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OR2B6 Gene

protein-coding   GIFtS: 51
GCID: GC06P027925

Olfactory Receptor, Family 2, Subfamily B, Member 6


(Previous symbols: OR2B6P, OR2B1, OR2B1P, OR2B5)
  See OR2B6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily B, Member 61 2     OR5-402 3
OR2B11 2 3     OR6-312 3
OR2B1P1 2 3     OR5-412
OR2B51 2 3     dJ408B20.22
OR2B6P1 2 3     hs6M1-322
Olfactory Receptor 2B12 3     Olfactory Receptor 2B62
Olfactory Receptor 2B52 3     Olfactory Receptor, Family 2, Subfamily B, Member 1 Pseudogene2
Olfactory Receptor 5-402 3     Olfactory Receptor, Family 2, Subfamily B, Member 52
Olfactory Receptor 6-312 3     Olfactory Receptor, Family 2, Subfamily B, Member 6 Pseudogene2
Olfactory Receptor OR6-42 3     Hs6M1-323

External Ids:    HGNC: 82411   Entrez Gene: 262122   Ensembl: ENSG000001246577   UniProtKB: P581733   

Export aliases for OR2B6 gene to outside databases

Previous GC identifers: GC06U990191 GC06P028033 GC06P028034 GC06P028035


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2B6 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2B6 Gene:
OR2B6 (olfactory receptor, family 2, subfamily B, member 6) is a protein-coding gene. Diseases associated with OR2B6 include murray valley encephalitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2B11.

UniProtKB/Swiss-Prot: OR2B6_HUMAN, P58173
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2B6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2B6 gene promoter:
         C/EBPbeta   GATA-3   AML1a   LCR-F1   GATA-2   GATA-1   C/EBPalpha   CHOP-10   CP2   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2B6 promoter sequence
   Search Chromatin IP Primers for OR2B6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2B6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

OR2B6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2B6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P027925:  view genomic region     (about GC identifiers)

Start:
27,925,019 bp from pter      End:
27,925,957 bp from pter
Size:
939 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR2B6_HUMAN, P58173 (See protein sequence)
Recommended Name: Olfactory receptor 2B6  
Size: 313 amino acids; 35414 Da
Secondary accessions: O43883 Q6IF89 Q9H5B0

Explore the universe of human proteins at neXtProt for OR2B6: NX_P58173

Explore proteomics data for OR2B6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR2B6

    See OR2B6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036499.1  
    ENSEMBL proteins: 
     ENSP00000244623  
    Reactome Protein details: P58173

    OR2B6 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P58173

    ProtoNet protein and cluster: P58173

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2B6_HUMAN, P58173
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR2B6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2B6_HUMAN, P58173
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR2B6:
    olfactory receptor,family 2,subfamily B,member 6,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR2B6           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR2B6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OR2B6
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2B6_HUMAN, P58173: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR2B6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2B6 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43
    4GPCRs, Other
    GPCRs, Other


    Find genes that share SuperPaths with OR2B6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for OR2B6
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR2B6
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2B6):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2B6
    Interactions:

        Search GeneGlobe Interaction Network for OR2B6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR2B6 (ENSP000002446234) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10H2ENSP000003060954STRING: ENSP00000306095
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR10K1ENSP000002894514STRING: ENSP00000289451
    OR1A1ENSP000003052074STRING: ENSP00000305207
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR2B6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2B6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR2B6 gene: 
    NM_012367.1  

    Unigene Cluster for OR2B6:

    Olfactory receptor, family 2, subfamily B, member 6
    Hs.532145
    Unigene Representative Sequence: BC109251
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000244623(uc011dkx.2)
    miRNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OR2B6
      QuantiTect SYBR Green Assays in human, mouse, rat OR2B6
      QuantiFast Probe-based Assays in human, mouse, rat OR2B6

    Additional mRNA sequence: 

    BC109251.1 BC110457.2 

    1 DOTS entry:

    DT.102819813 

    7 AceView cDNA sequences:

    NM_003527 NM_012367 N68399 BX647290 R16006 R16107 N91195 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2B6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAATCCCC
    OR2B6 Expression
    About this image

    OR2B6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2B6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532145
        Custom PCR Arrays for OR2B6
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2B6 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr111 , 5 olfactory receptor 111, 5 81.68(n)1
    81.15(a)1
      13 (7.90 cM)5
    2180661  NM_146542.21  NP_666753.21 
     216385805 


    ENSEMBL Gene Tree for OR2B6 (if available)
    TreeFam Gene Tree for OR2B6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2B6 gene
    OR2B112  OR2B22  OR2B32  
    Selected SIMAP similar genes for OR2B6 using alignment to 1 protein entry:     OR2B6_HUMAN(see all similar genes):
    OR2B2    OR2B11    OR2B3    OR2G6    OR2J1    OR2J4P
    OR2W6P    6M1-16    OR2C1    OR2G3    OR2J2    OR2B8P
    OR2G2    OR2H2    OR2J3    OR2W3    OLFR 42A    OR2C3

    Find genes that share paralogs with OR2B6           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for OR2B6 (see all 8)
    PGOHUM00000243113 PGOHUM00000235884 PGOHUM00000245320 PGOHUM00000236803 PGOHUM00000242939


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2B6 (see all 112)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829831031,2
    --27923099(+) ATATGA/TCCTCA 1 -- us2k10--------
    rs1854191751,2
    --27923158(+) CATTAC/TATTTG 1 -- us2k10--------
    rs1439072181,2
    C--27923178(+) AGAAAA/GAGCAA 1 -- us2k10--------
    rs1486121611,2
    C--27923257(+) TTTTAA/GCACTT 1 -- us2k10--------
    rs93685381,2
    C,F,H--27923301(+) AATACT/AGACCA 1 -- us2k113Minor allele frequency- A:0.10NS EA NA 1208
    rs1420387051,2
    --27923315(+) TGATTA/CTATTC 1 -- us2k10--------
    rs1136955441,2
    C,F--27923321(+) TATTCC/TCTTAT 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1122875231,2
    C,F--27923594(+) TAATAG/ATTTAA 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs1506964381,2
    C--27923674(+) TGGTAA/GCAAGA 1 -- us2k10--------
    rs94682601,2
    C,H--27923745(+) GGGCTC/TTGAAC 1 -- us2k16Minor allele frequency- T:0.00NS EA 776

    HapMap Linkage Disequilibrium report for OR2B6 ( 27925019 - 27925957 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR2B6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830619CNV Loss17160897
    nsv883512CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR2B6
    DNA2.0 Custom Variant and Variant Library Synthesis for OR2B6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR2B6:    
    About MalaCards
    murray valley encephalitis

    1 disease from the University of Copenhagen DISEASES database for OR2B6:
    Murray Valley encephalitis

    Find genes that share disorders with OR2B6           About GenesLikeMe


    Export disorders for OR2B6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2B6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2B6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Distribution of olfactory receptor genes in the human genome. (PubMed id 9500546)1, 2, 3 Rouquier S.... Giorgi D. (Nat. Genet. 1998)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26212 HGNC: 8241 AceView: HIST1H2BOandOR2B6 Ensembl:ENSG00000124657 euGenes: HUgn26212
    ECgene: OR2B6 Kegg: 26212 H-InvDB: OR2B6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2B6 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2B6 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2B6 gene:
    Search GeneIP for patents involving OR2B6

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