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Aliases for OR2M2 Gene

Aliases for OR2M2 Gene

  • Olfactory Receptor, Family 2, Subfamily M, Member 2 2 3
  • OST423 3 4
  • Olfactory Receptor 2M2 3
  • OR2M2Q 3

External Ids for OR2M2 Gene

Summaries for OR2M2 Gene

Entrez Gene Summary for OR2M2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2M2 Gene

OR2M2 (Olfactory Receptor, Family 2, Subfamily M, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2M2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2M2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2M2 Gene

Genomics for OR2M2 Gene

Genomic Location for OR2M2 Gene

Start:
248,179,986 bp from pter
End:
248,181,029 bp from pter
Size:
1,044 bases
Orientation:
Plus strand

Genomic View for OR2M2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2M2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2M2 Gene

Regulatory Elements for OR2M2 Gene

Proteins for OR2M2 Gene

  • Protein details for OR2M2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R28-OR2M2_HUMAN
    Recommended name:
    Olfactory receptor 2M2
    Protein Accession:
    Q96R28
    Secondary Accessions:
    • A3KFT4

    Protein attributes for OR2M2 Gene

    Size:
    347 amino acids
    Molecular mass:
    39177 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2M2 Gene

Proteomics data for OR2M2 Gene at MOPED

Post-translational modifications for OR2M2 Gene

Other Protein References for OR2M2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2M2 Gene

Domains for OR2M2 Gene

Gene Families for OR2M2 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2M2 Gene

UniProtKB/Swiss-Prot:

OR2M2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q96R28
genes like me logo Genes that share domains with OR2M2: view

Function for OR2M2 Gene

Molecular function for OR2M2 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2M2: view

Phenotypes for OR2M2 Gene

GenomeRNAi human phenotypes for OR2M2:
genes like me logo Genes that share phenotypes with OR2M2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2M2 Gene

Localization for OR2M2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2M2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2M2 Gene COMPARTMENTS Subcellular localization image for OR2M2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2M2: view

Pathways for OR2M2 Gene

genes like me logo Genes that share pathways with OR2M2: view

Pathways by source for OR2M2 Gene

Interacting Proteins for OR2M2 Gene

Gene Ontology (GO) - Biological Process for OR2M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2M2: view

Transcripts for OR2M2 Gene

mRNA/cDNA for OR2M2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2M2 Gene

No ASD Table

Relevant External Links for OR2M2 Gene

GeneLoc Exon Structure for
OR2M2
ECgene alternative splicing isoforms for
OR2M2

Expression for OR2M2 Gene

mRNA expression in normal human tissues for OR2M2 Gene

SOURCE GeneReport for Unigene cluster for OR2M2 Gene Hs.534728

genes like me logo Genes that share expressions with OR2M2: view

Orthologs for OR2M2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2M2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469764 36
  • 98.6 (n)
  • 97.74 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 74 (a)
OneToMany
LOC514235 36
  • 75.27 (n)
  • 71.97 (a)
dog
(Canis familiaris)
Mammalia OR20H03 37
  • 78 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr1395 37
  • 57 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 54 (a)
OneToMany
Species with no ortholog for OR2M2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2M2 Gene

ENSEMBL:
Gene Tree for OR2M2 (if available)
TreeFam:
Gene Tree for OR2M2 (if available)

Paralogs for OR2M2 Gene

Selected SIMAP similar genes for OR2M2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2M2: view

Variants for OR2M2 Gene

Sequence variations from dbSNP and Humsavar for OR2M2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4244171 - 248,180,643(+) ATGCT(C/G)GAGTT reference, missense
rs4345832 -- 248,178,401(+) CTCAT(A/G)CATTT upstream-variant-2KB
rs4523547 -- 248,178,490(+) TCCCA(A/C)AATCT upstream-variant-2KB
rs4916104 - 248,180,688(+) GTCGT(C/T)GCAAA missense, reference
rs4916105 -- 248,181,140(+) GGACA(C/T)TAAAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR2M2 Gene

Variant ID Type Subtype PubMed ID
esv34503 CNV Gain 17911159
nsv515858 CNV Gain+Loss 19592680
nsv873442 CNV Gain 21882294
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
dgv564n71 CNV Gain 21882294
dgv565n71 CNV Loss 21882294
esv2728006 CNV Deletion 23290073
nsv468861 CNV Gain 19166990
esv2728017 CNV Deletion 23290073
nsv9103 CNV Loss 18304495
dgv566n71 CNV Gain 21882294
dgv567n71 CNV Gain 21882294

Relevant External Links for OR2M2 Gene

HapMap Linkage Disequilibrium report
OR2M2
Human Gene Mutation Database (HGMD)
OR2M2

Disorders for OR2M2 Gene

Relevant External Links for OR2M2

Genetic Association Database (GAD)
OR2M2
genes like me logo Genes that share disorders with OR2M2: view

No data available for UniProtKB/Swiss-Prot for OR2M2 Gene

Publications for OR2M2 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for OR2M2 Gene

Sources for OR2M2 Gene

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