Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR2J2 Gene

Aliases for OR2J2 Gene

  • Olfactory Receptor Family 2 Subfamily J Member 2 2 3 5
  • Olfactory Receptor OR6-19 3 4
  • Olfactory Receptor 6-8 3 4
  • Hs6M1-6 3 4
  • OR6-8 3 4
  • Olfactory Receptor, Family 2, Subfamily J, Member 2 2
  • Olfactory Receptor 2J2 3
  • DJ80I19.4 3
  • OR6.3.8 3
  • OR6-19 3
  • ORL684 3

External Ids for OR2J2 Gene

Previous GeneCards Identifiers for OR2J2 Gene

  • GC06P029198
  • GC06P028912
  • GC06P029249
  • GC06P029141
  • GC06P028948
  • GC06P029179

Summaries for OR2J2 Gene

Entrez Gene Summary for OR2J2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2J2 Gene

OR2J2 (Olfactory Receptor Family 2 Subfamily J Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2J1.

UniProtKB/Swiss-Prot for OR2J2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2J2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2J2 Gene

Genomics for OR2J2 Gene

Regulatory Elements for OR2J2 Gene

Enhancers for OR2J2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F028586 1.2 ENCODE 16.2 -586.1 -586138 1.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GPX6 GPX5 ZNF603P ZNF90P2 KRT18P1 OR2W1 OR2AD1P OR2P1P ENSG00000228364 OR2B3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2J2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2J2 Gene

29,173,303 bp from pter
29,174,574 bp from pter
1,272 bases
Plus strand

Genomic View for OR2J2 Gene

Genes around OR2J2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2J2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR2J2 Gene

  • Protein details for OR2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2J2
    Protein Accession:
    Secondary Accessions:
    • A6NCU9
    • A6NLD0
    • B0UY53
    • Q32N09
    • Q5ST39
    • Q5SUJ6
    • Q6IF24
    • Q9GZK2
    • Q9GZL3

    Protein attributes for OR2J2 Gene

    312 amino acids
    Molecular mass:
    35204 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2J2 Gene

Post-translational modifications for OR2J2 Gene

Other Protein References for OR2J2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2J2 Gene

Domains & Families for OR2J2 Gene

Gene Families for OR2J2 Gene

Protein Domains for OR2J2 Gene

Suggested Antigen Peptide Sequences for OR2J2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2J2: view

Function for OR2J2 Gene

Molecular function for OR2J2 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily J,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with OR2J2: view
genes like me logo Genes that share phenotypes with OR2J2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OR2J2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2J2 Gene

Localization for OR2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2J2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2J2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2J2: view

Pathways & Interactions for OR2J2 Gene

genes like me logo Genes that share pathways with OR2J2: view

Pathways by source for OR2J2 Gene

1 KEGG pathway for OR2J2 Gene

Interacting Proteins for OR2J2 Gene

Gene Ontology (GO) - Biological Process for OR2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2J2: view

No data available for SIGNOR curated interactions for OR2J2 Gene

Transcripts for OR2J2 Gene

mRNA/cDNA for OR2J2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2J2 Gene

Olfactory receptor, family 2, subfamily J, member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OR2J2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2J2 Gene

No ASD Table

Relevant External Links for OR2J2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2J2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2J2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR2J2 Gene

This gene is overexpressed in Testis (x26.7), Brain - Caudate (basal ganglia) (x4.5), and Brain - Hypothalamus (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of OR2J2 Gene:


SOURCE GeneReport for Unigene cluster for OR2J2 Gene:

genes like me logo Genes that share expression patterns with OR2J2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR2J2 Gene

Orthologs for OR2J2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2J2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC740101 34
  • 99.04 (n)
OR2J2 35
  • 97 (a)
(Bos Taurus)
Mammalia -- 35
  • 86 (a)
LOC789358 34
  • 85.96 (n)
(Mus musculus)
Mammalia Olfr137 35
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 60 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
Species where no ortholog for OR2J2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2J2 Gene

Gene Tree for OR2J2 (if available)
Gene Tree for OR2J2 (if available)

Paralogs for OR2J2 Gene

Paralogs for OR2J2 Gene

(447) SIMAP similar genes for OR2J2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2J2: view

Variants for OR2J2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR2J2 Gene

Three OR2J2 alleles are known: 6M1-6*01, 6M1-6*02 and 6M1-6*03. The sequence shown is that of allele 6M1-6*01.

Sequence variations from dbSNP and Humsavar for OR2J2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs112552228 -- 29,172,273(+) GGCTG(A/G)TCTCA upstream-variant-2KB
rs113310920 -- 29,172,641(+) TTCAC(G/T)TATCT upstream-variant-2KB
rs113640064 -- 29,172,272(+) AGGCT(A/G)GTCTC upstream-variant-2KB
rs114093208 -- 29,173,955(+) TCTTG(A/C)ACTGG reference, missense
rs114853162 -- 29,173,232(+) TATAA(A/G)TAAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2J2 Gene

Variant ID Type Subtype PubMed ID
nsv965701 CNV duplication 23825009
nsv830623 CNV gain 17160897
nsv823468 CNV loss 20364138
nsv601216 CNV gain 21841781
nsv526153 CNV loss 19592680
nsv517415 CNV loss 19592680
nsv462670 CNV loss 19166990
nsv428138 CNV gain+loss 18775914
nsv1145096 CNV deletion 24896259
nsv1122126 CNV deletion 24896259
nsv1074389 CNV deletion 25765185
nsv1032468 CNV loss 25217958
nsv1015796 CNV gain 25217958
esv3890805 CNV loss 25118596
esv3608473 CNV gain 21293372
esv2763545 CNV loss 21179565
esv2731758 CNV deletion 23290073
esv27226 CNV loss 19812545
dgv1723e212 CNV gain 25503493
dgv1722e212 CNV loss 25503493
dgv1173e214 CNV loss 21293372
dgv1172e214 CNV gain 21293372
dgv10338n54 CNV gain 21841781

Variation tolerance for OR2J2 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.04; 97.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2J2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for OR2J2 Gene

Relevant External Links for OR2J2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR2J2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2J2 Gene

Publications for OR2J2 Gene

  1. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Common variation contributes to the genetic architecture of social communication traits. (PMID: 24047820) St Pourcain B. … Smith G.D. (Mol Autism 2013) 3 64

Products for OR2J2 Gene

Sources for OR2J2 Gene

Loading form....