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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR2H1 Gene

protein-coding   GIFtS: 51
GCID: GC06P029424

olfactory receptor, family 2, subfamily H, member 1

(Previous names: olfactory receptor, family 2, subfamily H, member 8 )
(Previous symbols: OR2H6, OR2H8)
 Explore 3 diseases affiliated with
OR2H1 via our new
 Human Malady Compendium 
Biological research products
for OR2H1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Olfactory Receptor, Family 2, Subfamily H, Member 11 2     OLFR42A-9004.14/9026.22 3
OR2H61 2 3     6M1-162
OR2H81 2 3     HS6M1-162
OR6-21 2 3     OLFR42A-9004-142
Olfactory Receptor, Family 2, Subfamily H, Member 81 2     DJ994E9.41
Olfactory Receptor 2H62 3     Olfactory Receptor 2H12
Olfactory Receptor 2H82 3     Olfactory Receptor, Family 2, Subfamily H, Member 62
Olfactory Receptor 6-22 3     Hs6M1-163
Olfactory Receptor OR6-322 3     

External Ids:    HGNC: 82521   Entrez Gene: 267162   Ensembl: ENSG000002046887   UniProtKB: Q9GZK43   

Export aliases for OR2H1 gene to outside databases

Previous GC identifers: GC06U990209 GC06M029486 GC06P029196 GC06P029534 GC06Po29356


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR2H1:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors
(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many
neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of
odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the
olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: OR2H1_HUMAN, Q9GZK4
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2H1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR2H1 gene promoter:
         Nkx3-1   SRF   SRF (504 AA)   SREBP-1c   Nkx3-1 v1   SREBP-1b   Nkx3-1 v2   SREBP-1a   HOXA5   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2H1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR2H1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2H1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.32   Ensembl cytogenetic band:  6p22.1   HGNC chromosome: 6

OR2H1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2H1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P029424:  view genomic region     (about GC identifiers)

Start:
29,429,547 bp from pter      End:
29,430,494 bp from pter
Size:
948 bases      Orientation:
plus strand

6/7 alternative locations (see all 7):
Chr6+,ALT_REF_LOCI_5 29,340,835-29,346,704      Chr6+,ALT_REF_LOCI_4 29,348,856-29,354,726      Chr6+,ALT_REF_LOCI_2 29,421,536-29,467,864     
Chr6+,ALT_REF_LOCI_6 29,424,845-29,467,568      Chr6+,ALT_REF_LOCI_3 29,424,892-29,443,071      Chr6+,ALT_REF_LOCI_1 29,425,038-29,440,480     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OR2H1_HUMAN, Q9GZK4 (See protein sequence)
Recommended Name: Olfactory receptor 2H1  
Size: 316 amino acids; 35339 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B0S7T4 O43629 O43661 O43662 Q5SUN6 Q9GZK9

Explore the universe of human proteins at neXtProt for OR2H1: NX_Q9GZK4

HORDE protein sequence for OR2H1
OR2H1 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_112145.1  
ENSEMBL proteins: 
 ENSP00000366340   ENSP00000366337   ENSP00000366336   ENSP00000380010   ENSP00000393254  
Reactome Protein details: Q9GZK4
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Uscn Proteins for OR2H1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--


OR2H1 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for OR2H1


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OR2H1 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q9GZK4

ProtoNet protein and cluster: Q9GZK4

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR2H1_HUMAN, Q9GZK4
Similarity: Belongs to the G-protein coupled receptor 1 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: OR2H1_HUMAN, Q9GZK4
Function: Odorant receptor (Potential)

     Genatlas biochemistry entry for OR2H1:
olfactory receptor,family 2,subfamily H,member 1,G protein coupled receptor superfamily

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidOR2H1 3' UTR sequence
Inhib. RNA
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Gene Editing
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Clone
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Cell Line
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In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2H1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--


OR2H1 for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for OR2H1:
 Decreased POU5F1-GFP protein e 


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Signaling by GPCR
Signaling by GPCR1.00
Signal Transduction0.56
GPCR downstream signaling0.89
2Olfactory transduction
Olfactory transduction1.00
Olfactory Signaling Pathway0.77
3Class A/1 (Rhodopsin-like receptors)
GPCRs, Class A Rhodopsin-like0.41

Pathway sources
See GeneCards unified pathways
Show all pathways


1 BioSystems Pathway for OR2H1 
    GPCRs, Class A Rhodopsin-like

4        Reactome Pathways for OR2H1
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR2H1):
    Olfactory transduction


OR2H1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2H1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR2H1
Search CenterWatch for drugs/clinical trials and news about OR2H1 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR2H1 gene: 
NM_030883.3  

Unigene Clusters for OR2H1:

