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Aliases for OR2S2 Gene

Aliases for OR2S2 Gene

  • Olfactory Receptor Family 2 Subfamily S Member 2 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR9-3 3 4
  • Olfactory Receptor, Family 2, Subfamily S, Member 2 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 2, Subfamily S, Member 2 3
  • Olfactory Receptor 2S2 3
  • OST715 3
  • OR37A 3

External Ids for OR2S2 Gene

Previous GeneCards Identifiers for OR2S2 Gene

  • GC09M036269
  • GC09M036126

Summaries for OR2S2 Gene

Entrez Gene Summary for OR2S2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]

GeneCards Summary for OR2S2 Gene

OR2S2 (Olfactory Receptor Family 2 Subfamily S Member 2 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR13C8.

UniProtKB/Swiss-Prot for OR2S2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2S2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2S2 Gene

Genomics for OR2S2 Gene

Regulatory Elements for OR2S2 Gene

Enhancers for OR2S2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F036294 0.3 FANTOM5 10.1 -336.0 -336014 0.2 OR2S2 GNE OR13J1 PIR32038
GH09F036028 1.2 FANTOM5 Ensembl ENCODE 8 -71.5 -71491 2.3 JUN BHLHE40 CEBPB CEBPG EP300 RFX5 JUND ATF3 CEBPA STAT3 OR2S2 RECK OR13J1 OR2AM1P
GH09F036147 1.3 FANTOM5 Ensembl ENCODE 4.2 -193.5 -193521 8.6 ELF3 SIN3A RAD21 ZNF48 ZBTB40 RARA EGR1 ETV6 FOS CREM GLIPR2 CLTA GNE HMGB3P24 OR2S2 TLN1 OR13J1 CCIN
GH09F036035 0.9 FANTOM5 ENCODE 2.4 -80.1 -80096 4.6 SIN3A FEZF1 ZNF335 GLIS2 SCRT2 ZNF362 SP3 NFYC ZFP69B SMARCA4 RECK GLIPR2 ATP8B5P OR2S2 ENSG00000276730
GH09F035904 1.3 FANTOM5 Ensembl ENCODE 1.7 +50.1 50054 7.8 SIN3A ZNF48 YY1 SLC30A9 ZNF121 GLIS2 FOS ZNF263 SP3 REST HRCT1 LINC00961 TMEM8B PIGO OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 FANCG
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR2S2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2S2 Gene

35,957,108 bp from pter
35,958,154 bp from pter
1,047 bases
Minus strand

Genomic View for OR2S2 Gene

Genes around OR2S2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2S2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2S2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2S2 Gene

Proteins for OR2S2 Gene

  • Protein details for OR2S2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2S2
    Protein Accession:
    Secondary Accessions:
    • Q2M3L0
    • Q6IF19
    • Q96R42

    Protein attributes for OR2S2 Gene

    319 amino acids
    Molecular mass:
    35172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2S2 Gene

Post-translational modifications for OR2S2 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2S2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2S2 Gene

Domains & Families for OR2S2 Gene

Gene Families for OR2S2 Gene

Protein Domains for OR2S2 Gene

Suggested Antigen Peptide Sequences for OR2S2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2S2: view

Function for OR2S2 Gene

Molecular function for OR2S2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 14983052
genes like me logo Genes that share ontologies with OR2S2: view
genes like me logo Genes that share phenotypes with OR2S2: view

Animal Model Products

miRNA for OR2S2 Gene

miRTarBase miRNAs that target OR2S2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2S2 Gene

Localization for OR2S2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2S2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR2S2 Gene COMPARTMENTS Subcellular localization image for OR2S2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 14983052
genes like me logo Genes that share ontologies with OR2S2: view

Pathways & Interactions for OR2S2 Gene

genes like me logo Genes that share pathways with OR2S2: view

Pathways by source for OR2S2 Gene

1 KEGG pathway for OR2S2 Gene

Interacting Proteins for OR2S2 Gene

Gene Ontology (GO) - Biological Process for OR2S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 14983052
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2S2: view

No data available for SIGNOR curated interactions for OR2S2 Gene

Transcripts for OR2S2 Gene

mRNA/cDNA for OR2S2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2S2 Gene

No ASD Table

Relevant External Links for OR2S2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2S2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2S2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2S2 Gene:


SOURCE GeneReport for Unigene cluster for OR2S2 Gene:

genes like me logo Genes that share expression patterns with OR2S2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR2S2 Gene

Orthologs for OR2S2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2S2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OR2S2 34
  • 98.43 (n)
(Bos Taurus)
Mammalia OR2S2 34
  • 87.98 (n)
(Canis familiaris)
Mammalia LOC609676 34
  • 86 (n)
(Rattus norvegicus)
Mammalia Olr840 34
  • 84.54 (n)
(Mus musculus)
Mammalia Olfr155 34 16
  • 84.12 (n)
Species where no ortholog for OR2S2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2S2 Gene

Gene Tree for OR2S2 (if available)
Gene Tree for OR2S2 (if available)

Paralogs for OR2S2 Gene

(451) SIMAP similar genes for OR2S2 Gene using alignment to 1 proteins: Pseudogenes for OR2S2 Gene

genes like me logo Genes that share paralogs with OR2S2: view

Variants for OR2S2 Gene

Sequence variations from dbSNP and Humsavar for OR2S2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs112073479 -- 35,959,546(+) TGCAA(A/C)AGATT upstream-variant-2KB
rs114873782 -- 35,959,268(+) GTATA(A/G)GAGTG upstream-variant-2KB
rs114997937 -- 35,959,709(+) TCACT(A/G)TCTGT upstream-variant-2KB
rs115740909 -- 35,957,707(+) ACCTA(A/C)GGGGG reference, missense
rs116641426 -- 35,960,086(+) TTCCC(C/T)CATTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2S2 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv831546 CNV loss 17160897
nsv968611 CNV duplication 23825009

Variation tolerance for OR2S2 Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.98; 92.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2S2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2S2 Gene

Disorders for OR2S2 Gene

Relevant External Links for OR2S2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR2S2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2S2 Gene

Publications for OR2S2 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64

Products for OR2S2 Gene

Sources for OR2S2 Gene

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