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Aliases for OR2D2 Gene

Aliases for OR2D2 Gene

  • Olfactory Receptor Family 2 Subfamily D Member 2 2 3 5
  • Olfactory Receptor, Family 2, Subfamily D, Member 2 2 3
  • Olfactory Receptor OR11-88 3 4
  • Olfactory Receptor 11-610 3 4
  • Olfactory Receptor 2D1 3 4
  • OR11-610 3 4
  • OR2D1 3 4
  • HB2 3 4
  • Olfactory Receptor, Family 2, Subfamily D, Member 1 3
  • Hg27 3

External Ids for OR2D2 Gene

Previous HGNC Symbols for OR2D2 Gene

  • OR2D1

Previous GeneCards Identifiers for OR2D2 Gene

  • GC11U990178
  • GC11M007374
  • GC11M006874
  • GC11M006877

Summaries for OR2D2 Gene

Entrez Gene Summary for OR2D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2D2 Gene

OR2D2 (Olfactory Receptor Family 2 Subfamily D Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2D3.

UniProtKB/Swiss-Prot for OR2D2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2D2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2D2 Gene

Genomics for OR2D2 Gene

Regulatory Elements for OR2D2 Gene

Genomic Location for OR2D2 Gene

Chromosome:
11
Start:
6,891,490 bp from pter
End:
6,892,599 bp from pter
Size:
1,110 bases
Orientation:
Minus strand

Genomic View for OR2D2 Gene

Genes around OR2D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2D2 Gene

Proteins for OR2D2 Gene

  • Protein details for OR2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H210-OR2D2_HUMAN
    Recommended name:
    Olfactory receptor 2D2
    Protein Accession:
    Q9H210
    Secondary Accessions:
    • B9EIL5
    • O95224
    • Q6IF28
    • Q8NGH4
    • Q96R52

    Protein attributes for OR2D2 Gene

    Size:
    308 amino acids
    Molecular mass:
    34172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2D2 Gene

Proteomics data for OR2D2 Gene at MOPED

Post-translational modifications for OR2D2 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2D2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2D2 Gene

Domains & Families for OR2D2 Gene

Gene Families for OR2D2 Gene

Protein Domains for OR2D2 Gene

Suggested Antigen Peptide Sequences for OR2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H210

UniProtKB/Swiss-Prot:

OR2D2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2D2: view

Function for OR2D2 Gene

Molecular function for OR2D2 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily D,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR2D2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2D2 Gene

Localization for OR2D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2D2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2D2 Gene COMPARTMENTS Subcellular localization image for OR2D2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,NAS 9787077
genes like me logo Genes that share ontologies with OR2D2: view

Pathways & Interactions for OR2D2 Gene

genes like me logo Genes that share pathways with OR2D2: view

Pathways by source for OR2D2 Gene

1 KEGG pathway for OR2D2 Gene

Interacting Proteins for OR2D2 Gene

Gene Ontology (GO) - Biological Process for OR2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 9787077
genes like me logo Genes that share ontologies with OR2D2: view

No data available for SIGNOR curated interactions for OR2D2 Gene

Drugs & Compounds for OR2D2 Gene

No Compound Related Data Available

Transcripts for OR2D2 Gene

mRNA/cDNA for OR2D2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2D2 Gene

No ASD Table

Relevant External Links for OR2D2 Gene

GeneLoc Exon Structure for
OR2D2
ECgene alternative splicing isoforms for
OR2D2

Expression for OR2D2 Gene

mRNA expression in normal human tissues for OR2D2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2D2 Gene

This gene is overexpressed in Testis (x7.2) and Brain - Putamen (basal ganglia) (x5.0).

SOURCE GeneReport for Unigene cluster for OR2D2 Gene Hs.690210

genes like me logo Genes that share expression patterns with OR2D2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR2D2 Gene

Orthologs for OR2D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2D2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR2D2 35
  • 86.69 (n)
  • 84.42 (a)
OR2D2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100682782 35
  • 84.92 (n)
  • 86.23 (a)
-- 36
  • 84 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr715 35
  • 82.95 (n)
  • 85.34 (a)
Olfr715 16
Gm10081 36
  • 83 (a)
OneToMany
Olfr715 36
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr233 35
  • 81.98 (n)
  • 84.69 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493400 35
  • 53.91 (n)
  • 47.99 (a)
Str.13262 35
Species with no ortholog for OR2D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2D2 Gene

ENSEMBL:
Gene Tree for OR2D2 (if available)
TreeFam:
Gene Tree for OR2D2 (if available)

Paralogs for OR2D2 Gene

Paralogs for OR2D2 Gene

(450) SIMAP similar genes for OR2D2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2D2: view

Variants for OR2D2 Gene

Sequence variations from dbSNP and Humsavar for OR2D2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_046723 -
VAR_046724 -
VAR_046725 -
VAR_046726 -
VAR_062017 -

Structural Variations from Database of Genomic Variants (DGV) for OR2D2 Gene

Variant ID Type Subtype PubMed ID
nsv832061 CNV Loss 17160897

Variation tolerance for OR2D2 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.50; 94.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2D2 Gene

HapMap Linkage Disequilibrium report
OR2D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2D2 Gene

Disorders for OR2D2 Gene

Relevant External Links for OR2D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2D2

No disorders were found for OR2D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2D2 Gene

Publications for OR2D2 Gene

  1. Organization and evolution of olfactory receptor genes on human chromosome 11. (PMID: 9787077) Buettner J.A. … Evans G.A. (Genomics 1998) 2 3 4 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2D2 Gene

Sources for OR2D2 Gene

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