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OR2C3 Gene

protein-coding   GIFtS: 50
GCID: GC01M247693

Olfactory Receptor, Family 2, Subfamily C, Member 3

(Previous names: olfactory receptor, family 2, subfamily C, member 4)
(Previous symbols: OR2C4, OR2C5P)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily C, Member 31 2     Olfactory Receptor 2C52 3
OR2C41 2 3     Olfactory Receptor OR1-302 3
OR2C5P1 2 3     OST7422
Olfactory Receptor, Family 2, Subfamily C, Member 41 2     Olfactory Receptor 2C32
Olfactory Receptor 2C42 3     Olfactory Receptor, Family 2, Subfamily C, Member 5 Pseudogene2

External Ids:    HGNC: 150051   Entrez Gene: 814722   Ensembl: ENSG000001962427   UniProtKB: Q8N6283   

Export aliases for OR2C3 gene to outside databases

Previous GC identifers: GC01M245551 GC01M242929 GC01M243790 GC01M244640 GC01M244564 GC01M244019 GC01M245760


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2C3 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2C3 Gene:
OR2C3 (olfactory receptor, family 2, subfamily C, member 3) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2W1.

UniProtKB/Swiss-Prot: OR2C3_HUMAN, Q8N628
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2C3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the OR2C3 gene promoter:
         Tal-1   Brachyury   MyoD   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2C3 promoter sequence
   Search Chromatin IP Primers for OR2C3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2C3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

OR2C3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2C3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M247693:  view genomic region     (about GC identifiers)

Start:
247,694,854 bp from pter      End:
247,695,813 bp from pter
Size:
960 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR2C3_HUMAN, Q8N628 (See protein sequence)
Recommended Name: Olfactory receptor 2C3  
Size: 320 amino acids; 35376 Da
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Sequence caution: Sequence=AAH30717.1; Type=Erroneous initiation; Sequence=DAA04869.1; Type=Erroneous initiation;
Secondary accessions: Q5JQS4 Q6IEZ1 Q8NGW7

Explore the universe of human proteins at neXtProt for OR2C3: NX_Q8N628

Explore proteomics data for OR2C3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn6
  • HORDE protein sequence for OR2C3

    See OR2C3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_932340.3  
    ENSEMBL proteins: 
     ENSP00000355443  
    Reactome Protein details: Q8N628

    OR2C3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for OR2C3

     
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    Search eBioscience for ELISAs for OR2C3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8N628

    ProtoNet protein and cluster: Q8N628

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2C3_HUMAN, Q8N628
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR2C3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2C3_HUMAN, Q8N628
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR2C3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR2C3
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    miRNA
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    miRTarBase miRNAs that target OR2C3:
    hsa-mir-148a-3p (MIRT048031)

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    Search for qRT-PCR Assays for microRNAs that regulate OR2C3
    SwitchGear 3'UTR luciferase reporter plasmidOR2C3 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: OR2C3 (NM_198074)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2C3_HUMAN, Q8N628: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR2C3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2C3 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR2C3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for OR2C3
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2C3):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2C3
    Interactions:

        Search GeneGlobe Interaction Network for OR2C3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR2C3 (ENSP000003554434) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10A3ENSP000003539884STRING: ENSP00000353988
    OR1J4ENSP000003435214STRING: ENSP00000343521
    OR2Y1ENSP000003124034STRING: ENSP00000312403
    OR51E2ENSP000003801534STRING: ENSP00000380153
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR2C3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2C3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR2C3 gene: 
    NM_198074.4  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000366487(uc009xgy.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OR2C3 using miScript Target Protectors
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OR2C3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2C3
    Primer
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    OriGene qPCR primer pairs and template standards for OR2C3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat OR2C3
      QuantiTect SYBR Green Assays in human, mouse, rat OR2C3
      QuantiFast Probe-based Assays in human, mouse, rat OR2C3

    13 AceView cDNA sequences:

    AA807063 NM_198074 BF111921 BC030717 AI808878 BC034303 BX091277 AI554035 
    AI808477 AA634561 BG773223 AA642454 BG763148 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2C3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCAGTTCC
    OR2C3 Expression
    About this image

    OR2C3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2C3 Protein Expression
        Custom PCR Arrays for OR2C3
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2C3 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr2255 olfactory receptor 225   --   11 (37.75 cM) 59612966 


    ENSEMBL Gene Tree for OR2C3 (if available)
    TreeFam Gene Tree for OR2C3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2C3 gene
    OR2W12  OR2J22  OR2G22  OR2J12  OR2H22  OR2C12  OR2H12  OR2Y12  
    OR2W32  OR2J32  OR2G32  OR2G62  
    Selected SIMAP similar genes for OR2C3 using alignment to 1 protein entry:     OR2C3_HUMAN(see all similar genes):
    OR2G2    OR2J3    OR2B8P    OR2G3    OR2J1    OR2C1
    OR2G6    OR2J4P    OR2W1    OR2W6P    6M1-16    OLFR 42A
    OR2B2    OR2H1    OR2J2    OR2B11    OR2H2    OR2Y1

    Find genes that share paralogs with OR2C3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2C3 (see all 80)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115826031,2
    C,F,H--247696122(+) TGGATG/AGCATT 1 -- int113Minor allele frequency- A:0.05NS EA NA CSA WA 938
    rs558524761,2
    C--247696173(+) AGACTA/GGGTGG 1 -- int10--------
    rs1459371711,2
    C--247696175(+) ACTGG-/GTGGGGG 1 -- int10--------
    rs127308981,2
    C--247696176(+) CTGGGG/TGGGGG 1 -- int12Minor allele frequency- T:0.00NA 4
    rs576525521,2
    C--247696176(+) CTGGG-/G/G   
      G
    /T/TG
    GGGGG
    1 -- int10--------
    rs354670241,2
    C--247696177(+) TGGGT-/G/GG  
            
    GGGGT
    1 -- int10--------
    rs611810551,2
    C--247696177(+) TGGGT-/GGGGGGT 1 -- int10--------
    rs127493351,2
    C--247696178(+) GGGTGC/G/TGGGGT 1 -- int12NA 4
    rs1906788711,2
    --247696218(+) TGCAAA/GATCCT 1 -- int10--------
    rs1154332421,2
    C,F--247696317(+) GGGTGG/ATCATT 1 -- int11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for OR2C3 ( 247694854 - 247695813 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR2C3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873440CNV Gain21882294
    esv33129CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing OR2C3
    DNA2.0 Custom Variant and Variant Library Synthesis for OR2C3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR2C3           About GenesLikeMe

    Genetic Association Database (GAD): OR2C3

    Export disorders for OR2C3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2C3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2C3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PubMed id 19684603)1, 4 Trevino L.R.... Relling M.V. (Nat. Genet. 2009)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1 Fuchs T.... Shamir R. (Genomics 2002)
    7. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81472 HGNC: 15005 AceView: OR2C3 Ensembl:ENSG00000196242 euGenes: HUgn81472
    ECgene: OR2C3 Kegg: 81472 H-InvDB: OR2C3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2C3 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2C3 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2C3 gene:
    Search GeneIP for patents involving OR2C3

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     OriGene Antibodies for OR2C3   OriGene RNAi products in human, mouse, rat for OR2C3  
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     Novus Tissue Slides
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     Search Addgene for plasmids for OR2C3
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      eBioscience FlowRNA Probe Sets
           
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