OR2M5 Gene
protein-coding GIFtS: 39
GCID: GC01P248308
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olfactory receptor, family 2, subfamily M, member 5
(Previous symbol: OR2M5P)
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Aliases
for OR2M5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 2, Subfamily M, Member 51 2 | | OR2M5P1 2 3 | | Olfactory Receptor 2M52 | | Olfactory Receptor, Family 2, Subfamily M, Member 5 Pseudogene2 |
Export aliases for OR2M5 gene to outside databasesPrevious GC identifers: GC01P245198 GC01P244634 GC01P246375 |
Summaries
for OR2M5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR2M5:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR2M5_HUMAN, A3KFT3Function: Odorant receptor (Potential)
|
Genomic Views
for OR2M5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR2M5 gene promoter:
COUP-TF1 SRF Sox5 SRF (504 AA) COUP HNF-4alpha2 HNF-4alpha1 E47 COUP-TF Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR2M5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2M5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44OR2M5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P248308: view genomic region
(about GC identifiers)
Start:
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248,308,450 bp from pter |
End:
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248,309,385 bp from pter |
Size:
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936 bases |
Orientation:
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plus strand |
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Proteins
for OR2M5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR2M5_HUMAN, A3KFT3 (See
protein sequence)Recommended Name: Olfactory receptor 2M5 Size: 312 amino acids; 35112 Da
Subcellular location: Cell membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for OR2M5: NX_A3KFT3
HORDE protein sequence for OR2M5
OR2M5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001004690.1
ENSEMBL proteins: ENSP00000355432 Reactome Protein details: A3KFT3
Human Recombinant Protein Products for OR2M5:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR2M5 for ontologies About GeneDecksing
OR2M5 Antibody Products:
Assay Products for OR2M5: |
Protein
Domains /
Families
for OR2M5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR2M5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A3KFT3ProtoNet protein and cluster: A3KFT3 UniProtKB/Swiss-Prot: OR2M5_HUMAN, A3KFT3Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR2M5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: OR2M5_HUMAN, A3KFT3Function: Odorant receptor (Potential) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR2M5 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2M5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2M5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR2M5 (NM_001004690) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR2M5 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR2M5 |
|
Pathways & Interactions
for OR2M5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR2M5
1 
Kegg Pathway (Kegg details for OR2M5):
OR2M5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2M5
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for OR2M5 (ENSP000003554324) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for OR2M5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR2M5
Search CenterWatch for drugs/clinical trials and news about OR2M5
|
Transcripts
for OR2M5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR2M5 gene: NM_001004690.1 Unigene Cluster for OR2M5: Olfactory receptor, family 2, subfamily M, member 5 Hs.553580 Unigene Representative Sequence: NM_0010046901 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000366476(uc010pze.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2M5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2M5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR2M5 (NM_001004690) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR2M5 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR2M5 |
1 AceView cDNA sequence: NM_001004690
GeneLoc Exon Structure
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Expression
for OR2M5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR2M5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OR2M5 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.553580
SABiosciences Custom PCR Arrays for OR2M5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2M5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR2M5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2M5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2M5 |
Orthologs
for OR2M5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OR2M5 (if available)
TreeFam Gene Tree for OR2M5 (if available) |
Paralogs
for OR2M5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR2M5 gene
- OR2T352 OR2AK22 OR2V12 OR2M32 OR2L132 OR2T82 OR2M42 OR2T52
- OR2T272 OR2T332 OR2T102 OR2AJ12 OR2T112 OR2T292 OR2T62 OR2T12
- OR2T32 OR2V22 OR2M72 OR2T22 OR2L22 OR2T122 OR2L52 OR2AG12
- OR2Z12 OR2AE12 OR2M22 OR2T42 OR2L32 OR2T342 OR2L82 OR2AG22
18/457 SIMAP similar genes for OR2M5 using alignment to 1 protein entry: OR2M5_HUMAN(see all similar genes):OR2M2 OR2M3 OR2M7 OR2M4 OR2T12 OR2T2
OR2T33 OR2T8 OR2T1 OR2T35 OR2T7 OR2V2
OR2T11 OR2AJ1 OR2T27 OR2V1 OR2AE1 OR2AK2
OR2M5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for OR2M5
PGOHUM00000245306
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Genomic Variants
for OR2M5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR2M5 ( 248308450 - 248309385 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for OR2M5
5 CNVs: 6816 8353 8935 8354 2358 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for OR2M5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR2M5 for disorders About GeneDecksing
1  disease for OR2M5: About MalaCardsneuronitis
Export disorders for OR2M5 gene to outside databases
|
Publications
for OR2M5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR2M5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR2M5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (2004)
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External Searches for OR2M5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR2M5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR2M5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR2M5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR2M5 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR2M5 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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About This Section
| Patent Information for OR2M5 gene:
Search GeneIP for patents involving OR2M5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR2M5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR2M5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR2M5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2M5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR2M5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2M5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2M5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR2M5 | | OriGene Custom Protein Services for OR2M5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR2M5 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR2M5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2M5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR2M5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2M5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2M5 |
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 | | | OR2M5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibodies for OR2M5 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR2M5 |
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