Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR2F1 Gene

Aliases for OR2F1 Gene

  • Olfactory Receptor Family 2 Subfamily F Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 2, Subfamily F, Member 1 2 3
  • Olfactory Receptor-Like Protein OLF3 3 4
  • Olfactory Receptor 2F3 3 4
  • Olfactory Receptor 2F4 3 4
  • Olfactory Receptor 2F5 3 4
  • OR2F3P 3 4
  • OR2F3 3 4
  • OR2F4 3 4
  • OR2F5 3 4
  • OLF3 3 4
  • Olfactory Receptor, Family 2, Subfamily F, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 2, Subfamily F, Member 3 3
  • Olfactory Receptor, Family 2, Subfamily F, Member 4 3
  • Olfactory Receptor, Family 2, Subfamily F, Member 5 3
  • Olfactory Receptor OR7-7 3
  • OR14-60 3
  • OR7-139 3
  • OR7-140 3
  • 7M1-2 3

External Ids for OR2F1 Gene

Previous HGNC Symbols for OR2F1 Gene

  • OR2F4
  • OR2F5
  • OR2F3
  • OR2F3P

Previous GeneCards Identifiers for OR2F1 Gene

  • GC07P141903
  • GC07P142971
  • GC07P143049
  • GC07P143050
  • GC07P143094
  • GC07P143287
  • GC07P143657
  • GC07P143959

Summaries for OR2F1 Gene

Entrez Gene Summary for OR2F1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR2F1 Gene

OR2F1 (Olfactory Receptor Family 2 Subfamily F Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2D2.

UniProtKB/Swiss-Prot for OR2F1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2F1 Gene

Genomics for OR2F1 Gene

Regulatory Elements for OR2F1 Gene

Enhancers for OR2F1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR2F1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2F1 Gene

Chromosome:
7
Start:
143,907,126 bp from pter
End:
143,961,015 bp from pter
Size:
53,890 bases
Orientation:
Plus strand

Genomic View for OR2F1 Gene

Genes around OR2F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2F1 Gene

Proteins for OR2F1 Gene

  • Protein details for OR2F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13607-OR2F1_HUMAN
    Recommended name:
    Olfactory receptor 2F1
    Protein Accession:
    Q13607
    Secondary Accessions:
    • A4D2G1
    • Q6IFP7
    • Q96R49
    • Q9UDX1

    Protein attributes for OR2F1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35350 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2F1 Gene

Proteomics data for OR2F1 Gene at MOPED

Post-translational modifications for OR2F1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2F1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2F1 Gene

Domains & Families for OR2F1 Gene

Gene Families for OR2F1 Gene

Protein Domains for OR2F1 Gene

Suggested Antigen Peptide Sequences for OR2F1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13607

UniProtKB/Swiss-Prot:

OR2F1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2F1: view

Function for OR2F1 Gene

Molecular function for OR2F1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily F,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR2F1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2F1 Gene

Localization for OR2F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2F1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2F1 Gene COMPARTMENTS Subcellular localization image for OR2F1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2F1: view

Pathways & Interactions for OR2F1 Gene

genes like me logo Genes that share pathways with OR2F1: view

Pathways by source for OR2F1 Gene

1 KEGG pathway for OR2F1 Gene

Interacting Proteins for OR2F1 Gene

Gene Ontology (GO) - Biological Process for OR2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2F1: view

No data available for SIGNOR curated interactions for OR2F1 Gene

Drugs & Compounds for OR2F1 Gene

No Compound Related Data Available

Transcripts for OR2F1 Gene

mRNA/cDNA for OR2F1 Gene

(4) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2F1 Gene

No ASD Table

Relevant External Links for OR2F1 Gene

GeneLoc Exon Structure for
OR2F1
ECgene alternative splicing isoforms for
OR2F1

Expression for OR2F1 Gene

mRNA expression in normal human tissues for OR2F1 Gene

mRNA differential expression in normal tissues according to GTEx for OR2F1 Gene

This gene is overexpressed in Testis (x19.7).

SOURCE GeneReport for Unigene cluster for OR2F1 Gene Hs.553595

genes like me logo Genes that share expression patterns with OR2F1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR2F1 Gene

Orthologs for OR2F1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2F1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC613799 35
  • 87.97 (n)
  • 87.03 (a)
-- 36
  • 86 (a)
ManyToMany
-- 36
  • 86 (a)
ManyToMany
-- 36
  • 87 (a)
ManyToMany
-- 36
  • 85 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC100687207 35
  • 87.91 (n)
  • 87.07 (a)
-- 36
  • 87 (a)
ManyToMany
-- 36
  • 85 (a)
ManyToMany
cOR13M4 36
  • 86 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr453 35
  • 82.33 (n)
  • 86.75 (a)
Olfr453 16
Olfr38 36
  • 85 (a)
ManyToMany
Olfr452 36
  • 85 (a)
ManyToMany
Olfr453 36
  • 87 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC472567 35
  • 99.26 (n)
  • 98.42 (a)
OR2F1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr806 35
  • 82.86 (n)
  • 86.44 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
ManyToMany
-- 36
  • 77 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485994 35
  • 54.49 (n)
  • 46.18 (a)
Species with no ortholog for OR2F1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2F1 Gene

ENSEMBL:
Gene Tree for OR2F1 (if available)
TreeFam:
Gene Tree for OR2F1 (if available)

Paralogs for OR2F1 Gene

Paralogs for OR2F1 Gene

(453) SIMAP similar genes for OR2F1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR2F1 Gene

genes like me logo Genes that share paralogs with OR2F1: view

Variants for OR2F1 Gene

Sequence variations from dbSNP and Humsavar for OR2F1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2072164 - 143,960,334(+) ATGAC(C/T)GCTAT reference, missense
rs2072165 - 143,960,380(+) CATGC(A/G)TGGAG reference, missense
rs970779 -- 143,946,470(+) gtaaa(C/T)tcctc intron-variant
rs1012770 -- 143,947,225(+) ggtga(C/T)agatt intron-variant
rs1012771 -- 143,947,528(+) AAAAA(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR2F1 Gene

Variant ID Type Subtype PubMed ID
dgv2147e1 CNV Complex 17122850
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
esv2422489 CNV Duplication 17116639
nsv8227 CNV Gain+Loss 18304495
nsv522225 CNV Gain 19592680
esv1682998 OTHER Inversion 17803354
dgv842n27 CNV Gain 19166990
nsv889336 CNV Gain 21882294
dgv7520n71 CNV Gain 21882294
esv2752147 CNV Gain 17911159
nsv482912 CNV Loss 15286789
dgv2149e1 CNV Complex 17122850
esv2735282 CNV Deletion 23290073
nsv889340 CNV Gain 21882294
nsv831173 CNV Gain 17160897

Variation tolerance for OR2F1 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR2F1 Gene

Disorders for OR2F1 Gene

Relevant External Links for OR2F1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2F1

No disorders were found for OR2F1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2F1 Gene

Publications for OR2F1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3
  4. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3
  5. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for OR2F1 Gene

Sources for OR2F1 Gene

Content