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Aliases for OR2M5 Gene

Aliases for OR2M5 Gene

  • Olfactory Receptor Family 2 Subfamily M Member 5 2 3 5
  • OR2M5P 3 4
  • Olfactory Receptor, Family 2, Subfamily M, Member 5 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily M, Member 5 2
  • Olfactory Receptor 2M5 3

External Ids for OR2M5 Gene

Previous HGNC Symbols for OR2M5 Gene

  • OR2M5P

Previous GeneCards Identifiers for OR2M5 Gene

  • GC01P245198
  • GC01P244634
  • GC01P246375
  • GC01P248308

Summaries for OR2M5 Gene

Entrez Gene Summary for OR2M5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2M5 Gene

OR2M5 (Olfactory Receptor Family 2 Subfamily M Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2M7.

UniProtKB/Swiss-Prot for OR2M5 Gene

  • Odorant receptor.

Additional gene information for OR2M5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2M5 Gene

Genomics for OR2M5 Gene

Regulatory Elements for OR2M5 Gene

Enhancers for OR2M5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H248471 0.6 FANTOM5 12.4 +326.6 326605 0 HDGF TARDBP MAFG ZNF207 OR14I1 OR2T1 OR2M2 OR2M7 OR2M5 OR2M4 OR2T33 OR2T6 OR2M3 OR2T10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2M5 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2M5 Gene

Chromosome:
1
Start:
248,145,148 bp from pter
End:
248,146,086 bp from pter
Size:
939 bases
Orientation:
Plus strand

Genomic View for OR2M5 Gene

Genes around OR2M5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2M5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2M5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2M5 Gene

Proteins for OR2M5 Gene

  • Protein details for OR2M5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A3KFT3-OR2M5_HUMAN
    Recommended name:
    Olfactory receptor 2M5
    Protein Accession:
    A3KFT3

    Protein attributes for OR2M5 Gene

    Size:
    312 amino acids
    Molecular mass:
    35112 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2M5 Gene

Post-translational modifications for OR2M5 Gene

Other Protein References for OR2M5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2M5 Gene

Domains & Families for OR2M5 Gene

Gene Families for OR2M5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2M5 Gene

Suggested Antigen Peptide Sequences for OR2M5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A3KFT3

UniProtKB/Swiss-Prot:

OR2M5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2M5: view

Function for OR2M5 Gene

Molecular function for OR2M5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2M5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2M5: view

Phenotypes for OR2M5 Gene

GenomeRNAi human phenotypes for OR2M5:
genes like me logo Genes that share phenotypes with OR2M5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2M5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2M5 Gene

Localization for OR2M5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2M5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2M5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2M5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2M5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2M5 Gene

Pathways & Interactions for OR2M5 Gene

genes like me logo Genes that share pathways with OR2M5: view

Pathways by source for OR2M5 Gene

Interacting Proteins for OR2M5 Gene

Gene Ontology (GO) - Biological Process for OR2M5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2M5: view

No data available for SIGNOR curated interactions for OR2M5 Gene

Drugs & Compounds for OR2M5 Gene

No Compound Related Data Available

Transcripts for OR2M5 Gene

mRNA/cDNA for OR2M5 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2M5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR2M5 Gene

No ASD Table

Relevant External Links for OR2M5 Gene

GeneLoc Exon Structure for
OR2M5
ECgene alternative splicing isoforms for
OR2M5

Expression for OR2M5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2M5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2M5 Gene:

OR2M5

SOURCE GeneReport for Unigene cluster for OR2M5 Gene:

Hs.553580
genes like me logo Genes that share expression patterns with OR2M5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2M5 Gene

Orthologs for OR2M5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2M5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469763 33
  • 97.97 (n)
OR2M5 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC482235 33
  • 80.92 (n)
OR20H03 34
  • 78 (a)
OneToMany
cow
(Bos Taurus)
Mammalia OR2M3 33
  • 80.88 (n)
-- 34
  • 74 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr165 33 16 34
  • 74.28 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 53 (a)
OneToMany
Species where no ortholog for OR2M5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2M5 Gene

ENSEMBL:
Gene Tree for OR2M5 (if available)
TreeFam:
Gene Tree for OR2M5 (if available)

Paralogs for OR2M5 Gene

(457) SIMAP similar genes for OR2M5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR2M5 Gene

genes like me logo Genes that share paralogs with OR2M5: view

Variants for OR2M5 Gene

Sequence variations from dbSNP and Humsavar for OR2M5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001063673 -- 248,144,295(+) TTCTT(A/G)GTTTG upstream-variant-2KB
rs1002809149 -- 248,146,573(+) CACTT(A/G)GAATA downstream-variant-500B
rs1003192272 -- 248,146,308(+) TTTTT(C/T)ATTTA downstream-variant-500B
rs1005782307 -- 248,143,362(+) CAAGA(C/T)TCCAT upstream-variant-2KB
rs1006115820 -- 248,144,498(+) TTGAC(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2M5 Gene

Variant ID Type Subtype PubMed ID
dgv17e55 CNV loss 17911159
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv611n100 CNV gain 25217958
dgv612n100 CNV loss 25217958
dgv613n100 CNV loss 25217958
dgv904n54 CNV gain 21841781
esv2728006 CNV deletion 23290073
esv2728017 CNV deletion 23290073
esv2750832 CNV gain 17911159
esv2759014 CNV gain+loss 17122850
esv33129 CNV gain+loss 17666407
esv34503 CNV gain 17911159
esv3589540 CNV loss 21293372
esv3589541 CNV gain 21293372
esv3891415 CNV gain 25118596
nsv1006563 CNV gain+loss 25217958
nsv1011782 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv468861 CNV gain 19166990
nsv515858 CNV gain+loss 19592680
nsv549597 CNV gain 21841781
nsv549603 CNV loss 21841781
nsv549604 CNV gain 21841781
nsv549624 CNV loss 21841781
nsv945459 CNV duplication 23825009

Variation tolerance for OR2M5 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.99; 74.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2M5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2M5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2M5 Gene

Disorders for OR2M5 Gene

Relevant External Links for OR2M5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2M5

No disorders were found for OR2M5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2M5 Gene

Publications for OR2M5 Gene

  1. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I … Futreal PA (Nature 2011) 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 60

Products for OR2M5 Gene

Sources for OR2M5 Gene

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