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Aliases for OR2C1 Gene

Aliases for OR2C1 Gene

  • Olfactory Receptor Family 2 Subfamily C Member 1 2 3 5
  • Olfactory Receptor OR16-1 3 4
  • Olfactory Receptor OR16-2 3 4
  • Olfactory Receptor 2C2 3 4
  • OR2C2P 3 4
  • OLFmf3 3 4
  • Olfactory Receptor, Family 2, Subfamily C, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily C, Member 1 2
  • Olfactory Receptor 2C1 3

External Ids for OR2C1 Gene

Previous HGNC Symbols for OR2C1 Gene

  • OR2C2P

Previous GeneCards Identifiers for OR2C1 Gene

  • GC16P003435
  • GC16P003406
  • GC16P003345
  • GC16P003405
  • GC16P003322
  • GC16P003356

Summaries for OR2C1 Gene

Entrez Gene Summary for OR2C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2C1 Gene

OR2C1 (Olfactory Receptor Family 2 Subfamily C Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2H1.

UniProtKB/Swiss-Prot for OR2C1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2C1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2C1 Gene

Genomics for OR2C1 Gene

Regulatory Elements for OR2C1 Gene

Enhancers for OR2C1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F003296 0.3 FANTOM5 15.6 -60.4 -60352 0.2 POLR2A OR2C1 ZNF263 ZNF200 MEFV ZNF174 ZSCAN32 C16orf90 OR1F1 SLX4 CLUAP1
GH16F003295 0.3 FANTOM5 11 -60.7 -60692 0.1 POLR2A C16orf90 ZNF263 ZNF200 MEFV OR2C1 ZNF174 ZSCAN32 SLX4 ENSG00000279031 GC16P003377
GH16F003431 1.2 Ensembl ENCODE 11 +76.0 76024 1.0 PKNOX1 KLF17 RAD21 ZBTB40 RARA GLIS2 ELK1 EGR1 CBX5 ETV6 CREBBP THOC6 ZNF174 ZSCAN32 ZNF263 TIGD7 ZNF75A OR2C1 ZNF200 LOC105371055
GH16F003266 0.4 Ensembl 10.5 -88.9 -88889 0.4 GATAD2A CTCF CBX3 PKNOX1 MAX ZNF644 ZNF2 RAD21 TEAD3 ADNP ZNF75A ZNF200 TIGD7 NAA60 ZNF597 ZNF174 ZSCAN32 OR2C1 ZNF263 ENSG00000279330
GH16F003214 1.1 Ensembl ENCODE 10.5 -140.2 -140164 2.7 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF597 CLUAP1 TIGD7 MEFV CREBBP THOC6 ZNF200 ZNF75A ZNF263 NAA60
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR2C1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2C1 Gene

Chromosome:
16
Start:
3,355,889 bp from pter
End:
3,357,294 bp from pter
Size:
1,406 bases
Orientation:
Plus strand

Genomic View for OR2C1 Gene

Genes around OR2C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2C1 Gene

Proteins for OR2C1 Gene

  • Protein details for OR2C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95371-OR2C1_HUMAN
    Recommended name:
    Olfactory receptor 2C1
    Protein Accession:
    O95371
    Secondary Accessions:
    • A0AVA4
    • Q6IF34
    • Q6IF55

    Protein attributes for OR2C1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34412 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2C1 Gene

Post-translational modifications for OR2C1 Gene

Other Protein References for OR2C1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2C1 Gene

Domains & Families for OR2C1 Gene

Gene Families for OR2C1 Gene

Protein Domains for OR2C1 Gene

Suggested Antigen Peptide Sequences for OR2C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95371

UniProtKB/Swiss-Prot:

OR2C1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2C1: view

Function for OR2C1 Gene

Molecular function for OR2C1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily F,member 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2C1: view
genes like me logo Genes that share phenotypes with OR2C1: view

Animal Models for OR2C1 Gene

MGI Knock Outs for OR2C1:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OR2C1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OR2C1 Gene

Localization for OR2C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2C1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2C1 Gene COMPARTMENTS Subcellular localization image for OR2C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005938 cell cortex IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2C1: view

Pathways & Interactions for OR2C1 Gene

genes like me logo Genes that share pathways with OR2C1: view

Pathways by source for OR2C1 Gene

1 KEGG pathway for OR2C1 Gene

Interacting Proteins for OR2C1 Gene

Gene Ontology (GO) - Biological Process for OR2C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2C1: view

No data available for SIGNOR curated interactions for OR2C1 Gene

Transcripts for OR2C1 Gene

mRNA/cDNA for OR2C1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(91) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2C1 Gene

Olfactory receptor, family 2, subfamily C, member 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OR2C1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2C1 Gene

No ASD Table

Relevant External Links for OR2C1 Gene

GeneLoc Exon Structure for
OR2C1
ECgene alternative splicing isoforms for
OR2C1

Expression for OR2C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2C1 Gene

Protein differential expression in normal tissues from HIPED for OR2C1 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2C1 Gene



Protein tissue co-expression partners for OR2C1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OR2C1 Gene:

OR2C1

SOURCE GeneReport for Unigene cluster for OR2C1 Gene:

Hs.258574
genes like me logo Genes that share expression patterns with OR2C1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR2C1 Gene

Orthologs for OR2C1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2C1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR2C1 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR2C1 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 84 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1356 34
  • 81.92 (n)
mouse
(Mus musculus)
Mammalia Or2c1 55 Olfr15 34 16 35
  • 81.77 (n)
Or2aa1 55 Olfr223
  • chr11:59,589,131-59,590,087
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia OR2C1 35
  • 54 (a)
OneToOne
Species where no ortholog for OR2C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2C1 Gene

ENSEMBL:
Gene Tree for OR2C1 (if available)
TreeFam:
Gene Tree for OR2C1 (if available)

Paralogs for OR2C1 Gene

Paralogs for OR2C1 Gene

(457) SIMAP similar genes for OR2C1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR2C1 Gene

genes like me logo Genes that share paralogs with OR2C1: view

Variants for OR2C1 Gene

Sequence variations from dbSNP and Humsavar for OR2C1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1009429 -- 3,355,875(+) AGCTT(C/T)TTCTT upstream-variant-2KB
rs111785276 -- 3,353,973(+) TTTTT(-/C)TTTTC upstream-variant-2KB
rs112281420 -- 3,354,370(+) AATCT(C/T)CTAAT upstream-variant-2KB
rs112462454 -- 3,355,799(+) AAAAA(G/T)AGGTT upstream-variant-2KB
rs112698908 -- 3,357,018(+) AGCCC(G/T)AAGCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR2C1 Gene

Variant ID Type Subtype PubMed ID
dgv2694n100 CNV gain 25217958
dgv2695n100 CNV gain 25217958
nsv1044147 CNV loss 25217958
nsv1714 CNV insertion 18451855

Variation tolerance for OR2C1 Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.75; 91.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2C1 Gene

Human Gene Mutation Database (HGMD)
OR2C1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2C1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2C1 Gene

Disorders for OR2C1 Gene

Relevant External Links for OR2C1

Genetic Association Database (GAD)
OR2C1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2C1

No disorders were found for OR2C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2C1 Gene

Publications for OR2C1 Gene

  1. Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3. (PMID: 9847080) Centola M. … Kastner D.L. (Genome Res. 1998) 2 3 4 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR2C1 Gene

Sources for OR2C1 Gene

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