OR2B6 Gene
protein-coding GIFtS: 51
GCID: GC06P027925
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olfactory receptor, family 2, subfamily B, member 6
(Previous symbols: OR2B6P, OR2B1, OR2B1P, OR2B5)
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Aliases
for OR2B6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 2, Subfamily B, Member 61 2 | | Olfactory Receptor 2B52 3 | | OR2B11 2 3 | | Olfactory Receptor 5-402 3 | | OR2B1P1 2 3 | | Olfactory Receptor 6-312 3 | | OR2B51 2 3 | | Olfactory Receptor OR6-42 3 | | OR2B6P1 2 3 | | Hs6M1-323 | | OR5-401 2 3 | | Olfactory Receptor 2B62 | | OR6-311 2 3 | | Olfactory Receptor, Family 2, Subfamily B, Member 1 Pseudogene2 | | OR5-411 2 | | Olfactory Receptor, Family 2, Subfamily B, Member 52 | | DJ408B20.21 | | Olfactory Receptor, Family 2, Subfamily B, Member 6 Pseudogene2 | | Olfactory Receptor 2B12 3 | | Hs6M1-323 |
Export aliases for OR2B6 gene to outside databasesPrevious GC identifers: GC06U990191 GC06P028033 GC06P028034 GC06P028035 |
Summaries
for OR2B6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR2B6:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR2B6_HUMAN, P58173Function: Odorant receptor (Potential)
Gene Wiki entry for OR2B6
|
Genomic Views
for OR2B6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR2B6 gene promoter:
C/EBPbeta GATA-3 AML1a LCR-F1 GATA-2 GATA-1 C/EBPalpha CHOP-10 CP2 SEF-1 (1)
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR2B6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2B6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p22.1OR2B6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P027925: view genomic region
(about GC identifiers)
Start:
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27,925,019 bp from pter |
End:
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27,925,957 bp from pter |
Size:
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939 bases |
Orientation:
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plus strand |
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Proteins
for OR2B6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR2B6_HUMAN, P58173 (See
protein sequence)Recommended Name: Olfactory receptor 2B6 Size: 313 amino acids; 35414 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: O43883 Q6IF89 Q9H5B0Explore the universe of human proteins at neXtProt for OR2B6: NX_P58173
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P58173
HORDE protein sequence for OR2B6
OR2B6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036499.1
ENSEMBL proteins: ENSP00000244623 Reactome Protein details: P58173
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR2B6 for ontologies About GeneDecksing
OR2B6 Antibody Products:
Assay Products for OR2B6: |
Protein
Domains /
Families
for OR2B6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR2B6 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P58173ProtoNet protein and cluster: P58173 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR2B6_HUMAN, P58173Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR2B6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OR2B6_HUMAN, P58173Function: Odorant receptor (Potential) Genatlas biochemistry entry for OR2B6:olfactory receptor,family 2,subfamily B,member 6,G protein coupled receptor superfamily
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2B6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2B6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR2B6 (NM_012367) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR2B6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2B6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2B6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR2B6 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR2B6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | | | 3 | GPCRs, Other | | | 4 | Class A/1 (Rhodopsin-like receptors) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for OR2B6
4 
Reactome Pathways for OR2B6
1 
Kegg Pathway (Kegg details for OR2B6):
OR2B6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2B6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/273 Interacting proteins for OR2B6 (ENSP000002446234) via UniProtKB, MINT, STRING, and/or I2D (see all 273)About this table
|
Drugs & Compounds
for OR2B6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR2B6
Search CenterWatch for drugs/clinical trials and news about OR2B6
|
Transcripts
for OR2B6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR2B6 gene: NM_012367.1 Unigene Cluster for OR2B6: Olfactory receptor, family 2, subfamily B, member 6 Hs.532145 Unigene Representative Sequence: BC1092511 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000244623(uc011dkx.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2B6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2B6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR2B6 (NM_012367) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR2B6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2B6 |
Additional cDNA sequence: BC109251.1 BC110457.2 1 DOTS entry: DT.102819813 7 AceView cDNA sequences: NM_012367 NM_003527 BX647290 N68399 R16107 R16006 N91195
GeneLoc Exon Structure
|
Expression
for OR2B6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR2B6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAATCCCC
About this image
See OR2B6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR2B6
SOURCE GeneReport for Unigene cluster: Hs.532145
SABiosciences Custom PCR Arrays for OR2B6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2B6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR2B6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2B6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2B6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2B6 |
Orthologs
for OR2B6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OR2B6 (if available)
TreeFam Gene Tree for OR2B6 (if available) |
Paralogs
for OR2B6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR2B6 gene
- OR2J22 OR2W12 OR2J12 OR2B112 OR2H22 OR2B22 OR2B32 OR2H12
- OR2C12 OR2Y12 OR2G22 OR2J32 OR2W32 OR2G32 OR2C32 OR2G62
18/450 SIMAP similar genes for OR2B6 using alignment to 1 protein entry: OR2B6_HUMAN(see all similar genes):OR2B2 OR2B11 OR2B3 OR2G6 OR2J1 OR2J4P
OR2W6P 6M1-16 OR2C1 OR2G3 OR2J2 OR2B8P
OR2G2 OR2H2 OR2J3 OR2W3 OLFR 42A OR2C3
OR2B6 for paralogs About GeneDecksing
5/8 Pseudogenes.org Pseudogenes for OR2B6 (see all 8)
PGOHUM00000243113 PGOHUM00000235884 PGOHUM00000245320 PGOHUM00000236803 PGOHUM00000242939
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Genomic Variants
for OR2B6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR2B6 ( 27925019 - 27925957 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR2B6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR2B6 |
|
Disorders
/ Diseases
for OR2B6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR2B6 for disorders About GeneDecksing
3  diseases for OR2B6: About MalaCardsmurray valley encephalitis encephalitis neuronitis
1 disease from the University of Copenhagen DISEASES database for OR2B6:Murray Valley encephalitis Export disorders for OR2B6 gene to outside databases
|
Publications
for OR2B6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR2B6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR2B6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Distribution of olfactory receptor genes in the human genome. (PubMed id 9500546)1, 2, 3 Rouquier S.... Giorgi D. (1998)
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for OR2B6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR2B6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR2B6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR2B6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR2B6 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR2B6 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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| | |
About This Section
| Patent Information for OR2B6 gene:
Search GeneIP for patents involving OR2B6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR2B6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR2B6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR2B6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2B6 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR2B6 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2B6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2B6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for OR2B6 |
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 | | | OR2B6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2B6 |
|  |  |  | | | | Search ThermoFisher Antibodies for OR2B6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2B6 |
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