OR2H2 Gene
protein-coding GIFtS: 53
GCID: GC06P029555
|
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olfactory receptor, family 2, subfamily H, member 2
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Aliases for OR2H2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 2, Subfamily H, Member 21 2 | | OLFR42B2 | | OLFR22 3 5 | | DJ271M21.21 | | OR2H32 3 5 | | Olfactory Receptor 22 | | Hs6M1-123 | | Olfactory Receptor 2H22 | | Olfactory Receptor 2H32 3 | | Olfactory Receptor OR6-362 | | Olfactory Receptor-Like Protein FAT112 3 | | Olfactory Receptor, Family 2, Subfamily H, Member 32 | | FAT112 3 | | Hs6M1-123 |
Export aliases for OR2H2 gene to outside databasesPrevious GC identifers: GC06U990208 GC06P029666 GC06P029650 GC06P029667 |
Summaries for OR2H2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for OR2H2: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008) UniProtKB/Swiss-Prot: OR2H2_HUMAN, O95918Function: Odorant receptor (Potential) Gene Wiki entry for OR2H2
|
Genomic Views for OR2H2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1
- NT_167248.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OR2H2 gene promoter: Nkx3-1 v2 Nkx3-1 Egr-3 Hand1 Nkx3-1 v1 YY1 E47 Other transcription factors
Search SABiosciences Chromatin IP Primers for OR2H2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2H2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p22.2-p21.31OR2H2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P029555: view genomic region
(about GC identifiers)
Start:
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29,555,722 bp from pter |
End:
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29,556,657 bp from pter |
Size:
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936 bases |
Orientation:
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plus strand |
6 alternative locations:
| Chr6+,ALT_REF_LOCI_2 29,552,288-29,592,538 | Chr6+,ALT_REF_LOCI_5 29,470,309-29,471,371 | Chr6+,ALT_REF_LOCI_3 29,555,643-29,567,743 | | Chr6+,ALT_REF_LOCI_4 29,478,369-29,479,431 | Chr6+,ALT_REF_LOCI_1 29,555,796-29,565,158 | Chr6+,ALT_REF_LOCI_6 29,555,617-29,592,260 | |
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Proteins for OR2H2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: OR2H2_HUMAN, O95918 (See
protein sequence)Recommended Name: Olfactory receptor 2H2 Size: 312 amino acids; 34763 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q15062 Q2M1Y3 Q5STL8 Q5SUK1 Q6IFN7 Q6NTB7 Q96R14Explore the universe of human proteins at neXtProt for OR2H2: NX_O95918
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95918 HORDE protein sequence for OR2H2 OR2H2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009091.3 ENSEMBL proteins: ENSP00000373136 Reactome Protein details: O95918 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR2H2 for ontologies About GeneDecksing
OR2H2 Antibody Products: Assay Products for OR2H2: |
Protein
Domains / Families for OR2H2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR2H2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95918ProtoNet protein and cluster: O95918 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR2H2_HUMAN, O95918Similarity: Belongs to the G-protein coupled receptor 1 family |
Function for OR2H2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: OR2H2_HUMAN, O95918Function: Odorant receptor (Potential) Genatlas biochemistry entry for OR2H2:olfactory receptor,family 2,subfamily H,member 2,G protein coupled receptor superfamily
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2H2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2H2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR2H2 (NM_007160) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR2H2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2H2  |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR2H2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for OR2H2:
|
Pathways & Interactions for OR2H2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | | | 3 | Class A/1 (Rhodopsin-like receptors) | |
Pathway sources See GeneCards unified pathways Show all pathways
1 BioSystems Pathway for OR2H2 
4
Reactome Pathways for OR2H2
1
Kegg Pathway (Kegg details for OR2H2):
OR2H2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2H2
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
OR2H2 for ontologies About GeneDecksing
|
Drugs & Compounds for OR2H2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for OR2H2 Search CenterWatch for drugs/clinical trials and news about OR2H2 
|
Transcripts for OR2H2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for OR2H2 gene: NM_007160.3 Unigene Clusters for OR2H2: Olfactory receptor, family 2, subfamily H, member 2 Hs.529493 [show with all ESTs], Hs.697691 Unigene Representative Sequences: CD623793, BC1121761 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000383640(uc003nmr.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2H2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2H2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR2H2 (NM_007160) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR2H2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2H2  |
Additional cDNA sequence: BC069146.1 BC101683.1 BC112176.1 1 DOTS entry: DT.102831932 3 AceView cDNA sequences: AJ459832 AJ459831 AJ459839 GeneLoc Exon Structure
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Expression for OR2H2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR2H2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GATTCCTCAC
About this image See OR2H2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for OR2H2
SOURCE GeneReport for Unigene clusters: Hs.529493 Hs.697691 SABiosciences Custom PCR Arrays for OR2H2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2H2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR2H2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2H2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2H2 |
Orthologs for OR2H2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OR2H2 (if available) TreeFam Gene Tree for OR2H2 (if available)  |
Paralogs for OR2H2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for OR2H2 gene
- OR2J22 OR2W12 OR2J12 OR2B112 OR2B22 OR2B32 OR2H12 OR2C12
- OR2Y12 OR2G22 OR2B62 OR2W32 OR2J32 OR2G32 OR2C32 OR2G62
18/455 SIMAP similar genes for OR2H2 using alignment to 1 protein entry: OR2H2_HUMAN(see all similar genes):6M1-16 OR2H1 OLFR 42A OR2H5P OLFR 42B OR2G3 OR2W6P OR2B2 OR2J3 OR2B11 OR2B6 OR2B8P OR2C3 OR2G2 OR2J4P OR2B3 OR2C1 OR2G6
OR2H2 for paralogs About GeneDecksing
|
Genomic Variants for OR2H2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 6 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for OR2H2 ( 29555722 - 29556657 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for OR2H2 2 CNVs: 3598 36504  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR2H2 |
|
Disorders
/ Diseases for OR2H2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR2H2 for disorders About GeneDecksing
OMIM gene information: 600578
OMIM disorders: --
4 diseases for OR2H2: About MalaCardssystemic lupus erythematosus lupus erythematosus multiple sclerosis neuronitis Human Genome Epidemiology (HuGE) Navigator: OR2H2 (5 documents) Export disorders for OR2H2 gene to outside databases
|
Publications for OR2H2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR2H2 gene, integrated from 9 sources (see all 15): (articles sorted by number of sources associating them with OR2H2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
- Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites. (PubMed id 10880742)1, 2 Eklund A.C.... Ober C. (2000)
- Olfactory receptor-like genes are located in the human major histocompatibility complex. (PubMed id 7665158)1, 2 Fan W.... Weissman S.M. (1995)
- Sequence variations at the human leukocyte antigen-li nked olfactory receptor cluster do not influence female preferences for male od ors. (PubMed id 19833159)1 Thompson E.E....Ober C. (2010)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PubMed id 17971048)1 Burfoot R.K....Rubio J.P. (2008)
- Complex transcription and splicing of odorant receptor genes. (PubMed id 12637542)1 Volz A.... Ziegler A. (2003)
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External Searches for OR2H2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OR2H2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR2H2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR2H2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for OR2H2 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR2H2 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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| | |
About This Section
| Patent Information for OR2H2 gene: Search GeneIP for patents involving OR2H2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for OR2H2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for OR2H2 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR2H2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2H2 | | OriGene Protein Over-expression Lysate for OR2H2 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for OR2H2 | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2H2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2H2 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR2H2 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR2H2 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2H2 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR2H2 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2H2 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2H2 |
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 | | OR2H2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | ThermoFisher Antibodies for OR2H2 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2H2 |
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