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Aliases for OR2AT4 Gene

Aliases for OR2AT4 Gene

  • Olfactory Receptor, Family 2, Subfamily AT, Member 4 2 3
  • Olfactory Receptor OR11-265 Pseudogene 3
  • Olfactory Receptor OR11-265 4
  • Olfactory Receptor 2AT4 3
  • OR11-265 3

External Ids for OR2AT4 Gene

Summaries for OR2AT4 Gene

Entrez Gene Summary for OR2AT4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AT4 Gene

OR2AT4 (Olfactory Receptor, Family 2, Subfamily AT, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11L1.

UniProtKB/Swiss-Prot for OR2AT4 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2AT4 Gene

Genomics for OR2AT4 Gene

Genomic Location for OR2AT4 Gene

Start:
75,088,713 bp from pter
End:
75,089,754 bp from pter
Size:
1,042 bases
Orientation:
Minus strand

Genomic View for OR2AT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2AT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AT4 Gene

Regulatory Elements for OR2AT4 Gene

Proteins for OR2AT4 Gene

  • Protein details for OR2AT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NND4-O2AT4_HUMAN
    Recommended name:
    Olfactory receptor 2AT4
    Protein Accession:
    A6NND4
    Secondary Accessions:
    • B9EGZ8

    Protein attributes for OR2AT4 Gene

    Size:
    320 amino acids
    Molecular mass:
    35503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AT4 Gene

Proteomics data for OR2AT4 Gene at MOPED

Post-translational modifications for OR2AT4 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn7

Other Protein References for OR2AT4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2AT4 Gene

Domains for OR2AT4 Gene

Gene Families for OR2AT4 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2AT4 Gene

UniProtKB/Swiss-Prot:

O2AT4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • A6NND4
genes like me logo Genes that share domains with OR2AT4: view

Function for OR2AT4 Gene

Molecular function for OR2AT4 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2AT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2AT4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2AT4 Gene

Localization for OR2AT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AT4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2AT4 Gene COMPARTMENTS Subcellular localization image for OR2AT4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2AT4: view

Pathways for OR2AT4 Gene

genes like me logo Genes that share pathways with OR2AT4: view

Pathways by source for OR2AT4 Gene

Interacting Proteins for OR2AT4 Gene

Gene Ontology (GO) - Biological Process for OR2AT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AT4: view

Transcripts for OR2AT4 Gene

mRNA/cDNA for OR2AT4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AT4 Gene

No ASD Table

Relevant External Links for OR2AT4 Gene

GeneLoc Exon Structure for
OR2AT4
ECgene alternative splicing isoforms for
OR2AT4

Expression for OR2AT4 Gene

mRNA expression in normal human tissues for OR2AT4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR2AT4 Gene

SOURCE GeneReport for Unigene cluster for OR2AT4 Gene Hs.554515

genes like me logo Genes that share expressions with OR2AT4: view

Orthologs for OR2AT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2AT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC748690 36
  • 99.06 (n)
  • 99.37 (a)
OR2AT4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR2AT4 36
  • 90.18 (n)
  • 89.64 (a)
OR2AT4 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC609254 36
  • 90.83 (n)
  • 91.59 (a)
OR2AT4 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr520 36
  • 84.95 (n)
  • 88.39 (a)
Olfr520 16
Olfr520 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 75 (a)
OneToMany
-- 37
  • 71 (a)
OneToMany
-- 37
  • 58 (a)
OneToMany
-- 37
  • 62 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr35 36
  • 85.48 (n)
  • 89.03 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii BX088524.1 37
  • 24 (a)
ManyToMany
or102-1 37
  • 29 (a)
ManyToMany
or102-2 37
  • 31 (a)
ManyToMany
or102-3 37
  • 27 (a)
ManyToMany
or102-4 37
  • 27 (a)
ManyToMany
or102-5 37
  • 29 (a)
ManyToMany
or103-1 37
  • 35 (a)
ManyToMany
or103-2 37
  • 33 (a)
ManyToMany
or103-3 37
  • 30 (a)
ManyToMany
or103-4 37
  • 31 (a)
ManyToMany
or104-2 37
  • 31 (a)
ManyToMany
or105-1 37
  • 32 (a)
ManyToMany
or106-1 37
  • 22 (a)
ManyToMany
or106-10 37
  • 25 (a)
ManyToMany
or107-1 37
  • 25 (a)
ManyToMany
or108-1 37
  • 24 (a)
ManyToMany
or108-3 37
  • 23 (a)
ManyToMany
or109-1 37
  • 26 (a)
ManyToMany
or109-11 37
  • 24 (a)
ManyToMany
or109-13 37
  • 26 (a)
ManyToMany
or109-2 37
  • 25 (a)
ManyToMany
or109-4 37
  • 23 (a)
ManyToMany
or109-5 37
  • 24 (a)
ManyToMany
or110-1 37
  • 23 (a)
ManyToMany
or110-2 37
  • 23 (a)
ManyToMany
or111-1 37
  • 25 (a)
ManyToMany
or111-10 37
  • 26 (a)
ManyToMany
or111-11 37
  • 26 (a)
ManyToMany
or111-2 37
  • 25 (a)
ManyToMany
or111-3 37
  • 26 (a)
ManyToMany
or111-4 37
  • 27 (a)
ManyToMany
or111-5 37
  • 27 (a)
ManyToMany
or111-6 37
  • 30 (a)
ManyToMany
or111-7 37
  • 29 (a)
ManyToMany
or111-8 37
  • 24 (a)
ManyToMany
or111-9 37
  • 27 (a)
ManyToMany
Species with no ortholog for OR2AT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR2AT4 Gene

ENSEMBL:
Gene Tree for OR2AT4 (if available)
TreeFam:
Gene Tree for OR2AT4 (if available)

Paralogs for OR2AT4 Gene

Paralogs for OR2AT4 Gene

Selected SIMAP similar genes for OR2AT4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR2AT4 Gene

genes like me logo Genes that share paralogs with OR2AT4: view

Variants for OR2AT4 Gene

Sequence variations from dbSNP and Humsavar for OR2AT4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4146884 -- 75,088,425(+) TTTTT(G/T)ATTTG downstream-variant-500B
rs4944974 -- 75,090,329(+) CTTTC(C/T)GACTC upstream-variant-2KB
rs4944975 -- 75,091,230(+) CCTCT(A/G)TGAAT upstream-variant-2KB
rs7122948 -- 75,089,784(+) AAACC(A/G)TAGAA upstream-variant-2KB
rs11236324 -- 75,089,555(+) ACCAC(A/G)GCCAC reference, synonymous-codon

Relevant External Links for OR2AT4 Gene

HapMap Linkage Disequilibrium report
OR2AT4

No data available for Structural Variations from Database of Genomic Variants (DGV) for OR2AT4 Gene

Disorders for OR2AT4 Gene

Relevant External Links for OR2AT4

Genetic Association Database (GAD)
OR2AT4
genes like me logo Genes that share disorders with OR2AT4: view

No data available for UniProtKB/Swiss-Prot for OR2AT4 Gene

Publications for OR2AT4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4. (PMID: 24999593) Busse D. … Benecke H. (J. Invest. Dermatol. 2014) 3
  3. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PMID: 17068223) Duerr R.H. … Cho J.H. (Science 2006) 49
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for OR2AT4 Gene

  • antibodies-online peptides for OR2AT4
  • antibodies-online antibodies for OR2AT4
  • antibodies-online kits for OR2AT4

Sources for OR2AT4 Gene

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