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Aliases for OR2D2 Gene

Aliases for OR2D2 Gene

  • Olfactory Receptor Family 2 Subfamily D Member 2 2 3 5
  • Olfactory Receptor OR11-88 3 4
  • Olfactory Receptor 11-610 3 4
  • Olfactory Receptor 2D1 3 4
  • OR11-610 3 4
  • OR2D1 3 4
  • HB2 3 4
  • Olfactory Receptor, Family 2, Subfamily D, Member 2 2
  • Olfactory Receptor, Family 2, Subfamily D, Member 1 3
  • Olfactory Receptor 2D2 3
  • Hg27 3

External Ids for OR2D2 Gene

Previous HGNC Symbols for OR2D2 Gene

  • OR2D1

Previous GeneCards Identifiers for OR2D2 Gene

  • GC11U990178
  • GC11M007374
  • GC11M006874
  • GC11M006877

Summaries for OR2D2 Gene

Entrez Gene Summary for OR2D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2D2 Gene

OR2D2 (Olfactory Receptor Family 2 Subfamily D Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2D3.

UniProtKB/Swiss-Prot for OR2D2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2D2 Gene

Additional gene information for OR2D2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2D2 Gene

Genomics for OR2D2 Gene

Regulatory Elements for OR2D2 Gene

Enhancers for OR2D2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H006654 1.2 FANTOM5 ENCODE 2.5 +236.8 236841 3 FOXA2 MLX RARA ZNF366 EGR2 HMG20B SP5 ZNF398 NR2F2 ZNF184 RRP8 FAM160A2 DCHS1 ENSG00000254641 LOC100506258 LOC644169 ILK APBB1 OR2D2 TRIM3
GH11H006742 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.5 +147.4 147367 6.5 HDAC1 PKNOX1 RB1 NFRKB SIN3A YBX1 BATF TCF12 ZNF766 GATA2 ILK OR2AG2 CAVIN3 RRP8 ENSG00000254641 TAF10 OR10A4 APBB1 SMPD1 OR2AG1
GH11H006863 0.3 FANTOM5 2.2 +29.2 29224 0 OR2AG1 OR10A4 OR2AG2 OR2D3 OR10A2 OR2D2 OR6A2 DCHS1
GH11H006501 0.3 FANTOM5 1.6 +390.5 390477 0.4 ARFIP2 TIMM10B APBB1 ILK RRP8 SMPD1 OR2D2 DNHD1 PIR42127
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2D2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR2D2 Gene

Genomic Locations for OR2D2 Gene
1,110 bases
Minus strand

Genomic View for OR2D2 Gene

Genes around OR2D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2D2 Gene

Proteins for OR2D2 Gene

  • Protein details for OR2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2D2
    Protein Accession:
    Secondary Accessions:
    • B9EIL5
    • O95224
    • Q6IF28
    • Q8NGH4
    • Q96R52

    Protein attributes for OR2D2 Gene

    308 amino acids
    Molecular mass:
    34172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2D2 Gene

Post-translational modifications for OR2D2 Gene

  • Glycosylation at posLast=55
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2D2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2D2 Gene

Domains & Families for OR2D2 Gene

Gene Families for OR2D2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2D2 Gene

Suggested Antigen Peptide Sequences for OR2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2D2: view

Function for OR2D2 Gene

Molecular function for OR2D2 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily D,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9787077
genes like me logo Genes that share ontologies with OR2D2: view
genes like me logo Genes that share phenotypes with OR2D2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2D2 Gene

Localization for OR2D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2D2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2D2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS,IBA 9787077
genes like me logo Genes that share ontologies with OR2D2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2D2 Gene

Pathways & Interactions for OR2D2 Gene

genes like me logo Genes that share pathways with OR2D2: view

Pathways by source for OR2D2 Gene

1 KEGG pathway for OR2D2 Gene

Interacting Proteins for OR2D2 Gene

Gene Ontology (GO) - Biological Process for OR2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS,IBA 9787077
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2D2: view

No data available for SIGNOR curated interactions for OR2D2 Gene

Drugs & Compounds for OR2D2 Gene

No Compound Related Data Available

Transcripts for OR2D2 Gene

mRNA/cDNA for OR2D2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2D2 Gene

No ASD Table

Relevant External Links for OR2D2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2D2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2D2 Gene

This gene is overexpressed in Testis (x7.2) and Brain - Putamen (basal ganglia) (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of OR2D2 Gene:


SOURCE GeneReport for Unigene cluster for OR2D2 Gene:

genes like me logo Genes that share expression patterns with OR2D2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2D2 Gene

Orthologs for OR2D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2D2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR2D2 33 34
  • 86.69 (n)
(Canis familiaris)
Mammalia -- 34
  • 85 (a)
LOC100682782 33
  • 84.92 (n)
-- 34
  • 84 (a)
(Mus musculus)
Mammalia Gm10081 34
  • 83 (a)
Or2d2 52 Olfr715 33 34
  • 82.95 (n)
Olfr715b 16
Or10ak7 52 Olfr1328
  • chr4:118,933,902-118,934,894
Or10ak8 52 Olfr1329
  • chr4:118,916,527-118,917,519
Or13p9-ps 52 Olfr1343-ps1
  • chr4:118,672,624-118,673,522
(Rattus norvegicus)
Mammalia Olr233 33
  • 81.98 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
-- 34
  • 70 (a)
-- 34
  • 70 (a)
-- 34
  • 70 (a)
-- 34
  • 68 (a)
-- 34
  • 68 (a)
-- 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493400 33
  • 53.91 (n)
Str.13262 33
Species where no ortholog for OR2D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2D2 Gene

Gene Tree for OR2D2 (if available)
Gene Tree for OR2D2 (if available)

Paralogs for OR2D2 Gene

Paralogs for OR2D2 Gene

(450) SIMAP similar genes for OR2D2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2D2: view

Variants for OR2D2 Gene

Sequence variations from dbSNP and Humsavar for OR2D2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000798176 -- 6,894,396(+) ACAAC(A/C/T)AATCT upstream-variant-2KB
rs1001595515 -- 6,893,847(+) TGGTG(C/T)GGGTT upstream-variant-2KB
rs1004203642 -- 6,892,631(+) CCCCC(A/T)TCATA upstream-variant-2KB
rs1004256617 -- 6,892,216(+) CAAAG(C/T)GTGAA reference, synonymous-codon
rs1005038888 -- 6,893,013(+) CAGGA(-/G)GCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2D2 Gene

Variant ID Type Subtype PubMed ID
nsv832061 CNV loss 17160897
nsv1046129 CNV loss 25217958
nsv1035138 CNV gain 25217958

Variation tolerance for OR2D2 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.50; 94.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2D2 Gene

Disorders for OR2D2 Gene

Relevant External Links for OR2D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR2D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2D2 Gene

Publications for OR2D2 Gene

  1. Organization and evolution of olfactory receptor genes on human chromosome 11. (PMID: 9787077) Buettner JA … Evans GA (Genomics 1998) 2 3 4 60
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR2D2 Gene

Sources for OR2D2 Gene

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