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Aliases for OR2H1 Gene

Aliases for OR2H1 Gene

  • Olfactory Receptor Family 2 Subfamily H Member 1 2 3 5
  • Olfactory Receptor, Family 2, Subfamily H, Member 8 2 3
  • Olfactory Receptor OR6-32 3 4
  • Olfactory Receptor 2H6 3 4
  • Olfactory Receptor 2H8 3 4
  • Olfactory Receptor 6-2 3 4
  • OLFR42A-9004.14/9026.2 3 4
  • HS6M1-16 3 4
  • OR2H6 3 4
  • OR2H8 3 4
  • OR6-2 3 4
  • Olfactory Receptor, Family 2, Subfamily H, Member 1 2
  • Olfactory Receptor, Family 2, Subfamily H, Member 6 3
  • Olfactory Receptor 2H1 3
  • OLFR42A-9004-14 3
  • DJ994E9.4 3
  • 6M1-16 3

External Ids for OR2H1 Gene

Previous HGNC Symbols for OR2H1 Gene

  • OR2H6
  • OR2H8

Previous GeneCards Identifiers for OR2H1 Gene

  • GC06U990209
  • GC06M029486
  • GC06P029196
  • GC06P029534
  • GC06P029424
  • GC06Po29356

Summaries for OR2H1 Gene

Entrez Gene Summary for OR2H1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2H1 Gene

OR2H1 (Olfactory Receptor Family 2 Subfamily H Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2H2.

UniProtKB/Swiss-Prot for OR2H1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2H1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2H1 Gene

Genomics for OR2H1 Gene

Regulatory Elements for OR2H1 Gene

Enhancers for OR2H1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F029509 0.4 FANTOM5 10.8 +52.2 52177 0.1 IKZF1 EBF1 RELA LINC01015 OR11A1 OR2H1 OR5V1 OR10C1 OR2H2 PIRC24 LOC105375009
GH06F029708 0.9 FANTOM5 Ensembl ENCODE 7.4 +252.3 252255 2.6 PKNOX1 BHLHE40 CEBPB CEBPG EBF1 ATF2 IKZF1 PRDM1 TRIM28 HLA-F ZFP57 HLA-J IFITM4P HLA-H HCG4P5 ZNRD1ASP OR2H1 HLA-A HLA-K
GH06F029467 0.7 FANTOM5 1.9 +10.6 10567 0.3 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR2H1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2H1 Gene

Chromosome:
6
Start:
29,457,133 bp from pter
End:
29,464,328 bp from pter
Size:
7,196 bases
Orientation:
Plus strand

Genomic View for OR2H1 Gene

Genes around OR2H1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2H1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR2H1 Gene

  • Protein details for OR2H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZK4-OR2H1_HUMAN
    Recommended name:
    Olfactory receptor 2H1
    Protein Accession:
    Q9GZK4
    Secondary Accessions:
    • B0S7T4
    • O43629
    • O43661
    • O43662
    • Q5SUN6
    • Q9GZK9

    Protein attributes for OR2H1 Gene

    Size:
    316 amino acids
    Molecular mass:
    35339 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2H1 Gene

Post-translational modifications for OR2H1 Gene

No data available for DME Specific Peptides for OR2H1 Gene

Domains & Families for OR2H1 Gene

Gene Families for OR2H1 Gene

Protein Domains for OR2H1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZK4

UniProtKB/Swiss-Prot:

OR2H1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2H1: view

Function for OR2H1 Gene

Molecular function for OR2H1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily H,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2H1: view
genes like me logo Genes that share phenotypes with OR2H1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2H1 Gene

Localization for OR2H1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2H1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2H1 Gene COMPARTMENTS Subcellular localization image for OR2H1 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for OR2H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2H1: view

Pathways & Interactions for OR2H1 Gene

genes like me logo Genes that share pathways with OR2H1: view

Pathways by source for OR2H1 Gene

1 KEGG pathway for OR2H1 Gene

Interacting Proteins for OR2H1 Gene

Gene Ontology (GO) - Biological Process for OR2H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2H1: view

No data available for SIGNOR curated interactions for OR2H1 Gene

Transcripts for OR2H1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2H1 Gene

No ASD Table

Relevant External Links for OR2H1 Gene

GeneLoc Exon Structure for
OR2H1
ECgene alternative splicing isoforms for
OR2H1

Expression for OR2H1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2H1 Gene

mRNA differential expression in normal tissues according to GTEx for OR2H1 Gene

This gene is overexpressed in Testis (x50.2).

Protein differential expression in normal tissues from HIPED for OR2H1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2H1 Gene



Protein tissue co-expression partners for OR2H1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OR2H1 Gene:

OR2H1

SOURCE GeneReport for Unigene cluster for OR2H1 Gene:

Hs.434715
genes like me logo Genes that share expression patterns with OR2H1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR2H1 Gene

Orthologs for OR2H1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2H1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC462525 34
  • 98 (n)
OR2H1 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR2H1 34
  • 87.39 (n)
-- 35
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Or2h1 55 Olfr91 34 16 35
  • 85.36 (n)
Olfr90 35
  • 83 (a)
OneToMany
Or2h1b 55 Olfr93 35
  • 81 (a)
OneToMany
Olfr92 35
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1749 34
  • 85.04 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 51 (a)
OneToMany
Species where no ortholog for OR2H1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2H1 Gene

ENSEMBL:
Gene Tree for OR2H1 (if available)
TreeFam:
Gene Tree for OR2H1 (if available)

Paralogs for OR2H1 Gene

Paralogs for OR2H1 Gene

(434) SIMAP similar genes for OR2H1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2H1: view

Variants for OR2H1 Gene

Sequence variations from dbSNP and Humsavar for OR2H1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10651941 -- 29,460,373(+) GCTAA(-/T)TTTTT intron-variant, upstream-variant-2KB
rs111400701 -- 29,462,847(+) TATGA(A/G)AGGGA intron-variant, utr-variant-3-prime
rs112876066 -- 29,463,150(+) TTGAA(A/G)AACAG intron-variant, utr-variant-3-prime
rs113585136 -- 29,462,891(+) AATTG(A/G)GTGAG intron-variant, utr-variant-3-prime
rs114121257 -- 29,463,671(+) GTTAG(C/T)TTAGT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OR2H1 Gene

Variant ID Type Subtype PubMed ID
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv830624 CNV loss 17160897
nsv969371 CNV duplication 23825009

Variation tolerance for OR2H1 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.80; 66.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2H1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2H1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2H1 Gene

Disorders for OR2H1 Gene

Relevant External Links for OR2H1

Genetic Association Database (GAD)
OR2H1
Human Genome Epidemiology (HuGE) Navigator
OR2H1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2H1

No disorders were found for OR2H1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2H1 Gene

Publications for OR2H1 Gene

  1. Refining the association of MHC with multiple sclerosis in African Americans. (PMID: 20466734) McElroy J.P. … Gourraud P.A. (Hum. Mol. Genet. 2010) 3 46 64
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Complex transcription and splicing of odorant receptor genes. (PMID: 12637542) Volz A. … Ziegler A. (J. Biol. Chem. 2003) 3 4 64

Products for OR2H1 Gene

Sources for OR2H1 Gene

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