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OR2J3 Gene

protein-coding   GIFtS: 50
GCID: GC06P029079

Olfactory Receptor, Family 2, Subfamily J, Member 3

  Search for OR2J3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily J, Member 31 2     HS6M1-32
Olfactory Receptor 6-62 3     OR6-162
Olfactory Receptor OR6-162 3     OR6.3.62
OR6-62 3     ORL6712
C3HEXS2 5     Olfactory Receptor 2J32
6M1-32     Hs6M1-33

External Ids:    HGNC: 82611   Entrez Gene: 4421862   Ensembl: ENSG000002047017   OMIM: 6150165   UniProtKB: O760013   

Export aliases for OR2J3 gene to outside databases

Previous GC identifers: GC06U990203 GC06P029188 GC06P028887


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2J3 Gene:
This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors
interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a
smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants,
including cut grass. This gene is situated in a cluster of similar olfactory-receptor coding genes on chromosome
6. (provided by RefSeq, May 2013)

GeneCards Summary for OR2J3 Gene:
OR2J3 (olfactory receptor, family 2, subfamily J, member 3) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2W1.

UniProtKB/Swiss-Prot: OR2J3_HUMAN, O76001
Function: Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound
typically described as 'green grassy' or the smell of 'cut grass'

Gene Wiki entry for OR2J3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the OR2J3 gene promoter:
         Nkx3-1   GR   GR-beta   FOXO3   Nkx3-1 v1   FOXO3b   CREB   deltaCREB   FOXO3a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2J3 promoter sequence
   Search Chromatin IP Primers for OR2J3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2J3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.2-p21.31

OR2J3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2J3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P029079:  view genomic region     (about GC identifiers)

Start:
29,079,668 bp from pter      End:
29,080,600 bp from pter
Size:
933 bases      Orientation:
plus strand

Selected alternative locations (see all 7):
Chr6+,NT_167249 420,553-421,488      Chr6+,NT_167246 383,070-384,005      Chr6+,NT_113891.2 598,545-599,480     
Chr6+,NT_167247 383,215-383,988      Chr6+,NT_167248 383,072-384,007      Chr6+,NT_167245 383,078-384,013     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR2J3_HUMAN, O76001 (See protein sequence)
Recommended Name: Olfactory receptor 2J3  
Size: 311 amino acids; 34950 Da
Secondary accessions: B0UY52 B9EH11 Q5SUJ7 Q6IF25 Q96R15 Q9GZK5 Q9GZL4 Q9GZL5

Explore the universe of human proteins at neXtProt for OR2J3: NX_O76001

Explore proteomics data for OR2J3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn8
  • HORDE protein sequence for OR2J3

    See OR2J3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005216.2  
    ENSEMBL proteins: 
     ENSP00000366374  
    Reactome Protein details: O76001

    OR2J3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for OR2J3

     
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    OR2J3 Antibody Products:

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    Search eBioscience for ELISAs for OR2J3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O76001

    ProtoNet protein and cluster: O76001

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2J3_HUMAN, O76001
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR2J3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2J3_HUMAN, O76001
    Function: Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound
    typically described as 'green grassy' or the smell of 'cut grass'

         Genatlas biochemistry entry for OR2J3:
    olfactory receptor,family 2,subfamily J,member 3,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR2J3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR2J3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OR2J3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OR2J3

    miRNA
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    miRTarBase miRNAs that target OR2J3:
    hsa-mir-26b-5p (MIRT028828), hsa-mir-335-5p (MIRT016787)

    Block miRNA regulation of human, mouse, rat OR2J3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate OR2J3
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    GenScript: all cDNA clones in your preferred vector: OR2J3 (NM_001005216)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OR2J3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2J3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2J3_HUMAN, O76001: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR2J3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2J3 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    Find genes that share SuperPaths with OR2J3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR2J3
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR2J3
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2J3):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2J3
    Interactions:

        Search GeneGlobe Interaction Network for OR2J3

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR2J3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2J3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR2J3 gene: 
    NM_001005216.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377169(uc011dll.2)
    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate OR2J3
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    Predesigned siRNA for gene silencing in human, mouse, rat OR2J3
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    GenScript: all cDNA clones in your preferred vector: OR2J3 (NM_001005216)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OR2J3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2J3
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OR2J3
      QuantiTect SYBR Green Assays in human, mouse, rat OR2J3
      QuantiFast Probe-based Assays in human, mouse, rat OR2J3

    2 AceView cDNA sequences:

    AJ459863 NM_001005216 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2J3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTCCAGC
    OR2J3 Expression
    About this image

