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OR2L13 Gene

protein-coding   GIFtS: 51
GCID: GC01P248100

Olfactory Receptor, Family 2, Subfamily L, Member 13


(Previous symbol: OR2L14)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily L, Member 131 2
OR2L141 2 3
Olfactory Receptor 2L142 3
Olfactory Receptor 2L132
Olfactory Receptor, Family 2, Subfamily L, Member 142

External Ids:    HGNC: 195781   Entrez Gene: 2845212   Ensembl: ENSG000001960717   UniProtKB: Q8N3493   

Export aliases for OR2L13 gene to outside databases

Previous GC identifers: GC00U915464 GC01P244426 GC01P246167


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2L13 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2L13 Gene:
OR2L13 (olfactory receptor, family 2, subfamily L, member 13) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2L8.

UniProtKB/Swiss-Prot: OR2LD_HUMAN, Q8N349
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2L13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2L13 gene promoter:
         USF1   AML1a   Bach2   PPAR-alpha   Pax-3   POU2F1   USF-1   POU2F1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2L13 promoter sequence
   Search Chromatin IP Primers for OR2L13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2L13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

OR2L13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2L13 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P248100:  view genomic region     (about GC identifiers)

Start:
248,262,678 bp from pter      End:
248,263,613 bp from pter
Size:
936 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR2LD_HUMAN, Q8N349 (See protein sequence)
Recommended Name: Olfactory receptor 2L13  
Size: 312 amino acids; 35634 Da
Secondary accessions: Q5VUR5

Explore the universe of human proteins at neXtProt for OR2L13: NX_Q8N349

Explore proteomics data for OR2L13 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn20
  • HORDE protein sequence for OR2L13

    See OR2L13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_787107.1  
    ENSEMBL proteins: 
     ENSP00000350836   ENSP00000355434  
    Reactome Protein details: Q8N349

    OR2L13 Human Recombinant Protein Products:

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    antibodies-online peptides for OR2L13

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    antibodies-online antibodies for OR2L13 (10 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8N349

    ProtoNet protein and cluster: Q8N349

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2LD_HUMAN, Q8N349
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR2L13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2LD_HUMAN, Q8N349
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
    GO:0005515protein binding IPI19945174
         
    Find genes that share ontologies with OR2L13           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OR2L13:
     Decreased Salmonella enterica  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR2L13

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate OR2L13:
    hsa-miR-203 hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidOR2L13 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2LD_HUMAN, Q8N349: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR2L13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2L13 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR2L13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for OR2L13
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2L13):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2L13
    Interactions:

        Search GeneGlobe Interaction Network for OR2L13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR2L13 (ENSP000003508364) via UniProtKB, MINT, STRING, and/or I2D (see all 274)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10K2ENSP000003242514STRING: ENSP00000324251
    OR2Y1ENSP000003124034STRING: ENSP00000312403
    OR4E2ENSP000003861954STRING: ENSP00000386195
    OR51G2ENSP000003225934STRING: ENSP00000322593
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0008150biological_process ND--

    Find genes that share ontologies with OR2L13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2L13 (OR2LD)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR2L13 gene: 
    NM_175911.2  

    Unigene Cluster for OR2L13:

    Olfactory receptor, family 2, subfamily L, member 13
    Hs.372936  [show with all ESTs]
    Unigene Representative Sequence: NM_175911
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358120 ENST00000366478(uc001ids.3)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate OR2L13:
    hsa-miR-203 hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidOR2L13 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OR2L13
    Predesigned siRNA for gene silencing in human, mouse, rat OR2L13
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    GenScript: all cDNA clones in your preferred vector: OR2L13 (NM_175911)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OR2L13
      QuantiTect SYBR Green Assays in human, mouse, rat OR2L13
      QuantiFast Probe-based Assays in human, mouse, rat OR2L13

    Additional mRNA sequence: BC028158.1 

    2 DOTS entries:

    DT.91692363  DT.97814243 

    8 AceView cDNA sequences:

    CR599101 BI912805 BI912668 NM_175911 BC028158 BM921225 AL539245 AL539244 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2L13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAAGGTAAA
    OR2L13 Expression
    About this image

    OR2L13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2L13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.372936
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2L13 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr1661 , 5 olfactory receptor 1661, 5 80.13(n)1
    85.02(a)1
      16 (12.07 cM)5
    2590711  NM_147068.11  NP_667279.11 
     194868405 


    ENSEMBL Gene Tree for OR2L13 (if available)
    TreeFam Gene Tree for OR2L13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2L13 gene
    OR2L82  OR2AK22  OR2AJ12  OR2L22  OR2L32  OR2AE12  OR2L52  
    Selected SIMAP similar genes for OR2L13 using alignment to 1 protein entry:     OR2LD_HUMAN(see all similar genes):
    OR2L2    OR2L3    OR2L5    OR2L8    OR2AJ1    OR2AK2
    OR2T1    OR2T11    OR2V2    OR2T2    OR2T29    OR2T35
    OR2T4    OR2T5    OR2V1    OR2T33    OR2T6    OR2T8

    Find genes that share paralogs with OR2L13           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2L13 (see all 4198)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs731375001,2
    C,F--218482105(+) AGGAAT/CATCAT 1 -- us2k13Minor allele frequency- C:0.06WA CSA 122
    rs1415668241,2
    --218482273(+) ACACAC/GTTTGT 1 -- us2k10--------
    rs1878934561,2
    --218482290(+) AAAATA/GTATGG 1 -- us2k10--------
    rs1921401881,2
    --218482299(+) GGGCCA/GGGCGC 1 -- us2k10--------
    rs1461798701,2
    C--218482330(+) CCAACA/TCTTTC 1 -- us2k10--------
    rs121190171,2
    C,A--218482438(+) CGGGCT/GTGGTG 1 -- us2k17Minor allele frequency- G:0.00NA WA 14
    rs1129816191,2
    C--218482539(+) GCCACT/CGCACT 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs360369211,2
    C--218482553(+) GCCTGA/GGCCAC 1 -- us2k12Minor allele frequency- G:0.00NA 4
    rs618574951,2
    C--218482556(+) TGGGCG/CACAGA 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1924689881,2
    --218482557(+) GGGCCA/GCAGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR2L13 ( 248262678 - 248263613 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR2L13 (see all 34):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727995CNV Deletion23290073
    esv2727984CNV Deletion23290073
    dgv75e201CNV Deletion23290073
    esv3861CNV Deletion18987735
    esv2613716CNV Deletion19546169
    dgv111e199CNV Deletion23128226
    esv2663706CNV Deletion23128226
    esv2727929CNV Deletion23290073
    esv2728006CNV Deletion23290073
    esv2035728CNV Deletion18987734

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR2L13           About GenesLikeMe

    Genetic Association Database (GAD): OR2L13
    Human Genome Epidemiology (HuGE) Navigator: OR2L13 (1 document)

    Export disorders for OR2L13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2L13 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2L13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system. (PubMed id 19945174)1 Naz R.K. and Dhandapani L. (J. Reprod. Immunol. 2010)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284521 HGNC: 19578 AceView: OR2L13 Ensembl:ENSG00000196071 euGenes: HUgn284521
    ECgene: OR2L13 Kegg: 284521 H-InvDB: OR2L13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2L13 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2L13 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2L13 gene:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OR2L13
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