Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR2H1 Gene

Aliases for OR2H1 Gene

  • Olfactory Receptor, Family 2, Subfamily H, Member 1 2 3
  • Olfactory Receptor, Family 2, Subfamily H, Member 8 2 3
  • Olfactory Receptor OR6-32 3 4
  • Olfactory Receptor 2H6 3 4
  • Olfactory Receptor 2H8 3 4
  • Olfactory Receptor 6-2 3 4
  • OLFR42A-9004.14/9026.2 3 4
  • HS6M1-16 3 4
  • OR2H6 3 4
  • OR2H8 3 4
  • OR6-2 3 4
  • Olfactory Receptor, Family 2, Subfamily H, Member 6 3
  • Olfactory Receptor 2H1 3
  • OLFR42A-9004-14 3
  • DJ994E9.4 3
  • 6M1-16 3

External Ids for OR2H1 Gene

Previous HGNC Symbols for OR2H1 Gene

  • OR2H6
  • OR2H8

Previous GeneCards Identifiers for OR2H1 Gene

  • GC06U990209
  • GC06M029486
  • GC06P029196
  • GC06P029534
  • GC06P029424
  • GC06Po29356

Summaries for OR2H1 Gene

Entrez Gene Summary for OR2H1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2H1 Gene

OR2H1 (Olfactory Receptor, Family 2, Subfamily H, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2C1.

UniProtKB/Swiss-Prot for OR2H1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2H1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2H1 Gene

Genomics for OR2H1 Gene

Regulatory Elements for OR2H1 Gene

Genomic Location for OR2H1 Gene

Start:
29,457,181 bp from pter
End:
29,464,328 bp from pter
Size:
7,148 bases
Orientation:
Plus strand

Genomic View for OR2H1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR2H1 Gene

  • Protein details for OR2H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZK4-OR2H1_HUMAN
    Recommended name:
    Olfactory receptor 2H1
    Protein Accession:
    Q9GZK4
    Secondary Accessions:
    • B0S7T4
    • O43629
    • O43661
    • O43662
    • Q5SUN6
    • Q9GZK9

    Protein attributes for OR2H1 Gene

    Size:
    316 amino acids
    Molecular mass:
    35339 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2H1 Gene

Proteomics data for OR2H1 Gene at MOPED

Post-translational modifications for OR2H1 Gene

Other Protein References for OR2H1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2H1 Gene

Domains for OR2H1 Gene

Gene Families for OR2H1 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2H1 Gene

Suggested Antigen Peptide Sequences for OR2H1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZK4

UniProtKB/Swiss-Prot:

OR2H1_HUMAN :
  • Q9GZK4
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2H1: view

Function for OR2H1 Gene

Molecular function for OR2H1 Gene

GENATLAS Biochemistry: olfactory receptor,family 2,subfamily H,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2H1: view

Phenotypes for OR2H1 Gene

GenomeRNAi human phenotypes for OR2H1:
genes like me logo Genes that share phenotypes with OR2H1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2H1 Gene

Localization for OR2H1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2H1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2H1 Gene COMPARTMENTS Subcellular localization image for OR2H1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2H1: view

Pathways for OR2H1 Gene

genes like me logo Genes that share pathways with OR2H1: view

Pathways by source for OR2H1 Gene

1 KEGG pathway for OR2H1 Gene

Interacting Proteins for OR2H1 Gene

Gene Ontology (GO) - Biological Process for OR2H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2H1: view

Transcripts for OR2H1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for OR2H1 Gene

No ASD Table

Relevant External Links for OR2H1 Gene

GeneLoc Exon Structure for
OR2H1
ECgene alternative splicing isoforms for
OR2H1

Expression for OR2H1 Gene

mRNA expression in normal human tissues for OR2H1 Gene

mRNA differential expression in normal tissues according to GTEx for OR2H1 Gene

This gene is overexpressed in Testis (50.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OR2H1 Gene

SOURCE GeneReport for Unigene cluster for OR2H1 Gene Hs.434715

genes like me logo Genes that share expressions with OR2H1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR2H1 Gene

Orthologs for OR2H1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2H1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC462525 35
  • 98 (n)
  • 96.2 (a)
OR2H1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
OneToMany
OR2H1 35
  • 87.39 (n)
  • 84.94 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 59 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr90 36
  • 83 (a)
OneToMany
Olfr91 35
  • 85.36 (n)
  • 84.62 (a)
Olfr91 16
Olfr91 36
  • 85 (a)
OneToMany
Olfr92 36
  • 80 (a)
OneToMany
Olfr93 36
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1749 35
  • 85.04 (n)
  • 84.94 (a)
Species with no ortholog for OR2H1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2H1 Gene

ENSEMBL:
Gene Tree for OR2H1 (if available)
TreeFam:
Gene Tree for OR2H1 (if available)

Paralogs for OR2H1 Gene

Paralogs for OR2H1 Gene

Selected SIMAP similar genes for OR2H1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2H1: view

Variants for OR2H1 Gene

Sequence variations from dbSNP and Humsavar for OR2H1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1345228 -- 29,464,613(-) TGACA(C/T)ACCAC downstream-variant-500B
rs2021729 -- 29,461,615(-) CTTAT(C/T)GTCAT utr-variant-5-prime
rs2073148 -- 29,462,393(-) CTGAG(A/G)GGCAC synonymous-codon, reference
rs2143668 -- 29,464,396(+) CAAAC(A/T)TAATA downstream-variant-500B
rs2523439 -- 29,459,743(-) GGATG(A/C/T)GGCAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2H1 Gene

Variant ID Type Subtype PubMed ID
nsv830624 CNV Loss 17160897

Relevant External Links for OR2H1 Gene

HapMap Linkage Disequilibrium report
OR2H1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2H1 Gene

Disorders for OR2H1 Gene

Relevant External Links for OR2H1

Genetic Association Database (GAD)
OR2H1
Human Genome Epidemiology (HuGE) Navigator
OR2H1
genes like me logo Genes that share disorders with OR2H1: view

No data available for UniProtKB/Swiss-Prot for OR2H1 Gene

Publications for OR2H1 Gene

  1. Complex transcription and splicing of odorant receptor genes. (PMID: 12637542) Volz A. … Ziegler A. (J. Biol. Chem. 2003) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48

Products for OR2H1 Gene

Sources for OR2H1 Gene

Back to Top

Content