OR2AP1 Gene
protein-coding GIFtS: 33
GCID: GC12P055968
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olfactory receptor, family 2, subfamily AP, member 1(Previous names: olfactory receptor, family 2, subfamily AP, member 1 pseudogene...)
(Previous symbol: OR2AP1P)
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Aliases
for OR2AP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
|---|
| Olfactory Receptor, Family 2, Subfamily AP, Member 11 2 | | OR2AP1P1 2 3 | | Olfactory Receptor, Family 2, Subfamily AP, Member 1 Pseudogene1 2 | | Olfactory Receptor OR12-92 3 | | Olfactory Receptor 2AP12 | | Seven Transmembrane Helix Receptor2 |
Export aliases for OR2AP1 gene to outside databasesPrevious GC identifers: GC12P054255 GC12P054256 |
Summaries
for OR2AP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR2AP1:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: O2AP1_HUMAN, Q8NGE2Function: Odorant receptor (Potential)
Gene Wiki entry for OR2AP1
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Genomic Views
for OR2AP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for OR2AP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR2AP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2AP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.2 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13.2OR2AP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P055968: view genomic region
(about GC identifiers)
Start:
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55,968,199 bp from pter |
End:
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55,969,125 bp from pter |
Size:
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927 bases |
Orientation:
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plus strand |
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Proteins
for OR2AP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: O2AP1_HUMAN, Q8NGE2 (See
protein sequence)Recommended Name: Olfactory receptor 2AP1 Size: 309 amino acids; 34902 Da
Subcellular location: Cell membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for OR2AP1: NX_Q8NGE2
HORDE protein sequence for OR2AP1
OR2AP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001245214.1
ENSEMBL proteins: ENSP00000323423 Reactome Protein details: Q8NGE2
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR2AP1 for ontologies About GeneDecksing
OR2AP1 Antibody Products:
Assay Products for OR2AP1: |
Protein
Domains /
Families
for OR2AP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR2AP1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NGE2ProtoNet protein and cluster: Q8NGE2 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: O2AP1_HUMAN, Q8NGE2Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR2AP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: O2AP1_HUMAN, Q8NGE2Function: Odorant receptor (Potential)
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR2AP1 for ontologies About GeneDecksing
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Pathways & Interactions
for OR2AP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR2AP1
OR2AP1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2AP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/271 Interacting proteins for OR2AP1 (ENSP000003234234) via UniProtKB, MINT, STRING, and/or I2D (see all 271)About this table
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Drugs & Compounds
for OR2AP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR2AP1
Search CenterWatch for drugs/clinical trials and news about OR2AP1 / O2AP1
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Transcripts
for OR2AP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for OR2AP1 gene: NM_001258285.1 Unigene Cluster for OR2AP1: Olfactory receptor, family 2, subfamily AP, member 1 Hs.742584 Unigene Representative Sequence: NM_0012582851 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000321688
GeneLoc Exon Structure
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Expression
for OR2AP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR2AP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OR2AP1 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.742584
SABiosciences Custom PCR Arrays for OR2AP1
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2AP1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat OR2AP1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2AP1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2AP1 |
Orthologs
for OR2AP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for OR2AP1 (if available)
TreeFam Gene Tree for OR2AP1 (if available) |
Paralogs
for OR2AP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR2AP1 gene
- OR6C702 OR6C652 OR6C62 OR6C32 OR6C752 OR6C42 OR6C762 OR6C12
- OR6C682 OR6C22 OR6C742
18/452 SIMAP similar genes for OR2AP1 using alignment to 1 protein entry: O2AP1_HUMAN(see all similar genes):OR6C4 OR6C74 OR6C3 OR6C75 OR6C76 OR6C1
OR6C2 OR6C65 OR6C6 OR6C70 OR6C68 OR6M1
OR6S1 OR6T1 OR10R3P OR2G3 OR5A2 OR6J1
OR2AP1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for OR2AP1
PGOHUM00000239799
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Genomic Variants
for OR2AP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for OR2AP1 ( 55968199 - 55969125 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR2AP1: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for OR2AP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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OR2AP1 for disorders About GeneDecksing
1  disease for OR2AP1: About MalaCardsneuronitis
Export disorders for OR2AP1 gene to outside databases
|
Publications
for OR2AP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for OR2AP1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR2AP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for OR2AP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing OR2AP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing OR2AP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR2AP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR2AP1 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR2AP1 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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About This Section
| Patent Information for OR2AP1 gene:
Search GeneIP for patents involving OR2AP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR2AP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR2AP1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR2AP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2AP1 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR2AP1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2AP1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2AP1 |
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| | | | Search Tocris compounds for OR2AP1 |
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 | | | OR2AP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for OR2AP1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR2AP1 |
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