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Aliases for OR2D2 Gene

Aliases for OR2D2 Gene

  • Olfactory Receptor, Family 2, Subfamily D, Member 2 2 3
  • Olfactory Receptor OR11-88 3 4
  • Olfactory Receptor 11-610 3 4
  • Olfactory Receptor 2D1 3 4
  • OR11-610 3 4
  • OR2D1 3 4
  • HB2 3 4
  • Olfactory Receptor, Family 2, Subfamily D, Member 1 3
  • Olfactory Receptor 2D2 3
  • Hg27 3

External Ids for OR2D2 Gene

Previous Symbols for OR2D2 Gene

  • OR2D1

Summaries for OR2D2 Gene

Entrez Gene Summary for OR2D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2D2 Gene

OR2D2 (Olfactory Receptor, Family 2, Subfamily D, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A42.

UniProtKB/Swiss-Prot for OR2D2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2D2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2D2 Gene

Genomics for OR2D2 Gene

Genomic Location for OR2D2 Gene

Start:
6,891,490 bp from pter
End:
6,892,599 bp from pter
Size:
1,110 bases
Orientation:
Minus strand

Genomic View for OR2D2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2D2 Gene

Regulatory Elements for OR2D2 Gene

Proteins for OR2D2 Gene

  • Protein details for OR2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H210-OR2D2_HUMAN
    Recommended name:
    Olfactory receptor 2D2
    Protein Accession:
    Q9H210
    Secondary Accessions:
    • B9EIL5
    • O95224
    • Q6IF28
    • Q8NGH4
    • Q96R52

    Protein attributes for OR2D2 Gene

    Size:
    308 amino acids
    Molecular mass:
    34172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2D2 Gene

Proteomics data for OR2D2 Gene at MOPED

Post-translational modifications for OR2D2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn5

Other Protein References for OR2D2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2D2 Gene

Domains for OR2D2 Gene

Gene Families for OR2D2 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2D2 Gene

Suggested Antigen Peptide Sequences for OR2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H210

UniProtKB/Swiss-Prot:

OR2D2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9H210
genes like me logo Genes that share domains with OR2D2: view

Function for OR2D2 Gene

Molecular function for OR2D2 Gene

GENATLAS Biochemistry: olfactory receptor,family 2,subfamily D,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9787077
genes like me logo Genes that share ontologies with OR2D2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2D2 Gene

Localization for OR2D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2D2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2D2 Gene COMPARTMENTS Subcellular localization image for OR2D2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 9787077
genes like me logo Genes that share ontologies with OR2D2: view

Pathways for OR2D2 Gene

genes like me logo Genes that share pathways with OR2D2: view

Pathways by source for OR2D2 Gene

1 KEGG pathway for OR2D2 Gene

Interacting Proteins for OR2D2 Gene

Gene Ontology (GO) - Biological Process for OR2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 9787077
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 9787077
genes like me logo Genes that share ontologies with OR2D2: view

Transcripts for OR2D2 Gene

mRNA/cDNA for OR2D2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2D2 Gene

No ASD Table

Relevant External Links for OR2D2 Gene

GeneLoc Exon Structure for
OR2D2
ECgene alternative splicing isoforms for
OR2D2

Expression for OR2D2 Gene

mRNA expression in normal human tissues for OR2D2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2D2 Gene

This gene is overexpressed in Testis (7.2) and Brain - Putamen (basal ganglia) (5.0).

SOURCE GeneReport for Unigene cluster for OR2D2 Gene Hs.690210

genes like me logo Genes that share expressions with OR2D2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for OR2D2 Gene

Orthologs for OR2D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2D2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR2D2 35
  • 86.69 (n)
  • 84.42 (a)
OR2D2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
LOC100682782 35
  • 84.92 (n)
  • 86.23 (a)
mouse
(Mus musculus)
Mammalia Gm10081 16
Gm10081 36
  • 83 (a)
OneToMany
Olfr715 35
  • 82.95 (n)
  • 85.34 (a)
Olfr715 36
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr233 35
  • 81.98 (n)
  • 84.69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493400 35
  • 53.91 (n)
  • 47.99 (a)
Str.13262 35
Species with no ortholog for OR2D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2D2 Gene

ENSEMBL:
Gene Tree for OR2D2 (if available)
TreeFam:
Gene Tree for OR2D2 (if available)

Paralogs for OR2D2 Gene

Selected SIMAP similar genes for OR2D2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2D2: view

Variants for OR2D2 Gene

Sequence variations from dbSNP and Humsavar for OR2D2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1449123 -- 6,893,878(+) gaagg(A/C)aacat upstream-variant-2KB
rs1463177 -- 6,892,926(+) TTTCC(A/C/G)TGAAA upstream-variant-2KB
rs1463178 -- 6,892,941(+) AGACA(C/T)GAAGG upstream-variant-2KB
rs1551015 -- 6,893,306(+) TTTAC(A/G)AGTCA upstream-variant-2KB
rs1965207 - 6,892,012(+) CTCAG(C/T)ATGAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR2D2 Gene

Variant ID Type Subtype PubMed ID
nsv832061 CNV Loss 17160897

Relevant External Links for OR2D2 Gene

HapMap Linkage Disequilibrium report
OR2D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2D2 Gene

Disorders for OR2D2 Gene

No disorders were found for OR2D2 Gene.

No data available for UniProtKB/Swiss-Prot for OR2D2 Gene

Publications for OR2D2 Gene

  1. Organization and evolution of olfactory receptor genes on human chromosome 11. (PMID: 9787077) Buettner J.A. … Evans G.A. (Genomics 1998) 2 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. Genomic analysis of orthologous mouse and human olfactory receptor loci. (PMID: 11416212) Lane R.P. … Trask B.J. (Proc. Natl. Acad. Sci. U.S.A. 2001) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for OR2D2 Gene

Sources for OR2D2 Gene

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