gene

Variant ID Type Subtype PubMed ID
dgv116n67 CNV loss 20364138
dgv165e212 CNV gain 25503493
dgv166e212 CNV loss 25503493
dgv167e212 CNV loss 25503493
dgv168e212 CNV loss 25503493
dgv17e55 CNV loss 17911159
dgv20n17 CNV loss 16327808
dgv29n111 CNV deletion 26073780
dgv323n106 OTHER inversion 24896259
dgv5n14 CNV loss 18776910
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv617n100 CNV gain 25217958
dgv618n100 CNV loss 25217958
dgv620n100 CNV loss 25217958
dgv621n100 CNV gain+loss 25217958
dgv622n100 CNV loss 25217958
dgv623n100 CNV loss 25217958
dgv624n100 CNV gain+loss 25217958
dgv625n100 CNV gain 25217958
dgv626n100 CNV loss 25217958
dgv627n100 CNV loss 25217958
dgv628n100 CNV loss 25217958
dgv629n100 CNV gain+loss 25217958
dgv630n100 CNV gain+loss 25217958
dgv631n100 CNV gain 25217958
dgv632n100 CNV loss 25217958
dgv633n100 CNV gain+loss 25217958
dgv634n100 CNV loss 25217958
dgv635n100 CNV loss 25217958
dgv636n100 CNV gain+loss 25217958
dgv637n100 CNV loss 25217958
dgv638n100 CNV gain 25217958
dgv639n100 CNV gain 25217958
dgv7e213 CNV loss 24956385
dgv906n54 CNV gain 21841781
dgv909n54 CNV loss 21841781
dgv910n54 CNV loss 21841781
dgv911n54 CNV loss 21841781
dgv913n54 CNV loss 21841781
dgv914n54 CNV loss 21841781
dgv915n54 CNV loss 21841781
dgv916n54 CNV loss 21841781
dgv917n54 CNV loss 21841781
dgv918n54 CNV loss 21841781
esv2421359 CNV deletion 20811451
esv2660478 CNV deletion 23128226
esv2669131 CNV deletion 23128226
esv27363 CNV loss 19812545
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv2759015 CNV gain+loss 17122850
esv2760083 CNV gain+loss 21179565
esv2763780 CNV loss 21179565
esv29940 CNV loss 18421352
esv33052 CNV gain+loss 17666407
esv3589558 CNV loss 21293372
esv3589559 CNV loss 21293372
esv3589560 CNV gain 21293372
esv3891415 CNV gain 25118596
nsv1003091 CNV gain 25217958
nsv1003605 CNV gain 25217958
nsv1004790 CNV gain 25217958
nsv1005629 CNV loss 25217958
nsv1008002 CNV loss 25217958
nsv1010059 CNV loss 25217958
nsv1013273 CNV gain 25217958
nsv1068651 CNV deletion 25765185
nsv1079019 OTHER inversion 25765185
nsv1150779 OTHER inversion 26484159
nsv1160483 CNV duplication 26073780
nsv428357 CNV loss 18775914
nsv433194 CNV loss 18776910
nsv442637 CNV loss 18776908
nsv469750 CNV loss 16826518
nsv471517 CNV loss 19718026
nsv514048 CNV loss 21397061
nsv515858 CNV gain+loss 19592680
nsv5365 CNV deletion 18451855
nsv5376 CNV insertion 18451855
nsv549603 CNV loss 21841781
nsv549641 CNV gain 21841781
nsv549644 CNV loss 21841781
nsv549668 CNV loss 21841781
nsv7193 OTHER inversion 18451855
nsv821623 CNV loss 15273396
nsv827864 CNV loss 20364138
nsv9191 CNV gain+loss 18304495
nsv945695 OTHER complex 23825009

Variation tolerance for OR2T10 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.17; 69.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2T10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2T10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for OR2T10 Gene

Disorders for OR2T10 Gene

Relevant External Links for OR2T10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2T10

No disorders were found for OR2T10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T10 Gene

Publications for OR2T10 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for OR2T10 Gene

Sources for OR2T10 Gene

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