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Aliases for OR2S2 Gene

Aliases for OR2S2 Gene

  • Olfactory Receptor, Family 2, Subfamily S, Member 2 (Gene/Pseudogene) 2 3
  • Olfactory Receptor OR9-3 3 4
  • Olfactory Receptor 2S2 3
  • OST715 3
  • OR37A 3

External Ids for OR2S2 Gene

Summaries for OR2S2 Gene

Entrez Gene Summary for OR2S2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2S2 Gene

OR2S2 (Olfactory Receptor, Family 2, Subfamily S, Member 2 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR2S2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2S2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2S2 Gene

Genomics for OR2S2 Gene

Genomic Location for OR2S2 Gene

Start:
35,957,108 bp from pter
End:
35,958,154 bp from pter
Size:
1,047 bases
Orientation:
Minus strand

Genomic View for OR2S2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2S2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2S2 Gene

Regulatory Elements for OR2S2 Gene

Proteins for OR2S2 Gene

  • Protein details for OR2S2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQN1-OR2S1_HUMAN
    Recommended name:
    Olfactory receptor 2S2
    Protein Accession:
    Q9NQN1
    Secondary Accessions:
    • Q2M3L0
    • Q6IF19
    • Q96R42

    Protein attributes for OR2S2 Gene

    Size:
    319 amino acids
    Molecular mass:
    35172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2S2 Gene

Proteomics data for OR2S2 Gene at MOPED

Post-translational modifications for OR2S2 Gene

Other Protein References for OR2S2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2S2 Gene

Domains for OR2S2 Gene

Gene Families for OR2S2 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2S2 Gene

Suggested Antigen Peptide Sequences for OR2S2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQN1

UniProtKB/Swiss-Prot:

OR2S1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9NQN1
genes like me logo Genes that share domains with OR2S2: view

Function for OR2S2 Gene

Molecular function for OR2S2 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 14983052
genes like me logo Genes that share ontologies with OR2S2: view

Phenotypes for OR2S2 Gene

GenomeRNAi human phenotypes for OR2S2:
genes like me logo Genes that share phenotypes with OR2S2: view

miRNA for OR2S2 Gene

miRTarBase miRNAs that target OR2S2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OR2S2 Gene

Localization for OR2S2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2S2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2S2 Gene COMPARTMENTS Subcellular localization image for OR2S2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 14983052
genes like me logo Genes that share ontologies with OR2S2: view

Pathways for OR2S2 Gene

genes like me logo Genes that share pathways with OR2S2: view

Pathways by source for OR2S2 Gene

1 KEGG pathway for OR2S2 Gene

Interacting Proteins for OR2S2 Gene

Gene Ontology (GO) - Biological Process for OR2S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 14983052
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 14983052
genes like me logo Genes that share ontologies with OR2S2: view

Transcripts for OR2S2 Gene

mRNA/cDNA for OR2S2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2S2 Gene

No ASD Table

Relevant External Links for OR2S2 Gene

GeneLoc Exon Structure for
OR2S2
ECgene alternative splicing isoforms for
OR2S2

Expression for OR2S2 Gene

mRNA expression in normal human tissues for OR2S2 Gene

SOURCE GeneReport for Unigene cluster for OR2S2 Gene Hs.553540

genes like me logo Genes that share expressions with OR2S2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR2S2 Gene

Orthologs for OR2S2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2S2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR2S2 35
  • 98.43 (n)
  • 96.55 (a)
cow
(Bos Taurus)
Mammalia OR2S2 35
  • 87.98 (n)
  • 87.15 (a)
dog
(Canis familiaris)
Mammalia LOC609676 35
  • 86 (n)
  • 84.01 (a)
mouse
(Mus musculus)
Mammalia Olfr155 35
  • 84.12 (n)
  • 82.13 (a)
Olfr29-ps1 16
rat
(Rattus norvegicus)
Mammalia Olr840 35
  • 84.54 (n)
  • 82.76 (a)
Species with no ortholog for OR2S2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2S2 Gene

ENSEMBL:
Gene Tree for OR2S2 (if available)
TreeFam:
Gene Tree for OR2S2 (if available)

Paralogs for OR2S2 Gene

Selected SIMAP similar genes for OR2S2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2S2: view

No data available for Paralogs for OR2S2 Gene

Variants for OR2S2 Gene

Sequence variations from dbSNP and Humsavar for OR2S2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs750147 -- 35,957,033(-) TCTCA(A/C)TCTAA downstream-variant-500B
rs2233552 -- 35,958,956(-) TACTA(C/T)CGATA upstream-variant-2KB
rs2233553 -- 35,958,862(-) CTCCA(A/G)CAAAT upstream-variant-2KB
rs2233554 -- 35,958,669(-) AATTT(A/T)GCGCA upstream-variant-2KB
rs2233555 -- 35,958,336(-) AGCAA(A/C)TTCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2S2 Gene

Variant ID Type Subtype PubMed ID
nsv831546 CNV Loss 17160897
nsv893049 CNV Gain 21882294

Relevant External Links for OR2S2 Gene

HapMap Linkage Disequilibrium report
OR2S2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2S2 Gene

Disorders for OR2S2 Gene

Relevant External Links for OR2S2

Genetic Association Database (GAD)
OR2S2
Human Genome Epidemiology (HuGE) Navigator
OR2S2
genes like me logo Genes that share disorders with OR2S2: view

No data available for UniProtKB/Swiss-Prot for OR2S2 Gene

Publications for OR2S2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 48
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4

Products for OR2S2 Gene

Sources for OR2S2 Gene

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