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Aliases for OR2AT4 Gene

Aliases for OR2AT4 Gene

  • Olfactory Receptor Family 2 Subfamily AT Member 4 2 3 5
  • Olfactory Receptor, Family 2, Subfamily AT, Member 4 2 3
  • Olfactory Receptor OR11-265 Pseudogene 3
  • Olfactory Receptor OR11-265 4
  • OR11-265 3

External Ids for OR2AT4 Gene

Previous GeneCards Identifiers for OR2AT4 Gene

  • GC00U903081
  • GC11M074527
  • GC11M074477
  • GC11M074799

Summaries for OR2AT4 Gene

Entrez Gene Summary for OR2AT4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AT4 Gene

OR2AT4 (Olfactory Receptor Family 2 Subfamily AT Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for OR2AT4 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2AT4 Gene

Genomics for OR2AT4 Gene

Regulatory Elements for OR2AT4 Gene

Genomic Location for OR2AT4 Gene

Chromosome:
11
Start:
75,088,713 bp from pter
End:
75,089,754 bp from pter
Size:
1,042 bases
Orientation:
Minus strand

Genomic View for OR2AT4 Gene

Genes around OR2AT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2AT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2AT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AT4 Gene

Proteins for OR2AT4 Gene

  • Protein details for OR2AT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NND4-O2AT4_HUMAN
    Recommended name:
    Olfactory receptor 2AT4
    Protein Accession:
    A6NND4
    Secondary Accessions:
    • B9EGZ8

    Protein attributes for OR2AT4 Gene

    Size:
    320 amino acids
    Molecular mass:
    35503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AT4 Gene

Proteomics data for OR2AT4 Gene at MOPED

Post-translational modifications for OR2AT4 Gene

  • Glycosylation at Asn 7
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2AT4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AT4 Gene

Domains & Families for OR2AT4 Gene

Gene Families for OR2AT4 Gene

Protein Domains for OR2AT4 Gene

Suggested Antigen Peptide Sequences for OR2AT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NND4

UniProtKB/Swiss-Prot:

O2AT4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AT4: view

Function for OR2AT4 Gene

Molecular function for OR2AT4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2AT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR2AT4: view
genes like me logo Genes that share phenotypes with OR2AT4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2AT4 Gene

Localization for OR2AT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AT4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2AT4 Gene COMPARTMENTS Subcellular localization image for OR2AT4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2AT4: view

Pathways & Interactions for OR2AT4 Gene

genes like me logo Genes that share pathways with OR2AT4: view

Pathways by source for OR2AT4 Gene

Interacting Proteins for OR2AT4 Gene

Gene Ontology (GO) - Biological Process for OR2AT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AT4: view

No data available for SIGNOR curated interactions for OR2AT4 Gene

Drugs & Compounds for OR2AT4 Gene

No Compound Related Data Available

Transcripts for OR2AT4 Gene

mRNA/cDNA for OR2AT4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AT4 Gene

No ASD Table

Relevant External Links for OR2AT4 Gene

GeneLoc Exon Structure for
OR2AT4
ECgene alternative splicing isoforms for
OR2AT4

Expression for OR2AT4 Gene

mRNA expression in normal human tissues for OR2AT4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2AT4 Gene



SOURCE GeneReport for Unigene cluster for OR2AT4 Gene Hs.554515

genes like me logo Genes that share expression patterns with OR2AT4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR2AT4 Gene

Orthologs for OR2AT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2AT4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR2AT4 35
  • 90.18 (n)
  • 89.64 (a)
OR2AT4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC609254 35
  • 90.83 (n)
  • 91.59 (a)
OR2AT4 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr520 35
  • 84.95 (n)
  • 88.39 (a)
Olfr520 16
Olfr520 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC748690 35
  • 99.06 (n)
  • 99.37 (a)
OR2AT4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr35 35
  • 85.48 (n)
  • 89.03 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii or102-1 36
  • 29 (a)
ManyToMany
or102-2 36
  • 31 (a)
ManyToMany
or102-3 36
  • 27 (a)
ManyToMany
or102-4 36
  • 27 (a)
ManyToMany
or102-5 36
  • 29 (a)
ManyToMany
or103-1 36
  • 35 (a)
ManyToMany
or103-2 36
  • 33 (a)
ManyToMany
or103-3 36
  • 30 (a)
ManyToMany
or103-4 36
  • 31 (a)
ManyToMany
or104-2 36
  • 31 (a)
ManyToMany
or105-1 36
  • 32 (a)
ManyToMany
or106-1 36
  • 22 (a)
ManyToMany
or106-10 36
  • 25 (a)
ManyToMany
or107-1 36
  • 25 (a)
ManyToMany
or108-1 36
  • 24 (a)
ManyToMany
or108-3 36
  • 23 (a)
ManyToMany
or109-1 36
  • 26 (a)
ManyToMany
or109-11 36
  • 24 (a)
ManyToMany
or109-13 36
  • 26 (a)
ManyToMany
or109-2 36
  • 25 (a)
ManyToMany
or111-9 36
  • 27 (a)
ManyToMany
or111-8 36
  • 24 (a)
ManyToMany
or111-7 36
  • 29 (a)
ManyToMany
or111-6 36
  • 30 (a)
ManyToMany
or111-5 36
  • 27 (a)
ManyToMany
or111-4 36
  • 27 (a)
ManyToMany
or111-3 36
  • 26 (a)
ManyToMany
or111-2 36
  • 25 (a)
ManyToMany
or111-11 36
  • 26 (a)
ManyToMany
or111-10 36
  • 26 (a)
ManyToMany
or111-1 36
  • 25 (a)
ManyToMany
or110-2 36
  • 23 (a)
ManyToMany
or110-1 36
  • 23 (a)
ManyToMany
or109-5 36
  • 24 (a)
ManyToMany
or109-4 36
  • 23 (a)
ManyToMany
BX088524.1 36
  • 24 (a)
ManyToMany
Species with no ortholog for OR2AT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR2AT4 Gene

ENSEMBL:
Gene Tree for OR2AT4 (if available)
TreeFam:
Gene Tree for OR2AT4 (if available)

Paralogs for OR2AT4 Gene

(458) SIMAP similar genes for OR2AT4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR2AT4 Gene

genes like me logo Genes that share paralogs with OR2AT4: view

No data available for Paralogs for OR2AT4 Gene

Variants for OR2AT4 Gene

Sequence variations from dbSNP and Humsavar for OR2AT4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs4146884 -- 75,088,425(+) TTTTT(G/T)ATTTG downstream-variant-500B
rs4944974 -- 75,090,329(+) CTTTC(C/T)GACTC upstream-variant-2KB
rs4944975 -- 75,091,230(+) CCTCT(A/G)TGAAT upstream-variant-2KB
rs7122948 -- 75,089,784(+) AAACC(A/G)TAGAA upstream-variant-2KB
rs11236324 -- 75,089,555(+) ACCAC(A/G)GCCAC reference, synonymous-codon

Variation tolerance for OR2AT4 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2AT4 Gene

HapMap Linkage Disequilibrium report
OR2AT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR2AT4 Gene

Disorders for OR2AT4 Gene

Relevant External Links for OR2AT4

Genetic Association Database (GAD)
OR2AT4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2AT4

No disorders were found for OR2AT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2AT4 Gene

Publications for OR2AT4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4. (PMID: 24999593) Busse D. … Benecke H. (J. Invest. Dermatol. 2014) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2AT4 Gene

Sources for OR2AT4 Gene

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