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Aliases for OR2B11 Gene

Aliases for OR2B11 Gene

  • Olfactory Receptor Family 2 Subfamily B Member 11 2 3 5
  • Olfactory Receptor, Family 2, Subfamily B, Member 11 2

External Ids for OR2B11 Gene

Previous GeneCards Identifiers for OR2B11 Gene

  • GC01M244563
  • GC01M243940
  • GC01M245680
  • GC01M247614

Summaries for OR2B11 Gene

Entrez Gene Summary for OR2B11 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2B11 Gene

OR2B11 (Olfactory Receptor Family 2 Subfamily B Member 11) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2B3.

UniProtKB/Swiss-Prot for OR2B11 Gene

  • Odorant receptor.

Gene Wiki entry for OR2B11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2B11 Gene

Genomics for OR2B11 Gene

Regulatory Elements for OR2B11 Gene

Enhancers for OR2B11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F247415 0.7 ENCODE 12.7 +35.9 35860 2.1 TBP MTA2 TEAD4 CEBPB TBX21 TEAD3 EED IKZF1 NBN ETV6 OR2B11 ZNF496 NLRP3 PIR61874
GH01F247494 0.5 ENCODE 12.3 -43.0 -43012 0.1 ATF3 IKZF1 SPI1 OR2B11 GCSAML-AS1 OR2C3 OR2G3 ZNF496 OR2W5 GCSAML
GH01F247401 1.1 FANTOM5 Ensembl ENCODE 12.2 +50.0 49987 1.5 IKZF1 MLLT1 TBX21 MAFK NLRP3 OR2B11 ZNF496 OR2G3 AHCTF1
GH01F247455 0.7 Ensembl 6 -4.1 -4119 1.0 REST TCF7L2 OR2B11 OR2W5
GH01F247456 0.7 FANTOM5 Ensembl 5.6 -5.4 -5405 1.2 ENSG00000235749 ENSG00000236817 NLRP3 OR2B11 ENSG00000227671 OR2W5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR2B11 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2B11 Gene

Chromosome:
1
Start:
247,451,029 bp from pter
End:
247,451,982 bp from pter
Size:
954 bases
Orientation:
Minus strand

Genomic View for OR2B11 Gene

Genes around OR2B11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2B11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2B11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2B11 Gene

Proteins for OR2B11 Gene

  • Protein details for OR2B11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JQS5-OR2BB_HUMAN
    Recommended name:
    Olfactory receptor 2B11
    Protein Accession:
    Q5JQS5
    Secondary Accessions:
    • B2RP03

    Protein attributes for OR2B11 Gene

    Size:
    317 amino acids
    Molecular mass:
    35342 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2B11 Gene

Post-translational modifications for OR2B11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR2B11 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2B11 Gene

Domains & Families for OR2B11 Gene

Gene Families for OR2B11 Gene

Protein Domains for OR2B11 Gene

Suggested Antigen Peptide Sequences for OR2B11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JQS5

UniProtKB/Swiss-Prot:

OR2BB_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2B11: view

Function for OR2B11 Gene

Molecular function for OR2B11 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2B11: view
genes like me logo Genes that share phenotypes with OR2B11: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2B11 Gene

Localization for OR2B11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2B11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2B11 Gene COMPARTMENTS Subcellular localization image for OR2B11 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2B11: view

Pathways & Interactions for OR2B11 Gene

genes like me logo Genes that share pathways with OR2B11: view

Pathways by source for OR2B11 Gene

Gene Ontology (GO) - Biological Process for OR2B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2B11: view

No data available for SIGNOR curated interactions for OR2B11 Gene

Transcripts for OR2B11 Gene

mRNA/cDNA for OR2B11 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2B11 Gene

Olfactory receptor, family 2, subfamily B, member 11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2B11 Gene

No ASD Table

Relevant External Links for OR2B11 Gene

GeneLoc Exon Structure for
OR2B11
ECgene alternative splicing isoforms for
OR2B11

Expression for OR2B11 Gene

mRNA expression in normal human tissues for OR2B11 Gene

mRNA differential expression in normal tissues according to GTEx for OR2B11 Gene

This gene is overexpressed in Whole Blood (x14.2) and Adipose - Visceral (Omentum) (x6.7).

NURSA nuclear receptor signaling pathways regulating expression of OR2B11 Gene:

OR2B11

SOURCE GeneReport for Unigene cluster for OR2B11 Gene:

Hs.446999
genes like me logo Genes that share expression patterns with OR2B11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR2B11 Gene

Orthologs for OR2B11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2B11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR2B11 35
  • 99 (a)
OneToOne
LOC469158 34
  • 98.95 (n)
cow
(Bos Taurus)
Mammalia OR2B11 34 35
  • 86.39 (n)
dog
(Canis familiaris)
Mammalia LOC607036 34
  • 85.02 (n)
OR2B11 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or2b11 55 Olfr222 34 16 35
  • 84.02 (n)
Or2b28 55 Olfr1367
  • chr13:21,346,930-21,347,877
rat
(Rattus norvegicus)
Mammalia Olr1462 34
  • 83.28 (n)
oppossum
(Monodelphis domestica)
Mammalia OR2B11 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OR2B11 35
  • 61 (a)
OneToOne
Species where no ortholog for OR2B11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2B11 Gene

ENSEMBL:
Gene Tree for OR2B11 (if available)
TreeFam:
Gene Tree for OR2B11 (if available)

Paralogs for OR2B11 Gene

Paralogs for OR2B11 Gene

(457) SIMAP similar genes for OR2B11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2B11: view

Variants for OR2B11 Gene

Sequence variations from dbSNP and Humsavar for OR2B11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10733112 -- 247,450,586(+) ATTGT(C/T)TGAAA downstream-variant-500B
rs10802505 -- 247,452,478(+) GAGGC(A/G)GGCGG upstream-variant-2KB
rs10925030 -- 247,452,056(+) TTGAT(C/G)ACTTT upstream-variant-2KB
rs10925031 -- 247,452,741(+) AATGA(A/G)ACCCC upstream-variant-2KB
rs10925032 -- 247,453,277(+) TTGAT(A/G)TTCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2B11 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV gain+loss 17666407
nsv1011097 CNV gain 25217958

Variation tolerance for OR2B11 Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.87; 99.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2B11 Gene

Human Gene Mutation Database (HGMD)
OR2B11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2B11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2B11 Gene

Disorders for OR2B11 Gene

Relevant External Links for OR2B11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2B11

No disorders were found for OR2B11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2B11 Gene

Publications for OR2B11 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. (PMID: 24823311) Guan W. … Steffen L.M. (Circ Cardiovasc Genet 2014) 3 64
  3. Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. (PMID: 19098911) Villani A.C. … Franchimont D. (Nat. Genet. 2009) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR2B11 Gene

Sources for OR2B11 Gene

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