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Aliases for OR2F2 Gene

Aliases for OR2F2 Gene

  • Olfactory Receptor Family 2 Subfamily F Member 2 2 3 5
  • Olfactory Receptor OR7-6 3 4
  • Olfactory Receptor 7-1 3 4
  • OR7-1 3 4
  • Olfactory Receptor, Family 2, Subfamily F, Member 2 2
  • Olfactory Receptor 2F2 3

External Ids for OR2F2 Gene

Previous GeneCards Identifiers for OR2F2 Gene

  • GC07U990170
  • GC07P143025
  • GC07P143069
  • GC07P143265
  • GC07P143632
  • GC07P143937

Summaries for OR2F2 Gene

Entrez Gene Summary for OR2F2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2F2 Gene

OR2F2 (Olfactory Receptor Family 2 Subfamily F Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2F1.

UniProtKB/Swiss-Prot for OR2F2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2F2 Gene

Additional gene information for OR2F2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2F2 Gene

Genomics for OR2F2 Gene

Regulatory Elements for OR2F2 Gene

Enhancers for OR2F2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H143933 0.7 ENCODE 0.7 +0.2 239 2 FOXA2 RFX1 HLF MAFG CEBPG ZFHX2 GATA3 MAFF JUND ZNF316 ARHGEF35 OR2F1 TCAF1 OR2A7 OR2F2 LOC100422324
GH07H143929 0.6 ENCODE 0.4 -5.3 -5291 1 FOSL1 PKNOX1 JUND MCM3 FOS BATF ARHGEF35 OR2A1 CASP2 OR2F1 TCAF1 LOC154761 OR2A5 OR2F2
GH07H143978 0.7 ENCODE 0.3 +44.3 44306 2 ATF1 TAL1 JUN TCF12 CTBP1 GATA2 NCOR1 FOS TRIM24 ATF7 OR2F1 OR2A25 OR2A41P LOC154761 LOC100422324 OR2F2
GH07H143972 0.6 ENCODE 0.3 +39.0 38951 2 ELF3 TAL1 CEBPB ELF1 ZNF217 JUND GATA3 CTBP1 TCF7L2 OR6B1 OR2A5 LOC100422324 OR2F2
GH07H143910 0.4 ENCODE 0.3 -25.1 -25084 0 HLF MAFK OR2F1 OR2F2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2F2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2F2 Gene

Chromosome:
7
Start:
143,935,166 bp from pter
End:
143,936,279 bp from pter
Size:
1,114 bases
Orientation:
Plus strand

Genomic View for OR2F2 Gene

Genes around OR2F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2F2 Gene

Proteins for OR2F2 Gene

  • Protein details for OR2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95006-OR2F2_HUMAN
    Recommended name:
    Olfactory receptor 2F2
    Protein Accession:
    O95006
    Secondary Accessions:
    • A4D2G0
    • Q6IFP8

    Protein attributes for OR2F2 Gene

    Size:
    317 amino acids
    Molecular mass:
    35294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2F2 Gene

Post-translational modifications for OR2F2 Gene

  • Glycosylation at posLast=55
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2F2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2F2 Gene

Domains & Families for OR2F2 Gene

Gene Families for OR2F2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2F2 Gene

Suggested Antigen Peptide Sequences for OR2F2 Gene

Graphical View of Domain Structure for InterPro Entry

O95006

UniProtKB/Swiss-Prot:

OR2F2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2F2: view

Function for OR2F2 Gene

Molecular function for OR2F2 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily F,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2F2: view

Phenotypes for OR2F2 Gene

GenomeRNAi human phenotypes for OR2F2:
genes like me logo Genes that share phenotypes with OR2F2: view

Animal Model Products

CRISPR Products

miRNA for OR2F2 Gene

miRTarBase miRNAs that target OR2F2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2F2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2F2 Gene

Localization for OR2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2F2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2F2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2F2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2F2 Gene

Pathways & Interactions for OR2F2 Gene

genes like me logo Genes that share pathways with OR2F2: view

Pathways by source for OR2F2 Gene

1 KEGG pathway for OR2F2 Gene

Interacting Proteins for OR2F2 Gene

Gene Ontology (GO) - Biological Process for OR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2F2: view

No data available for SIGNOR curated interactions for OR2F2 Gene

Drugs & Compounds for OR2F2 Gene

No Compound Related Data Available

Transcripts for OR2F2 Gene

mRNA/cDNA for OR2F2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2F2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR2F2 Gene

No ASD Table

Relevant External Links for OR2F2 Gene

GeneLoc Exon Structure for
OR2F2
ECgene alternative splicing isoforms for
OR2F2

Expression for OR2F2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2F2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2F2 Gene

This gene is overexpressed in Testis (x28.0), Brain - Caudate (basal ganglia) (x6.7), Brain - Nucleus accumbens (basal ganglia) (x6.3), Cervix - Ectocervix (x6.0), and Cervix - Endocervix (x5.8).

