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Aliases for OR2F1 Gene

Aliases for OR2F1 Gene

  • Olfactory Receptor, Family 2, Subfamily F, Member 1 (Gene/Pseudogene) 2 3
  • OLF3 3 4 6
  • Olfactory Receptor-Like Protein OLF3 3 4
  • Olfactory Receptor 2F3 3 4
  • Olfactory Receptor 2F4 3 4
  • Olfactory Receptor 2F5 3 4
  • OR2F3P 3 4
  • OR2F3 3 4
  • OR2F4 3 4
  • OR2F5 3 4
  • Olfactory Receptor, Family 2, Subfamily F, Member 1 2
  • Olfactory Receptor, Family 2, Subfamily F, Member 3 3
  • Olfactory Receptor, Family 2, Subfamily F, Member 4 3
  • Olfactory Receptor, Family 2, Subfamily F, Member 5 3
  • Olfactory Receptor OR7-7 3
  • Olfactory Receptor 2F1 3
  • OR14-60 3
  • OR7-139 3
  • OR7-140 3

External Ids for OR2F1 Gene

Previous Symbols for OR2F1 Gene

  • OR2F4
  • OR2F5
  • OR2F3
  • OR2F3P

Summaries for OR2F1 Gene

Entrez Gene Summary for OR2F1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2F1 Gene

OR2F1 (Olfactory Receptor, Family 2, Subfamily F, Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A42.

UniProtKB/Swiss-Prot for OR2F1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2F1 Gene

Genomics for OR2F1 Gene

Genomic Location for OR2F1 Gene

Start:
143,959,927 bp from pter
End:
143,961,015 bp from pter
Size:
1,089 bases
Orientation:
Plus strand

Genomic View for OR2F1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2F1 Gene

Regulatory Elements for OR2F1 Gene

Proteins for OR2F1 Gene

  • Protein details for OR2F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13607-OR2F1_HUMAN
    Recommended name:
    Olfactory receptor 2F1
    Protein Accession:
    Q13607
    Secondary Accessions:
    • A4D2G1
    • Q6IFP7
    • Q96R49
    • Q9UDX1

    Protein attributes for OR2F1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35350 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2F1 Gene

Proteomics data for OR2F1 Gene at MOPED

Post-translational modifications for OR2F1 Gene

Other Protein References for OR2F1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2F1 Gene

Domains for OR2F1 Gene

Gene Families for OR2F1 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2F1 Gene

UniProtKB/Swiss-Prot:

OR2F1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q13607
genes like me logo Genes that share domains with OR2F1: view

Function for OR2F1 Gene

Molecular function for OR2F1 Gene

GENATLAS Biochemistry: olfactory receptor,family 2,subfamily F,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2F1: view

Phenotypes for OR2F1 Gene

genes like me logo Genes that share phenotypes with OR2F1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2F1 Gene

Localization for OR2F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2F1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2F1 Gene COMPARTMENTS Subcellular localization image for OR2F1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2F1: view

Pathways for OR2F1 Gene

genes like me logo Genes that share pathways with OR2F1: view

Pathways by source for OR2F1 Gene

1 KEGG pathway for OR2F1 Gene

Interacting Proteins for OR2F1 Gene

Gene Ontology (GO) - Biological Process for OR2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 9500546
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2F1: view

Transcripts for OR2F1 Gene

mRNA/cDNA for OR2F1 Gene

(4) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2F1 Gene

No ASD Table

Relevant External Links for OR2F1 Gene

GeneLoc Exon Structure for
OR2F1
ECgene alternative splicing isoforms for
OR2F1

Expression for OR2F1 Gene

mRNA expression in normal human tissues for OR2F1 Gene

mRNA differential expression in normal tissues according to GTEx for OR2F1 Gene

This gene is overexpressed in Testis (19.7).

SOURCE GeneReport for Unigene cluster for OR2F1 Gene Hs.553595

genes like me logo Genes that share expressions with OR2F1: view

Orthologs for OR2F1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2F1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC472567 36
  • 99.26 (n)
  • 98.42 (a)
OR2F1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 86 (a)
ManyToMany
-- 37
  • 86 (a)
ManyToMany
-- 37
  • 87 (a)
ManyToMany
-- 37
  • 85 (a)
ManyToMany
LOC613799 36
  • 87.97 (n)
  • 87.03 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 87 (a)
ManyToMany
-- 37
  • 85 (a)
ManyToMany
cOR13M4 37
  • 86 (a)
ManyToMany
LOC100687207 36
  • 87.91 (n)
  • 87.07 (a)
mouse
(Mus musculus)
Mammalia Olfr38 37
  • 85 (a)
ManyToMany
Olfr452 37
  • 85 (a)
ManyToMany
Olfr453 36
  • 82.33 (n)
  • 86.75 (a)
Olfr453 16
Olfr453 37
  • 87 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 79 (a)
ManyToMany
-- 37
  • 77 (a)
ManyToMany
-- 37
  • 79 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr806 36
  • 82.86 (n)
  • 86.44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485994 36
  • 54.49 (n)
  • 46.18 (a)
Species with no ortholog for OR2F1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2F1 Gene

ENSEMBL:
Gene Tree for OR2F1 (if available)
TreeFam:
Gene Tree for OR2F1 (if available)

Paralogs for OR2F1 Gene

Selected SIMAP similar genes for OR2F1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR2F1 Gene

genes like me logo Genes that share paralogs with OR2F1: view

Variants for OR2F1 Gene

Sequence variations from dbSNP and Humsavar for OR2F1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2072164 - 143,960,334(+) ATGAC(C/T)GCTAT reference, missense
rs2072165 - 143,960,380(+) CATGC(A/G)TGGAG reference, missense
rs2072166 -- 143,960,708(+) CTCAC(A/G)GTGGT reference, synonymous-codon
rs2189875 -- 143,959,822(+) AGACT(C/G)TCATT upstream-variant-2KB
rs3216975 -- 143,959,063(+) CCGGT(-/G)GGCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2F1 Gene

Variant ID Type Subtype PubMed ID
dgv2147e1 CNV Complex 17122850
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
esv2422489 CNV Duplication 17116639
nsv8227 CNV Gain+Loss 18304495
nsv522225 CNV Gain 19592680
esv1682998 OTHER Inversion 17803354
dgv842n27 CNV Gain 19166990
nsv889336 CNV Gain 21882294
dgv7520n71 CNV Gain 21882294
esv2752147 CNV Gain 17911159
nsv482912 CNV Loss 15286789
dgv2149e1 CNV Complex 17122850
esv2735282 CNV Deletion 23290073
nsv889340 CNV Gain 21882294
nsv831173 CNV Gain 17160897

Relevant External Links for OR2F1 Gene

HapMap Linkage Disequilibrium report
OR2F1

Disorders for OR2F1 Gene

No disorders were found for OR2F1 Gene.

No data available for UniProtKB/Swiss-Prot for OR2F1 Gene

Publications for OR2F1 Gene

  1. The evolution of mammalian olfactory receptor genes. (PMID: 9017400) Issel-Tarver L. … Rine J. (Genetics 1997) 3 4
  2. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4

Products for OR2F1 Gene

Sources for OR2F1 Gene

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