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Aliases for OR2L8 Gene

Aliases for OR2L8 Gene

  • Olfactory Receptor Family 2 Subfamily L Member 8 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 2, Subfamily L, Member 8 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 2, Subfamily L, Member 8 2
  • Olfactory Receptor OR1-46 4

External Ids for OR2L8 Gene

Previous GeneCards Identifiers for OR2L8 Gene

  • GC01U990406
  • GC01P244438
  • GC01P246178
  • GC01P248112

Summaries for OR2L8 Gene

Entrez Gene Summary for OR2L8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR2L8 Gene

OR2L8 (Olfactory Receptor Family 2 Subfamily L Member 8 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2L3.

UniProtKB/Swiss-Prot for OR2L8 Gene

  • Odorant receptor.

Gene Wiki entry for OR2L8 Gene

Additional gene information for OR2L8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2L8 Gene

Genomics for OR2L8 Gene

Regulatory Elements for OR2L8 Gene

Genomic Locations for OR2L8 Gene

Genomic Locations for OR2L8 Gene
939 bases
Plus strand

Genomic View for OR2L8 Gene

Genes around OR2L8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2L8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2L8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2L8 Gene

Proteins for OR2L8 Gene

  • Protein details for OR2L8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2L8
    Protein Accession:
    Secondary Accessions:
    • Q6IF03

    Protein attributes for OR2L8 Gene

    312 amino acids
    Molecular mass:
    35444 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2L8 Gene

Post-translational modifications for OR2L8 Gene

  • Glycosylation at posLast=55 and Asn88

Other Protein References for OR2L8 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2L8 Gene

Domains & Families for OR2L8 Gene

Gene Families for OR2L8 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2L8 Gene

Suggested Antigen Peptide Sequences for OR2L8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2L8: view

Function for OR2L8 Gene

Molecular function for OR2L8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2L8: view

Phenotypes for OR2L8 Gene

GenomeRNAi human phenotypes for OR2L8:
genes like me logo Genes that share phenotypes with OR2L8: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2L8 Gene

Localization for OR2L8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2L8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2L8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2L8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2L8 Gene

Pathways & Interactions for OR2L8 Gene

genes like me logo Genes that share pathways with OR2L8: view

Pathways by source for OR2L8 Gene

Interacting Proteins for OR2L8 Gene

Gene Ontology (GO) - Biological Process for OR2L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0008150 biological_process ND --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR2L8: view

No data available for SIGNOR curated interactions for OR2L8 Gene

Drugs & Compounds for OR2L8 Gene

No Compound Related Data Available

Transcripts for OR2L8 Gene

mRNA/cDNA for OR2L8 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2L8 Gene

No ASD Table

Relevant External Links for OR2L8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2L8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2L8 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2L8 Gene:


SOURCE GeneReport for Unigene cluster for OR2L8 Gene:

genes like me logo Genes that share expression patterns with OR2L8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2L8 Gene

Orthologs for OR2L8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for OR2L8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100615576 33
  • 98.08 (n)
Species where no ortholog for OR2L8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2L8 Gene

Gene Tree for OR2L8 (if available)
Gene Tree for OR2L8 (if available)

Paralogs for OR2L8 Gene

Paralogs for OR2L8 Gene

(446) SIMAP similar genes for OR2L8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR2L8: view

Variants for OR2L8 Gene

Sequence variations from dbSNP and Humsavar for OR2L8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000084688 -- 247,949,745(+) GAGGT(A/G)ATGGG intron-variant, reference, synonymous-codon
rs1001559828 -- 247,950,198(+) GTGGA(A/T)CTAAT intron-variant, downstream-variant-500B
rs1001560346 -- 247,947,058(+) TTTTG(C/T)TTACC intron-variant, upstream-variant-2KB
rs1001904959 -- 247,947,393(+) CTGGT(A/G)ATCTT intron-variant, upstream-variant-2KB
rs1003944438 -- 247,948,332(+) CATAG(G/T)TATTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2L8 Gene

Variant ID Type Subtype PubMed ID
nsv549603 CNV loss 21841781
nsv549604 CNV gain 21841781
nsv945443 CNV duplication 23825009
nsv549602 CNV loss 21841781
nsv549601 CNV loss 21841781
nsv549597 CNV gain 21841781
nsv515858 CNV gain+loss 19592680
nsv1013273 CNV gain 25217958
nsv1008024 CNV gain 25217958
esv3891415 CNV gain 25118596
esv3589522 CNV gain 21293372
esv34503 CNV gain 17911159
esv33129 CNV gain+loss 17666407
esv2762235 CNV gain 21179565
esv2759014 CNV gain+loss 17122850
esv2750832 CNV gain 17911159
esv2727929 CNV deletion 23290073
dgv608n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv606n100 CNV gain 25217958
dgv605n100 CNV gain 25217958
dgv604n100 CNV gain 25217958

Variation tolerance for OR2L8 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2L8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2L8 Gene

Disorders for OR2L8 Gene

Relevant External Links for OR2L8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR2L8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2L8 Gene

Publications for OR2L8 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 60
  3. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR2L8 Gene

Sources for OR2L8 Gene

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