OR2K2 Gene
protein-coding GIFtS: 48
GCID: GC09M114089
|
|
olfactory receptor, family 2, subfamily K, member 2
(Previous symbol: OR2AR1P)
| |
Aliases
for OR2K2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 2, Subfamily K, Member 21 2 | | OR2AN1P2 | | HTPCRH061 2 3 | | Olfactory Receptor 2K22 | | OR2AR1P1 2 3 | | Olfactory Receptor, Family 2, Subfamily AN, Member 1 Pseudogene2 | | HSHTPCRH061 2 | | Olfactory Receptor, Family 2, Subfamily AR, Member 1 Pseudogene2 | | Olfactory Receptor OR9-172 3 | | |
Export aliases for OR2K2 gene to outside databasesPrevious GC identifers: GC09M104887 GC09M105821 GC09M107547 GC09M109469 GC09M111169 GC09M113129 |
Summaries
for OR2K2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR2K2:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR2K2_HUMAN, Q8NGT1Function: Odorant receptor (Potential)
Gene Wiki entry for OR2K2
|
Genomic Views
for OR2K2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR2K2 gene promoter:
AML1a XBP-1 Cdc5 Tal-1beta MEF-2A c-Rel aMEF-2 ITF-2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR2K2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2K2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q31.3 Ensembl cytogenetic band: 9q31.3 HGNC cytogenetic band: 9q31.3OR2K2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M114089: view genomic region
(about GC identifiers)
Start:
|
114,089,766 bp from pter |
End:
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114,090,713 bp from pter |
Size:
|
948 bases |
Orientation:
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minus strand |
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Proteins
for OR2K2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR2K2_HUMAN, Q8NGT1 (See
protein sequence)Recommended Name: Olfactory receptor 2K2 Size: 345 amino acids; 38473 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: It is uncertain whether Met-1 or Met-30 is the initiator
Sequence caution: Sequence=BAC05929.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAH73239.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q2TA61 Q5VYK4 Q6IFI5Explore the universe of human proteins at neXtProt for OR2K2: NX_Q8NGT1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NGT1
HORDE protein sequence for OR2K2
OR2K2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_995581.1
ENSEMBL proteins: ENSP00000305055 ENSP00000363550 Reactome Protein details: Q8NGT1
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR2K2 for ontologies About GeneDecksing
OR2K2 Antibody Products:
Assay Products for OR2K2: |
Protein
Domains /
Families
for OR2K2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR2K2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NGT1ProtoNet protein and cluster: Q8NGT1 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR2K2_HUMAN, Q8NGT1Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR2K2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OR2K2_HUMAN, Q8NGT1Function: Odorant receptor (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2K2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2K2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for OR2K2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2K2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2K2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR2K2 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR2K2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR2K2
1 
Kegg Pathway (Kegg details for OR2K2):
OR2K2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2K2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/273 Interacting proteins for OR2K2 (ENSP000003050554) via UniProtKB, MINT, STRING, and/or I2D (see all 273)About this table
|
Drugs & Compounds
for OR2K2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR2K2
Search CenterWatch for drugs/clinical trials and news about OR2K2
|
Transcripts
for OR2K2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR2K2 gene: NM_205859.1 Unigene Cluster for OR2K2: Olfactory receptor, family 2, subfamily K, member 2 Hs.381312 Unigene Representative Sequence: NM_2058592 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000302681(uc011lwp.2) ENST00000374428
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2K2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2K2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR2K2 (NM_205859) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR2K2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2K2 |
Additional cDNA sequence: BC111086.1 X64977.1 1 DOTS entry: DT.102827561 2 AceView cDNA sequences: NM_205859 X64977
GeneLoc Exon Structure
|
Expression
for OR2K2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR2K2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OR2K2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR2K2
SOURCE GeneReport for Unigene cluster: Hs.381312
SABiosciences Custom PCR Arrays for OR2K2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2K2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR2K2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2K2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2K2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2K2 |
Orthologs
for OR2K2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR2K2 gene from 2/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Olfr2671 , 5 |
olfactory receptor 2671, 5 |
85.65(n)1
88.35(a)1 |
|
4 (32.35 cM)5
2589221 NM_146920.21 NP_667131.21
587847795 |
zebrafish
(Danio rerio) |
Actinopterygii |
or101-16 |
odorant receptor, family B, subfamily 101, member ... |
39(a) |
1 → many |
21(39151877-39153417) |
ENSEMBL Gene Tree for OR2K2 (if available)
TreeFam Gene Tree for OR2K2 (if available) |
Paralogs
for OR2K2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR2K2 gene
- OR13C82 OR13C32 OR13J12 OR13C22 OR13C42 OR13C92 OR13F12 OR13D12
- OR13C52 OR2S22 OR13H12
18/459 SIMAP similar genes for OR2K2 using alignment to 1 protein entry: OR2K2_HUMAN(see all similar genes):OR13F1 OR13C2 OR13C9 OR2S2 OR13C3 OR13D1
OR13C4 OR2G3 OR2W6P OR13C5 OR13C8 OR2B2
OR2G6 OR2J4P OR13J1 OR2B11 OR2B8P OR7-139
OR2K2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for OR2K2
PGOHUM00000233105 PGOHUM00000236742
|
Genomic Variants
for OR2K2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR2K2 ( 114089766 - 114090713 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR2K2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR2K2 |
|
Disorders
/ Diseases
for OR2K2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR2K2 for disorders About GeneDecksing
1  disease for OR2K2: About MalaCardsneuronitis
Export disorders for OR2K2 gene to outside databases
|
Publications
for OR2K2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR2K2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR2K2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Ancient genomic architecture for mammalian olfactory receptor clusters. (PubMed id 17010214)1, 3 Aloni R....Lancet D. (2006)
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PubMed id 1370859)1, 3 Parmentier M.... Vassart G. (1992)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for OR2K2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR2K2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR2K2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR2K2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR2K2 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR2K2 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
|
| | |
About This Section
| Patent Information for OR2K2 gene:
Search GeneIP for patents involving OR2K2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR2K2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR2K2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR2K2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2K2 | | | OriGene Protein Over-expression Lysate for OR2K2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR2K2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2K2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2K2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR2K2 | | OriGene Custom Protein Services for OR2K2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR2K2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR2K2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2K2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR2K2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2K2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2K2 |
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 |  |  |  | |
| | | | Search Tocris compounds for OR2K2 |
| |  |  |  |  | | | | |
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 | | | OR2K2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2K2 |
|  |  |  | | | | ThermoFisher Antibodies for OR2K2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2K2 |
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