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Aliases for OR2K2 Gene

Aliases for OR2K2 Gene

  • Olfactory Receptor Family 2 Subfamily K Member 2 2 3 5
  • Olfactory Receptor, Family 2, Subfamily K, Member 2 2 3
  • Olfactory Receptor OR9-17 3 4
  • HTPCRH06 3 4
  • OR2AR1P 3 4
  • Olfactory Receptor, Family 2, Subfamily AN, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily AR, Member 1 Pseudogene 3
  • HSHTPCRH06 3
  • OR2AN1P 3

External Ids for OR2K2 Gene

Previous HGNC Symbols for OR2K2 Gene

  • OR2AR1P

Previous GeneCards Identifiers for OR2K2 Gene

  • GC09M104887
  • GC09M105821
  • GC09M107547
  • GC09M109469
  • GC09M111169
  • GC09M113129
  • GC09M114089

Summaries for OR2K2 Gene

Entrez Gene Summary for OR2K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2K2 Gene

OR2K2 (Olfactory Receptor Family 2 Subfamily K Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR13C7.

UniProtKB/Swiss-Prot for OR2K2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2K2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2K2 Gene

Genomics for OR2K2 Gene

Regulatory Elements for OR2K2 Gene

Enhancers for OR2K2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR2K2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2K2 Gene

Chromosome:
9
Start:
111,327,370 bp from pter
End:
111,330,173 bp from pter
Size:
2,804 bases
Orientation:
Minus strand

Genomic View for OR2K2 Gene

Genes around OR2K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2K2 Gene

Proteins for OR2K2 Gene

  • Protein details for OR2K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGT1-OR2K2_HUMAN
    Recommended name:
    Olfactory receptor 2K2
    Protein Accession:
    Q8NGT1
    Secondary Accessions:
    • Q2TA61
    • Q5VYK4
    • Q6IFI5

    Protein attributes for OR2K2 Gene

    Size:
    345 amino acids
    Molecular mass:
    38473 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05929.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH73239.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for OR2K2 Gene

Proteomics data for OR2K2 Gene at MOPED

Post-translational modifications for OR2K2 Gene

  • Glycosylation at Asn 34
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2K2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

  • Abcam antibodies for OR2K2

No data available for DME Specific Peptides for OR2K2 Gene

Domains & Families for OR2K2 Gene

Gene Families for OR2K2 Gene

Protein Domains for OR2K2 Gene

Suggested Antigen Peptide Sequences for OR2K2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGT1

UniProtKB/Swiss-Prot:

OR2K2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2K2: view

Function for OR2K2 Gene

Molecular function for OR2K2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR2K2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2K2 Gene

Localization for OR2K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2K2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2K2 Gene COMPARTMENTS Subcellular localization image for OR2K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2K2: view

Pathways & Interactions for OR2K2 Gene

genes like me logo Genes that share pathways with OR2K2: view

Pathways by source for OR2K2 Gene

Interacting Proteins for OR2K2 Gene

Gene Ontology (GO) - Biological Process for OR2K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2K2: view

No data available for SIGNOR curated interactions for OR2K2 Gene

Drugs & Compounds for OR2K2 Gene

No Compound Related Data Available

Transcripts for OR2K2 Gene

mRNA/cDNA for OR2K2 Gene

(3) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2K2 Gene

No ASD Table

Relevant External Links for OR2K2 Gene

GeneLoc Exon Structure for
OR2K2
ECgene alternative splicing isoforms for
OR2K2

Expression for OR2K2 Gene

mRNA expression in normal human tissues for OR2K2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2K2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.0), Muscle - Skeletal (x6.6), and Brain - Substantia nigra (x6.4).

SOURCE GeneReport for Unigene cluster for OR2K2 Gene Hs.381312

genes like me logo Genes that share expression patterns with OR2K2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR2K2 Gene

Orthologs for OR2K2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2K2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC539574 35
  • 87.55 (n)
  • 86.39 (a)
OR2K2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100856036 35
  • 87.66 (n)
  • 85.76 (a)
OR2K2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr267 35
  • 85.15 (n)
  • 87.5 (a)
Olfr267 16
Olfr267 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC473017 35
  • 99.05 (n)
  • 98.1 (a)
OR2K2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr854 35
  • 84.47 (n)
  • 87.38 (a)
oppossum
(Monodelphis domestica)
Mammalia OR2K2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
ManyToMany
Species with no ortholog for OR2K2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2K2 Gene

ENSEMBL:
Gene Tree for OR2K2 (if available)
TreeFam:
Gene Tree for OR2K2 (if available)

Paralogs for OR2K2 Gene

(458) SIMAP similar genes for OR2K2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR2K2 Gene

genes like me logo Genes that share paralogs with OR2K2: view

Variants for OR2K2 Gene

Sequence variations from dbSNP and Humsavar for OR2K2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs113030209 -- 111,327,310(+) CAAAT(A/G)CAAAT downstream-variant-500B
rs113103751 -- 111,329,130(+) GACAG(A/G)GAGGC intron-variant, upstream-variant-2KB
rs113499953 -- 111,329,153(+) AAGCC(A/G)AGATT intron-variant, upstream-variant-2KB
rs113799875 -- 111,327,729(+) AAAGC(C/G/T)TTGTT reference, missense
rs114391938 -- 111,330,389(+) TTATT(A/G)TTTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2K2 Gene

Variant ID Type Subtype PubMed ID
nsv893722 CNV Gain 21882294

Variation tolerance for OR2K2 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.97; 74.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR2K2 Gene

Disorders for OR2K2 Gene

Relevant External Links for OR2K2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2K2

No disorders were found for OR2K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2K2 Gene

Publications for OR2K2 Gene

  1. Ancient genomic architecture for mammalian olfactory receptor clusters. (PMID: 17010214) Aloni R. … Lancet D. (Genome Biol. 2006) 2 3 67
  2. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M. … Vassart G. (Nature 1992) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3
  5. Multiple loci are associated with white blood cell phenotypes. (PMID: 21738480) Nalls M.A. … Ganesh S.K. (PLoS Genet. 2011) 3

Products for OR2K2 Gene

Sources for OR2K2 Gene

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