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Aliases for OR2M4 Gene

Aliases for OR2M4 Gene

  • Olfactory Receptor, Family 2, Subfamily M, Member 4 2 3
  • Olfactory Receptor TPCR100 3 4
  • Olfactory Receptor OR1-55 3 4
  • HTPCRX18 3 4
  • OST710 3 4
  • Novel 7 Transmembrane Receptor (Rhodopsin Family) Protein 3
  • Olfactory Receptor 2M4 3
  • HSHTPCRX18 3
  • TPCR100 3
  • OR1-55 3

External Ids for OR2M4 Gene

Summaries for OR2M4 Gene

Entrez Gene Summary for OR2M4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2M4 Gene

OR2M4 (Olfactory Receptor, Family 2, Subfamily M, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2M4 Gene

  • Odorant receptor.

Gene Wiki entry for OR2M4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2M4 Gene

Genomics for OR2M4 Gene

Genomic Location for OR2M4 Gene

Start:
248,238,929 bp from pter
End:
248,239,864 bp from pter
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR2M4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2M4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2M4 Gene

Regulatory Elements for OR2M4 Gene

Proteins for OR2M4 Gene

  • Protein details for OR2M4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R27-OR2M4_HUMAN
    Recommended name:
    Olfactory receptor 2M4
    Protein Accession:
    Q96R27
    Secondary Accessions:
    • Q15611
    • Q8NG82

    Protein attributes for OR2M4 Gene

    Size:
    311 amino acids
    Molecular mass:
    35071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2M4 Gene

Proteomics data for OR2M4 Gene at MOPED

Post-translational modifications for OR2M4 Gene

Other Protein References for OR2M4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2M4 Gene

Domains for OR2M4 Gene

Gene Families for OR2M4 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2M4 Gene

UniProtKB/Swiss-Prot:

OR2M4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q96R27
genes like me logo Genes that share domains with OR2M4: view

Function for OR2M4 Gene

Molecular function for OR2M4 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2M4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
genes like me logo Genes that share ontologies with OR2M4: view

Phenotypes for OR2M4 Gene

GenomeRNAi human phenotypes for OR2M4:
genes like me logo Genes that share phenotypes with OR2M4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2M4 Gene

Localization for OR2M4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2M4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2M4 Gene COMPARTMENTS Subcellular localization image for OR2M4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2M4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 9119360
genes like me logo Genes that share ontologies with OR2M4: view

Pathways for OR2M4 Gene

genes like me logo Genes that share pathways with OR2M4: view

Pathways by source for OR2M4 Gene

1 BioSystems pathway for OR2M4 Gene
1 KEGG pathway for OR2M4 Gene

Interacting Proteins for OR2M4 Gene

Gene Ontology (GO) - Biological Process for OR2M4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 9119360
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 9119360
genes like me logo Genes that share ontologies with OR2M4: view

Transcripts for OR2M4 Gene

mRNA/cDNA for OR2M4 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2M4 Gene

No ASD Table

Relevant External Links for OR2M4 Gene

GeneLoc Exon Structure for
OR2M4
ECgene alternative splicing isoforms for
OR2M4

Expression for OR2M4 Gene

mRNA expression in normal human tissues for OR2M4 Gene

mRNA differential expression in normal tissues according to GTEx for OR2M4 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (7.5), Brain - Frontal Cortex (BA9) (7.3), Brain - Hypothalamus (6.4), Brain - Cortex (6.0), Brain - Spinal cord (cervical c-1) (5.5), and Brain - Substantia nigra (4.2).

SOURCE GeneReport for Unigene cluster for OR2M4 Gene Hs.381309

genes like me logo Genes that share expressions with OR2M4: view

Orthologs for OR2M4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2M4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469765 36
  • 98.93 (n)
  • 98.39 (a)
OR2M4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR2M4 36
  • 82.47 (n)
  • 82.9 (a)
OR2M4 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 75 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr315 37
  • 56 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 53 (a)
OneToMany
Species with no ortholog for OR2M4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2M4 Gene

ENSEMBL:
Gene Tree for OR2M4 (if available)
TreeFam:
Gene Tree for OR2M4 (if available)

Paralogs for OR2M4 Gene

Selected SIMAP similar genes for OR2M4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2M4: view

Variants for OR2M4 Gene

Sequence variations from dbSNP and Humsavar for OR2M4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4130948 -- 248,238,584(+) ATTTA(A/G)CAATA upstream-variant-2KB
rs4130949 -- 248,238,615(+) TCCTA(A/G)GTTTT upstream-variant-2KB
rs4130950 -- 248,238,834(+) AACTG(C/T)CCAGT upstream-variant-2KB
rs4347239 -- 248,237,814(+) AGATG(A/G)GCCAC upstream-variant-2KB
rs4354568 -- 248,237,487(+) tatct(C/G)tacta upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2M4 Gene

Variant ID Type Subtype PubMed ID
nsv515858 CNV Gain+Loss 19592680
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
dgv564n71 CNV Gain 21882294
dgv565n71 CNV Loss 21882294
esv2728006 CNV Deletion 23290073
nsv468861 CNV Gain 19166990
nsv9103 CNV Loss 18304495
dgv566n71 CNV Gain 21882294
dgv567n71 CNV Gain 21882294
nsv873456 CNV Loss 21882294
dgv568n71 CNV Loss 21882294
nsv873459 CNV Loss 21882294

Relevant External Links for OR2M4 Gene

HapMap Linkage Disequilibrium report
OR2M4

Disorders for OR2M4 Gene

No disorders were found for OR2M4 Gene.

No data available for UniProtKB/Swiss-Prot for OR2M4 Gene

Publications for OR2M4 Gene

  1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M. … Vassart G. (Nature 1992) 2 3 4
  2. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P. … Parmentier M. (Genomics 1997) 2 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for OR2M4 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate OR2M4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for OR2M4
    • Block miRNA regulation of OR2M4 using miScript Target Protectors

    Sources for OR2M4 Gene

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