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OR2B2 Gene

protein-coding   GIFtS: 48
GCID: GC06M027955

Olfactory Receptor, Family 2, Subfamily B, Member 2

(Previous names: olfactory receptor, family 2, subfamily B, member 9)
(Previous symbol: OR2B9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily B, Member 21 2     OR2B2Q2
OR2B91 2 3     dJ193B12.42
Olfactory Receptor, Family 2, Subfamily B, Member 91 2     hs6M1-102
Olfactory Receptor 2B92 3     Olfactory Receptor 2B22
Olfactory Receptor 6-12 3     Olfactory Receptor OR6-22
OR6-12 3     Hs6M1-103

External Ids:    HGNC: 139661   Entrez Gene: 816972   Ensembl: ENSG000001681317   UniProtKB: Q9GZK33   

Export aliases for OR2B2 gene to outside databases

Previous GC identifers: GC06M027936 GC06M027987 GC06M027895 GC06M027910 GC06M027930


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2B2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2B2 Gene:
OR2B2 (olfactory receptor, family 2, subfamily B, member 2) is a protein-coding gene. Diseases associated with OR2B2 include irritable bowel syndrome, and nephrolithiasis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2B6.

UniProtKB/Swiss-Prot: OR2B2_HUMAN, Q9GZK3
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2B2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2B2 gene promoter:
         Nkx3-1   Max1   USF1   Brachyury   CUTL1   SRY   FOXJ2 (long isoform)   HOXA5   USF-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2B2 promoter sequence
   Search Chromatin IP Primers for OR2B2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3-p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.3-p21.3

OR2B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2B2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M027955:  view genomic region     (about GC identifiers)

Start:
27,879,027 bp from pter      End:
27,880,097 bp from pter
Size:
1,071 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR2B2_HUMAN, Q9GZK3 (See protein sequence)
Recommended Name: Olfactory receptor 2B2  
Size: 357 amino acids; 40412 Da
Secondary accessions: B2RNH2 Q9GZL2 Q9Y299

Explore the universe of human proteins at neXtProt for OR2B2: NX_Q9GZK3

Explore proteomics data for OR2B2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR2B2

    See OR2B2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149046.2  
    ENSEMBL proteins: 
     ENSP00000304419  
    Reactome Protein details: Q9GZK3

    OR2B2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9GZK3

    ProtoNet protein and cluster: Q9GZK3

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2B2_HUMAN, Q9GZK3
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR2B2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2B2_HUMAN, Q9GZK3
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR2B2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR2B2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2B2_HUMAN, Q9GZK3: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR2B2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2B2 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR2B2
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR2B2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2B2):
        Olfactory transduction


    OR2B2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2B2
    Interactions:

        Search GeneGlobe Interaction Network for OR2B2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR2B2 (ENSP000003044194) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10AD1ENSP000003086894STRING: ENSP00000308689
    OR10H2ENSP000003060954STRING: ENSP00000306095
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR10K1ENSP000002894514STRING: ENSP00000289451
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR2B2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2B2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR2B2 gene: 
    NM_033057.2  

    Unigene Cluster for OR2B2:

    Olfactory receptor, family 2, subfamily B, member 2
    Hs.307111
    Unigene Representative Sequence: NM_033057
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303324(uc011dkw.2)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat OR2B2
      QuantiFast Probe-based Assays in human, mouse, rat OR2B2

    Additional mRNA sequence: 

    AJ459866.1 BC136881.1 BC136901.1 

    2 AceView cDNA sequences:

    AJ459866 NM_033057 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2B2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR2B2 Expression
    About this image

    OR2B2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2B2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.307111
        Custom PCR Arrays for OR2B2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2B2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR2B2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr13591 , 5 olfactory receptor 13591, 5 82.53(n)1
    85.94(a)1
      13 (7.93 cM)5
    2580671  NM_001011820.11  NP_001011820.11 
     217030035 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004866231 olfactory receptor 5I1-like 58.58(n)
    49.51(a)
      100486623  XM_002934305.2  XP_002934351.2 


    ENSEMBL Gene Tree for OR2B2 (if available)
    TreeFam Gene Tree for OR2B2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2B2 gene
    OR2B62  OR2B112  OR2B32  
    Selected SIMAP similar genes for OR2B2 using alignment to 1 protein entry:     OR2B2_HUMAN(see all similar genes):
    OR2B6    OR2B3    OR2J4P    OR2B11    OLFR 42A    6M1-16
    OR2G3    OR2J1    OR2J3    OR2W6P    OR2B8P    OR2C1
    OR2G6    OR2C3    OR2G2    OR2H1    OR2H2    OR2J2

    OR2B2 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for OR2B2 (see all 11)
    PGOHUM00000243099 PGOHUM00000243111 PGOHUM00000243550 PGOHUM00000233050 PGOHUM00000235915


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2B2 (see all 96)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs728487551,2
    C,F--27878553(+) GTTCTT/CAAGAC 1 -- ds50014Minor allele frequency- C:0.06CSA WA NA 242
    rs1846731011,2
    --27878562(+) ACTTGC/TGCAAT 1 -- ds50010--------
    rs1116392431,2
    C,F--27878609(+) CTGTCG/AACATT 1 -- ds50014Minor allele frequency- A:0.05CSA WA 123
    rs1498781,2
    C,F,A,H--27878738(-) AAAAAA/CAAGGA 1 -- ds500131Minor allele frequency- N:0.00EA NA NS WA CSA 2880
    rs1405499911,2
    C--27878799(+) TTCTA-/TGTGTGT 1 -- ds50010--------
    rs1891460641,2
    --27878846(+) ATTACC/TGAAGA 1 -- ds50010--------
    rs1928627461,2
    --27878860(+) GATTTA/CTGGAT 1 -- ds50010--------
    rs1479250331,2
    C,F--27879055(+) TACAAT/AAGTTT 2 /Y /F mis11Minor allele frequency- A:0.00NA 4418
    rs2003843541,2
    --27879092(+) ACTTGC/TGGAGA 2 T A mis10--------
    rs733926981,2
    C,F--27879093(+) CTTGCG/AGAGAA 2 /S syn14Minor allele frequency- A:0.02WA NA EU 5965

    HapMap Linkage Disequilibrium report for OR2B2 ( 27879027 - 27880097 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OR2B2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731742CNV Deletion23290073
    nsv830619CNV Loss17160897
    nsv883512CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR2B2
    DNA2.0 Custom Variant and Variant Library Synthesis for OR2B2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for OR2B2:    
    About MalaCards
    irritable bowel syndrome    nephrolithiasis    neuronitis


    OR2B2 for disorders           About GeneDecksing


    Export disorders for OR2B2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2B2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2B2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81697 HGNC: 13966 AceView: OR2B2 Ensembl:ENSG00000168131 euGenes: HUgn81697
    ECgene: OR2B2 Kegg: 81697 H-InvDB: OR2B2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2B2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2B2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2B2 gene:
    Search GeneIP for patents involving OR2B2

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     OriGene Antibodies for OR2B2   OriGene RNAi products in human, mouse, rat for OR2B2  
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     Block miRNA regulation of human, mouse, rat OR2B2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR2B2
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OR2B2
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR2B2
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