Protein differential expression in normal tissues from HIPED for OR2F2 Gene

This gene is overexpressed in Blymphocyte (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2F2 Gene



Protein tissue co-expression partners for OR2F2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2F2 Gene:

OR2F2

SOURCE GeneReport for Unigene cluster for OR2F2 Gene:

Hs.553596
genes like me logo Genes that share expression patterns with OR2F2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2F2 Gene

Orthologs for OR2F2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC472566 33
  • 98.21 (n)
OR2F2 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 87 (a)
ManyToMany
-- 34
  • 87 (a)
ManyToMany
-- 34
  • 86 (a)
ManyToMany
-- 34
  • 83 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 85 (a)
ManyToMany
-- 34
  • 84 (a)
ManyToMany
cOR13M4 34
  • 84 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr453 34
  • 84 (a)
ManyToMany
Olfr38 34
  • 83 (a)
ManyToMany
Or2f2 52 Olfr452 33 16 34
  • 82.86 (n)
rat
(Rattus norvegicus)
Mammalia Olr808 33
  • 82.33 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
ManyToMany
-- 34
  • 76 (a)
ManyToMany
-- 34
  • 75 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488194 33
  • 56 (n)
Species where no ortholog for OR2F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2F2 Gene

ENSEMBL:
Gene Tree for OR2F2 (if available)
TreeFam:
Gene Tree for OR2F2 (if available)

Paralogs for OR2F2 Gene

Paralogs for OR2F2 Gene

(455) SIMAP similar genes for OR2F2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR2F2: view

Variants for OR2F2 Gene

Sequence variations from dbSNP and Humsavar for OR2F2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000403539 -- 143,934,578(+) GCATC(G/T)TGGAA intron-variant, upstream-variant-2KB
rs1002193646 -- 143,933,540(+) AGGTG(C/T)CATAA intron-variant, upstream-variant-2KB
rs1002868650 -- 143,936,345(+) ATGGG(G/T)TGTGG intron-variant, downstream-variant-500B
rs1003200142 -- 143,935,084(+) ATCTT(-/G)GCCTT intron-variant, upstream-variant-2KB
rs1005793930 -- 143,934,862(+) GCCTG(A/G)GACTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2F2 Gene

Variant ID Type Subtype PubMed ID
dgv11664n54 CNV gain 21841781
dgv6725n100 CNV gain 25217958
dgv842n27 CNV gain 19166990
esv1682998 OTHER inversion 17803354
esv2422489 CNV duplication 17116639
esv2735282 CNV deletion 23290073
esv2752147 CNV gain 17911159
esv2759570 CNV gain+loss 17122850
esv3615312 CNV gain 21293372
esv3615313 CNV gain 21293372
esv3891223 CNV loss 25118596
nsv1016831 CNV gain 25217958
nsv1021504 CNV loss 25217958
nsv428188 CNV gain+loss 18775914
nsv469570 CNV gain+loss 16826518
nsv471645 CNV gain+loss 15918152
nsv522225 CNV gain 19592680
nsv608682 CNV gain 21841781
nsv8227 CNV gain+loss 18304495
nsv966903 CNV duplication 23825009

Variation tolerance for OR2F2 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.81; 94.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2F2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2F2 Gene

Disorders for OR2F2 Gene

Relevant External Links for OR2F2

Genetic Association Database (GAD)
OR2F2
Human Genome Epidemiology (HuGE) Navigator
OR2F2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2F2

No disorders were found for OR2F2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2F2 Gene

Publications for OR2F2 Gene

  1. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PMID: 20855565) Peloso GM … Brousseau ME (Journal of lipid research 2010) 3 45 60
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2016) 3 60

Products for OR2F2 Gene

Sources for OR2F2 Gene

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