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Aliases for OR2AP1 Gene

Aliases for OR2AP1 Gene

  • Olfactory Receptor, Family 2, Subfamily AP, Member 1 2 3
  • Olfactory Receptor, Family 2, Subfamily AP, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR12-9 3 4
  • OR2AP1P 3 4
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor 2AP1 3

External Ids for OR2AP1 Gene

Previous HGNC Symbols for OR2AP1 Gene

  • OR2AP1P

Previous GeneCards Identifiers for OR2AP1 Gene

  • GC12P054255
  • GC12P054256
  • GC12P055968

Summaries for OR2AP1 Gene

Entrez Gene Summary for OR2AP1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AP1 Gene

OR2AP1 (Olfactory Receptor, Family 2, Subfamily AP, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C3.

UniProtKB/Swiss-Prot for OR2AP1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2AP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2AP1 Gene

Genomics for OR2AP1 Gene

Genomic Location for OR2AP1 Gene

Start:
55,574,415 bp from pter
End:
55,575,344 bp from pter
Size:
930 bases
Orientation:
Plus strand

Genomic View for OR2AP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2AP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AP1 Gene

No data available for Regulatory Elements for OR2AP1 Gene

Proteins for OR2AP1 Gene

  • Protein details for OR2AP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGE2-O2AP1_HUMAN
    Recommended name:
    Olfactory receptor 2AP1
    Protein Accession:
    Q8NGE2
    Secondary Accessions:

    Protein attributes for OR2AP1 Gene

    Size:
    309 amino acids
    Molecular mass:
    34902 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AP1 Gene

Proteomics data for OR2AP1 Gene at MOPED

Post-translational modifications for OR2AP1 Gene

Other Protein References for OR2AP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AP1 Gene

Domains for OR2AP1 Gene

Gene Families for OR2AP1 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2AP1 Gene

Suggested Antigen Peptide Sequences for OR2AP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGE2

UniProtKB/Swiss-Prot:

O2AP1_HUMAN :
  • Q8NGE2
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AP1: view

Function for OR2AP1 Gene

Molecular function for OR2AP1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2AP1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2AP1 Gene

Localization for OR2AP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AP1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2AP1 Gene COMPARTMENTS Subcellular localization image for OR2AP1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2AP1: view

Pathways for OR2AP1 Gene

genes like me logo Genes that share pathways with OR2AP1: view

Pathways by source for OR2AP1 Gene

Interacting Proteins for OR2AP1 Gene

Gene Ontology (GO) - Biological Process for OR2AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AP1: view

Transcripts for OR2AP1 Gene

mRNA/cDNA for OR2AP1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AP1 Gene

No ASD Table

Relevant External Links for OR2AP1 Gene

GeneLoc Exon Structure for
OR2AP1
ECgene alternative splicing isoforms for
OR2AP1

Expression for OR2AP1 Gene

mRNA expression in normal human tissues for OR2AP1 Gene

SOURCE GeneReport for Unigene cluster for OR2AP1 Gene Hs.742584

genes like me logo Genes that share expressions with OR2AP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR2AP1 Gene

Orthologs for OR2AP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2AP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC467025 35
  • 99.03 (n)
  • 98.06 (a)
OR2AP1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC515967 35
  • 87.92 (n)
  • 84.79 (a)
OR2AP1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 68 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr765 36
  • 87 (a)
OneToMany
Olfr767 35
  • 86.19 (n)
  • 89.64 (a)
Olfr767 36
  • 90 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr878 35
  • 86.47 (n)
  • 89.29 (a)
Species with no ortholog for OR2AP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2AP1 Gene

ENSEMBL:
Gene Tree for OR2AP1 (if available)
TreeFam:
Gene Tree for OR2AP1 (if available)

Paralogs for OR2AP1 Gene

Paralogs for OR2AP1 Gene

Selected SIMAP similar genes for OR2AP1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR2AP1 Gene

genes like me logo Genes that share paralogs with OR2AP1: view

Variants for OR2AP1 Gene

Sequence variations from dbSNP and Humsavar for OR2AP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1124741 -- 55,574,157(-) ATGAG(A/G)CAAGT upstream-variant-2KB
rs1896038 -- 55,574,714(-) GCAAA(G/T)AAATA missense, reference
rs2371189 -- 55,572,573(-) TTCAG(G/T)CTTTA upstream-variant-2KB
rs2887968 -- 55,572,644(-) AGATG(C/T)CCTCT upstream-variant-2KB
rs3064656 -- 55,573,186(-) ATATA(-/TA)TGTAt upstream-variant-2KB

Relevant External Links for OR2AP1 Gene

HapMap Linkage Disequilibrium report
OR2AP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR2AP1 Gene

Disorders for OR2AP1 Gene

No disorders were found for OR2AP1 Gene.

No data available for UniProtKB/Swiss-Prot for OR2AP1 Gene

Publications for OR2AP1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for OR2AP1 Gene

Sources for OR2AP1 Gene

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