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Aliases for OR2T1 Gene

Aliases for OR2T1 Gene

  • Olfactory Receptor Family 2 Subfamily T Member 1 2 3 5
  • Olfactory Receptor OR1-61 3 4
  • Olfactory Receptor 1-25 3 4
  • OR1-25 3 4
  • Olfactory Receptor, Family 2, Subfamily T, Member 1 2
  • Olfactory Receptor 2T1 3

External Ids for OR2T1 Gene

Previous GeneCards Identifiers for OR2T1 Gene

  • GC01U990267
  • GC01M243796
  • GC01P244617
  • GC01P245467
  • GC01P244876
  • GC01P246635
  • GC01P248569

Summaries for OR2T1 Gene

Entrez Gene Summary for OR2T1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T1 Gene

OR2T1 (Olfactory Receptor Family 2 Subfamily T Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T6.

UniProtKB/Swiss-Prot for OR2T1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T1 Gene

Additional gene information for OR2T1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T1 Gene

Genomics for OR2T1 Gene

Regulatory Elements for OR2T1 Gene

Enhancers for OR2T1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H248803 1.1 Ensembl ENCODE 10.2 +402.5 402467 3 HDGF RB1 BATF RAD21 ZNF143 ZNF207 RUNX3 CREM IKZF2 THAP11 SH3BP5L RNU6-1205P OR2T1 GC01P248810 LOC100131533
GH01H248471 0.6 FANTOM5 17.3 +68.7 68705 0 HDGF TARDBP MAFG ZNF207 OR14I1 OR2T1 OR2M2 OR2M7 OR2M5 OR2M4 OR2T33 OR2T6 OR2M3 OR2T10
GH01H248443 0.7 dbSUPER 11.6 +45.7 45709 10 PKNOX1 ZNF687 SOX6 TRIM22 BACH1 TARDBP ZNF24 MLLT1 NFE2 ATF7 OR2T1 ENSG00000229255 SH3BP5L OR2T2 OR2T3
GH01H248686 0.6 ENCODE 11.1 +284.0 283997 0 CTCF TRIM22 EBF1 RAD21 EED ZNF143 SMC3 ETV6 MLLT1 SPI1 OR2T1 LOC101928226 OR2T27
GH01H248438 0.5 dbSUPER 11.6 +36.2 36184 1 SMARCA5 ZNF687 NR2F1 IKZF1 OR2T1 ENSG00000229255 OR2T34 SH3BP5L OR2T7 OR2T2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2T1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2T1 Gene

Chromosome:
1
Start:
248,403,048 bp from pter
End:
248,408,020 bp from pter
Size:
4,973 bases
Orientation:
Plus strand

Genomic View for OR2T1 Gene

Genes around OR2T1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2T1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2T1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T1 Gene

Proteins for OR2T1 Gene

  • Protein details for OR2T1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43869-OR2T1_HUMAN
    Recommended name:
    Olfactory receptor 2T1
    Protein Accession:
    O43869
    Secondary Accessions:
    • Q6IEZ9

    Protein attributes for OR2T1 Gene

    Size:
    369 amino acids
    Molecular mass:
    41996 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T1 Gene

Post-translational modifications for OR2T1 Gene

  • Glycosylation at posLast=5656
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2T1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2T1 Gene

Domains & Families for OR2T1 Gene

Gene Families for OR2T1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2T1 Gene

Suggested Antigen Peptide Sequences for OR2T1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43869

UniProtKB/Swiss-Prot:

OR2T1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2T1: view

Function for OR2T1 Gene

Molecular function for OR2T1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily T,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T1: view
genes like me logo Genes that share phenotypes with OR2T1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2T1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2T1 Gene

Localization for OR2T1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2T1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2T1 Gene

Pathways & Interactions for OR2T1 Gene

genes like me logo Genes that share pathways with OR2T1: view

Pathways by source for OR2T1 Gene

1 KEGG pathway for OR2T1 Gene

Interacting Proteins for OR2T1 Gene

Gene Ontology (GO) - Biological Process for OR2T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T1: view

No data available for SIGNOR curated interactions for OR2T1 Gene

Drugs & Compounds for OR2T1 Gene

No Compound Related Data Available

Transcripts for OR2T1 Gene

mRNA/cDNA for OR2T1 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2T1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T1 Gene

No ASD Table

Relevant External Links for OR2T1 Gene

GeneLoc Exon Structure for
OR2T1
ECgene alternative splicing isoforms for
OR2T1

Expression for OR2T1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2T1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2T1 Gene:

OR2T1

SOURCE GeneReport for Unigene cluster for OR2T1 Gene:

Hs.626885
genes like me logo Genes that share expression patterns with OR2T1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2T1 Gene

Orthologs for OR2T1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100609051 33
  • 99.46 (n)
OR2T1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR2T1 33
  • 87.21 (n)
cow
(Bos Taurus)
Mammalia OR2T1 33 34
  • 86.6 (n)
oppossum
(Monodelphis domestica)
Mammalia OR2T1 34
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1606 33
  • 83.86 (n)
mouse
(Mus musculus)
Mammalia Or2t1 52 Olfr31 33 16 34
  • 83.76 (n)
Or2t26 52 Olfr1395
  • chr11:49,148,259-49,149,209
Or2z2 52 Olfr30
  • chr11:58,455,003-58,455,947
Species where no ortholog for OR2T1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T1 Gene

ENSEMBL:
Gene Tree for OR2T1 (if available)
TreeFam:
Gene Tree for OR2T1 (if available)

Paralogs for OR2T1 Gene

(447) SIMAP similar genes for OR2T1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2T1: view

Variants for OR2T1 Gene

Sequence variations from dbSNP and Humsavar for OR2T1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs193920936 Uncertain significance 248,406,130(+) ATATC(A/G)GCACA reference, missense
rs1000570223 -- 248,405,052(+) TTCTC(A/C)ATAGC upstream-variant-2KB
rs1003245865 -- 248,404,192(+) TACAT(A/G)TACGT upstream-variant-2KB
rs1004215866 -- 248,404,029(+) AAGAT(C/T)ATCCT upstream-variant-2KB
rs1004919910 -- 248,407,507(+) GCCAA(C/G)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR2T1 Gene

Variant ID Type Subtype PubMed ID
dgv17e55 CNV loss 17911159
dgv20n17 CNV loss 16327808
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv613n100 CNV loss 25217958
dgv906n54 CNV gain 21841781
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv2759015 CNV gain+loss 17122850
esv3891415 CNV gain 25118596
nsv1001474 CNV gain 25217958
nsv1004790 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv428357 CNV loss 18775914
nsv511035 OTHER complex 20534489
nsv515858 CNV gain+loss 19592680
nsv5332 CNV deletion 18451855
nsv5343 CNV insertion 18451855
nsv549603 CNV loss 21841781
nsv549630 CNV loss 21841781

Variation tolerance for OR2T1 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2T1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2T1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2T1 Gene

Disorders for OR2T1 Gene

Relevant External Links for OR2T1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2T1

No disorders were found for OR2T1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2T1 Gene

Publications for OR2T1 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 2 3 4 60
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 60
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60

Products for OR2T1 Gene

Sources for OR2T1 Gene

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