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Aliases for OR2D3 Gene

Aliases for OR2D3 Gene

  • Olfactory Receptor, Family 2, Subfamily D, Member 3 2 3
  • Olfactory Receptor OR11-89 3 4
  • Olfactory Receptor 2D3 3
  • OR11-89 3

External Ids for OR2D3 Gene

Summaries for OR2D3 Gene

Entrez Gene Summary for OR2D3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2D3 Gene

OR2D3 (Olfactory Receptor, Family 2, Subfamily D, Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A42.

UniProtKB/Swiss-Prot for OR2D3 Gene

  • Odorant receptor.

Gene Wiki entry for OR2D3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2D3 Gene

Genomics for OR2D3 Gene

Genomic Location for OR2D3 Gene

Start:
6,920,974 bp from pter
End:
6,922,043 bp from pter
Size:
1,070 bases
Orientation:
Plus strand

Genomic View for OR2D3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2D3 Gene

Regulatory Elements for OR2D3 Gene

Proteins for OR2D3 Gene

  • Protein details for OR2D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGH3-OR2D3_HUMAN
    Recommended name:
    Olfactory receptor 2D3
    Protein Accession:
    Q8NGH3
    Secondary Accessions:
    • B2RP06
    • Q6IFG8
    • Q96R51

    Protein attributes for OR2D3 Gene

    Size:
    330 amino acids
    Molecular mass:
    37489 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06044.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2D3 Gene

Proteomics data for OR2D3 Gene at MOPED

Post-translational modifications for OR2D3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn21

Other Protein References for OR2D3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2D3 Gene

Domains for OR2D3 Gene

Gene Families for OR2D3 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2D3 Gene

UniProtKB/Swiss-Prot:

OR2D3_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGH3
genes like me logo Genes that share domains with OR2D3: view

Function for OR2D3 Gene

Molecular function for OR2D3 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2D3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2D3 Gene

Localization for OR2D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2D3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2D3 Gene COMPARTMENTS Subcellular localization image for OR2D3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2D3: view

Pathways for OR2D3 Gene

genes like me logo Genes that share pathways with OR2D3: view

Pathways by source for OR2D3 Gene

Interacting Proteins for OR2D3 Gene

Gene Ontology (GO) - Biological Process for OR2D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2D3: view

Transcripts for OR2D3 Gene

mRNA/cDNA for OR2D3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2D3 Gene

Olfactory receptor, family 2, subfamily D, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR2D3 Gene

No ASD Table

Relevant External Links for OR2D3 Gene

GeneLoc Exon Structure for
OR2D3
ECgene alternative splicing isoforms for
OR2D3

Expression for OR2D3 Gene

mRNA expression in normal human tissues for OR2D3 Gene

SOURCE GeneReport for Unigene cluster for OR2D3 Gene Hs.446766

genes like me logo Genes that share expressions with OR2D3: view

Orthologs for OR2D3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2D3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466421 36
  • 98.79 (n)
  • 98.18 (a)
OR2D3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR2D3 36
  • 86.73 (n)
  • 88.85 (a)
OR2D3 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR10F05 36
  • 87.69 (n)
  • 88.54 (a)
OR10F05 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr707 16
Olfr716 36
  • 80.36 (n)
  • 79.62 (a)
Olfr716 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 51 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
-- 37
  • 52 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr234 36
  • 81.95 (n)
  • 80.25 (a)
Species with no ortholog for OR2D3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2D3 Gene

ENSEMBL:
Gene Tree for OR2D3 (if available)
TreeFam:
Gene Tree for OR2D3 (if available)

Paralogs for OR2D3 Gene

Selected SIMAP similar genes for OR2D3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2D3: view

Variants for OR2D3 Gene

Sequence variations from dbSNP and Humsavar for OR2D3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1120882 -- 6,919,876(-) attgt(A/G)tatat upstream-variant-2KB
rs1120883 -- 6,919,668(-) gtccc(C/T)aaact upstream-variant-2KB
rs1120884 -- 6,919,518(-) taaca(A/G)accca upstream-variant-2KB
rs1120885 -- 6,919,440(-) atacc(C/T)actct upstream-variant-2KB
rs1388535 -- 6,922,023(-) ATGTT(A/G)CCATA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR2D3 Gene

Variant ID Type Subtype PubMed ID
nsv832061 CNV Loss 17160897
nsv896973 CNV Loss 21882294

Relevant External Links for OR2D3 Gene

HapMap Linkage Disequilibrium report
OR2D3

Disorders for OR2D3 Gene

No disorders were found for OR2D3 Gene.

No data available for UniProtKB/Swiss-Prot for OR2D3 Gene

Publications for OR2D3 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2D3 Gene

Sources for OR2D3 Gene

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