Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR2M7 Gene

Aliases for OR2M7 Gene

  • Olfactory Receptor Family 2 Subfamily M Member 7 2 3 5
  • Olfactory Receptor, Family 2, Subfamily M, Member 7 2 3
  • Olfactory Receptor OR1-58 3 4
  • OR2M7 D 3
  • OR2M7 N 3
  • OR2M7 O 3
  • OR1-58 3

External Ids for OR2M7 Gene

Previous GeneCards Identifiers for OR2M7 Gene

  • GC00U903059
  • GC01M245385
  • GC01M244795
  • GC01M246553
  • GC01M248486

Summaries for OR2M7 Gene

Entrez Gene Summary for OR2M7 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2M7 Gene

OR2M7 (Olfactory Receptor Family 2 Subfamily M Member 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2M7 Gene

  • Odorant receptor.

Gene Wiki entry for OR2M7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2M7 Gene

Genomics for OR2M7 Gene

Regulatory Elements for OR2M7 Gene

Enhancers for OR2M7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR2M7 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2M7 Gene

Chromosome:
1
Start:
248,323,630 bp from pter
End:
248,324,568 bp from pter
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR2M7 Gene

Genes around OR2M7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2M7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2M7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2M7 Gene

Proteins for OR2M7 Gene

  • Protein details for OR2M7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG81-OR2M7_HUMAN
    Recommended name:
    Olfactory receptor 2M7
    Protein Accession:
    Q8NG81
    Secondary Accessions:
    • B2RNL0
    • Q6IEX6

    Protein attributes for OR2M7 Gene

    Size:
    312 amino acids
    Molecular mass:
    34902 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2M7 Gene

Proteomics data for OR2M7 Gene at MOPED

Post-translational modifications for OR2M7 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2M7 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2M7 Gene

Domains & Families for OR2M7 Gene

Gene Families for OR2M7 Gene

Protein Domains for OR2M7 Gene

Suggested Antigen Peptide Sequences for OR2M7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG81

UniProtKB/Swiss-Prot:

OR2M7_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2M7: view

Function for OR2M7 Gene

Molecular function for OR2M7 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR2M7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2M7 Gene

Localization for OR2M7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2M7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2M7 Gene COMPARTMENTS Subcellular localization image for OR2M7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2M7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2M7: view

Pathways & Interactions for OR2M7 Gene

genes like me logo Genes that share pathways with OR2M7: view

Pathways by source for OR2M7 Gene

Interacting Proteins for OR2M7 Gene

Gene Ontology (GO) - Biological Process for OR2M7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2M7: view

No data available for SIGNOR curated interactions for OR2M7 Gene

Drugs & Compounds for OR2M7 Gene

No Compound Related Data Available

Transcripts for OR2M7 Gene

mRNA/cDNA for OR2M7 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2M7 Gene

No ASD Table

Relevant External Links for OR2M7 Gene

GeneLoc Exon Structure for
OR2M7
ECgene alternative splicing isoforms for
OR2M7

Expression for OR2M7 Gene

mRNA expression in normal human tissues for OR2M7 Gene

SOURCE GeneReport for Unigene cluster for OR2M7 Gene Hs.530570

genes like me logo Genes that share expression patterns with OR2M7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR2M7 Gene

Orthologs for OR2M7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2M7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469767 35
  • 99.25 (n)
  • 98.72 (a)
OR2M7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 73 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR20H03 36
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr164 36
  • 70 (a)
ManyToMany
Species with no ortholog for OR2M7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2M7 Gene

ENSEMBL:
Gene Tree for OR2M7 (if available)
TreeFam:
Gene Tree for OR2M7 (if available)

Paralogs for OR2M7 Gene

(449) SIMAP similar genes for OR2M7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2M7: view

Variants for OR2M7 Gene

Sequence variations from dbSNP and Humsavar for OR2M7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7555310 - 248,324,336(+) TGGGT(A/G)CAGTG reference, missense
rs4916130 - 248,324,036(+) CACAG(A/C)AGAAG reference, missense
rs7555424 - 248,324,466(+) TGAAA(A/G)GATGG reference, missense
rs4916129 - 248,323,998(+) TGTGT(C/T)ATTGC reference, missense
rs4551626 -- 248,325,826(+) CATAA(G/T)AGGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2M7 Gene

Variant ID Type Subtype PubMed ID
nsv515858 CNV Gain+Loss 19592680
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
nsv9103 CNV Loss 18304495
dgv566n71 CNV Gain 21882294
dgv567n71 CNV Gain 21882294
nsv873459 CNV Loss 21882294
nsv873461 CNV Gain 21882294
nsv873462 CNV Loss 21882294
esv2728128 CNV Deletion 23290073
dgv20n17 CNV Loss 16327808

Variation tolerance for OR2M7 Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.70; 91.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR2M7 Gene

Disorders for OR2M7 Gene

Relevant External Links for OR2M7

Genetic Association Database (GAD)
OR2M7
Human Genome Epidemiology (HuGE) Navigator
OR2M7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2M7

No disorders were found for OR2M7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2M7 Gene

Publications for OR2M7 Gene

  1. Web-based, participant-driven studies yield novel genetic associations for common traits. (PMID: 20585627) Eriksson N. … Mountain J. (PLoS Genet. 2010) 3 48 67
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2M7 Gene

Sources for OR2M7 Gene

Content