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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR2L13 Gene

protein-coding   GIFtS: 51
GCID: GC01P248100

Olfactory Receptor, Family 2, Subfamily L, Member 13


(Previous symbol: OR2L14)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 2, Subfamily L, Member 131 2
OR2L141 2 3
Olfactory Receptor 2L142 3
Olfactory Receptor 2L132
Olfactory Receptor, Family 2, Subfamily L, Member 142

External Ids:    HGNC: 195781   Entrez Gene: 2845212   Ensembl: ENSG000001960717   UniProtKB: Q8N3493   

Export aliases for OR2L13 gene to outside databases

Previous GC identifers: GC00U915464 GC01P244426 GC01P246167


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR2L13 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2L13 Gene: 
OR2L13 (olfactory receptor, family 2, subfamily L, member 13) is a protein-coding gene. Diseases associated with OR2L13 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2L8.

UniProtKB/Swiss-Prot: OR2LD_HUMAN, Q8N349
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2L13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR2L13 gene promoter:
         USF1   AML1a   Bach2   PPAR-alpha   Pax-3   POU2F1   USF-1   POU2F1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2L13 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR2L13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2L13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

OR2L13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2L13 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P248100:  view genomic region     (about GC identifiers)

Start:
248,262,678 bp from pter      End:
248,263,613 bp from pter
Size:
936 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OR2LD_HUMAN, Q8N349 (See protein sequence)
Recommended Name: Olfactory receptor 2L13  
Size: 312 amino acids; 35634 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q5VUR5

Explore the universe of human proteins at neXtProt for OR2L13: NX_Q8N349

Explore proteomics data for OR2L13 at MOPED 

HORDE protein sequence for OR2L13
OR2L13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

OR2L13 Protein Expression

REFSEQ proteins: NP_787107.1  
ENSEMBL proteins: 
 ENSP00000350836   ENSP00000355434  
Reactome Protein details: Q8N349
Human Recombinant Protein Products for OR2L13: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

OR2L13 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
OR2: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8N349

ProtoNet protein and cluster: Q8N349

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR2LD_HUMAN, Q8N349
Similarity: Belongs to the G-protein coupled receptor 1 family


OR2L13 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: OR2LD_HUMAN, Q8N349
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
GO:0005515protein binding IPI19945174
     
OR2L13 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for OR2L13:
 Decreased Salmonella enterica  

Animal Models:
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SwitchGear 3'UTR luciferase reporter plasmidOR2L13 3' UTR sequence
Inhib. RNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR2L13 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory transduction
Olfactory Signaling Pathway0.81
Olfactory transduction0.81
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



4        Reactome Pathways for OR2L13
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR2L13):
    Olfactory transduction


OR2L13 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2L13

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/274 Interacting proteins for OR2L13 (ENSP000003508364) via UniProtKB, MINT, STRING, and/or I2D (see all 274)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
GNALENSP000003340514STRING: ENSP00000334051
GNGT1ENSP000002485724STRING: ENSP00000248572
OR10A3ENSP000003539884STRING: ENSP00000353988
OR10A4ENSP000003691574STRING: ENSP00000369157
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0008150biological_process ND--

OR2L13 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR2L13 (OR2LD)

Search CenterWatch for drugs/clinical trials and news about OR2L13 / OR2LD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR2L13 gene: 
NM_175911.2  

Unigene Cluster for OR2L13:

Olfactory receptor, family 2, subfamily L, member 13
Hs.372936  [show with all ESTs]
Unigene Representative Sequence: NM_175911
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000358120 ENST00000366478(uc001ids.3)
miRNA
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2 QIAGEN miScript miRNA Assays for microRNAs that regulate OR2L13:
hsa-miR-203 hsa-miR-656
SwitchGear 3'UTR luciferase reporter plasmidOR2L13 3' UTR sequence
Inhib. RNA
Products:
     
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                     Customized lentivirus expression plasmids for stable overexpression of OR2L13 
Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2L13

