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Aliases for OR2T1 Gene

Aliases for OR2T1 Gene

  • Olfactory Receptor, Family 2, Subfamily T, Member 1 2 3
  • Olfactory Receptor OR1-61 3 4
  • Olfactory Receptor 1-25 3 4
  • OR1-25 3 4
  • Olfactory Receptor 2T1 3

External Ids for OR2T1 Gene

Summaries for OR2T1 Gene

Entrez Gene Summary for OR2T1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2T1 Gene

OR2T1 (Olfactory Receptor, Family 2, Subfamily T, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2V2.

UniProtKB/Swiss-Prot for OR2T1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2T1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2T1 Gene

Genomics for OR2T1 Gene

Genomic Location for OR2T1 Gene

Start:
248,405,995 bp from pter
End:
248,407,104 bp from pter
Size:
1,110 bases
Orientation:
Plus strand

Genomic View for OR2T1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2T1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2T1 Gene

Regulatory Elements for OR2T1 Gene

Proteins for OR2T1 Gene

  • Protein details for OR2T1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43869-OR2T1_HUMAN
    Recommended name:
    Olfactory receptor 2T1
    Protein Accession:
    O43869
    Secondary Accessions:
    • Q6IEZ9

    Protein attributes for OR2T1 Gene

    Size:
    369 amino acids
    Molecular mass:
    41996 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2T1 Gene

Proteomics data for OR2T1 Gene at MOPED

Post-translational modifications for OR2T1 Gene

Other Protein References for OR2T1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2T1 Gene

Domains for OR2T1 Gene

Gene Families for OR2T1 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2T1 Gene

UniProtKB/Swiss-Prot:

OR2T1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • O43869
genes like me logo Genes that share domains with OR2T1: view

Function for OR2T1 Gene

Molecular function for OR2T1 Gene

GENATLAS Biochemistry: olfactory receptor,family 2,subfamily T,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2T1: view

Phenotypes for OR2T1 Gene

GenomeRNAi human phenotypes for OR2T1:
genes like me logo Genes that share phenotypes with OR2T1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2T1 Gene

Localization for OR2T1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2T1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2T1 Gene COMPARTMENTS Subcellular localization image for OR2T1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2T1: view

Pathways for OR2T1 Gene

genes like me logo Genes that share pathways with OR2T1: view

Pathways by source for OR2T1 Gene

1 KEGG pathway for OR2T1 Gene

Interacting Proteins for OR2T1 Gene

Gene Ontology (GO) - Biological Process for OR2T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2T1: view

Transcripts for OR2T1 Gene

mRNA/cDNA for OR2T1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2T1 Gene

No ASD Table

Relevant External Links for OR2T1 Gene

GeneLoc Exon Structure for
OR2T1
ECgene alternative splicing isoforms for
OR2T1

Expression for OR2T1 Gene

mRNA expression in normal human tissues for OR2T1 Gene

SOURCE GeneReport for Unigene cluster for OR2T1 Gene Hs.626885

genes like me logo Genes that share expressions with OR2T1: view

Orthologs for OR2T1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2T1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100609051 36
  • 99.46 (n)
  • 99.46 (a)
OR2T1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR2T1 36
  • 86.6 (n)
  • 92.52 (a)
OR2T1 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR2T1 36
  • 87.21 (n)
  • 91.82 (a)
mouse
(Mus musculus)
Mammalia Olfr31 36
  • 83.76 (n)
  • 87.26 (a)
Olfr31 16
Olfr31 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR2T1 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1606 36
  • 83.86 (n)
  • 86.94 (a)
Species with no ortholog for OR2T1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2T1 Gene

ENSEMBL:
Gene Tree for OR2T1 (if available)
TreeFam:
Gene Tree for OR2T1 (if available)

Paralogs for OR2T1 Gene

Selected SIMAP similar genes for OR2T1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2T1: view

Variants for OR2T1 Gene

Sequence variations from dbSNP and Humsavar for OR2T1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1538694 -- 248,405,798(+) CACAC(A/G)CATAC upstream-variant-2KB
rs4592280 -- 248,405,333(-) TTCAC(C/T)GATTA upstream-variant-2KB
rs6695780 -- 248,407,139(+) ATGGG(A/G)GACTC downstream-variant-500B
rs6695885 -- 248,407,266(+) gttgt(A/G/T)gtttt downstream-variant-500B
rs11485457 -- 248,404,243(+) CAGCA(C/G)AGACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2T1 Gene

Variant ID Type Subtype PubMed ID
nsv515858 CNV Gain+Loss 19592680
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
dgv566n71 CNV Gain 21882294
dgv567n71 CNV Gain 21882294
nsv873462 CNV Loss 21882294
dgv20n17 CNV Loss 16327808
essv15752 CNV CNV 17122850
dgv206e1 CNV Complex 17122850
nsv428357 CNV Loss 18775914
nsv5332 CNV Loss 18451855
esv2750835 CNV Gain 17911159
dgv569n71 CNV Gain+Loss 21882294
dgv570n71 CNV Gain 21882294
nsv873468 CNV Loss 21882294
dgv571n71 CNV Gain 21882294
nsv511035 CNV Complex 20534489
nsv5343 CNV Insertion 18451855

Relevant External Links for OR2T1 Gene

HapMap Linkage Disequilibrium report
OR2T1

Disorders for OR2T1 Gene

No disorders were found for OR2T1 Gene.

No data available for UniProtKB/Swiss-Prot for OR2T1 Gene

Publications for OR2T1 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for OR2T1 Gene

Sources for OR2T1 Gene

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