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OR2M4 Gene

protein-coding   GIFtS: 49
GCID: GC01P248402

Olfactory Receptor, Family 2, Subfamily M, Member 4

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily M, Member 41 2     HSHTPCRX182
Olfactory Receptor OR1-552 3     OR1-552
Olfactory Receptor TPCR1002 3     TPCR1002
HTPCRX182 3     Novel 7 Transmembrane Receptor (Rhodopsin Family) Protein2
OST7102 3     Olfactory Receptor 2M42

External Ids:    HGNC: 82701   Entrez Gene: 262452   Ensembl: ENSG000001711807   UniProtKB: Q96R273   

Export aliases for OR2M4 gene to outside databases

Previous GC identifers: GC01P246270 GC01M243650 GC01P244450 GC01P245299 GC01P244730 GC01P246468


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2M4 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2M4 Gene:
OR2M4 (olfactory receptor, family 2, subfamily M, member 4) is a protein-coding gene. Diseases associated with OR2M4 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T35.

UniProtKB/Swiss-Prot: OR2M4_HUMAN, Q96R27
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2M4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2M4 gene promoter:
         TBP   FAC1   POU2F1   FOXC1   POU2F1a   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2M4 promoter sequence
   Search Chromatin IP Primers for OR2M4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2M4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

OR2M4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2M4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P248402:  view genomic region     (about GC identifiers)

Start:
248,402,231 bp from pter      End:
248,403,163 bp from pter
Size:
933 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR2M4_HUMAN, Q96R27 (See protein sequence)
Recommended Name: Olfactory receptor 2M4  
Size: 311 amino acids; 35071 Da
Secondary accessions: Q15611 Q8NG82

Explore the universe of human proteins at neXtProt for OR2M4: NX_Q96R27

Explore proteomics data for OR2M4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR2M4

    See OR2M4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_059974.1  
    ENSEMBL proteins: 
     ENSP00000306688  
    Reactome Protein details: Q96R27

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q96R27

    ProtoNet protein and cluster: Q96R27

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2M4_HUMAN, Q96R27
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR2M4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2M4_HUMAN, Q96R27
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity NAS9119360
         
    OR2M4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OR2M4:
     Increased cell number in G1, a 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2M4_HUMAN, Q96R27: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane NAS9119360

    OR2M4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2M4 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3GPCRs, Other
    GPCRs, Other

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR2M4
        GPCRs, Other

    1 Reactome Pathway for OR2M4
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2M4):
        Olfactory transduction


    OR2M4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2M4
    Interactions:

        Search GeneGlobe Interaction Network for OR2M4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR2M4 (ENSP000003066884) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR1C1ENSP000003861384STRING: ENSP00000386138
    OR1D2ENSP000003275854STRING: ENSP00000327585
    OR2T1ENSP000003554304STRING: ENSP00000355430
    OR2T6ENSP000003479654STRING: ENSP00000347965
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell NAS9119360
    GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS9119360

    OR2M4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2M4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR2M4 gene: 
    NM_017504.1  

    Unigene Cluster for OR2M4:

    Olfactory receptor, family 2, subfamily M, member 4
    Hs.381309
    Unigene Representative Sequence: NM_017504
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000306687(uc010pzh.2)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat OR2M4
      QuantiFast Probe-based Assays in human, mouse, rat OR2M4

    Additional mRNA sequence: 

    X64992.1 X89666.1 

    1 DOTS entry:

    DT.91906286 

    2 AceView cDNA sequences:

    X64992 X89666 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2M4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACCAGCTT
    OR2M4 Expression
    About this image

    OR2M4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2M4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.381309
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for OR2M4 (if available)
    TreeFam Gene Tree for OR2M4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2M4 gene
    OR2T352  OR2V22  OR2V12  OR2M32  OR2T72  OR2M72  OR2T82  OR2T22  
    OR2T122  OR2T272  OR2M52  OR2Z12  OR2T332  OR2AG12  OR2T52  OR2T102  
    OR2M22  OR2T42  OR2T342  OR2T112  OR2T292  OR2T62  OR2T12  OR2AG22  
    OR2T32  
    Selected SIMAP similar genes for OR2M4 using alignment to 1 protein entry:     OR2M4_HUMAN(see all similar genes):
    OR2M3    OR2M5    OR2M7    OR2M2    OR2T2    OR2T35
    OR2V2    OR2T11    OR2T33    OR2T10    OR2T12    OR2T8
    OR2V1    OR2AJ1    OR2T1    OR2T27    OR2T7    OR2L2

    OR2M4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2M4 (see all 109)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1165195501,2
    C,F--248400235(+) TACCAA/GCCAAA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1390086261,2
    --248400482(+) CAAACC/GAAATC 1 -- us2k10--------
    rs1118087251,2
    C,F--248400518(+) ACCACG/AATCAA 1 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs1812909451,2
    --248400586(+) ACAACC/GAATGA 1 -- us2k10--------
    rs1852570591,2
    C--248400588(+) AACCAA/GTGACA 1 -- us2k10--------
    rs762660881,2
    C,F--248400602(+) ACCACA/CTGATT 1 -- us2k15Minor allele frequency- C:0.08WA CSA NA 244
    rs1896315471,2
    --248400630(+) AAAGGC/GCTTAG 1 -- us2k10--------
    rs1162237471,2
    F--248400650(+) AACATC/TGCTTC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1436875621,2
    C--248400656(+) GCTTCA/GTGTTA 1 -- us2k10--------
    rs359335911,2
    C,F--248400695(+) TCATGC/TGTGTA 1 -- us2k12Minor allele frequency- T:0.50CSA 4

    HapMap Linkage Disequilibrium report for OR2M4 ( 248402231 - 248403163 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR2M4 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728006CNV Deletion23290073
    nsv873456CNV Loss21882294
    nsv9103CNV Loss18304495
    dgv568n71CNV Loss21882294
    dgv565n71CNV Loss21882294
    nsv873459CNV Loss21882294
    dgv17e55CNV Loss17911159
    dgv567n71CNV Gain21882294
    esv2750832CNV Gain17911159
    dgv564n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR2M4:    
    About MalaCards
    neuronitis


    OR2M4 for disorders           About GeneDecksing


    Export disorders for OR2M4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2M4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2M4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PubMed id 9119360)1, 2, 3 Vanderhaeghen P.... Parmentier M. (Genomics 1997)
    2. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PubMed id 1370859)1, 2, 3 Parmentier M.... Vassart G. (Nature 1992)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    6. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26245 HGNC: 8270 AceView: OR2M4 Ensembl:ENSG00000171180 euGenes: HUgn26245
    ECgene: OR2M4 Kegg: 26245 H-InvDB: OR2M4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2M4 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2M4 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2M4 gene:
    Search GeneIP for patents involving OR2M4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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