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Aliases for OR2H2 Gene

Aliases for OR2H2 Gene

  • Olfactory Receptor Family 2 Subfamily H Member 2 2 3 5
  • Olfactory Receptor-Like Protein FAT11 3 4
  • Olfactory Receptor 2H3 3 4
  • Hs6M1-12 3 4
  • FAT11 3 4
  • OLFR2 3 4
  • OR2H3 3 4
  • Olfactory Receptor, Family 2, Subfamily H, Member 2 2
  • Olfactory Receptor, Family 2, Subfamily H, Member 3 3
  • Olfactory Receptor OR6-36 3
  • Olfactory Receptor 2H2 3
  • Olfactory Receptor 2 3
  • DJ271M21.2 3
  • OLFR42B 3

External Ids for OR2H2 Gene

Previous GeneCards Identifiers for OR2H2 Gene

  • GC06U990208
  • GC06P029666
  • GC06P029650
  • GC06P029667
  • GC06P029555
  • GC06P029636
  • GC06P030071
  • GC06P030322
  • GC06P030474

Summaries for OR2H2 Gene

Entrez Gene Summary for OR2H2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2H2 Gene

OR2H2 (Olfactory Receptor Family 2 Subfamily H Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2H1.

UniProtKB/Swiss-Prot for OR2H2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2H2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2H2 Gene

Genomics for OR2H2 Gene

Regulatory Elements for OR2H2 Gene

Enhancers for OR2H2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F029626 1.3 Ensembl ENCODE 10.1 +40.4 40420 3.3 ATF1 PKNOX1 ARNT SIN3A FEZF1 GLI4 ZNF2 GLIS2 ZNF143 KLF7 GNL1 ZFP57 OR2H2 HLA-H HLA-J HLA-U GABBR1
GH06F030194 1.1 ENCODE 9.9 +608.0 607950 1.6 ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF302 SP3 SP5 MXD4 ZHX2 HCG18 GTF2H4 PPP1R10 ETF1P1 DHX16 PAIP1P1 ZNRD1ASP HCG4P7 TRIM31 GNL1
GH06F029631 1 ENCODE 10.1 +45.6 45626 3.8 HDGF GLI4 GLIS2 KLF7 KDM4B ZNF263 SP3 SP5 REST MBD2 GNL1 HLA-H OR2H2 HLA-U MICE GABBR1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2H2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2H2 Gene

29,587,378 bp from pter
29,591,012 bp from pter
3,635 bases
Plus strand

Genomic View for OR2H2 Gene

Genes around OR2H2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2H2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2H2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR2H2 Gene

  • Protein details for OR2H2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2H2
    Protein Accession:
    Secondary Accessions:
    • Q15062
    • Q2M1Y3
    • Q5STL8
    • Q5SUK1
    • Q6IFN7
    • Q6NTB7
    • Q96R14

    Protein attributes for OR2H2 Gene

    312 amino acids
    Molecular mass:
    34763 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2H2 Gene

Post-translational modifications for OR2H2 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2H2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2H2 Gene

Domains & Families for OR2H2 Gene

Gene Families for OR2H2 Gene

Protein Domains for OR2H2 Gene

Suggested Antigen Peptide Sequences for OR2H2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2H2: view

Function for OR2H2 Gene

Molecular function for OR2H2 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily H,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2H2: view
genes like me logo Genes that share phenotypes with OR2H2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2H2 Gene

Localization for OR2H2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2H2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2H2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2H2: view

Pathways & Interactions for OR2H2 Gene

genes like me logo Genes that share pathways with OR2H2: view

Pathways by source for OR2H2 Gene

1 KEGG pathway for OR2H2 Gene

Interacting Proteins for OR2H2 Gene

Gene Ontology (GO) - Biological Process for OR2H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 7665158
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0007618 mating TAS 7665158
genes like me logo Genes that share ontologies with OR2H2: view

No data available for SIGNOR curated interactions for OR2H2 Gene

Transcripts for OR2H2 Gene

mRNA/cDNA for OR2H2 Gene

(2) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2H2 Gene

No ASD Table

Relevant External Links for OR2H2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2H2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2H2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2H2 Gene

This gene is overexpressed in Testis (x6.4), Brain - Putamen (basal ganglia) (x5.1), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Brain - Caudate (basal ganglia) (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of OR2H2 Gene:


SOURCE GeneReport for Unigene cluster for OR2H2 Gene:

genes like me logo Genes that share expression patterns with OR2H2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR2H2 Gene

Orthologs for OR2H2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2H2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100615382 34
  • 97.01 (n)
OR2H2 35
  • 95 (a)
(Rattus norvegicus)
Mammalia Olr1750 34
  • 86.86 (n)
(Mus musculus)
Mammalia Or2h2 55 Olfr90 34 16
  • 85.88 (n)
Olfr132 35
  • 60 (a)
Or2h2b-ps 55 Olfr753-ps1
  • chr17:37,169,711-37,170,646
Or2h2c 55 Olfr92
  • chr17:37,111,045-37,111,980
(Bos Taurus)
Mammalia -- 35
  • 84 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 52 (a)
Species where no ortholog for OR2H2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2H2 Gene

Gene Tree for OR2H2 (if available)
Gene Tree for OR2H2 (if available)

Paralogs for OR2H2 Gene

Paralogs for OR2H2 Gene

(449) SIMAP similar genes for OR2H2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2H2: view

Variants for OR2H2 Gene

Sequence variations from dbSNP and Humsavar for OR2H2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs111578865 -- 29,588,163(+) ACCAC(A/G)AGTTG reference, synonymous-codon
rs112249386 -- 29,590,638(+) TGAAT(G/T)AATGA utr-variant-3-prime
rs112414841 -- 29,585,362(+) AGAAC(A/C)TTTGC upstream-variant-2KB
rs112461475 -- 29,591,000(+) CAGGC(A/G)CAGTG utr-variant-3-prime
rs113086575 -- 29,585,390(+) TCAGT(G/T)TCCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2H2 Gene

Variant ID Type Subtype PubMed ID
nsv970099 CNV duplication 23825009
nsv5239 CNV deletion 18451855
nsv519288 CNV loss 19592680
nsv1145096 CNV deletion 24896259
nsv1122126 CNV deletion 24896259
nsv1074389 CNV deletion 25765185
esv3608481 CNV loss 21293372
esv2759411 CNV gain+loss 17122850

Variation tolerance for OR2H2 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.63; 86.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2H2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2H2 Gene

Disorders for OR2H2 Gene

Relevant External Links for OR2H2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR2H2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2H2 Gene

Publications for OR2H2 Gene

  1. Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors. (PMID: 19833159) Thompson E.E. … Ober C. (Hum. Immunol. 2010) 3 46 64
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  3. SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PMID: 17971048) Burfoot R.K. … Rubio J.P. (Tissue Antigens 2008) 3 46 64
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for OR2H2 Gene

Sources for OR2H2 Gene

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