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Aliases for OR2L3 Gene

Aliases for OR2L3 Gene

  • Olfactory Receptor Family 2 Subfamily L Member 3 2 3 5
  • Olfactory Receptor, Family 2, Subfamily L, Member 3 2

External Ids for OR2L3 Gene

Previous GeneCards Identifiers for OR2L3 Gene

  • GC01U990411
  • GC01P245109
  • GC01P244550
  • GC01P246290
  • GC01P248223

Summaries for OR2L3 Gene

Entrez Gene Summary for OR2L3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2L3 Gene

OR2L3 (Olfactory Receptor Family 2 Subfamily L Member 3) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2L8.

UniProtKB/Swiss-Prot for OR2L3 Gene

  • Odorant receptor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2L3 Gene

Genomics for OR2L3 Gene

Regulatory Elements for OR2L3 Gene

Enhancers for OR2L3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G248471 0.6 FANTOM5 7.3 +411.1 411071 0.4 HDGF TARDBP MAFG ZNF207 OR14I1 OR2T1 OR2M2 OR2M7 OR2M5 OR2M4 OR2T33 OR2T6 OR2M3 OR2T10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2L3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2L3 Gene

Chromosome:
1
Start:
248,060,682 bp from pter
End:
248,061,620 bp from pter
Size:
939 bases
Orientation:
Plus strand

Genomic View for OR2L3 Gene

Genes around OR2L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2L3 Gene

Proteins for OR2L3 Gene

  • Protein details for OR2L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG85-OR2L3_HUMAN
    Recommended name:
    Olfactory receptor 2L3
    Protein Accession:
    Q8NG85
    Secondary Accessions:
    • B9EH44

    Protein attributes for OR2L3 Gene

    Size:
    312 amino acids
    Molecular mass:
    35282 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2L3 Gene

Post-translational modifications for OR2L3 Gene

  • Glycosylation at posLast=55 and Asn88
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2L3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2L3 Gene

Domains & Families for OR2L3 Gene

Gene Families for OR2L3 Gene

Protein Domains for OR2L3 Gene

Suggested Antigen Peptide Sequences for OR2L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG85

UniProtKB/Swiss-Prot:

OR2L3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2L3: view

Function for OR2L3 Gene

Molecular function for OR2L3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2L3: view
genes like me logo Genes that share phenotypes with OR2L3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2L3 Gene

Localization for OR2L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2L3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2L3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2L3: view

Pathways & Interactions for OR2L3 Gene

genes like me logo Genes that share pathways with OR2L3: view

Pathways by source for OR2L3 Gene

Interacting Proteins for OR2L3 Gene

Gene Ontology (GO) - Biological Process for OR2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA,IEA --
GO:0008150 biological_process ND --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR2L3: view

No data available for SIGNOR curated interactions for OR2L3 Gene

Drugs & Compounds for OR2L3 Gene

No Compound Related Data Available

Transcripts for OR2L3 Gene

mRNA/cDNA for OR2L3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2L3 Gene

Olfactory receptor, family 2, subfamily L, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2L3 Gene

No ASD Table

Relevant External Links for OR2L3 Gene

GeneLoc Exon Structure for
OR2L3
ECgene alternative splicing isoforms for
OR2L3

Expression for OR2L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2L3 Gene

mRNA differential expression in normal tissues according to GTEx for OR2L3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.0) and Pituitary (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of OR2L3 Gene:

OR2L3

SOURCE GeneReport for Unigene cluster for OR2L3 Gene:

Hs.690412
genes like me logo Genes that share expression patterns with OR2L3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2L3 Gene

Orthologs for OR2L3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469759 34
  • 98.4 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 84 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
-- 35
  • 80 (a)
ManyToMany
-- 35
  • 79 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 82 (a)
ManyToMany
-- 35
  • 82 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
-- 35
  • 80 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr167 35
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 69 (a)
OneToMany
Species where no ortholog for OR2L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2L3 Gene

ENSEMBL:
Gene Tree for OR2L3 (if available)
TreeFam:
Gene Tree for OR2L3 (if available)

Paralogs for OR2L3 Gene

Paralogs for OR2L3 Gene

(440) SIMAP similar genes for OR2L3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2L3: view

Variants for OR2L3 Gene

Sequence variations from dbSNP and Humsavar for OR2L3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000208081 -- 248,060,682(+) GCCCC(A/G)TGGAA intron-variant, reference, missense
rs1000541941 -- 248,061,924(+) TGAAG(A/T)TGGCA intron-variant, downstream-variant-500B
rs1001866091 -- 248,060,170(+) AACAT(A/C)TGATT intron-variant, upstream-variant-2KB
rs1006290712 -- 248,062,112(+) TTCAA(A/T)TTAGG intron-variant, downstream-variant-500B
rs1006305576 -- 248,059,787(+) TGACT(C/G)CACTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2L3 Gene

Variant ID Type Subtype PubMed ID
dgv604n100 CNV gain 25217958
dgv606n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv608n100 CNV gain 25217958
dgv610n100 CNV loss 25217958
esv2727929 CNV deletion 23290073
esv2750832 CNV gain 17911159
esv2759014 CNV gain+loss 17122850
esv2762235 CNV gain 21179565
esv33129 CNV gain+loss 17666407
esv34503 CNV gain 17911159
esv3575883 CNV gain 25503493
esv3589533 CNV loss 21293372
esv3891415 CNV gain 25118596
nsv1008024 CNV gain 25217958
nsv1013071 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv515858 CNV gain+loss 19592680
nsv549597 CNV gain 21841781
nsv549601 CNV loss 21841781
nsv549603 CNV loss 21841781
nsv549604 CNV gain 21841781
nsv549621 CNV loss 21841781
nsv945453 CNV duplication 23825009

Variation tolerance for OR2L3 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.86; 86.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2L3 Gene

Disorders for OR2L3 Gene

Relevant External Links for OR2L3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2L3

No disorders were found for OR2L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2L3 Gene

Publications for OR2L3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR2L3 Gene

Sources for OR2L3 Gene

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