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Aliases for OR2B2 Gene

Aliases for OR2B2 Gene

  • Olfactory Receptor Family 2 Subfamily B Member 2 2 3 5
  • Olfactory Receptor, Family 2, Subfamily B, Member 9 2 3
  • Olfactory Receptor 2B9 3 4
  • Olfactory Receptor 6-1 3 4
  • Hs6M1-10 3 4
  • OR2B9 3 4
  • OR6-1 3 4
  • Olfactory Receptor, Family 2, Subfamily B, Member 2 2
  • Olfactory Receptor OR6-2 3
  • Olfactory Receptor 2B2 3
  • DJ193B12.4 3
  • OR2B2Q 3

External Ids for OR2B2 Gene

Previous HGNC Symbols for OR2B2 Gene

  • OR2B9

Previous GeneCards Identifiers for OR2B2 Gene

  • GC06M027936
  • GC06M027987
  • GC06M027895
  • GC06M027910
  • GC06M027930
  • GC06M027955
  • GC06M027972
  • GC06M027975
  • GC06M027997
  • GC06M028024
  • GC06M028041
  • GC06M028066

Summaries for OR2B2 Gene

Entrez Gene Summary for OR2B2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2B2 Gene

OR2B2 (Olfactory Receptor Family 2 Subfamily B Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2B6.

UniProtKB/Swiss-Prot for OR2B2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2B2 Gene

Additional gene information for OR2B2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2B2 Gene

Genomics for OR2B2 Gene

Regulatory Elements for OR2B2 Gene

Enhancers for OR2B2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H027834 2.1 FANTOM5 Ensembl ENCODE dbSUPER 14.7 +75.1 75104 6 FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC MEF2D ZNF610 RCOR2 NBN ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN12 ZSCAN9 HNRNPA1P1 HIST1H2BPS2 OR2B2 CD83P1 LOC442172
GH06H027126 1.7 Ensembl ENCODE dbSUPER 14.6 +774.4 774374 22 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZFP41 MEF2D SSRP1 ZNF610 ZKSCAN8 ABT1 HMGN4 ZNF322 BTN2A3P BTN2A1 LOC102724851 BTN2A2 ZNF391 ENSG00000261839
GH06H027751 1.4 Ensembl ENCODE 14.7 +159.1 159055 2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZKSCAN8 ZKSCAN3 ZSCAN12 HNRNPA1P1 ZKSCAN4 ZNF603P HIST1H2BPS2 OR2B2 CD83P1 LOC442172
GH06H028141 1.4 ENCODE dbSUPER 14.6 -229.9 -229893 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 ZNF603P ZKSCAN3 ZKSCAN4 ZSCAN12 ZKSCAN8 HNRNPA1P1 ZNF391 ZSCAN23 OR2B2 HIST1H2BPS2
GH06H027600 1.4 Ensembl ENCODE 14.6 +310.8 310802 2 HDGF ARNT SIN3A ZNF2 ZNF766 ZNF302 ZNF548 SP3 JUNB REST ZKSCAN8 ZKSCAN3 ZSCAN23 ZSCAN12 HNRNPA1P1 ZNF322 ZKSCAN4 ZNF192P1 ENSG00000261839 PGBD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2B2 Gene

Chromosome:
6
Start:
27,911,185 bp from pter
End:
27,912,396 bp from pter
Size:
1,212 bases
Orientation:
Minus strand

Genomic View for OR2B2 Gene

Genes around OR2B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2B2 Gene

Proteins for OR2B2 Gene

  • Protein details for OR2B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZK3-OR2B2_HUMAN
    Recommended name:
    Olfactory receptor 2B2
    Protein Accession:
    Q9GZK3
    Secondary Accessions:
    • B2RNH2
    • Q9GZL2
    • Q9Y299

    Protein attributes for OR2B2 Gene

    Size:
    357 amino acids
    Molecular mass:
    40412 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2B2 Gene

