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Aliases for OR2M3 Gene

Aliases for OR2M3 Gene

  • Olfactory Receptor Family 2 Subfamily M Member 3 2 3 5
  • Olfactory Receptor OR1-54 3 4
  • Olfactory Receptor 2M6 3 4
  • OR2M3P 3 4
  • OR2M6 3 4
  • Olfactory Receptor, Family 2, Subfamily M, Member 3 Pseudogene 3
  • Novel 7 Transmembrane Receptor (Rhodopsin Family) Protein 3
  • Olfactory Receptor, Family 2, Subfamily M, Member 3 2
  • Olfactory Receptor, Family 2, Subfamily M, Member 6 3
  • Olfactory Receptor 2M3 3
  • OR1-54 3
  • OST003 3

External Ids for OR2M3 Gene

Previous HGNC Symbols for OR2M3 Gene

  • OR2M6
  • OR2M3P

Previous GeneCards Identifiers for OR2M3 Gene

  • GC01P245264
  • GC01P244692
  • GC01P246432
  • GC01P248366

Summaries for OR2M3 Gene

Entrez Gene Summary for OR2M3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2M3 Gene

OR2M3 (Olfactory Receptor Family 2 Subfamily M Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2M5.

UniProtKB/Swiss-Prot for OR2M3 Gene

  • Odorant receptor.

Gene Wiki entry for OR2M3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2M3 Gene

Genomics for OR2M3 Gene

Regulatory Elements for OR2M3 Gene

Enhancers for OR2M3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F248471 0.5 FANTOM5 10.4 +268.7 268685 0.4 HDGF TARDBP OR14I1 OR2T1 OR2M2 OR2M7 OR2M5 OR2M4 OR2T33 OR2T6 OR2M3 OR2T10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2M3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2M3 Gene

Chromosome:
1
Start:
248,203,068 bp from pter
End:
248,204,006 bp from pter
Size:
939 bases
Orientation:
Plus strand

Genomic View for OR2M3 Gene

Genes around OR2M3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2M3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2M3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2M3 Gene

Proteins for OR2M3 Gene

  • Protein details for OR2M3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG83-OR2M3_HUMAN
    Recommended name:
    Olfactory receptor 2M3
    Protein Accession:
    Q8NG83
    Secondary Accessions:
    • B9EH06
    • Q6IEY0

    Protein attributes for OR2M3 Gene

    Size:
    312 amino acids
    Molecular mass:
    34827 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2M3 Gene

Post-translational modifications for OR2M3 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2M3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2M3 Gene

Domains & Families for OR2M3 Gene

Gene Families for OR2M3 Gene

Protein Domains for OR2M3 Gene

Suggested Antigen Peptide Sequences for OR2M3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG83

UniProtKB/Swiss-Prot:

OR2M3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2M3: view

Function for OR2M3 Gene

Molecular function for OR2M3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2M3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2M3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2M3 Gene

Localization for OR2M3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2M3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2M3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2M3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2M3: view

Pathways & Interactions for OR2M3 Gene

genes like me logo Genes that share pathways with OR2M3: view

Pathways by source for OR2M3 Gene

Gene Ontology (GO) - Biological Process for OR2M3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2M3: view

No data available for SIGNOR curated interactions for OR2M3 Gene

Transcripts for OR2M3 Gene

mRNA/cDNA for OR2M3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2M3 Gene

No ASD Table

Relevant External Links for OR2M3 Gene

GeneLoc Exon Structure for
OR2M3
ECgene alternative splicing isoforms for
OR2M3

Expression for OR2M3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2M3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2M3 Gene:

OR2M3

SOURCE GeneReport for Unigene cluster for OR2M3 Gene:

Hs.553581
genes like me logo Genes that share expression patterns with OR2M3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR2M3 Gene

Orthologs for OR2M3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2M3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC741161 34
  • 98.4 (n)
OR2M3 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR2M5 34
  • 84.89 (n)
OR20H03 35
  • 79 (a)
OneToMany
cow
(Bos Taurus)
Mammalia OR2M5 34
  • 81.24 (n)
-- 35
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1570 34
  • 75.93 (n)
mouse
(Mus musculus)
Mammalia Or2m12 55 Olfr164 34 16
  • 75.32 (n)
Olfr1394 35
  • 55 (a)
ManyToMany
Or2m13 55 Olfr165
  • chr16:19,407,079-19,408,017
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 53 (a)
OneToMany
Species where no ortholog for OR2M3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2M3 Gene

ENSEMBL:
Gene Tree for OR2M3 (if available)
TreeFam:
Gene Tree for OR2M3 (if available)

Paralogs for OR2M3 Gene

(454) SIMAP similar genes for OR2M3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2M3: view

Variants for OR2M3 Gene

Sequence variations from dbSNP and Humsavar for OR2M3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111410363 -- 248,202,910(+) AGATT(C/T)TATAT upstream-variant-2KB
rs111499490 -- 248,202,424(+) GCTGA(A/G)TATCT upstream-variant-2KB
rs111669252 -- 248,201,919(+) ACAGT(G/T)GTCAA upstream-variant-2KB
rs111962188 -- 248,202,026(+) TGGAT(A/G)TATTA upstream-variant-2KB
rs11204611 -- 248,201,395(+) TCTAA(C/T)GCCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2M3 Gene

Variant ID Type Subtype PubMed ID
nsv945462 CNV duplication 23825009
nsv9103 CNV loss 18304495
nsv549629 CNV gain 21841781
nsv549626 CNV loss 21841781
nsv549604 CNV gain 21841781
nsv549603 CNV loss 21841781
nsv549597 CNV gain 21841781
nsv515858 CNV gain+loss 19592680
nsv468861 CNV gain 19166990
nsv1013273 CNV gain 25217958
nsv1006563 CNV gain+loss 25217958
nsv1001474 CNV gain 25217958
esv3891415 CNV gain 25118596
esv3589544 CNV gain 21293372
esv34503 CNV gain 17911159
esv2750832 CNV gain 17911159
esv2728017 CNV deletion 23290073
esv2728006 CNV deletion 23290073
dgv905n54 CNV gain 21841781
dgv904n54 CNV gain 21841781
dgv85e214 CNV loss 21293372
dgv614n100 CNV loss 25217958
dgv613n100 CNV loss 25217958
dgv612n100 CNV loss 25217958
dgv611n100 CNV gain 25217958
dgv608n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv606n100 CNV gain 25217958
dgv17e55 CNV loss 17911159

Variation tolerance for OR2M3 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2M3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2M3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2M3 Gene

Disorders for OR2M3 Gene

Relevant External Links for OR2M3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2M3

No disorders were found for OR2M3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2M3 Gene

Publications for OR2M3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR2M3 Gene

Sources for OR2M3 Gene

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