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Aliases for OR2AK2 Gene

Aliases for OR2AK2 Gene

  • Olfactory Receptor Family 2 Subfamily AK Member 2 2 3 5
  • Olfactory Receptor OR1-47 3 4
  • Olfactory Receptor 2AK1 3 4
  • OR2AK1P 3 4
  • Olfactory Receptor, Family 2, Subfamily AK, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily AK, Member 2 2
  • Olfactory Receptor 2AK2 3
  • OR1-47 3

External Ids for OR2AK2 Gene

Previous HGNC Symbols for OR2AK2 Gene

  • OR2AK1P

Previous GeneCards Identifiers for OR2AK2 Gene

  • GC00U903038
  • GC01P245027
  • GC01P244440
  • GC01P246195
  • GC01P248128

Summaries for OR2AK2 Gene

Entrez Gene Summary for OR2AK2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AK2 Gene

OR2AK2 (Olfactory Receptor Family 2 Subfamily AK Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2L3.

UniProtKB/Swiss-Prot for OR2AK2 Gene

  • Odorant receptor.

Gene Wiki entry for OR2AK2 Gene

Additional gene information for OR2AK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2AK2 Gene

Genomics for OR2AK2 Gene

Regulatory Elements for OR2AK2 Gene

Enhancers for OR2AK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H247966 0.4 Ensembl 0.7 +1.7 1668 0.6 SPI1 OR2T8 OR2AK2 OR2L9P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2AK2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR2AK2 Gene

Genomic Locations for OR2AK2 Gene
1,154 bases
Plus strand

Genomic View for OR2AK2 Gene

Genes around OR2AK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2AK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2AK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AK2 Gene

Proteins for OR2AK2 Gene

  • Protein details for OR2AK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2AK2
    Protein Accession:
    Secondary Accessions:
    • B2RND1
    • Q6IF05

    Protein attributes for OR2AK2 Gene

    335 amino acids
    Molecular mass:
    37763 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC06164.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2AK2 Gene

Post-translational modifications for OR2AK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR2AK2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AK2 Gene

Domains & Families for OR2AK2 Gene

Gene Families for OR2AK2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2AK2 Gene

Suggested Antigen Peptide Sequences for OR2AK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AK2: view

Function for OR2AK2 Gene

Molecular function for OR2AK2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2AK2: view
genes like me logo Genes that share phenotypes with OR2AK2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2AK2 Gene

Localization for OR2AK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AK2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2AK2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2AK2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2AK2 Gene

Pathways & Interactions for OR2AK2 Gene

genes like me logo Genes that share pathways with OR2AK2: view

Pathways by source for OR2AK2 Gene

Interacting Proteins for OR2AK2 Gene

Gene Ontology (GO) - Biological Process for OR2AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AK2: view

No data available for SIGNOR curated interactions for OR2AK2 Gene

Drugs & Compounds for OR2AK2 Gene

No Compound Related Data Available

Transcripts for OR2AK2 Gene

mRNA/cDNA for OR2AK2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AK2 Gene

No ASD Table

Relevant External Links for OR2AK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2AK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2AK2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2AK2 Gene

This gene is overexpressed in Testis (x8.2), Brain - Nucleus accumbens (basal ganglia) (x4.2), and Brain - Spinal cord (cervical c-1) (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of OR2AK2 Gene:


SOURCE GeneReport for Unigene cluster for OR2AK2 Gene:

genes like me logo Genes that share expression patterns with OR2AK2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2AK2 Gene

Orthologs for OR2AK2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2AK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC469755 33
  • 99.3 (n)
(Bos Taurus)
Mammalia OR2AK2 34
  • 78 (a)
(Canis familiaris)
Mammalia OR2AK2 34
  • 78 (a)
(Mus musculus)
Mammalia Or2ak5 52 Olfr318 33 34
  • 77.23 (n)
Or2ak7 52 Olfr320 16 34
  • 75 (a)
Or2ak4 52 Olfr316 34
  • 75 (a)
Or2ak6 52 Olfr319 34
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
Species where no ortholog for OR2AK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2AK2 Gene

Gene Tree for OR2AK2 (if available)
Gene Tree for OR2AK2 (if available)

Paralogs for OR2AK2 Gene

Paralogs for OR2AK2 Gene

(444) SIMAP similar genes for OR2AK2 Gene using alignment to 1 proteins: Pseudogenes for OR2AK2 Gene

genes like me logo Genes that share paralogs with OR2AK2: view

Variants for OR2AK2 Gene

Sequence variations from dbSNP and Humsavar for OR2AK2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001008245 -- 247,966,320(+) ATATG(A/G)CTTCA intron-variant, reference, missense
rs1003403095 -- 247,964,171(+) GCCTC(C/T)AGTGA intron-variant, upstream-variant-2KB
rs1005234155 -- 247,965,280(+) TTTAT(C/T)TCTGA intron-variant, upstream-variant-2KB
rs1005522643 -- 247,964,462(+) ACTCT(A/T)TTGGA intron-variant, upstream-variant-2KB
rs1005986418 -- 247,964,195(+) GACAC(A/G)TTCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2AK2 Gene

Variant ID Type Subtype PubMed ID
nsv549603 CNV loss 21841781
nsv549604 CNV gain 21841781
nsv9080 CNV gain 18304495
nsv549602 CNV loss 21841781
nsv549601 CNV loss 21841781
nsv549597 CNV gain 21841781
nsv515858 CNV gain+loss 19592680
nsv508070 OTHER sequence alteration 20534489
nsv1013273 CNV gain 25217958
nsv1008024 CNV gain 25217958
esv3891415 CNV gain 25118596
esv3589522 CNV gain 21293372
esv34503 CNV gain 17911159
esv33129 CNV gain+loss 17666407
esv2762235 CNV gain 21179565
esv2759014 CNV gain+loss 17122850
esv2750832 CNV gain 17911159
esv2727929 CNV deletion 23290073
dgv608n100 CNV gain 25217958
dgv607n100 CNV loss 25217958
dgv606n100 CNV gain 25217958
dgv605n100 CNV gain 25217958
dgv604n100 CNV gain 25217958

Variation tolerance for OR2AK2 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.19; 90.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2AK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2AK2 Gene

Disorders for OR2AK2 Gene

Relevant External Links for OR2AK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR2AK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2AK2 Gene

Publications for OR2AK2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR2AK2 Gene

Sources for OR2AK2 Gene

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