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Aliases for OR2F2 Gene

Aliases for OR2F2 Gene

  • Olfactory Receptor, Family 2, Subfamily F, Member 2 2 3
  • Olfactory Receptor OR7-6 3 4
  • Olfactory Receptor 7-1 3 4
  • OR7-1 3 4
  • Olfactory Receptor 2F2 3

External Ids for OR2F2 Gene

Previous GeneCards Identifiers for OR2F2 Gene

  • GC07U990170
  • GC07P143025
  • GC07P143069
  • GC07P143265
  • GC07P143632

Summaries for OR2F2 Gene

Entrez Gene Summary for OR2F2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2F2 Gene

OR2F2 (Olfactory Receptor, Family 2, Subfamily F, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A42.

UniProtKB/Swiss-Prot for OR2F2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2F2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2F2 Gene

Genomics for OR2F2 Gene

Regulatory Elements for OR2F2 Gene

Genomic Location for OR2F2 Gene

143,935,166 bp from pter
143,936,279 bp from pter
1,114 bases
Plus strand

Genomic View for OR2F2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2F2 Gene

Proteins for OR2F2 Gene

  • Protein details for OR2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2F2
    Protein Accession:
    Secondary Accessions:
    • A4D2G0
    • Q6IFP8

    Protein attributes for OR2F2 Gene

    317 amino acids
    Molecular mass:
    35294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2F2 Gene

Proteomics data for OR2F2 Gene at MOPED

Post-translational modifications for OR2F2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2F2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

No data available for DME Specific Peptides for OR2F2 Gene

Domains for OR2F2 Gene

Gene Families for OR2F2 Gene

Protein Domains for OR2F2 Gene

Suggested Antigen Peptide Sequences for OR2F2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2F2: view

Function for OR2F2 Gene

Molecular function for OR2F2 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily F,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2F2: view

Animal Model Products

CRISPR Products

miRNA for OR2F2 Gene

miRTarBase miRNAs that target OR2F2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2F2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OR2F2 Gene

Localization for OR2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2F2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR2F2 Gene COMPARTMENTS Subcellular localization image for OR2F2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2F2: view

Pathways for OR2F2 Gene

genes like me logo Genes that share pathways with OR2F2: view

Pathways by source for OR2F2 Gene

1 KEGG pathway for OR2F2 Gene

Interacting Proteins for OR2F2 Gene

Gene Ontology (GO) - Biological Process for OR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2F2: view

Transcripts for OR2F2 Gene

mRNA/cDNA for OR2F2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2F2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2F2 Gene

No ASD Table

Relevant External Links for OR2F2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2F2 Gene

mRNA expression in normal human tissues for OR2F2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2F2 Gene

This gene is overexpressed in Testis (28.0), Brain - Caudate (basal ganglia) (6.7), Brain - Nucleus accumbens (basal ganglia) (6.3), Cervix - Ectocervix (6.0), and Cervix - Endocervix (5.8).

Protein differential expression in normal tissues for OR2F2 Gene

This gene is overexpressed in Blymphocyte (68.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR2F2 Gene

SOURCE GeneReport for Unigene cluster for OR2F2 Gene Hs.553596

genes like me logo Genes that share expressions with OR2F2: view

Expression partners for OR2F2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR2F2 Gene

Orthologs for OR2F2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2F2 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Olfr452 35
  • 82.86 (n)
  • 85.4 (a)
Olfr452 16
Olfr38 36
  • 83 (a)
Olfr452 36
  • 85 (a)
Olfr453 36
  • 84 (a)
(Pan troglodytes)
Mammalia LOC472566 35
  • 98.21 (n)
  • 96.53 (a)
OR2F2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Olr808 35
  • 82.33 (n)
  • 85.71 (a)
(Bos Taurus)
Mammalia -- 36
  • 87 (a)
-- 36
  • 87 (a)
-- 36
  • 86 (a)
-- 36
  • 83 (a)
(Canis familiaris)
Mammalia -- 36
  • 84 (a)
-- 36
  • 85 (a)
cOR13M4 36
  • 84 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
-- 36
  • 75 (a)
-- 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488194 35
  • 56 (n)
  • 49.17 (a)
Species with no ortholog for OR2F2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2F2 Gene

Gene Tree for OR2F2 (if available)
Gene Tree for OR2F2 (if available)

Paralogs for OR2F2 Gene

(455) SIMAP similar genes for OR2F2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR2F2: view

Variants for OR2F2 Gene

Sequence variations from dbSNP and Humsavar for OR2F2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs984764 -- 143,936,204(+) ACTTT(A/G)AGAAG downstream-variant-500B
rs2240358 -- 143,935,172(+) CTTTG(A/G)TTCAA upstream-variant-2KB
rs2240359 - 143,935,525(+) CTGTG(C/T)AGCCC reference, missense
rs4286866 -- 143,935,920(+) TCCAG(G/T)CCAGA missense, reference
rs6464562 -- 143,933,716(+) gcaaa(G/T)ctaac upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2F2 Gene

Variant ID Type Subtype PubMed ID
dgv2147e1 CNV Complex 17122850
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
esv2422489 CNV Duplication 17116639
nsv8227 CNV Gain+Loss 18304495
nsv522225 CNV Gain 19592680
nsv469570 CNV Complex 16826518
nsv471645 CNV Gain+Loss 15918152
esv1682998 OTHER Inversion 17803354
dgv842n27 CNV Gain 19166990
nsv889336 CNV Gain 21882294
dgv7520n71 CNV Gain 21882294
esv2752147 CNV Gain 17911159
nsv482912 CNV Loss 15286789
dgv2149e1 CNV Complex 17122850
esv2735282 CNV Deletion 23290073

Relevant External Links for OR2F2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2F2 Gene

Disorders for OR2F2 Gene

Relevant External Links for OR2F2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for OR2F2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OR2F2 Gene

Publications for OR2F2 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PMID: 20855565) Peloso G.M. … Brousseau M.E. (J. Lipid Res. 2010) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for OR2F2 Gene

Sources for OR2F2 Gene

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