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Aliases for OR2J3 Gene

Aliases for OR2J3 Gene

  • Olfactory Receptor, Family 2, Subfamily J, Member 3 2 3
  • Olfactory Receptor OR6-16 3 4
  • Olfactory Receptor 6-6 3 4
  • HS6M1-3 3 4
  • C3HEXS 3 6
  • OR6-6 3 4
  • Olfactory Receptor 2J3 3
  • OR6.3.6 3
  • OR6-16 3
  • ORL671 3
  • 6M1-3 3

External Ids for OR2J3 Gene

Summaries for OR2J3 Gene

Entrez Gene Summary for OR2J3 Gene

  • This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a cluster of similar olfactory-receptor coding genes on chromosome 6. [provided by RefSeq, May 2013]

GeneCards Summary for OR2J3 Gene

OR2J3 (Olfactory Receptor, Family 2, Subfamily J, Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2C1.

UniProtKB/Swiss-Prot for OR2J3 Gene

  • Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as green grassy or the smell of cut grass.

Gene Wiki entry for OR2J3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2J3 Gene

Genomics for OR2J3 Gene

Genomic Location for OR2J3 Gene

Start:
29,111,810 bp from pter
End:
29,112,884 bp from pter
Size:
1,075 bases
Orientation:
Plus strand

Genomic View for OR2J3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2J3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for OR2J3 Gene

Proteins for OR2J3 Gene

  • Protein details for OR2J3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76001-OR2J3_HUMAN
    Recommended name:
    Olfactory receptor 2J3
    Protein Accession:
    O76001
    Secondary Accessions:
    • B0UY52
    • B9EH11
    • Q5SUJ7
    • Q6IF25
    • Q96R15
    • Q9GZK5
    • Q9GZL4
    • Q9GZL5

    Protein attributes for OR2J3 Gene

    Size:
    311 amino acids
    Molecular mass:
    34950 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2J3 Gene

Proteomics data for OR2J3 Gene at MOPED

Post-translational modifications for OR2J3 Gene

Other Protein References for OR2J3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2J3 Gene

Domains for OR2J3 Gene

Gene Families for OR2J3 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2J3 Gene

UniProtKB/Swiss-Prot:

OR2J3_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • O76001
genes like me logo Genes that share domains with OR2J3: view

Function for OR2J3 Gene

Molecular function for OR2J3 Gene

GENATLAS Biochemistry: olfactory receptor,family 2,subfamily J,member 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as green grassy or the smell of cut grass.

Gene Ontology (GO) - Molecular Function for OR2J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2J3: view

miRNA for OR2J3 Gene

miRTarBase miRNAs that target OR2J3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OR2J3 Gene

Localization for OR2J3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2J3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2J3 Gene COMPARTMENTS Subcellular localization image for OR2J3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2J3: view

Pathways for OR2J3 Gene

genes like me logo Genes that share pathways with OR2J3: view

Pathways by source for OR2J3 Gene

1 KEGG pathway for OR2J3 Gene

Interacting Proteins for OR2J3 Gene

Gene Ontology (GO) - Biological Process for OR2J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2J3: view

Transcripts for OR2J3 Gene

mRNA/cDNA for OR2J3 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2J3 Gene

No ASD Table

Relevant External Links for OR2J3 Gene

GeneLoc Exon Structure for
OR2J3
ECgene alternative splicing isoforms for
OR2J3

Expression for OR2J3 Gene

mRNA expression in normal human tissues for OR2J3 Gene

mRNA differential expression in normal tissues according to GTEx for OR2J3 Gene

This gene is overexpressed in Testis (31.4).

SOURCE GeneReport for Unigene cluster for OR2J3 Gene Hs.738947

genes like me logo Genes that share expressions with OR2J3: view

Orthologs for OR2J3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2J3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC471931 36
  • 99.04 (n)
  • 98.07 (a)
OR2J3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 88 (a)
OneToMany
-- 37
  • 88 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
OR2J3 36
  • 87.59 (n)
  • 90.94 (a)
mouse
(Mus musculus)
Mammalia Olfr1381 37
  • 56 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 60 (a)
OneToMany
Species with no ortholog for OR2J3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2J3 Gene

ENSEMBL:
Gene Tree for OR2J3 (if available)
TreeFam:
Gene Tree for OR2J3 (if available)

Paralogs for OR2J3 Gene

Paralogs for OR2J3 Gene

Selected SIMAP similar genes for OR2J3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2J3: view

Variants for OR2J3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR2J3 Gene

O76001-OR2J3_HUMAN
Variants Ala-113 and Gln-226 exhibit a reduced ability to smell C3HEX [MIM:615082]. When both variants are present in the same haplotype (allele 6M1-3*02), the response to C3HEX is abolished. African populations have a higher proportion of the C3HEX-nonresponsive haplotype than other populations. All haplotypes containing Gln-226 show low levels of surface expression

Sequence variations from dbSNP and Humsavar for OR2J3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3116838 -- 29,110,374(+) TTAGG(C/T)GAACA upstream-variant-2KB
rs3116839 -- 29,112,918(+) TTCAC(G/T)CACTC downstream-variant-500B
rs3129106 -- 29,113,384(+) AATAG(G/T)AGAAC downstream-variant-500B
rs3130762 -- 29,110,010(+) TGAAC(C/G)CTGTG upstream-variant-2KB
rs3130763 -- 29,111,379(+) gcagg(C/T)tcatg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2J3 Gene

Variant ID Type Subtype PubMed ID
nsv830623 CNV Gain 17160897
dgv6444n71 CNV Loss 21882294
nsv428138 CNV Gain+Loss 18775914

Relevant External Links for OR2J3 Gene

HapMap Linkage Disequilibrium report
OR2J3
Human Gene Mutation Database (HGMD)
OR2J3

Disorders for OR2J3 Gene

(1) OMIM Diseases for OR2J3 Gene (615016)

Relevant External Links for OR2J3

Genetic Association Database (GAD)
OR2J3
Human Genome Epidemiology (HuGE) Navigator
OR2J3
genes like me logo Genes that share disorders with OR2J3: view

No data available for UniProtKB/Swiss-Prot for OR2J3 Gene

Publications for OR2J3 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 49
  5. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 49

Products for OR2J3 Gene

Sources for OR2J3 Gene

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