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Aliases for OR2M5 Gene

Aliases for OR2M5 Gene

  • Olfactory Receptor, Family 2, Subfamily M, Member 5 2 3
  • OR2M5P 3 4
  • Olfactory Receptor, Family 2, Subfamily M, Member 5 Pseudogene 3
  • Olfactory Receptor 2M5 3

External Ids for OR2M5 Gene

Previous HGNC Symbols for OR2M5 Gene

  • OR2M5P

Previous GeneCards Identifiers for OR2M5 Gene

  • GC01P245198
  • GC01P244634
  • GC01P246375
  • GC01P248308

Summaries for OR2M5 Gene

Entrez Gene Summary for OR2M5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2M5 Gene

OR2M5 (Olfactory Receptor, Family 2, Subfamily M, Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2M5 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2M5 Gene

Genomics for OR2M5 Gene

Regulatory Elements for OR2M5 Gene

Genomic Location for OR2M5 Gene

Start:
248,145,148 bp from pter
End:
248,146,086 bp from pter
Size:
939 bases
Orientation:
Plus strand

Genomic View for OR2M5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2M5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2M5 Gene

Proteins for OR2M5 Gene

  • Protein details for OR2M5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A3KFT3-OR2M5_HUMAN
    Recommended name:
    Olfactory receptor 2M5
    Protein Accession:
    A3KFT3
    Secondary Accessions:

    Protein attributes for OR2M5 Gene

    Size:
    312 amino acids
    Molecular mass:
    35112 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2M5 Gene

Proteomics data for OR2M5 Gene at MOPED

Post-translational modifications for OR2M5 Gene

Other Protein References for OR2M5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2M5 Gene

Domains for OR2M5 Gene

Gene Families for OR2M5 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2M5 Gene

Suggested Antigen Peptide Sequences for OR2M5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A3KFT3

UniProtKB/Swiss-Prot:

OR2M5_HUMAN :
  • A3KFT3
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2M5: view

Function for OR2M5 Gene

Molecular function for OR2M5 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2M5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2M5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2M5 Gene

Localization for OR2M5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2M5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2M5 Gene COMPARTMENTS Subcellular localization image for OR2M5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2M5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2M5: view

Pathways for OR2M5 Gene

genes like me logo Genes that share pathways with OR2M5: view

Pathways by source for OR2M5 Gene

Interacting Proteins for OR2M5 Gene

Gene Ontology (GO) - Biological Process for OR2M5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2M5: view

Transcripts for OR2M5 Gene

mRNA/cDNA for OR2M5 Gene

(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2M5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR2M5
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2M5 Gene

No ASD Table

Relevant External Links for OR2M5 Gene

GeneLoc Exon Structure for
OR2M5
ECgene alternative splicing isoforms for
OR2M5

Expression for OR2M5 Gene

mRNA expression in normal human tissues for OR2M5 Gene

SOURCE GeneReport for Unigene cluster for OR2M5 Gene Hs.553580

genes like me logo Genes that share expressions with OR2M5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR2M5 Gene

Orthologs for OR2M5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2M5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469763 35
  • 97.97 (n)
  • 96.15 (a)
OR2M5 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 74 (a)
OneToMany
OR2M3 35
  • 80.88 (n)
  • 75.32 (a)
dog
(Canis familiaris)
Mammalia LOC482235 35
  • 80.92 (n)
  • 77.49 (a)
OR20H03 36
  • 78 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr165 35
  • 74.28 (n)
  • 71.38 (a)
Olfr165 36
  • 71 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 53 (a)
OneToMany
Species with no ortholog for OR2M5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2M5 Gene

ENSEMBL:
Gene Tree for OR2M5 (if available)
TreeFam:
Gene Tree for OR2M5 (if available)

Paralogs for OR2M5 Gene

Selected SIMAP similar genes for OR2M5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR2M5 Gene

genes like me logo Genes that share paralogs with OR2M5: view

Variants for OR2M5 Gene

Sequence variations from dbSNP and Humsavar for OR2M5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6698764 -- 248,146,227(+) AAATA(A/T)TTCTT downstream-variant-500B
rs7414032 -- 248,144,015(+) GTTTC(A/G)AAAGC upstream-variant-2KB
rs9435910 -- 248,144,301(+) GTTTG(C/T)AGATG upstream-variant-2KB
rs11204593 -- 248,143,506(+) ACTCA(A/C)CAGGC upstream-variant-2KB
rs12032106 -- 248,145,027(+) TGGTC(A/T)TACTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2M5 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV Gain+Loss 17666407
dgv204e1 CNV Complex 17122850
esv34503 CNV Gain 17911159
nsv515858 CNV Gain+Loss 19592680
nsv873442 CNV Gain 21882294
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
dgv564n71 CNV Gain 21882294
dgv565n71 CNV Loss 21882294
esv2728006 CNV Deletion 23290073
nsv468861 CNV Gain 19166990
esv2728017 CNV Deletion 23290073

Relevant External Links for OR2M5 Gene

HapMap Linkage Disequilibrium report
OR2M5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2M5 Gene

Disorders for OR2M5 Gene

No disorders were found for OR2M5 Gene.

No data available for UniProtKB/Swiss-Prot for OR2M5 Gene

Publications for OR2M5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  3. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I. … Futreal P.A. (Nature 2011) 4

Products for OR2M5 Gene

Sources for OR2M5 Gene

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