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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR2I1P Gene

pseudogene   GIFtS: 26
GCID: GC06P029782

olfactory receptor, family 2, subfamily I, member 1 pseudogene


(Previous symbols: OR2I1, OR2I3P, OR2I4P, OR2I2)
 Explore 1 disease affiliated with
OR2I1P via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OR2I1P    

Aliases
for OR2I1P gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Olfactory Receptor, Family 2, Subfamily I, Member 1 Pseudogene1 2     OR2I7P2
OR2I21 2 3     OR2I8P2
OR2I3P1 2 3     OR2I9P2
OR2I4P1 2 3     OR6-12
HS6M1-141 2     OR6-342
OR2I11 2     Putative Olfactory Receptor 2I23
OR2I5P2     Putative Olfactory Receptor 2I33
OR2I62     Putative Olfactory Receptor 2I43

External Ids:    HGNC: 82581   Entrez Gene: 4421972   Ensembl: ENSG000002379887   UniProtKB: Q8NGU43   

Export aliases for OR2I1P gene to outside databases

Previous GC identifers: GC06U990205 GC06P029629 GC06P029632 GC06P029521 GC06Pm29435 GC06P029522 GC06P029603


Summaries
for OR2I1P gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OR2I1P:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors
(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many
neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of
odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the
olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: OR2I1_HUMAN, Q8NGU4
Function: Odorant receptor (Potential)




Genomic Views
for OR2I1P gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for OR2I1P
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for OR2I1P

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2I1P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

OR2I1P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2I1P gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P029782:  view genomic region     (about GC identifiers)

Start:
 29,520,966 bp from pter      End:
 29,521,937 bp from pter
Size:
 972 bases      Orientation:
 plus strand

6 alternative locations:
Chr6+,ALT_REF_LOCI_5 29,435,517-29,436,575      Chr6+,ALT_REF_LOCI_3 29,520,950-29,532,932      Chr6+,ALT_REF_LOCI_4 29,443,542-29,444,600     
Chr6+,ALT_REF_LOCI_2 29,517,602-29,557,734      Chr6+,ALT_REF_LOCI_1 29,521,110-29,530,354      Chr6+,ALT_REF_LOCI_6 29,520,916-29,557,441     

Proteins
for OR2I1P gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OR2I1_HUMAN, Q8NGU4 (See protein sequence)
Recommended Name: Putative olfactory receptor 2I1  
Size: 316 amino acids; 34115 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for OR2I1P: NX_Q8NGU4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NGU4

    • HORDE protein sequence for OR2I1P
    OR2I1P Protein expression data from MOPED and PaxDb: --
    Reactome Protein details: Q8NGU4
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    OR2I1P for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for OR2I1P gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OR2I1P for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR019424 7TM_GPCR_olfarory/Srsx
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGU4

    ProtoNet protein and cluster: Q8NGU4

    1 Blocks protein family: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2I1_HUMAN, Q8NGU4
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for OR2I1P gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OR2I1_HUMAN, Q8NGU4
    Function: Odorant receptor (Potential)

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--


    OR2I1P for ontologies           About GeneDecksing



    Pathways & Interactions
    for OR2I1P gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    2Olfactory transduction
    		Olfactory Signaling Pathway0.77

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for OR2I1P
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR



    OR2I1P for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2I1P

    Drugs & Compounds
    for OR2I1P gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Transcripts
    for OR2I1P gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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    About This Section
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453522 ENST00000449341

    miRNA
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    Inhib. RNA
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    GeneLoc Exon Structure


    Expression
    for OR2I1P gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR2I1P expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image    SABiosciences Custom PCR Arrays for OR2I1P
    Primer
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    In Situ
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    Orthologs
    for OR2I1P gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for OR2I1P (if available)
    TreeFam Gene Tree for OR2I1P (if available) 

    Paralogs
    for OR2I1P gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for OR2I1P gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for OR2I1P gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OR2I1P for disorders           About GeneDecksing

    1 disease for OR2I1P:    About MalaCards
    neuronitis


    Export disorders for OR2I1P gene to outside databases

    Publications
    for OR2I1P gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed article for OR2I1P gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR2I1P)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (2004)

    External Searches for OR2I1P gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OR2I1P gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 442197 HGNC: 8258 Ensembl:ENSG00000237988 euGenes: HUgn442197 ECgene: OR2I1P
    H-InvDB: OR2I1P

    Other Databases showing OR2I1P gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing OR2I1P gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR2I1P Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2I1P The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    Intellectual Property
    for OR2I1P gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OR2I1P gene:
    Search GeneIP for patents involving OR2I1P

    GeneCards and IP:
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