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Aliases for OR2L2 Gene

Aliases for OR2L2 Gene

  • Olfactory Receptor, Family 2, Subfamily L, Member 2 2 3
  • Olfactory Receptor 2L12 3 4
  • Olfactory Receptor 2L4 3 4
  • HTPCRH07 3 4
  • OR2L12 3 4
  • OR2L4P 3 4
  • Olfactory Receptor, Family 2, Subfamily L, Member 4 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily L, Member 12 3
  • Olfactory Receptor OR1-48 Pseudogene 3
  • Olfactory Receptor 2L2 3
  • HSHTPCRH07 3
  • OR1-48 3

External Ids for OR2L2 Gene

Previous HGNC Symbols for OR2L2 Gene

  • OR2L4P
  • OR2L12

Previous GeneCards Identifiers for OR2L2 Gene

  • GC01U990263
  • GC01P245100
  • GC01P244527
  • GC01P246268
  • GC01P248201

Summaries for OR2L2 Gene

Entrez Gene Summary for OR2L2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2L2 Gene

OR2L2 (Olfactory Receptor, Family 2, Subfamily L, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2L5.

UniProtKB/Swiss-Prot for OR2L2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2L2 Gene

Genomics for OR2L2 Gene

Regulatory Elements for OR2L2 Gene

Genomic Location for OR2L2 Gene

248,038,172 bp from pter
248,039,305 bp from pter
1,134 bases
Plus strand

Genomic View for OR2L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2L2 Gene

Proteins for OR2L2 Gene

  • Protein details for OR2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2L2
    Protein Accession:
    Secondary Accessions:
    • Q2M3T5

    Protein attributes for OR2L2 Gene

    312 amino acids
    Molecular mass:
    35495 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2L2 Gene

Proteomics data for OR2L2 Gene at MOPED

Post-translational modifications for OR2L2 Gene

  • Glycosylation at Asn5 and Asn88
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2L2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2L2 Gene

Domains for OR2L2 Gene

Gene Families for OR2L2 Gene

  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2L2 Gene

Suggested Antigen Peptide Sequences for OR2L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8NH16
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2L2: view

Function for OR2L2 Gene

Molecular function for OR2L2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2L2: view

Animal Model Products

CRISPR Products

miRNA for OR2L2 Gene

miRTarBase miRNAs that target OR2L2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2L2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OR2L2 Gene

Localization for OR2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2L2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR2L2 Gene COMPARTMENTS Subcellular localization image for OR2L2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2L2: view

Pathways for OR2L2 Gene

genes like me logo Genes that share pathways with OR2L2: view

Pathways by source for OR2L2 Gene

Interacting Proteins for OR2L2 Gene

Gene Ontology (GO) - Biological Process for OR2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0008150 biological_process ND --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2L2: view

Transcripts for OR2L2 Gene

mRNA/cDNA for OR2L2 Gene

(2) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2L2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2L2 Gene

No ASD Table

Relevant External Links for OR2L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2L2 Gene

mRNA expression in normal human tissues for OR2L2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2L2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.9), Testis (6.7), Brain - Substantia nigra (5.0), Brain - Putamen (basal ganglia) (4.8), and Brain - Hippocampus (4.4).

SOURCE GeneReport for Unigene cluster for OR2L2 Gene Hs.684888

genes like me logo Genes that share expressions with OR2L2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR2L2 Gene

Orthologs for OR2L2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR2L2 35
  • 82.69 (n)
  • 80.77 (a)
-- 36
  • 83 (a)
-- 36
  • 80 (a)
-- 36
  • 81 (a)
-- 36
  • 80 (a)
(Mus musculus)
Mammalia Olfr167 35
  • 79.8 (n)
  • 79.8 (a)
Olfr167 16
Olfr167 36
  • 79 (a)
(Pan troglodytes)
Mammalia LOC469758 35
  • 98.72 (n)
  • 98.08 (a)
(Rattus norvegicus)
Mammalia LOC100911043 35
  • 79.91 (n)
  • 79.15 (a)
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
-- 36
  • 78 (a)
-- 36
  • 79 (a)
-- 36
  • 82 (a)
-- 36
  • 80 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
Species with no ortholog for OR2L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2L2 Gene

Gene Tree for OR2L2 (if available)
Gene Tree for OR2L2 (if available)

Paralogs for OR2L2 Gene

Paralogs for OR2L2 Gene

Selected SIMAP similar genes for OR2L2 Gene using alignment to 1 proteins: Pseudogenes for OR2L2 Gene

genes like me logo Genes that share paralogs with OR2L2: view

Variants for OR2L2 Gene

Sequence variations from dbSNP and Humsavar for OR2L2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_053144 -
VAR_053145 -

Structural Variations from Database of Genomic Variants (DGV) for OR2L2 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV Gain+Loss 17666407
dgv204e1 CNV Complex 17122850
esv34503 CNV Gain 17911159
nsv515858 CNV Gain+Loss 19592680
nsv873442 CNV Gain 21882294
dgv205e1 CNV Complex 17122850
esv2750832 CNV Gain 17911159
esv2727929 CNV Deletion 23290073
nsv873445 CNV Loss 21882294
esv2663706 CNV Deletion 23128226
dgv75e201 CNV Deletion 23290073

Relevant External Links for OR2L2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2L2 Gene

Disorders for OR2L2 Gene

No disorders were found for OR2L2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR2L2 Gene

Publications for OR2L2 Gene

  1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M. … Vassart G. (Nature 1992) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for OR2L2 Gene

Sources for OR2L2 Gene

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