OR2B3 Gene
protein-coding GIFtS: 47
GCID: GC06M029054
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olfactory receptor, family 2, subfamily B, member 3(Previous names: olfactory receptor, family 2, subfamily B, member 3 pseudogene...)
(Previous symbol: OR2B3P)
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Aliases
for OR2B3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 2, Subfamily B, Member 31 2 | | 6M1-12 | | OR2B3P1 2 3 | | OR6-142 | | OR6-41 2 3 | | Hs6M1-13 | | Olfactory Receptor 6-42 3 | | Putative Olfactory Receptor 2B32 | | Olfactory Receptor OR6-142 3 | | Hs6M1-13 | | Olfactory Receptor, Family 2, Subfamily B, Member 3 Pseudogene1 | | |
Export aliases for OR2B3 gene to outside databasesPrevious GC identifers: GC06U990213 GC06M029167 GC06Mo28984 |
Summaries
for OR2B3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR2B3:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR2B3_HUMAN, O76000Function: Odorant receptor (Potential)
Gene Wiki entry for OR2B3
|
Genomic Views
for OR2B3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1
- NT_167248.1 NT_167249.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR2B3 gene promoter:
C/EBPbeta AML1a HNF-4alpha2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 HNF-4alpha1 PPAR-gamma1 HOXA5 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR2B3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2B3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p22.2-p21.31OR2B3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M029054: view genomic region
(about GC identifiers)
Start:
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29,054,087 bp from pter |
End:
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29,055,025 bp from pter |
Size:
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939 bases |
Orientation:
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minus strand |
6/7 alternative locations (see all 7):
| Chr6-,ALT_REF_LOCI_1 29,054,028-29,063,433 | Chr6-,ALT_REF_LOCI_3 29,053,997-29,066,140 | Chr6-,ALT_REF_LOCI_2 29,050,654-29,090,947 | | Chr6-,ALT_REF_LOCI_4 28,977,045-28,978,150 | Chr6-,ALT_REF_LOCI_5 28,968,946-28,970,051 | Chr6-,ALT_REF_LOCI_6 29,053,987-29,090,673 | |
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Proteins
for OR2B3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR2B3_HUMAN, O76000 (See
protein sequence)Recommended Name: Putative olfactory receptor 2B3 Size: 313 amino acids; 35543 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B0UYQ1 Q5ST41 Q96R13Explore the universe of human proteins at neXtProt for OR2B3: NX_O76000
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O76000
HORDE protein sequence for OR2B3
OR2B3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001005226.1
ENSEMBL proteins: ENSP00000366378 Reactome Protein details: O76000
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR2B3 for ontologies About GeneDecksing
OR2B3 Antibody Products:
Assay Products for OR2B3: |
Protein
Domains /
Families
for OR2B3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR2B3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O76000ProtoNet protein and cluster: O76000 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR2B3_HUMAN, O76000Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR2B3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OR2B3_HUMAN, O76000Function: Odorant receptor (Potential) Genatlas biochemistry entry for OR2B3:olfactory receptor,family 2,subfamily B,member 3,G protein coupled receptor superfamily
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2B3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR2B3 (NM_001005226) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR2B3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2B3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2B3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR2B3 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR2B3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | | | 3 | Class A/1 (Rhodopsin-like receptors) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for OR2B3
4 
Reactome Pathways for OR2B3
1 
Kegg Pathway (Kegg details for OR2B3):
OR2B3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2B3
|
Drugs & Compounds
for OR2B3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR2B3
Search CenterWatch for drugs/clinical trials and news about OR2B3
|
Transcripts
for OR2B3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR2B3 gene: NM_001005226.2 Unigene Cluster for OR2B3: Olfactory receptor, family 2, subfamily B, member 3 Hs.553835 Unigene Representative Sequence: NM_0010052261 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000377173(uc003nlx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2B3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2B3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR2B3 (NM_001005226) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR2B3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2B3 |
Additional cDNA sequence: BC136817.1 BC136818.1 1 AceView cDNA sequence: NM_001005226
GeneLoc Exon Structure
|
Expression
for OR2B3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR2B3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAACTCCC
About this image
See OR2B3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR2B3
SOURCE GeneReport for Unigene cluster: Hs.553835
SABiosciences Custom PCR Arrays for OR2B3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2B3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat OR2B3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2B3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2B3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2B3 |
Orthologs
for OR2B3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OR2B3 (if available)
TreeFam Gene Tree for OR2B3 (if available) |
Paralogs
for OR2B3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR2B3 gene
- OR2J22 OR2W12 OR2J12 OR2B112 OR2H22 OR2B22 OR2H12 OR2C12
- OR2Y12 OR2G22 OR2B62 OR2W32 OR2J32 OR2G32 OR2C32 OR2G62
18/440 SIMAP similar genes for OR2B3 using alignment to 1 protein entry: OR2B3_HUMAN(see all similar genes):OR2B2 OR2B11 OR2B6 OR2G6 OR2J4P OR2W6P
OLFR 42A OR2W3 OR2B8P OR2C1 OR2G3 OR2J3
OR2G2 6M1-16 OR2H1 OR2H2 OR2J1 OR2W1
OR2B3 for paralogs About GeneDecksing
|
Genomic Variants
for OR2B3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR2B3 ( 29054087 - 29055025 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR2B3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR2B3 |
|
Disorders
/ Diseases
for OR2B3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR2B3 for disorders About GeneDecksing
3  diseases for OR2B3: About MalaCardssystemic lupus erythematosus lupus erythematosus neuronitis
Human Genome Epidemiology (HuGE) Navigator: OR2B3 (2 documents)
Export disorders for OR2B3 gene to outside databases
|
Publications
for OR2B3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR2B3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR2B3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- Distinguishing protein-coding and noncoding genes in the human genome. (PubMed id 18040051)1 Clamp M....Lander E.S. (2007)
- Complex transcription and splicing of odorant receptor genes. (PubMed id 12637542)1 Volz A.... Ziegler A. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for OR2B3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing OR2B3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR2B3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR2B3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR2B3 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR2B3 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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| | |
About This Section
| Patent Information for OR2B3 gene:
Search GeneIP for patents involving OR2B3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR2B3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR2B3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR2B3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2B3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR2B3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2B3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2B3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR2B3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR2B3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2B3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR2B3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2B3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2B3 |
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 | | | OR2B3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2B3 |
|  |  |  | | | | Search ThermoFisher Antibodies for OR2B3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2B3 |
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