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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR2S2 Gene

protein-coding   GIFtS: 53
GCID: GC09M035947

Olfactory Receptor, Family 2, Subfamily S, Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 2, Subfamily S, Member 21 2
Olfactory Receptor OR9-32 3
OR37A2
OST7152
Olfactory Receptor 2S22

External Ids:    HGNC: 82761   Entrez Gene: 566562   Ensembl: ENSG000001227187   UniProtKB: Q9NQN13   

Export aliases for OR2S2 gene to outside databases

Previous GC identifers: GC09M036269 GC09M036126


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR2S2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2S2 Gene: 
OR2S2 (olfactory receptor, family 2, subfamily S, member 2) is a protein-coding gene. Diseases associated with OR2S2 include narcolepsy, and neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR13C8.

UniProtKB/Swiss-Prot: OR2S1_HUMAN, Q9NQN1
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2S2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR2S2 gene promoter:
         Nkx3-1 v4   FOXD3   MyoD   Nkx3-1 v1   Egr-2   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2S2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR2S2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2S2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

OR2S2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2S2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M035947:  view genomic region     (about GC identifiers)

Start:
35,957,139 bp from pter      End:
35,958,095 bp from pter
Size:
957 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OR2S1_HUMAN, Q9NQN1 (See protein sequence)
Recommended Name: Olfactory receptor 2S2  
Size: 319 amino acids; 35172 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q2M3L0 Q6IF19 Q96R42

Explore the universe of human proteins at neXtProt for OR2S2: NX_Q9NQN1

Explore proteomics data for OR2S2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NQN1

  • HORDE protein sequence for OR2S2
    OR2S2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR2S2 Protein Expression
    REFSEQ proteins: NP_063950.2  
    ENSEMBL proteins: 
     ENSP00000344040  
    Reactome Protein details: Q9NQN1
    Human Recombinant Protein Products for OR2S2: 
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    GenScript Custom Purified and Recombinant Proteins Services for OR2S2
    Novus Biologicals OR2S2 Protein
    Novus Biologicals OR2S2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OR2S2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS14983052

    OR2S2 for ontologies           About GeneDecksing



    OR2S2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for OR2S2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9NQN1

    ProtoNet protein and cluster: Q9NQN1

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2S1_HUMAN, Q9NQN1
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR2S2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2S1_HUMAN, Q9NQN1
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity NAS14983052
         
    OR2S2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OR2S2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OR2S2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OR2S2 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2S2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR2S2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Class A/1 (Rhodopsin-like receptors)
    GPCRs, Class A Rhodopsin-like0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR2S2
        GPCRs, Class A Rhodopsin-like


    4        Reactome Pathways for OR2S2
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR2S2):
        Olfactory transduction


    OR2S2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2S2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/273 Interacting proteins for OR2S2 (ENSP000003440404) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR1D2ENSP000003275854STRING: ENSP00000327585
    OR1G1ENSP000003315454STRING: ENSP00000331545
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell NAS14983052
    GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS14983052

    OR2S2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR2S2 (OR2S1)

    Search CenterWatch for drugs/clinical trials and news about OR2S2 / OR2S1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR2S2 gene: 
    NM_019897.2  

    Unigene Cluster for OR2S2:

    Olfactory receptor, family 2, subfamily S, member 2
    Hs.553540
    Unigene Representative Sequence: BC104869
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000341959(uc011lpi.2)
    miRNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR2S2
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2S2
    Sirion Biotech Customized lentivirus for stable overexpression of OR2S2 
                         Customized lentivirus expression plasmids for stable overexpression of OR2S2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2S2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2S2

    Additional mRNA sequence: 

    BC104869.1 BC113651.1 

    1 DOTS entry:

    DT.91895012 

    1 AceView cDNA sequence:

    NM_019897 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR2S2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCAGACA
    OR2S2 Expression
    About this image


    See OR2S2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OR2S2

    SOURCE GeneReport for Unigene cluster: Hs.553540
        SABiosciences Custom PCR Arrays for OR2S2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2S2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2S2 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr29-ps15
    Olfr1551
    olfactory receptor 29, pseudogene 15
    olfactory receptor 1551
    84.12(n)1
    82.13(a)1
      4 (23.05 cM)5
    298451  NM_019473.11  NP_062346.11 
     437813815 


    ENSEMBL Gene Tree for OR2S2 (if available)
    TreeFam Gene Tree for OR2S2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR2S2 gene
    OR13C82  OR13C22  OR13C32  OR13J12  OR2K22  OR13C42  OR13C92  OR13F12  
    OR13D12  OR13C52  OR13H12  
    18/452 SIMAP similar genes for OR2S2 using alignment to 1 protein entry:     OR2S1_HUMAN(see all similar genes):
    OR13C8    OR13C2    OR13C3    OR13C4    OR13C5    OR13C9
    OR2K2    OR13D1    OR2G3    OR13F1    OR2F1    OR2G6
    OR10J4    OR13J1    OR2B11    OR2B8P    OR2C1    OR2C3

    OR2S2 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for OR2S2
    PGOHUM00000236028 PGOHUM00000236029 PGOHUM00000236452 PGOHUM00000236453 PGOHUM00000236743


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/128 SNPs in OR2S2 are shown (see all 128)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123466551,2
    C,F,H--35956713(+) TGAGTG/ATAATA 1 -- ds500112Minor allele frequency- A:0.06NS EA NA WA 1568
    rs1431059951,2
    C--35956816(+) TCTCAC/TGTCCC 1 -- ds50010--------
    rs1461486361,2
    --35956817(+) CTCACA/GTCCCT 1 -- ds50010--------
    rs123466391,2
    C,F,H--35956867(+) TCATGC/TTTTCA 1 -- ds50016Minor allele frequency- T:0.03NS EA CSA WA 539
    rs1401452731,2
    --35956898(+) TTTACC/TGTATG 1 -- ds50010--------
    rs1818414671,2
    --35957001(+) GAAAAG/TTTTAA 1 -- ds50010--------
    rs1457700181,2
    --35957006(+) GTTTAA/TTATCT 1 -- ds50010--------
    rs7501471,2
    C,F,O,A,H--35957030(-) TCTCAC/ATCTAA 1 -- ds500110Minor allele frequency- A:0.08NS EA NA WA CSA 682
    rs1485233851,2
    --35957044(+) CATTAC/TAGGTC 1 -- ds50010--------
    rs1427992481,2
    C--35957112(+) GGTGAC/TAATCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OR2S2 ( 35957139 - 35958095 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR2S2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831546CNV Loss17160897
    nsv893049CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OR2S2:    About MalaCards
    narcolepsy    neuronitis


    OR2S2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OR2S2
    Human Genome Epidemiology (HuGE) Navigator: OR2S2 (2 documents)

    Export disorders for OR2S2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR2S2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR2S2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
    6. Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human. (PubMed id 12906860)1 Hoppe R....Strotmann J. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Small subfamily of olfactory receptor genes: structural features, expression pattern and genomic organization. (PubMed id 10452948)1 Strotmann J....Breer H. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56656 HGNC: 8276 AceView: OR2S2 Ensembl:ENSG00000122718 euGenes: HUgn56656
    ECgene: OR2S2 Kegg: 56656 H-InvDB: OR2S2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR2S2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2S2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR2S2 gene:
    Search GeneIP for patents involving OR2S2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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