Post-translational modifications for OR2B2 Gene

  • Glycosylation at posLast=55
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2B2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2B2 Gene

Domains & Families for OR2B2 Gene

Gene Families for OR2B2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2B2 Gene

Suggested Antigen Peptide Sequences for OR2B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZK3

UniProtKB/Swiss-Prot:

OR2B2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2B2: view

Function for OR2B2 Gene

Molecular function for OR2B2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2B2 Gene

Gene Ontology (GO) - Molecular Function for OR2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2B2: view
genes like me logo Genes that share phenotypes with OR2B2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2B2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2B2 Gene

Localization for OR2B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2B2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2B2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2B2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2B2 Gene

Pathways & Interactions for OR2B2 Gene

genes like me logo Genes that share pathways with OR2B2: view

Pathways by source for OR2B2 Gene

1 KEGG pathway for OR2B2 Gene

Interacting Proteins for OR2B2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000304419%0d%0a9606.ENSP00000248572%0d%0a9606.ENSP00000367869%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000312262%0d%0a9606.ENSP00000359719%0d%0a
Selected Interacting proteins: ENSP00000304419 Q9GZK3-OR2B2_HUMAN for OR2B2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2B2: view

No data available for SIGNOR curated interactions for OR2B2 Gene

Drugs & Compounds for OR2B2 Gene

No Compound Related Data Available

Transcripts for OR2B2 Gene

mRNA/cDNA for OR2B2 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2B2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR2B2 Gene

No ASD Table

Relevant External Links for OR2B2 Gene

GeneLoc Exon Structure for
OR2B2
ECgene alternative splicing isoforms for
OR2B2

Expression for OR2B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2B2 Gene

Protein differential expression in normal tissues from HIPED for OR2B2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (43.4) and Heart (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2B2 Gene



Protein tissue co-expression partners for OR2B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2B2 Gene:

OR2B2

SOURCE GeneReport for Unigene cluster for OR2B2 Gene:

Hs.307111
genes like me logo Genes that share expression patterns with OR2B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2B2 Gene

Orthologs for OR2B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2B2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC783002 33
  • 86.26 (n)
-- 34
  • 85 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Or2b2b 52 Olfr1360 16 34
  • 86 (a)
Or2b2 52 Olfr1359 33
  • 82.53 (n)
rat
(Rattus norvegicus)
Mammalia Olr1654 33
  • 81.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
ManyToMany
-- 34
  • 71 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 54 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486623 33
  • 58.58 (n)
Species where no ortholog for OR2B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2B2 Gene

ENSEMBL:
Gene Tree for OR2B2 (if available)
TreeFam:
Gene Tree for OR2B2 (if available)

Paralogs for OR2B2 Gene

Paralogs for OR2B2 Gene

(426) SIMAP similar genes for OR2B2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2B2: view

Variants for OR2B2 Gene

Sequence variations from dbSNP and Humsavar for OR2B2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1001369490 -- 27,914,379(+) AACCC(A/G/T)CAAAC upstream-variant-2KB
rs1002218474 -- 27,911,571(+) AAAAA(A/C)GTGAC reference, missense
rs1003041414 -- 27,913,111(+) CCCTC(-/A)AAAAA upstream-variant-2KB
rs1005575547 -- 27,913,218(+) GTAAT(A/G)TGATA upstream-variant-2KB
rs1005788505 -- 27,914,263(+) CCAAG(G/T)TCTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2B2 Gene

Variant ID Type Subtype PubMed ID
esv2731742 CNV deletion 23290073
nsv601208 CNV loss 21841781
nsv830619 CNV loss 17160897

Variation tolerance for OR2B2 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.85; 73.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2B2 Gene

Disorders for OR2B2 Gene

Relevant External Links for OR2B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2B2

No disorders were found for OR2B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2B2 Gene

Publications for OR2B2 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR2B2 Gene

Sources for OR2B2 Gene

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