Olfactory receptor, family 2, subfamily H, member 1
Hs.434715  [show with all ESTs], Hs.714219 , Hs.740793  [show with all ESTs]
Unigene Representative Sequences: AK127984, AJ459846, NM_030883
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000377136 ENST00000377133(uc003nmi.3) ENST00000484371 ENST00000377132(uc003nmj.1)
ENST00000396792(uc021ytr.1) ENST00000473369(uc010jri.2) ENST00000484554
ENST00000442615

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OR2H1
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate OR2H1
SwitchGear 3'UTR luciferase reporter plasmidOR2H1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR2H1 (see all 4)
OriGene shRNA RFP: OR2H1
OriGene siRNA: OR2H1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR2H1
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2H1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2H1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: OR2H1 (NM_030883)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2H1 
Primer
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OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2H1
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2H1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2H1

Additional cDNA sequence: 

AJ459835.1 AJ459836.1 AJ459848.1 AJ459850.1 BC036097.2 BC048991.2 

6 DOTS entries:

DT.100011856  DT.99932691  DT.100000127  DT.100689082  DT.100017840  DT.423778 

16 AceView cDNA sequences:

AJ459845 AJ459840 AJ459835 NM_030883 BC036097 AK127984 AJ459838 AJ459846 
BC048991 AJ459848 AJ459847 AJ459844 AJ459843 AJ459849 AJ459836 AJ459850 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR2H1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAATACACA

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See OR2H1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR2H1

SOURCE GeneReport for Unigene clusters: Hs.434715 Hs.714219 Hs.740793
    SABiosciences Custom PCR Arrays for OR2H1
Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2H1
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2H1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2H1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2H1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for OR2H1 (if available)
TreeFam Gene Tree for OR2H1 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR2H1 gene
OR2J22  OR2W12  OR2J12  OR2B112  OR2H22  OR2B22  OR2B32  OR2C12  
OR2Y12  OR2G22  OR2B62  OR2W32  OR2J32  OR2G32  OR2C32  OR2G62  
18/439 SIMAP similar genes for OR2H1 using alignment to 1 protein entry:     OR2H1_HUMAN(see all similar genes):
6M1-16    OLFR 42A    OR2H2    OR2H5P    OLFR 42B    OR2G3
OR2W6P    OR2J1    OR2J3    OR2B11    OR2B2    OR2B8P
OR2C3    OR2G6    OR2J4P    OR2W5    OR2B3    OR2B6

OR2H1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/199 NCBI SNPs in OR2H1 are shown (see all 199    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1447996271,2
--29424235(+) TGAGCC/TGAGAT 1 -- us2k10--------
rs1869468851,2
--29424300(+) AAAAAA/TTAAAT 1 -- us2k10--------
rs1913387691,2
--29424366(+) TCACAC/TGACCC 1 -- us2k10--------
rs1835220021,2
--29424482(+) GGAAAC/TCACCC 1 -- us2k10--------
rs1485679731,2
--29424523(+) TTATCA/CCAAAA 1 -- us2k10--------
rs1420020321,2
--29424817(+) TCTCCC/TCATAT 1 -- us2k10--------
rs1507038031,2
--29424848(+) AGGATA/GGCTTC 1 -- us2k10--------
rs1181329141,2
--29424869(+) AACAAT/ACCACA 1 -- us2k11Minor allele frequency- A:0.01EA 120
rs1151117921,2
--29424989(+) GGTAAG/AGGAAG 1 -- us2k11Minor allele frequency- A:0.01WA 118
rs1893295911,2
--29425016(+) AAGGGC/GATATA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OR2H1 ( 29429547 - 29430494 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for OR2H1: --

SABiosciences Cancer Mutation PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for OR2H1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OR2H1 for disorders           About GeneDecksing

3 diseases for OR2H1:    About MalaCards
systemic lupus erythematosus    lupus erythematosus    neuronitis

Human Genome Epidemiology (HuGE) Navigator: OR2H1 (4 documents)

Export disorders for OR2H1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR2H1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with OR2H1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
  3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
  4. Complex transcription and splicing of odorant receptor genes. (PubMed id 12637542)1, 2 Volz A.... Ziegler A. (2003)
  5. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
  6. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
  7. Refining the association of MHC with multiple scleros is in African Americans. (PubMed id 20466734)1 McElroy J.P....Gourraud P.A. (2010)
  8. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
  9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 26716 HGNC: 8252 AceView: OR2H1 Ensembl:ENSG00000204688 euGenes: HUgn26716
ECgene: OR2H1 Kegg: 26716 H-InvDB: OR2H1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR2H1 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR2H1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR2H1 gene:
Search GeneIP for patents involving OR2H1

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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