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Aliases for OR2B6 Gene

Aliases for OR2B6 Gene

  • Olfactory Receptor, Family 2, Subfamily B, Member 6 2 3
  • Olfactory Receptor OR6-4 3 4
  • Olfactory Receptor 5-40 3 4
  • Olfactory Receptor 6-31 3 4
  • Olfactory Receptor 2B1 3 4
  • Olfactory Receptor 2B5 3 4
  • Hs6M1-32 3 4
  • OR6-31 3 4
  • OR2B1P 3 4
  • OR2B6P 3 4
  • OR5-40 3 4
  • OR2B1 3 4
  • OR2B5 3 4
  • Olfactory Receptor, Family 2, Subfamily B, Member 6 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily B, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily B, Member 5 3
  • Olfactory Receptor 2B6 3
  • DJ408B20.2 3
  • OR5-41 3

External Ids for OR2B6 Gene

Previous HGNC Symbols for OR2B6 Gene

  • OR2B6P
  • OR2B1
  • OR2B1P
  • OR2B5

Previous GeneCards Identifiers for OR2B6 Gene

  • GC06U990191
  • GC06P028033
  • GC06P028034
  • GC06P028035

Summaries for OR2B6 Gene

Entrez Gene Summary for OR2B6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2B6 Gene

OR2B6 (Olfactory Receptor, Family 2, Subfamily B, Member 6) is a Protein Coding gene. Diseases associated with OR2B6 include murray valley encephalitis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2B3.

UniProtKB/Swiss-Prot for OR2B6 Gene

  • Odorant receptor.

Gene Wiki entry for OR2B6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2B6 Gene

Genomics for OR2B6 Gene

Regulatory Elements for OR2B6 Gene

Genomic Location for OR2B6 Gene

27,957,241 bp from pter
27,958,182 bp from pter
942 bases
Plus strand

Genomic View for OR2B6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2B6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2B6 Gene

Proteins for OR2B6 Gene

  • Protein details for OR2B6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2B6
    Protein Accession:
    Secondary Accessions:
    • O43883
    • Q6IF89
    • Q9H5B0

    Protein attributes for OR2B6 Gene

    313 amino acids
    Molecular mass:
    35414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2B6 Gene

Proteomics data for OR2B6 Gene at MOPED

Post-translational modifications for OR2B6 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2B6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2B6 Gene

Domains for OR2B6 Gene

Gene Families for OR2B6 Gene

  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2B6 Gene

Suggested Antigen Peptide Sequences for OR2B6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P58173
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2B6: view

Function for OR2B6 Gene

Molecular function for OR2B6 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily B,member 6,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2B6: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2B6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2B6 Gene

Localization for OR2B6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2B6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR2B6 Gene COMPARTMENTS Subcellular localization image for OR2B6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2B6: view

Pathways for OR2B6 Gene

genes like me logo Genes that share pathways with OR2B6: view

Pathways by source for OR2B6 Gene

1 KEGG pathway for OR2B6 Gene

Interacting Proteins for OR2B6 Gene

Gene Ontology (GO) - Biological Process for OR2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2B6: view

Transcripts for OR2B6 Gene

mRNA/cDNA for OR2B6 Gene

(7) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2B6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2B6 Gene

No ASD Table

Relevant External Links for OR2B6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2B6 Gene

mRNA expression in normal human tissues for OR2B6 Gene

mRNA differential expression in normal tissues according to GTEx for OR2B6 Gene

This gene is overexpressed in Whole Blood (12.5).

Protein differential expression in normal tissues for OR2B6 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR2B6 Gene

SOURCE GeneReport for Unigene cluster for OR2B6 Gene Hs.532145

genes like me logo Genes that share expressions with OR2B6: view

Expression partners for OR2B6 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR2B6 Gene

Orthologs for OR2B6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2B6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR2B6 35
  • 86.51 (n)
  • 83.61 (a)
OR2B6 36
  • 83 (a)
(Mus musculus)
Mammalia Olfr11 35
  • 81.68 (n)
  • 81.15 (a)
Olfr11 16
Olfr11 36
  • 81 (a)
(Pan troglodytes)
Mammalia LOC471910 35
  • 98.83 (n)
  • 97.12 (a)
OR2B6 36
  • 97 (a)
(Canis familiaris)
Mammalia OR2B6 36
  • 82 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
-- 36
  • 45 (a)
-- 36
  • 41 (a)
-- 36
  • 66 (a)
-- 36
  • 72 (a)
Species with no ortholog for OR2B6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2B6 Gene

Gene Tree for OR2B6 (if available)
Gene Tree for OR2B6 (if available)

Paralogs for OR2B6 Gene

Paralogs for OR2B6 Gene

Selected SIMAP similar genes for OR2B6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2B6: view

Variants for OR2B6 Gene

Sequence variations from dbSNP and Humsavar for OR2B6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs904142 -- 27,957,678(-) GATGC(A/G)GCTGC synonymous-codon, reference
rs7767176 - 27,957,589(+) TGGCC(A/G)TCATG missense, reference
rs9368538 -- 27,955,523(+) AATAC(A/T)GACCA upstream-variant-2KB
rs9380030 - 27,958,049(+) GGACC(A/G)AGGAA reference, missense
rs9468260 -- 27,955,967(+) GGGCT(C/T)TGAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2B6 Gene

Variant ID Type Subtype PubMed ID
nsv883512 CNV Gain 21882294
nsv830619 CNV Loss 17160897

Relevant External Links for OR2B6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2B6 Gene

Disorders for OR2B6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for OR2B6 Gene in MalaCards »

(1) Diseases for OR2B6 Gene including...

(1) University of Copenhagen DISEASES for OR2B6 Gene

genes like me logo Genes that share disorders with OR2B6: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for OR2B6 Gene

Publications for OR2B6 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2B6 Gene

Sources for OR2B6 Gene

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