Additional mRNA sequence: BC028158.1 

2 DOTS entries:

DT.91692363  DT.97814243 

8 AceView cDNA sequences:

CR599101 BM921225 BI912668 BC028158 BI912805 NM_175911 AL539244 AL539245 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR2L13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTAAGGTAAA
OR2L13 Expression
About this image


See OR2L13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR2L13

SOURCE GeneReport for Unigene cluster: Hs.372936
    SABiosciences Custom PCR Arrays for OR2L13
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2L13
In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for OR2L13 gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr1661 , 5 olfactory receptor 1661, 5 79.74(n)1
84.24(a)1
  16 (12.07 cM)5
2590711  NM_147068.11  NP_667279.11 
 194868405 


ENSEMBL Gene Tree for OR2L13 (if available)
TreeFam Gene Tree for OR2L13 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR2L13 gene
OR2L82  OR2AK22  OR2AJ12  OR2L22  OR2L32  OR2L52  
18/433 SIMAP similar genes for OR2L13 using alignment to 1 protein entry:     OR2LD_HUMAN(see all similar genes):
OR2L2    OR2L3    OR2L5    OR2L8    OR2AJ1    OR2AK2
OR2T1    OR2T11    OR2V2    OR2T2    OR2T29    OR2T35
OR2T4    OR2T5    OR2V1    OR2T33    OR2T6    OR2T8

OR2L13 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/4198 SNPs in OR2L13 are shown (see all 4198)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs731375001,2
C,F--218482105(+) AGGAAT/CATCAT 1 -- us2k13Minor allele frequency- C:0.06WA CSA 122
rs1415668241,2
--218482273(+) ACACAC/GTTTGT 1 -- us2k10--------
rs1878934561,2
--218482290(+) AAAATA/GTATGG 1 -- us2k10--------
rs1921401881,2
--218482299(+) GGGCCA/GGGCGC 1 -- us2k10--------
rs1461798701,2
C--218482330(+) CCAACA/TCTTTC 1 -- us2k10--------
rs121190171,2
C,A--218482438(+) CGGGCT/GTGGTG 1 -- us2k17Minor allele frequency- G:0.00NA WA 14
rs1129816191,2
C--218482539(+) GCCACT/CGCACT 1 -- us2k11Minor allele frequency- C:0.00CSA 1
rs360369211,2
C--218482553(+) GCCTGA/GGCCAC 1 -- us2k12Minor allele frequency- G:0.00NA 4
rs618574951,2
C--218482556(+) TGGGCG/CACAGA 1 -- us2k11Minor allele frequency- C:0.00NA 2
rs1924689881,2
--218482557(+) GGGCCA/GCAGAG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OR2L13 ( 248262678 - 248263613 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/34 variations for OR2L13 (see all 34):    About this table     
Variant IDTypeSubtypePubMed ID
esv2727995CNV Deletion23290073
esv2727984CNV Deletion23290073
dgv75e201CNV Deletion23290073
esv3861CNV Deletion18987735
esv2613716CNV Deletion19546169
dgv111e199CNV Deletion23128226
esv2663706CNV Deletion23128226
esv2727929CNV Deletion23290073
esv2728006CNV Deletion23290073
esv2035728CNV Deletion18987734

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for OR2L13:    About MalaCards
neuronitis    


OR2L13 for disorders           About GeneDecksing

Genetic Association Database (GAD): OR2L13
Human Genome Epidemiology (HuGE) Navigator: OR2L13 (1 document)

Export disorders for OR2L13 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR2L13 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR2L13)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system. (PubMed id 19945174)1 Naz R.K. and Dhandapani L. (2010)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 284521 HGNC: 19578 AceView: OR2L13 Ensembl:ENSG00000196071 euGenes: HUgn284521
ECgene: OR2L13 Kegg: 284521 H-InvDB: OR2L13

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR2L13 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR2L13 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR2L13 gene:
Search GeneIP for patents involving OR2L13

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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