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Aliases for OR2C1 Gene

Aliases for OR2C1 Gene

  • Olfactory Receptor, Family 2, Subfamily C, Member 1 2 3
  • Olfactory Receptor OR16-1 3 4
  • Olfactory Receptor OR16-2 3 4
  • Olfactory Receptor 2C2 3 4
  • OR2C2P 3 4
  • OLFmf3 3 4
  • Olfactory Receptor, Family 2, Subfamily C, Member 2 Pseudogene 3
  • Olfactory Receptor 2C1 3

External Ids for OR2C1 Gene

Previous HGNC Symbols for OR2C1 Gene

  • OR2C2P

Previous GeneCards Identifiers for OR2C1 Gene

  • GC16P003435
  • GC16P003406
  • GC16P003345
  • GC16P003405

Summaries for OR2C1 Gene

Entrez Gene Summary for OR2C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2C1 Gene

OR2C1 (Olfactory Receptor, Family 2, Subfamily C, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2G2.

UniProtKB/Swiss-Prot for OR2C1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2C1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2C1 Gene

Genomics for OR2C1 Gene

Regulatory Elements for OR2C1 Gene

Genomic Location for OR2C1 Gene

3,322,968 bp from pter
3,357,352 bp from pter
34,385 bases
Plus strand

Genomic View for OR2C1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2C1 Gene

Proteins for OR2C1 Gene

  • Protein details for OR2C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2C1
    Protein Accession:
    Secondary Accessions:
    • A0AVA4
    • Q6IF34
    • Q6IF55

    Protein attributes for OR2C1 Gene

    312 amino acids
    Molecular mass:
    34412 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2C1 Gene

Proteomics data for OR2C1 Gene at MOPED

Post-translational modifications for OR2C1 Gene

Other Protein References for OR2C1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2C1 Gene

Domains for OR2C1 Gene

Gene Families for OR2C1 Gene

  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2C1 Gene

Suggested Antigen Peptide Sequences for OR2C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O95371
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2C1: view

Function for OR2C1 Gene

Molecular function for OR2C1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily F,member 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2C1: view

Phenotypes for OR2C1 Gene

genes like me logo Genes that share phenotypes with OR2C1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2C1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2C1 Gene

Localization for OR2C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2C1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR2C1 Gene COMPARTMENTS Subcellular localization image for OR2C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005938 cell cortex IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2C1: view

Pathways for OR2C1 Gene

genes like me logo Genes that share pathways with OR2C1: view

Pathways by source for OR2C1 Gene

1 KEGG pathway for OR2C1 Gene

Interacting Proteins for OR2C1 Gene

Gene Ontology (GO) - Biological Process for OR2C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell TAS 9847080
genes like me logo Genes that share ontologies with OR2C1: view

Transcripts for OR2C1 Gene

mRNA/cDNA for OR2C1 Gene

(91) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2C1 Gene

Olfactory receptor, family 2, subfamily C, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2C1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2C1 Gene

No ASD Table

Relevant External Links for OR2C1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2C1 Gene

mRNA expression in normal human tissues for OR2C1 Gene

Protein differential expression in normal tissues for OR2C1 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR2C1 Gene

SOURCE GeneReport for Unigene cluster for OR2C1 Gene Hs.258574

genes like me logo Genes that share expressions with OR2C1: view

Expression partners for OR2C1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR2C1 Gene

Orthologs for OR2C1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2C1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Olfr15 35
  • 81.77 (n)
  • 82.85 (a)
Olfr15 16
Olfr15 36
  • 82 (a)
(Rattus norvegicus)
Mammalia Olr1356 35
  • 81.92 (n)
  • 85.62 (a)
(Bos Taurus)
Mammalia OR2C1 36
  • 87 (a)
(Canis familiaris)
Mammalia OR2C1 36
  • 87 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
-- 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
(Pan troglodytes)
Mammalia OR2C1 36
  • 54 (a)
Species with no ortholog for OR2C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2C1 Gene

Gene Tree for OR2C1 (if available)
Gene Tree for OR2C1 (if available)

Paralogs for OR2C1 Gene

Paralogs for OR2C1 Gene

Selected SIMAP similar genes for OR2C1 Gene using alignment to 1 proteins: Pseudogenes for OR2C1 Gene

genes like me logo Genes that share paralogs with OR2C1: view

Variants for OR2C1 Gene

Sequence variations from dbSNP and Humsavar for OR2C1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs37843 -- 3,326,006(+) GCTCA(A/C)TGCAA intron-variant
rs37844 -- 3,326,189(+) CTCCC(A/G)AAGTG intron-variant
rs37845 -- 3,328,342(+) TCTCA(A/G)ATCAA intron-variant
rs37846 -- 3,328,450(+) TGTAC(G/T)CTGTG intron-variant
rs166097 -- 3,330,008(+) tcggc(C/T)tccca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR2C1 Gene

Variant ID Type Subtype PubMed ID
nsv905212 CNV Gain 21882294
nsv1714 CNV Insertion 18451855

Relevant External Links for OR2C1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2C1 Gene

Disorders for OR2C1 Gene

Relevant External Links for OR2C1

Genetic Association Database (GAD)

No disorders were found for OR2C1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OR2C1 Gene

Publications for OR2C1 Gene

  1. Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3. (PMID: 9847080) Centola M. … Kastner D.L. (Genome Res. 1998) 2 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2C1 Gene

Sources for OR2C1 Gene

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