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Aliases for OR2J2 Gene

Aliases for OR2J2 Gene

  • Olfactory Receptor, Family 2, Subfamily J, Member 2 2 3
  • Olfactory Receptor OR6-19 3 4
  • Olfactory Receptor 6-8 3 4
  • Hs6M1-6 3 4
  • OR6-8 3 4
  • Olfactory Receptor 2J2 3
  • DJ80I19.4 3
  • OR6.3.8 3
  • OR6-19 3
  • ORL684 3

External Ids for OR2J2 Gene

Previous GeneCards Identifiers for OR2J2 Gene

  • GC06P029198
  • GC06P028912
  • GC06P029249
  • GC06P029141
  • GC06P028948

Summaries for OR2J2 Gene

Entrez Gene Summary for OR2J2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2J2 Gene

OR2J2 (Olfactory Receptor, Family 2, Subfamily J, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2C1.

UniProtKB/Swiss-Prot for OR2J2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2J2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2J2 Gene

Genomics for OR2J2 Gene

Regulatory Elements for OR2J2 Gene

Genomic Location for OR2J2 Gene

Start:
29,173,303 bp from pter
End:
29,174,574 bp from pter
Size:
1,272 bases
Orientation:
Plus strand

Genomic View for OR2J2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR2J2 Gene

  • Protein details for OR2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76002-OR2J2_HUMAN
    Recommended name:
    Olfactory receptor 2J2
    Protein Accession:
    O76002
    Secondary Accessions:
    • A6NCU9
    • A6NLD0
    • B0UY53
    • Q32N09
    • Q5ST39
    • Q5SUJ6
    • Q6IF24
    • Q9GZK2
    • Q9GZL3

    Protein attributes for OR2J2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35204 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2J2 Gene

Proteomics data for OR2J2 Gene at MOPED

Post-translational modifications for OR2J2 Gene

Other Protein References for OR2J2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2J2 Gene

Domains for OR2J2 Gene

Gene Families for OR2J2 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2J2 Gene

Suggested Antigen Peptide Sequences for OR2J2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76002

UniProtKB/Swiss-Prot:

OR2J2_HUMAN :
  • O76002
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2J2: view

Function for OR2J2 Gene

Molecular function for OR2J2 Gene

GENATLAS Biochemistry: olfactory receptor,family 2,subfamily J,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2J2: view

Phenotypes for OR2J2 Gene

GenomeRNAi human phenotypes for OR2J2:
genes like me logo Genes that share phenotypes with OR2J2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2J2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2J2 Gene

Localization for OR2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2J2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2J2 Gene COMPARTMENTS Subcellular localization image for OR2J2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2J2: view

Pathways for OR2J2 Gene

genes like me logo Genes that share pathways with OR2J2: view

Pathways by source for OR2J2 Gene

1 KEGG pathway for OR2J2 Gene

Interacting Proteins for OR2J2 Gene

Gene Ontology (GO) - Biological Process for OR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2J2: view

Transcripts for OR2J2 Gene

mRNA/cDNA for OR2J2 Gene

(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2J2 Gene

Olfactory receptor, family 2, subfamily J, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2J2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR2J2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2J2 Gene

No ASD Table

Relevant External Links for OR2J2 Gene

GeneLoc Exon Structure for
OR2J2
ECgene alternative splicing isoforms for
OR2J2

Expression for OR2J2 Gene

mRNA expression in normal human tissues for OR2J2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2J2 Gene

This gene is overexpressed in Testis (26.7), Brain - Caudate (basal ganglia) (4.5), and Brain - Hypothalamus (4.3).

SOURCE GeneReport for Unigene cluster for OR2J2 Gene Hs.163518

genes like me logo Genes that share expressions with OR2J2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for OR2J2 Gene

Orthologs for OR2J2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2J2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC740101 35
  • 99.04 (n)
  • 97.75 (a)
OR2J2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 86 (a)
OneToMany
LOC789358 35
  • 85.96 (n)
  • 85.53 (a)
mouse
(Mus musculus)
Mammalia Olfr137 36
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
Species with no ortholog for OR2J2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2J2 Gene

ENSEMBL:
Gene Tree for OR2J2 (if available)
TreeFam:
Gene Tree for OR2J2 (if available)

Paralogs for OR2J2 Gene

Paralogs for OR2J2 Gene

Selected SIMAP similar genes for OR2J2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2J2: view

Variants for OR2J2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR2J2 Gene

O76002-OR2J2_HUMAN
Three OR2J2 alleles are known: 6M1-6*01, 6M1-6*02 and 6M1-6*03. The sequence shown is that of allele 6M1-6*01

Sequence variations from dbSNP and Humsavar for OR2J2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2206042 -- 29,174,699(+) TCAGT(A/C)TCACA downstream-variant-500B
rs3116855 - 29,173,855(+) TCTGC(C/T)ACACC missense, reference
rs3116856 - 29,174,072(+) GTTGG(C/T)TGCGG missense, reference
rs3129153 -- 29,171,710(+) GCATT(A/C)GGAAA upstream-variant-2KB
rs3129154 -- 29,172,009(+) CAATA(C/T)TTGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2J2 Gene

Variant ID Type Subtype PubMed ID
nsv830623 CNV Gain 17160897
dgv6444n71 CNV Loss 21882294
nsv428138 CNV Gain+Loss 18775914
nsv883522 CNV Gain+Loss 21882294
esv2731758 CNV Deletion 23290073
esv27226 CNV Loss 19812545
nsv823468 CNV Loss 20364138
nsv462670 CNV Loss 19166990
nsv517415 CNV Loss 19592680
nsv883523 CNV Loss 21882294
nsv526153 CNV Loss 19592680
dgv6445n71 CNV Loss 21882294
nsv883525 CNV Loss 21882294

Relevant External Links for OR2J2 Gene

HapMap Linkage Disequilibrium report
OR2J2
Human Gene Mutation Database (HGMD)
OR2J2

Disorders for OR2J2 Gene

Relevant External Links for OR2J2

Genetic Association Database (GAD)
OR2J2
Human Genome Epidemiology (HuGE) Navigator
OR2J2
genes like me logo Genes that share disorders with OR2J2: view

No data available for UniProtKB/Swiss-Prot for OR2J2 Gene

Publications for OR2J2 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48
  5. Common variation contributes to the genetic architecture of social communication traits. (PMID: 24047820) St Pourcain B. … Smith G.D. (Mol Autism 2013) 3

Products for OR2J2 Gene

Sources for OR2J2 Gene

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