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Aliases for OR2G6 Gene

Aliases for OR2G6 Gene

  • Olfactory Receptor Family 2 Subfamily G Member 6 2 3 5
  • Olfactory Receptor, Family 2, Subfamily G, Member 6 2

External Ids for OR2G6 Gene

Previous GeneCards Identifiers for OR2G6 Gene

  • GC01P245011
  • GC01P246751
  • GC01P248684

Summaries for OR2G6 Gene

Entrez Gene Summary for OR2G6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2G6 Gene

OR2G6 (Olfactory Receptor Family 2 Subfamily G Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2C1.

UniProtKB/Swiss-Prot for OR2G6 Gene

  • Odorant receptor.

Gene Wiki entry for OR2G6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2G6 Gene

Genomics for OR2G6 Gene

Regulatory Elements for OR2G6 Gene

Enhancers for OR2G6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR2G6 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2G6 Gene

Chromosome:
1
Start:
248,521,647 bp from pter
End:
248,522,597 bp from pter
Size:
951 bases
Orientation:
Plus strand

Genomic View for OR2G6 Gene

Genes around OR2G6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2G6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2G6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2G6 Gene

Proteins for OR2G6 Gene

  • Protein details for OR2G6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TZ20-OR2G6_HUMAN
    Recommended name:
    Olfactory receptor 2G6
    Protein Accession:
    Q5TZ20
    Secondary Accessions:
    • B2RP33

    Protein attributes for OR2G6 Gene

    Size:
    316 amino acids
    Molecular mass:
    34890 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2G6 Gene

Proteomics data for OR2G6 Gene at MOPED

Post-translational modifications for OR2G6 Gene

  • Glycosylation at Asn 5 and Asn 6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2G6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2G6 Gene

Domains & Families for OR2G6 Gene

Gene Families for OR2G6 Gene

Protein Domains for OR2G6 Gene

Suggested Antigen Peptide Sequences for OR2G6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TZ20

UniProtKB/Swiss-Prot:

OR2G6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2G6: view

Function for OR2G6 Gene

Molecular function for OR2G6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2G6 Gene

Localization for OR2G6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2G6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2G6 Gene COMPARTMENTS Subcellular localization image for OR2G6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2G6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2G6: view

Pathways & Interactions for OR2G6 Gene

genes like me logo Genes that share pathways with OR2G6: view

Pathways by source for OR2G6 Gene

Interacting Proteins for OR2G6 Gene

Gene Ontology (GO) - Biological Process for OR2G6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2G6: view

No data available for SIGNOR curated interactions for OR2G6 Gene

Drugs & Compounds for OR2G6 Gene

No Compound Related Data Available

Transcripts for OR2G6 Gene

mRNA/cDNA for OR2G6 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2G6 Gene

No ASD Table

Relevant External Links for OR2G6 Gene

GeneLoc Exon Structure for
OR2G6
ECgene alternative splicing isoforms for
OR2G6

Expression for OR2G6 Gene

mRNA expression in normal human tissues for OR2G6 Gene

mRNA differential expression in normal tissues according to GTEx for OR2G6 Gene

This gene is overexpressed in Testis (x13.1) and Kidney - Cortex (x6.1).

SOURCE GeneReport for Unigene cluster for OR2G6 Gene Hs.553784

genes like me logo Genes that share expression patterns with OR2G6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR2G6 Gene

Orthologs for OR2G6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2G6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR2G6 35
  • 85.87 (n)
  • 87.7 (a)
-- 36
  • 68 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC607953 35
  • 85.14 (n)
  • 85.67 (a)
OR2G6 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1383 35
  • 62.89 (n)
  • 57 (a)
Olfr1383 16
Olfr1383 36
  • 55 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1398 35
  • 63.11 (n)
  • 59.67 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
Species with no ortholog for OR2G6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2G6 Gene

ENSEMBL:
Gene Tree for OR2G6 (if available)
TreeFam:
Gene Tree for OR2G6 (if available)

Paralogs for OR2G6 Gene

Paralogs for OR2G6 Gene

(450) SIMAP similar genes for OR2G6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2G6: view

Variants for OR2G6 Gene

Sequence variations from dbSNP and Humsavar for OR2G6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_053142 -
VAR_062020 -

Structural Variations from Database of Genomic Variants (DGV) for OR2G6 Gene

Variant ID Type Subtype PubMed ID
nsv515858 CNV Gain+Loss 19592680
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
dgv567n71 CNV Gain 21882294
nsv873462 CNV Loss 21882294
dgv20n17 CNV Loss 16327808
dgv206e1 CNV Complex 17122850
nsv428357 CNV Loss 18775914
esv2750835 CNV Gain 17911159
nsv873468 CNV Loss 21882294
dgv571n71 CNV Gain 21882294
nsv873474 CNV Gain 21882294
dgv572n71 CNV Gain+Loss 21882294
nsv7193 OTHER Inversion 18451855
dgv207e1 CNV Complex 17122850
nsv873483 CNV Gain+Loss 21882294
nsv873484 CNV Loss 21882294
dgv574n71 CNV Gain 21882294
dgv575n71 CNV Gain 21882294
nsv873494 CNV Loss 21882294
nsv5354 CNV Loss 18451855
nsv821623 CNV Loss 15273396
esv7998 OTHER Inversion 19470904
nsv499748 OTHER Inversion 21111241
nsv508707 CNV Loss 20534489
nsv873496 CNV Gain 21882294
esv1392907 OTHER Inversion 17803354
nsv442997 CNV Gain 18674749

Variation tolerance for OR2G6 Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.46; 85.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR2G6 Gene

Disorders for OR2G6 Gene

Relevant External Links for OR2G6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2G6

No disorders were found for OR2G6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2G6 Gene

Publications for OR2G6 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2G6 Gene

Sources for OR2G6 Gene

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