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Aliases for OR2L8 Gene

Aliases for OR2L8 Gene

  • Olfactory Receptor, Family 2, Subfamily L, Member 8 (Gene/Pseudogene) 2 3
  • Olfactory Receptor, Family 2, Subfamily L, Member 8 2
  • Olfactory Receptor OR1-46 4

External Ids for OR2L8 Gene

Summaries for OR2L8 Gene

Entrez Gene Summary for OR2L8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2L8 Gene

OR2L8 (Olfactory Receptor, Family 2, Subfamily L, Member 8 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR2L8 Gene

  • Odorant receptor.

Gene Wiki entry for OR2L8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2L8 Gene

Genomics for OR2L8 Gene

Regulatory Elements for OR2L8 Gene

Genomic Location for OR2L8 Gene

Start:
247,948,858 bp from pter
End:
247,949,796 bp from pter
Size:
939 bases
Orientation:
Plus strand

Genomic View for OR2L8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2L8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2L8 Gene

Proteins for OR2L8 Gene

  • Protein details for OR2L8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGY9-OR2L8_HUMAN
    Recommended name:
    Olfactory receptor 2L8
    Protein Accession:
    Q8NGY9
    Secondary Accessions:
    • Q6IF03

    Protein attributes for OR2L8 Gene

    Size:
    312 amino acids
    Molecular mass:
    35444 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2L8 Gene

Proteomics data for OR2L8 Gene at MOPED

Post-translational modifications for OR2L8 Gene

Other Protein References for OR2L8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2L8 Gene

Domains for OR2L8 Gene

Gene Families for OR2L8 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2L8 Gene

Suggested Antigen Peptide Sequences for OR2L8 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NGY9

UniProtKB/Swiss-Prot:

OR2L8_HUMAN :
  • Q8NGY9
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2L8: view

Function for OR2L8 Gene

Molecular function for OR2L8 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2L8: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2L8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2L8 Gene

Localization for OR2L8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2L8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2L8 Gene COMPARTMENTS Subcellular localization image for OR2L8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2L8: view

Pathways for OR2L8 Gene

genes like me logo Genes that share pathways with OR2L8: view

Pathways by source for OR2L8 Gene

Interacting Proteins for OR2L8 Gene

Gene Ontology (GO) - Biological Process for OR2L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0008150 biological_process ND --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2L8: view

Transcripts for OR2L8 Gene

mRNA/cDNA for OR2L8 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2L8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR2L8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2L8 Gene

No ASD Table

Relevant External Links for OR2L8 Gene

GeneLoc Exon Structure for
OR2L8
ECgene alternative splicing isoforms for
OR2L8

Expression for OR2L8 Gene

mRNA expression in normal human tissues for OR2L8 Gene

SOURCE GeneReport for Unigene cluster for OR2L8 Gene Hs.690212

genes like me logo Genes that share expressions with OR2L8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR2L8 Gene

Orthologs for OR2L8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for OR2L8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100615576 35
  • 98.08 (n)
  • 97.12 (a)
Species with no ortholog for OR2L8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2L8 Gene

ENSEMBL:
Gene Tree for OR2L8 (if available)
TreeFam:
Gene Tree for OR2L8 (if available)

Paralogs for OR2L8 Gene

Selected SIMAP similar genes for OR2L8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR2L8: view

No data available for Paralogs for OR2L8 Gene

Variants for OR2L8 Gene

Sequence variations from dbSNP and Humsavar for OR2L8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_053147 -
VAR_059987 -
VAR_059988 -
VAR_059989 -
VAR_062024 -

Structural Variations from Database of Genomic Variants (DGV) for OR2L8 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV Gain+Loss 17666407
nsv873440 CNV Gain 21882294
dgv204e1 CNV Complex 17122850
esv34503 CNV Gain 17911159
nsv515858 CNV Gain+Loss 19592680
nsv873442 CNV Gain 21882294
dgv205e1 CNV Complex 17122850
nsv873443 CNV Gain 21882294
esv2750832 CNV Gain 17911159
esv2727929 CNV Deletion 23290073

Relevant External Links for OR2L8 Gene

HapMap Linkage Disequilibrium report
OR2L8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2L8 Gene

Disorders for OR2L8 Gene

No disorders were found for OR2L8 Gene.

No data available for UniProtKB/Swiss-Prot for OR2L8 Gene

Publications for OR2L8 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2L8 Gene

Sources for OR2L8 Gene

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