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Aliases for OR2H2 Gene

Aliases for OR2H2 Gene

  • Olfactory Receptor, Family 2, Subfamily H, Member 2 2 3
  • OLFR2 3 4 6
  • OR2H3 3 4 6
  • Olfactory Receptor-Like Protein FAT11 3 4
  • Olfactory Receptor 2H3 3 4
  • Hs6M1-12 3 4
  • FAT11 3 4
  • Olfactory Receptor, Family 2, Subfamily H, Member 3 3
  • Olfactory Receptor OR6-36 3
  • Olfactory Receptor 2H2 3
  • Olfactory Receptor 2 3
  • DJ271M21.2 3
  • OLFR42B 3

External Ids for OR2H2 Gene

Previous GeneCards Identifiers for OR2H2 Gene

  • GC06U990208
  • GC06P029666
  • GC06P029650
  • GC06P029667
  • GC06P029555

Summaries for OR2H2 Gene

Entrez Gene Summary for OR2H2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2H2 Gene

OR2H2 (Olfactory Receptor, Family 2, Subfamily H, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2C1.

UniProtKB/Swiss-Prot for OR2H2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2H2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2H2 Gene

Genomics for OR2H2 Gene

Regulatory Elements for OR2H2 Gene

Genomic Location for OR2H2 Gene

29,586,041 bp from pter
29,589,038 bp from pter
2,998 bases
Plus strand

Genomic View for OR2H2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2H2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR2H2 Gene

  • Protein details for OR2H2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2H2
    Protein Accession:
    Secondary Accessions:
    • Q15062
    • Q2M1Y3
    • Q5STL8
    • Q5SUK1
    • Q6IFN7
    • Q6NTB7
    • Q96R14

    Protein attributes for OR2H2 Gene

    312 amino acids
    Molecular mass:
    34763 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2H2 Gene

Proteomics data for OR2H2 Gene at MOPED

Post-translational modifications for OR2H2 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2H2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

No data available for DME Specific Peptides for OR2H2 Gene

Domains for OR2H2 Gene

Gene Families for OR2H2 Gene

  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2H2 Gene

Suggested Antigen Peptide Sequences for OR2H2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O95918
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2H2: view

Function for OR2H2 Gene

Molecular function for OR2H2 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily H,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2H2: view

Phenotypes for OR2H2 Gene

genes like me logo Genes that share phenotypes with OR2H2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2H2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2H2 Gene

Localization for OR2H2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2H2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR2H2 Gene COMPARTMENTS Subcellular localization image for OR2H2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2H2: view

Pathways for OR2H2 Gene

genes like me logo Genes that share pathways with OR2H2: view

Pathways by source for OR2H2 Gene

1 KEGG pathway for OR2H2 Gene

Interacting Proteins for OR2H2 Gene

Gene Ontology (GO) - Biological Process for OR2H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 7665158
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007618 mating TAS 7665158
GO:0050911 detection of chemical stimulus involved in sensory perception of smell TAS 7665158
genes like me logo Genes that share ontologies with OR2H2: view

Transcripts for OR2H2 Gene

mRNA/cDNA for OR2H2 Gene

(17) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2H2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2H2 Gene

No ASD Table

Relevant External Links for OR2H2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2H2 Gene

mRNA expression in normal human tissues for OR2H2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2H2 Gene

This gene is overexpressed in Testis (6.4), Brain - Putamen (basal ganglia) (5.1), Brain - Nucleus accumbens (basal ganglia) (5.0), and Brain - Caudate (basal ganglia) (4.4).

SOURCE GeneReport for Unigene cluster for OR2H2 Gene Hs.529493

genes like me logo Genes that share expressions with OR2H2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR2H2 Gene

Orthologs for OR2H2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2H2 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Olfr90 35
  • 85.88 (n)
  • 88.6 (a)
Olfr90 16
Olfr132 36
  • 60 (a)
(Pan troglodytes)
Mammalia LOC100615382 35
  • 97.01 (n)
  • 95.74 (a)
OR2H2 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Olr1750 35
  • 86.86 (n)
  • 88.27 (a)
(Bos Taurus)
Mammalia -- 36
  • 84 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
Species with no ortholog for OR2H2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2H2 Gene

Gene Tree for OR2H2 (if available)
Gene Tree for OR2H2 (if available)

Paralogs for OR2H2 Gene

Paralogs for OR2H2 Gene

Selected SIMAP similar genes for OR2H2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2H2: view

Variants for OR2H2 Gene

Sequence variations from dbSNP and Humsavar for OR2H2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs362521 -- 29,588,982(-) ACAAT(A/G)TAATG downstream-variant-500B
rs1233387 - 29,588,087(-) CCAGC(A/G)CAGAC reference, missense
rs1233388 -- 29,585,950(-) TTATT(C/T)ATCCA upstream-variant-2KB
rs1233389 -- 29,584,706(-) GCCAT(A/C)GAGTT upstream-variant-2KB
rs1233390 -- 29,584,084(-) ttctg(C/T)agtct upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2H2 Gene

Variant ID Type Subtype PubMed ID
dgv1908e1 CNV Complex 17122850
essv18215 CNV CNV 17122850
nsv5239 CNV Loss 18451855
nsv519288 CNV Loss 19592680

Relevant External Links for OR2H2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2H2 Gene

Disorders for OR2H2 Gene

Relevant External Links for OR2H2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for OR2H2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OR2H2 Gene

Publications for OR2H2 Gene

  1. Olfactory receptor-like genes are located in the human major histocompatibility complex. (PMID: 7665158) Fan W. … Weissman S.M. (Genomics 1995) 3 4
  2. Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites. (PMID: 10880742) Eklund A.C. … Ober C. (Hum. Immunol. 2000) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for OR2H2 Gene

Sources for OR2H2 Gene

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