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OR2H2 Gene

protein-coding   GIFtS: 53
GCID: GC06P029555

Olfactory Receptor, Family 2, Subfamily H, Member 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily H, Member 21 2     dJ271M21.22
OLFR22 3 5     hs6M1-122
OR2H32 3 5     Olfactory Receptor 22
Olfactory Receptor 2H32 3     Olfactory Receptor 2H22
Olfactory Receptor-Like Protein FAT112 3     Olfactory Receptor OR6-362
FAT112 3     Olfactory Receptor, Family 2, Subfamily H, Member 32
OLFR42B2     Hs6M1-123

External Ids:    HGNC: 82531   Entrez Gene: 79322   Ensembl: ENSG000002046577   OMIM: 6005785   UniProtKB: O959183   

Export aliases for OR2H2 gene to outside databases

Previous GC identifers: GC06U990208 GC06P029666 GC06P029650 GC06P029667


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2H2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2H2 Gene:
OR2H2 (olfactory receptor, family 2, subfamily H, member 2) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2W1.

UniProtKB/Swiss-Prot: OR2H2_HUMAN, O95918
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2H2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2H2 gene promoter:
         Nkx3-1 v2   Nkx3-1   Egr-3   Hand1   Nkx3-1 v1   YY1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2H2 promoter sequence
   Search Chromatin IP Primers for OR2H2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2H2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.2-p21.31

OR2H2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2H2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P029555:  view genomic region     (about GC identifiers)

Start:
29,555,722 bp from pter      End:
29,556,657 bp from pter
Size:
936 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167244 859,193-860,255      Chr6+,NT_167248 859,014-860,076      Chr6+,NT_167245 859,040-860,102     
Chr6+,NT_167247 858,886-859,948      Chr6+,NT_167246 858,710-859,772      Chr6+,NT_113891.2 1,074,492-1,075,554     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR2H2_HUMAN, O95918 (See protein sequence)
Recommended Name: Olfactory receptor 2H2  
Size: 312 amino acids; 34763 Da
Secondary accessions: Q15062 Q2M1Y3 Q5STL8 Q5SUK1 Q6IFN7 Q6NTB7 Q96R14

Explore the universe of human proteins at neXtProt for OR2H2: NX_O95918

Explore proteomics data for OR2H2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn3
  • HORDE protein sequence for OR2H2

    See OR2H2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009091.3  
    ENSEMBL proteins: 
     ENSP00000373136  
    Reactome Protein details: O95918

    OR2H2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O95918

    ProtoNet protein and cluster: O95918

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2H2_HUMAN, O95918
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR2H2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2H2_HUMAN, O95918
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR2H2:
    olfactory receptor,family 2,subfamily H,member 2,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR2H2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for OR2H2:
     Increased gamma-H2AX phosphory  Large cells  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR2H2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2H2_HUMAN, O95918: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR2H2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2H2 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    Find genes that share SuperPaths with OR2H2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR2H2
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR2H2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2H2):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2H2
    Interactions:

        Search GeneGlobe Interaction Network for OR2H2

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS7665158
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007618mating TAS7665158
    GO:0050911detection of chemical stimulus involved in sensory perception of smell TAS7665158

    Find genes that share ontologies with OR2H2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2H2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR2H2 gene: 
    NM_007160.3  

    Unigene Cluster for OR2H2:

    Olfactory receptor, family 2, subfamily H, member 2
    Hs.529493  [show with all ESTs]
    Unigene Representative Sequence: CD623793
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000383640(uc003nmr.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat OR2H2
      QuantiFast Probe-based Assays in human, mouse, rat OR2H2

    Additional mRNA sequence: 

    AJ459831.1 AJ459832.1 AJ459839.1 

    1 DOTS entry:

    DT.102831932 

    3 AceView cDNA sequences:

    AJ459832 AJ459839 AJ459831 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2H2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTCCTCAC
    OR2H2 Expression
    About this image

    OR2H2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2H2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529493
        Custom PCR Arrays for OR2H2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2H2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr901 , 5 olfactory receptor 901, 5 85.88(n)1
    88.6(a)1
      17 (19.16 cM)5
    2584691  NM_146477.21  NP_666688.21 
     370851915 


    ENSEMBL Gene Tree for OR2H2 (if available)
    TreeFam Gene Tree for OR2H2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2H2 gene
    OR2W12  OR2J22  OR2G22  OR2J12  OR2C12  OR2H12  OR2Y12  OR2W32  
    OR2J32  OR2G32  OR2C32  OR2G62  
    Selected SIMAP similar genes for OR2H2 using alignment to 1 protein entry:     OR2H2_HUMAN(see all similar genes):
    6M1-16    OR2H1    OLFR 42A    OR2H5P    OLFR 42B    OR2G3
    OR2W6P    OR2B2    OR2B11    OR2B6    OR2B8P    OR2C3
    OR2G2    OR2J3    OR2J4P    OR2B3    OR2C1    OR2G6

    Find genes that share paralogs with OR2H2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2H2 (see all 112)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390970001,2
    --29553719(+) ACACAC/TGATGG 1 -- us2k10--------
    rs12333881,2
    C,F,O,H--29553727(-) TTATTC/TATCCA 1 -- us2k131Minor allele frequency- N:0.00NS EA NA WA CSA 3572
    rs1887893221,2
    --29553936(+) GGTACA/GTTAAA 1 -- us2k10--------
    rs1145557031,2
    C,F--29553962(+) GAAAGC/TGAAGG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1928330211,2
    C--29554055(+) CTGAGG/TTCAGG 1 -- us2k10--------
    rs1425405221,2
    --29554149(+) TGTAAA/TCCCCG 1 -- us2k10--------
    rs1509609911,2
    --29554171(+) GCTGAA/GGCAGG 1 -- us2k10--------
    rs1849680501,2
    C--29554258(+) ACGTGA/GCTCTA 1 -- us2k10--------
    rs289864331,2
    C--29554263(+) AAAAA-/ATTAGA 1 -- us2k10--------
    rs1152970261,2
    C,F--29554371(+) GATACT/CTGAAA 1 -- us2k11Minor allele frequency- C:0.04WA 118

    HapMap Linkage Disequilibrium report for OR2H2 ( 29555722 - 29556657 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for OR2H2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5239CNV Loss18451855
    nsv519288CNV Loss19592680
    essv18215CNV CNV17122850
    dgv1908e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600578    OMIM disorders: --


    Find genes that share disorders with OR2H2           About GenesLikeMe

    Genetic Association Database (GAD): OR2H2
    Human Genome Epidemiology (HuGE) Navigator: OR2H2 (5 documents)

    Export disorders for OR2H2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2H2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with OR2H2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors. (PubMed id 19833159)1, 4 Thompson E.E....Ober C. (Hum. Immunol. 2010)
    2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    3. SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PubMed id 17971048)1, 4 Burfoot R.K....Rubio J.P. (Tissue Antigens 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    8. Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites. (PubMed id 10880742)1, 2 Eklund A.C.... Ober C. (Hum. Immunol. 2000)
    9. Olfactory receptor-like genes are located in the human major histocompatibility complex. (PubMed id 7665158)1, 2 Fan W.... Weissman S.M. (Genomics 1995)
    10. Complex transcription and splicing of odorant receptor genes. (PubMed id 12637542)1 Volz A.... Ziegler A. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7932 HGNC: 8253 AceView: OR2H2.1 Ensembl:ENSG00000204657 euGenes: HUgn7932
    ECgene: OR2H2 Kegg: 7932 H-InvDB: OR2H2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2H2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2H2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2H2 gene:
    Search GeneIP for patents involving OR2H2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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