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OR2J1 Gene

protein-coding   GIFtS: 30
GCID: GC06P029070

Olfactory Receptor, Family 2, Subfamily J, Member 1 (Gene/Pseudogene)

(Previous names: olfactory receptor, family 2, subfamily J, member 1 pseudogene,...)
(Previous symbol: OR2J1P)
  See related disease
at
MalaCards
 

Aliases
for OR2J1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily J, Member 1
(Gene/Pseudogene)1 2
     OR6-152
OR2J1P1 2 3     dJ80I19.22
OR6-52 3     hs6M1-42
Olfactory Receptor, Family 2, Subfamily J, Member 11     Hs6M1-43
Olfactory Receptor, Family 2, Subfamily J, Member 1 Pseudogene1     Olfactory Receptor 6-53
6M1-4P2     

External Ids:    HGNC: 82591   Entrez Gene: 4421852   Ensembl: ENSG000002047027   UniProtKB: Q9GZK63   

Export aliases for OR2J1 gene to outside databases

Previous GC identifers: GC06U900570 GC06P029176 GC06P029069 GC06P028876 GC06Pi29069


Summaries
for OR2J1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2J1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2J1 Gene:
OR2J1 (olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)) is a protein-coding gene. Diseases associated with OR2J1 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2W1.

UniProtKB/Swiss-Prot: OR2J1_HUMAN, Q9GZK6
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2J1 Gene


Genomic Views
for OR2J1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus		 Regulatory elements:
   Search for regulatory transcription factor binding sites for OR2J1
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2J1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.2-p21.31

OR2J1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2J1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P029070:  view genomic region     (about GC identifiers)

Start:
 29,068,386 bp from pter      End:
 29,069,658 bp from pter
Size:
 1,273 bases      Orientation:
 plus strand

Selected alternative locations (see all 7):
Chr6+,NT_167245 372,136-373,071      Chr6+,NT_167249 409,611-410,546      Chr6+,NT_167246 372,128-373,063     
Chr6+,NT_167248 372,126-373,061      Chr6+,NT_167247 372,265-373,200      Chr6+,NT_113891.2 587,595-588,530     

Proteins
for OR2J1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OR2J1_HUMAN, Q9GZK6 (See protein sequence)
Recommended Name: Olfactory receptor 2J1  
Size: 312 amino acids; 35454 Da
Secondary accessions: A2AAS1 B0V1T2 Q9GZK1

Explore the universe of human proteins at neXtProt for OR2J1: NX_Q9GZK6

Explore proteomics data for OR2J1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn6

    • See OR2J1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000366376  
    Reactome Protein details: Q9GZK6

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    Domains /
    Families
    for OR2J1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9GZK6

    ProtoNet protein and cluster: Q9GZK6

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2J1_HUMAN, Q9GZK6
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR2J1 for domains           About GeneDecksing


    Function
    for OR2J1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2J1_HUMAN, Q9GZK6
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR2J1 for ontologies           About GeneDecksing


    Animal Models:
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    Localization
    for OR2J1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2J1_HUMAN, Q9GZK6: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR2J1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for OR2J1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2J1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    		Signaling by GPCR0.90
    		Signal Transduction0.58
    		GPCR downstream signaling0.90
    2Olfactory Signaling Pathway
    		Olfactory Signaling Pathway0.82
    3Peptide ligand-binding receptors
    		GPCRs, Class A Rhodopsin-like0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR2J1
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR2J1
        Olfactory Signaling Pathway



    OR2J1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2J1
    Interactions:

        Search GeneGlobe Interaction Network for OR2J1

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR2J1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for OR2J1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2J1



    Transcripts
    for OR2J1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377171
    miRNA
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    GeneLoc Exon Structure


    Expression
    for OR2J1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    OR2J1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR2J1 Expression
    About this image

    OR2J1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    OR2J1 Protein Expression
        Custom PCR Arrays for OR2J1
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    In Situ
    Assay Products:     
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    Orthologs
    for OR2J1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus    		   --

    ENSEMBL Gene Tree for OR2J1 (if available)
    TreeFam Gene Tree for OR2J1 (if available)

    Paralogs
    for OR2J1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for OR2J1 gene
    OR2W12  OR2J22  OR2G22  OR2H22  OR2C12  OR2H12  OR2Y12  OR2W32  
    OR2J32  OR2G32  OR2C32  OR2G62  
    Selected SIMAP similar genes for OR2J1 using alignment to 1 protein entry:     OR2J1_HUMAN(see all similar genes):
    OR2J2    OR2J3    OR2J4P    OR2W6P    OLFR 42A    OR2B2
    OR2C3    6M1-16    OR2B6    OR2C1    OR2G3    OR2H1
    OR2Y1    OR2B11    OR2B8P    OR2G6    OR2W1    OR2W3

    OR2J1 for paralogs           About GeneDecksing



    Genomic Variants
    for OR2J1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    OR2J1_HUMAN, Q9GZK6: A stop codon in the gene coding for this protein at position Gln-194 is responsible for functional
    diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans


    1 SNPs for OR2J1    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs31310871,2,4
    		----see VAR_0190662 mis40--------

    HapMap Linkage Disequilibrium report for OR2J1 (29068386 - 29069658 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OR2J1: --
    Human Gene Mutation Database (HGMD): OR2J1
    Site Specific Mutation Identification with PCR Assays
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    Disorders / Diseases
    for OR2J1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 1 disease for OR2J1:    About MalaCards
    neuronitis


    OR2J1 for disorders           About GeneDecksing


    Export disorders for OR2J1 gene to outside databases

    Publications
    for OR2J1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for OR2J1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2J1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
    3. Different noses for different people. (PubMed id 12730696)2 Menashe I.... Gilad Y. (Nat. Genet. 2003)
    4. (PubMed id )2 

    External Searches for OR2J1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OR2J1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 442185 HGNC: 8259 Ensembl:ENSG00000204702 euGenes: HUgn442185 ECgene: OR2J1
    H-InvDB: OR2J1

    Other Databases showing OR2J1 gene

    (According to HUGE)
    About This Section

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    Specialized Databases showing OR2J1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for OR2J1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for OR2J1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for OR2J1 gene:
    Search GeneIP for patents involving OR2J1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for OR2J1 gene

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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