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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR2C3 Gene

protein-coding   GIFtS: 51
GCID: GC01M247693

Olfactory Receptor, Family 2, Subfamily C, Member 3

(Previous names: olfactory receptor, family 2, subfamily C, member 4)
(Previous symbols: OR2C4, OR2C5P)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 2, Subfamily C, Member 31 2     Olfactory Receptor 2C52 3
OR2C41 2 3     Olfactory Receptor OR1-302 3
OR2C5P1 2 3     OST7422
Olfactory Receptor, Family 2, Subfamily C, Member 41 2     Olfactory Receptor 2C32
Olfactory Receptor 2C42 3     Olfactory Receptor, Family 2, Subfamily C, Member 5 Pseudogene2

External Ids:    HGNC: 150051   Entrez Gene: 814722   Ensembl: ENSG000001962427   UniProtKB: Q8N6283   

Export aliases for OR2C3 gene to outside databases

Previous GC identifers: GC01M245551 GC01M242929 GC01M243790 GC01M244640 GC01M244564 GC01M244019 GC01M245760


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR2C3 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2C3 Gene: 
OR2C3 (olfactory receptor, family 2, subfamily C, member 3) is a protein-coding gene. Diseases associated with OR2C3 include lymphoblastic leukemia, and neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2W1.

UniProtKB/Swiss-Prot: OR2C3_HUMAN, Q8N628
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2C3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR2C3 gene promoter:
         Tal-1   Brachyury   MyoD   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2C3 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR2C3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2C3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

OR2C3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2C3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M247693:  view genomic region     (about GC identifiers)

Start:
247,694,854 bp from pter      End:
247,695,813 bp from pter
Size:
960 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OR2C3_HUMAN, Q8N628 (See protein sequence)
Recommended Name: Olfactory receptor 2C3  
Size: 320 amino acids; 35376 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Sequence caution: Sequence=AAH30717.1; Type=Erroneous initiation; Sequence=DAA04869.1; Type=Erroneous initiation;
Secondary accessions: Q5JQS4 Q6IEZ1 Q8NGW7

Explore the universe of human proteins at neXtProt for OR2C3: NX_Q8N628

Explore proteomics data for OR2C3 at MOPED 

HORDE protein sequence for OR2C3
OR2C3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

OR2C3 Protein Expression

REFSEQ proteins: NP_932340.3  
ENSEMBL proteins: 
 ENSP00000355443  
Reactome Protein details: Q8N628
Human Recombinant Protein Products for OR2C3: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

OR2C3 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
OR2: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8N628

ProtoNet protein and cluster: Q8N628

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR2C3_HUMAN, Q8N628
Similarity: Belongs to the G-protein coupled receptor 1 family


OR2C3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: OR2C3_HUMAN, Q8N628
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR2C3 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR2C3 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory transduction
Olfactory Signaling Pathway0.81
Olfactory transduction0.81
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



4        Reactome Pathways for OR2C3
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR2C3):
    Olfactory transduction


OR2C3 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2C3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/273 Interacting proteins for OR2C3 (ENSP000003554434) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR10A3ENSP000003539884STRING: ENSP00000353988
OR1J4ENSP000003435214STRING: ENSP00000343521
OR5B2ENSP000003030764STRING: ENSP00000303076
OR5H2ENSP000003474184STRING: ENSP00000347418
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR2C3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR2C3

Search CenterWatch for drugs/clinical trials and news about OR2C3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR2C3 gene: 
NM_198074.4  

Unigene Cluster for OR2C3:

Olfactory receptor, family 2, subfamily C, member 3
Hs.730218
Unigene Representative Sequence: BC030717
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000366487(uc009xgy.3)
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Additional mRNA sequence: BC030717.1 

1 DOTS entry:

DT.95232699 

13 AceView cDNA sequences:

AA807063 BC034303 AI554035 AI808878 BC030717 BF111921 NM_198074 BX091277 
AA634561 BG773223 AI808477 AA642454 BG763148 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR2C3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGCAGTTCC
OR2C3 Expression
About this image


See OR2C3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR2C3

SOURCE GeneReport for Unigene cluster: Hs.730218
    SABiosciences Custom PCR Arrays for OR2C3
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for OR2C3 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr2255 olfactory receptor 225   --   11 (37.75 cM) 59612966 


ENSEMBL Gene Tree for OR2C3 (if available)
TreeFam Gene Tree for OR2C3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR2C3 gene
OR2W12  OR2J22  OR2J12  OR2B112  OR2H22  OR2B22  OR2B32  OR2H12  
OR2C12  OR2Y12  OR2G22  OR2B62  OR2W32  OR2J32  OR2G32  OR2G62  
18/450 SIMAP similar genes for OR2C3 using alignment to 1 protein entry:     OR2C3_HUMAN(see all similar genes):
OR2J3    OR2G2    OR2B8P    OR2G3    OR2J1    OR2C1
OR2G6    OR2J4P    OR2W1    OR2W6P    6M1-16    OLFR 42A
OR2B2    OR2H1    OR2J2    OR2B11    OR2H2    OR2Y1

OR2C3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/80 SNPs in OR2C3 are shown (see all 80)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0255414
----see VAR_0255412 P S mis40--------
VAR_0463784
----see VAR_0463782 R S mis40--------
VAR_0620164
----see VAR_0620162 L V mis40--------
VAR_0255404
----see VAR_0255402 T A mis40--------
rs115826031,2
C,F,H--247696122(+) TGGATG/AGCATT 1 -- int113Minor allele frequency- A:0.05NS EA NA CSA WA 938
rs558524761,2
C--247696173(+) AGACTA/GGGTGG 1 -- int10--------
rs1459371711,2
C--247696175(+) ACTGG-/GTGGGGG 1 -- int10--------
rs127308981,2
C--247696176(+) CTGGGG/TGGGGG 1 -- int12Minor allele frequency- T:0.00NA 4
rs576525521,2
C--247696176(+) CTGGG-/G/G   
  G
/T/TG
GGGGG
1 -- int10--------
rs354670241,2
C--247696177(+) TGGGT-/G/GG  
        
GGGGT
1 -- int10--------

HapMap Linkage Disequilibrium report for OR2C3 ( 247694854 - 247695813 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for OR2C3:    About this table     
Variant IDTypeSubtypePubMed ID
nsv873440CNV Gain21882294
esv33129CNV Gain+Loss17666407

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
3 diseases for OR2C3:    About MalaCards
lymphoblastic leukemia    neuronitis    leukemia


OR2C3 for disorders           About GeneDecksing

Genetic Association Database (GAD): OR2C3

Export disorders for OR2C3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR2C3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR2C3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Germline genomic variants associated with childhood a cute lymphoblastic leukemia. (PubMed id 19684603)1, 4 TreviA+o L.R....Relling M.V. (2009)
  2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  3. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1 Fuchs T.... Shamir R. (2002)
  7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 81472 HGNC: 15005 AceView: OR2C3 Ensembl:ENSG00000196242 euGenes: HUgn81472
ECgene: OR2C3 Kegg: 81472 H-InvDB: OR2C3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR2C3 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR2C3 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR2C3 gene:
Search GeneIP for patents involving OR2C3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Proteins for OR2C3
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for OR2C3
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Customized:
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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