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Aliases for OR2C1 Gene

Aliases for OR2C1 Gene

  • Olfactory Receptor Family 2 Subfamily C Member 1 2 3 5
  • Olfactory Receptor, Family 2, Subfamily C, Member 1 2 3
  • Olfactory Receptor OR16-1 3 4
  • Olfactory Receptor OR16-2 3 4
  • Olfactory Receptor 2C2 3 4
  • OR2C2P 3 4
  • OLFmf3 3 4
  • Olfactory Receptor, Family 2, Subfamily C, Member 2 Pseudogene 3

External Ids for OR2C1 Gene

Previous HGNC Symbols for OR2C1 Gene

  • OR2C2P

Previous GeneCards Identifiers for OR2C1 Gene

  • GC16P003435
  • GC16P003406
  • GC16P003345
  • GC16P003405

Summaries for OR2C1 Gene

Entrez Gene Summary for OR2C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2C1 Gene

OR2C1 (Olfactory Receptor Family 2 Subfamily C Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2G2.

UniProtKB/Swiss-Prot for OR2C1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2C1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2C1 Gene

Genomics for OR2C1 Gene

Regulatory Elements for OR2C1 Gene

Enhancers for OR2C1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR2C1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2C1 Gene

3,355,889 bp from pter
3,357,294 bp from pter
1,406 bases
Plus strand

Genomic View for OR2C1 Gene

Genes around OR2C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2C1 Gene

Proteins for OR2C1 Gene

  • Protein details for OR2C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2C1
    Protein Accession:
    Secondary Accessions:
    • A0AVA4
    • Q6IF34
    • Q6IF55

    Protein attributes for OR2C1 Gene

    312 amino acids
    Molecular mass:
    34412 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2C1 Gene

Proteomics data for OR2C1 Gene at MOPED

Post-translational modifications for OR2C1 Gene

Other Protein References for OR2C1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2C1 Gene

Domains & Families for OR2C1 Gene

Gene Families for OR2C1 Gene

Protein Domains for OR2C1 Gene

Suggested Antigen Peptide Sequences for OR2C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2C1: view

Function for OR2C1 Gene

Molecular function for OR2C1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily F,member 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR2C1: view

Animal Models for OR2C1 Gene

MGI Knock Outs for OR2C1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OR2C1 Gene

Localization for OR2C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2C1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR2C1 Gene COMPARTMENTS Subcellular localization image for OR2C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2C1: view

Pathways & Interactions for OR2C1 Gene

genes like me logo Genes that share pathways with OR2C1: view

Pathways by source for OR2C1 Gene

1 KEGG pathway for OR2C1 Gene

Interacting Proteins for OR2C1 Gene

Gene Ontology (GO) - Biological Process for OR2C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell TAS 9847080
genes like me logo Genes that share ontologies with OR2C1: view

No data available for SIGNOR curated interactions for OR2C1 Gene

Drugs & Compounds for OR2C1 Gene

No Compound Related Data Available

Transcripts for OR2C1 Gene

mRNA/cDNA for OR2C1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(91) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2C1 Gene

Olfactory receptor, family 2, subfamily C, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR2C1 Gene

No ASD Table

Relevant External Links for OR2C1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2C1 Gene

mRNA expression in normal human tissues for OR2C1 Gene

Protein differential expression in normal tissues from HIPED for OR2C1 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2C1 Gene

SOURCE GeneReport for Unigene cluster for OR2C1 Gene Hs.258574

genes like me logo Genes that share expression patterns with OR2C1: view

Protein tissue co-expression partners for OR2C1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR2C1 Gene

Orthologs for OR2C1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2C1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Olfr15 35
  • 81.77 (n)
  • 82.85 (a)
Olfr15 16
Olfr15 36
  • 82 (a)
(Rattus norvegicus)
Mammalia Olr1356 35
  • 81.92 (n)
  • 85.62 (a)
(Bos Taurus)
Mammalia OR2C1 36
  • 87 (a)
(Canis familiaris)
Mammalia OR2C1 36
  • 87 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
-- 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
(Pan troglodytes)
Mammalia OR2C1 36
  • 54 (a)
Species with no ortholog for OR2C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2C1 Gene

Gene Tree for OR2C1 (if available)
Gene Tree for OR2C1 (if available)

Paralogs for OR2C1 Gene

Paralogs for OR2C1 Gene

(457) SIMAP similar genes for OR2C1 Gene using alignment to 1 proteins: Pseudogenes for OR2C1 Gene

genes like me logo Genes that share paralogs with OR2C1: view

Variants for OR2C1 Gene

Sequence variations from dbSNP and Humsavar for OR2C1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1218762 - 3,355,986(+) TGATG(A/G)GCATA reference, missense
rs1218763 - 3,356,387(+) GCCTG(C/G)CTGGG reference, missense
rs11648783 - 3,356,626(+) AATCC(A/G)CTCTG reference, missense
rs4578649 -- 3,357,258(+) CTTAC(A/G)TAATG downstream-variant-500B
rs62000971 -- 3,356,019(+) TGATC(C/T)TTTTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR2C1 Gene

Variant ID Type Subtype PubMed ID
nsv905212 CNV Gain 21882294
nsv1714 CNV Insertion 18451855

Variation tolerance for OR2C1 Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.75; 91.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2C1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2C1 Gene

Disorders for OR2C1 Gene

Relevant External Links for OR2C1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR2C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2C1 Gene

Publications for OR2C1 Gene

  1. Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3. (PMID: 9847080) Centola M. … Kastner D.L. (Genome Res. 1998) 2 3 4 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2C1 Gene

Sources for OR2C1 Gene