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OR2C1 Gene

protein-coding   GIFtS: 50
GCID: GC16P003405

Olfactory Receptor, Family 2, Subfamily C, Member 1


(Previous symbol: OR2C2P)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily C, Member 11 2     Olfactory Receptor OR16-22 3
OR2C2P1 2 3     OLFmf32 3
Olfactory Receptor 2C22 3     Olfactory Receptor 2C12
Olfactory Receptor OR16-12 3     Olfactory Receptor, Family 2, Subfamily C, Member 2 Pseudogene2

External Ids:    HGNC: 82421   Entrez Gene: 49932   Ensembl: ENSG000001681587   UniProtKB: O953713   

Export aliases for OR2C1 gene to outside databases

Previous GC identifers: GC16P003435 GC16P003406 GC16P003345


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2C1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2C1 Gene:
OR2C1 (olfactory receptor, family 2, subfamily C, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2W1.

UniProtKB/Swiss-Prot: OR2C1_HUMAN, O95371
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2C1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2C1 gene promoter:
         SRF   Nkx3-1   Nkx3-1 v4   SRF (504 AA)   POU3F2 (N-Oct-5a)   Nkx3-1 v1   POU3F2   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2C1 promoter sequence
   Search Chromatin IP Primers for OR2C1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2C1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

OR2C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2C1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P003405:  view genomic region     (about GC identifiers)

Start:
3,405,941 bp from pter      End:
3,406,876 bp from pter
Size:
936 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR2C1_HUMAN, O95371 (See protein sequence)
Recommended Name: Olfactory receptor 2C1  
Size: 312 amino acids; 34412 Da
Secondary accessions: A0AVA4 Q6IF34 Q6IF55

Explore the universe of human proteins at neXtProt for OR2C1: NX_O95371

Explore proteomics data for OR2C1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR2C1

    See OR2C1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036500.2  
    ENSEMBL proteins: 
     ENSP00000307726  
    Reactome Protein details: O95371

    OR2C1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for OR2C1

     
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    antibodies-online proteins for OR2C1 (3 products) 

     
    antibodies-online peptides for OR2C1

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    antibodies-online antibodies for OR2C1 (11 products) 

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    Cloud-Clone Corp. CLIAs for OR2C1
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    antibodies-online kits for OR2C1 (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O95371

    ProtoNet protein and cluster: O95371

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2C1_HUMAN, O95371
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR2C1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2C1_HUMAN, O95371
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR2C1:
    olfactory receptor,family 1,subfamily F,member 3,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR2C1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for OR2C1:
     Decreased Hepatitis C virus re  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR2C1

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    Addgene plasmids for OR2C1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2C1_HUMAN, O95371: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005938cell cortex IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR2C1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2C1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    Find genes that share SuperPaths with OR2C1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR2C1
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR2C1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2C1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2C1
    Interactions:

        Search GeneGlobe Interaction Network for OR2C1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR2C1 (ENSP000003077264) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10AD1ENSP000003086894STRING: ENSP00000308689
    OR10P1ENSP000003080824STRING: ENSP00000308082
    OR10W1ENSP000003785164STRING: ENSP00000378516
    OR11G2ENSP000003499304STRING: ENSP00000349930
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0050911detection of chemical stimulus involved in sensory perception of smell TAS9847080

    Find genes that share ontologies with OR2C1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2C1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR2C1 gene: 
    NM_012368.2  

    Unigene Cluster for OR2C1:

    Olfactory receptor, family 2, subfamily C, member 1
    Hs.258574  [show with all ESTs]
    Unigene Representative Sequence: BX324671
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304936(uc002cuw.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat OR2C1
      QuantiFast Probe-based Assays in human, mouse, rat OR2C1

    Additional mRNA sequence: 

    BC069158.1 BC069456.1 BC126269.1 BC130328.1 

    1 DOTS entry:

    DT.91848850 

    Selected AceView cDNA sequences (see all 91):

    BE208132 AK093979 AA423932 CA413716 AX748391 AI313421 AA884695 BU101946 
    AI745304 AI263181 CR749782 AA969310 R85696 AA279687 AI572250 BU145762 
    BM746950 AA829635 BC051366 AW628313 BX101232 AI648586 BC069456 BX324672 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2C1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR2C1 Expression
    About this image

    OR2C1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2C1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.258574
        Custom PCR Arrays for OR2C1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2C1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr151 , 5 olfactory receptor 151, 5 81.77(n)1
    82.85(a)1
      16 (2.26 cM)5
    183121  NM_008762.21  NP_032788.21 
     38389755 


    ENSEMBL Gene Tree for OR2C1 (if available)
    TreeFam Gene Tree for OR2C1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2C1 gene
    OR2W12  OR2J22  OR2G22  OR2J12  OR2H22  OR2H12  OR2Y12  OR2W32  
    OR2J32  OR2G32  OR2C32  OR2G62  
    Selected SIMAP similar genes for OR2C1 using alignment to 1 protein entry:     OR2C1_HUMAN(see all similar genes):
    OR2B11    OR2G3    OR2J4P    OR2B2    OR2B8P    OR2C3
    OR2G6    OR2J1    OR2B3    OR2B6    OR2G2    OR2J3
    OR2W6P    OLFR 42A    OR2H1    OR2H2    OR2J2    OR2W1

    Find genes that share paralogs with OR2C1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for OR2C1
    PGOHUM00000243105 PGOHUM00000242015


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2C1 (see all 136)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890526191,2
    --3403918(+) ATTAAC/TAAGAG 1 -- us2k10--------
    rs116416451,2
    C,F,H--3403972(+) GTTTTA/TCtttt 1 -- us2k1 tfbs3 trp39Minor allele frequency- T:0.18WA NA CSA 136
    rs1998870951,2
    --3403985(+) TTCTT-/TCTTTTT 1 -- us2k10--------
    rs2004246751,2
    --3403986(+) TCTTT-/CTTTTT 1 -- us2k10--------
    rs2019653501,2
    C--3403990(+) TTTTT-/CTTTTT 1 -- us2k10--------
    rs1395055321,2
    --3404010(+) ACAGAG/TTCTAG 1 -- us2k10--------
    rs1496992241,2
    --3404022(+) TCTGTC/TGCCCA 1 -- us2k10--------
    rs1466553651,2
    --3404023(+) CTGTTG/TCCCAG 1 -- us2k10--------
    rs675471231,2
    C,F--3404069(+) ACTTCC/AGCCTC 1 -- us2k16Minor allele frequency- A:0.24WA CSA NA EA 363
    rs1129639931,2
    C,F--3404070(+) CTTCCC/GCCTCC 1 -- us2k12Minor allele frequency- G:0.00CSA 2

    HapMap Linkage Disequilibrium report for OR2C1 ( 3405941 - 3406876 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR2C1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1714CNV Insertion18451855
    nsv905212CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR2C1           About GenesLikeMe

    Genetic Association Database (GAD): OR2C1

    Export disorders for OR2C1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2C1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2C1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3. (PubMed id 9847080)1, 2, 3 Centola M....Kastner D.L. (Genome Res. 1998)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4993 HGNC: 8242 AceView: OR2C1andZNF75A Ensembl:ENSG00000168158 euGenes: HUgn4993
    ECgene: OR2C1 Kegg: 4993 H-InvDB: OR2C1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2C1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2C1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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