    OR2J3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2J3 Protein Expression
        Custom PCR Arrays for OR2J3
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2J3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for OR2J3 (if available)
    TreeFam Gene Tree for OR2J3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2J3 gene
    OR2W12  OR2J22  OR2G22  OR2J12  OR2H22  OR2C12  OR2H12  OR2Y12  
    OR2W32  OR2G32  OR2C32  OR2G62  
    Selected SIMAP similar genes for OR2J3 using alignment to 1 protein entry:     OR2J3_HUMAN(see all similar genes):
    OR2J4P    OR2J1    OR2J2    OR2W6P    OLFR 42A    OR2C3
    OR2B2    OR2B8P    6M1-16    OR2G3    OR2G6    OR2C1
    OR2G2    OR2H1    OR2Y1    OR2B3    OR2B6    OR2H2

    Find genes that share paralogs with OR2J3           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for OR2J3 (see all 7)
    PGOHUM00000243548 PGOHUM00000245375 PGOHUM00000236854 PGOHUM00000242990 PGOHUM00000247345


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    OR2J3_HUMAN, O76001: Variants Ala-113 and Gln-226 exhibit a reduced ability to smell C3HEX [MIM:615082]. When both
    variants are present in the same haplotype (allele 6M1-3*02), the response to C3HEX is abolished. African
    populations have a higher proportion of the C3HEX-nonresponsive haplotype than other populations. All haplotypes
    containing Gln-226 show low levels of surface expression


    Selected SNPs for OR2J3 (see all 80)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94615081,2
    C,A,H--29077677(+) ATATGT/CACTAA 1 -- us2k15Minor allele frequency- C:0.18WA NA 244
    rs1164080171,2
    C,F--29077689(+) TATAGC/TTCATG 1 -- us2k11Minor allele frequency- T:0.14WA 118
    rs1881994861,2
    --29077745(+) CATCAG/TGTAGA 1 -- us2k10--------
    rs31307621,2
    C,F,O,A,H--29077787(+) TGAACC/GCTGTG 1 -- us2k117Minor allele frequency- G:0.26NS EA NA WA CSA 922
    rs1408068191,2
    --29078002(+) TTCGTA/GTCATG 1 -- us2k10--------
    rs31168381,2
    C,F,O,A,H--29078151(+) TTAGGT/CGAACA 1 -- us2k132Minor allele frequency- C:0.29NS EA NA WA CSA 3257
    rs93939441,2
    C,F,H--29078234(+) ATTACG/ATTTTC 1 -- us2k110Minor allele frequency- A:0.10NS EA NA WA 920
    rs94684851,2
    C,F,H--29078316(+) AAAGAT/GTTTGT 1 -- us2k15Minor allele frequency- G:0.08NS EA WA 538
    rs1819870331,2
    --29078413(+) CTTGAC/TAGTTA 1 -- us2k10--------
    rs1432401961,2
    --29078651(+) ATCTAC/TCTATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR2J3 ( 29079668 - 29080600 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OR2J3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6444n71CNV Loss21882294
    nsv830623CNV Gain17160897
    nsv428138CNV Gain+Loss18775914

    Human Gene Mutation Database (HGMD): OR2J3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR2J3
    DNA2.0 Custom Variant and Variant Library Synthesis for OR2J3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615016   
    OMIM disorders: 615082  

    Find genes that share disorders with OR2J3           About GenesLikeMe

    Genetic Association Database (GAD): OR2J3
    Human Genome Epidemiology (HuGE) Navigator: OR2J3 (2 documents)

    Export disorders for OR2J3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2J3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with OR2J3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the 'grassy' smelling odor, cis-3-hexen-1-ol. (PubMed id 22714804)1, 2 McRae J.F....Newcomb R.D. (Chem. Senses 2012)
    2. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    4. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    7. Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain. (PubMed id 23656994)1 Garcia-Esparcia P....Ferrer I. (J. Neuropathol. Exp. Neurol. 2013)
    8. Common variation contributes to the genetic architecture of social communication traits. (PubMed id 24047820)1 St Pourcain B....Smith G.D. (Mol Autism 2013)
    9. A probabilistic classifier for olfactory receptor pseudogenes. (PubMed id 16939646)1 Menashe I....Lancet D. (BMC Bioinformatics 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 442186 HGNC: 8261 AceView: OR2J3 Ensembl:ENSG00000204701 euGenes: HUgn442186
    ECgene: OR2J3 Kegg: 442186 H-InvDB: OR2J3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2J3 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2J3 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/150

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