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Aliases for OR2AJ1 Gene

Aliases for OR2AJ1 Gene

  • Olfactory Receptor Family 2 Subfamily AJ Member 1 2 3 5
  • Olfactory Receptor, Family 2, Subfamily AJ, Member 1 Pseudogene 2 3
  • OR2AJ1P 3 4
  • Olfactory Receptor, Family 2, Subfamily AJ, Member 1 2
  • Olfactory Receptor OR1-52 3
  • OR2AJ1Q 3

External Ids for OR2AJ1 Gene

Previous HGNC Symbols for OR2AJ1 Gene

  • OR2AJ1P

Previous GeneCards Identifiers for OR2AJ1 Gene

  • GC01U901046
  • GC01P244423
  • GC01P246163
  • GC01P248097

Summaries for OR2AJ1 Gene

Entrez Gene Summary for OR2AJ1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AJ1 Gene

OR2AJ1 (Olfactory Receptor Family 2 Subfamily AJ Member 1) is a Pseudogene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2L2.

UniProtKB/Swiss-Prot for OR2AJ1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2AJ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2AJ1 Gene

Genomics for OR2AJ1 Gene

Regulatory Elements for OR2AJ1 Gene

Enhancers for OR2AJ1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F247905 1.1 Ensembl ENCODE 11 -27.0 -26966 2.0 HDAC1 PKNOX1 ZBTB40 FOS ZBTB2 POLR2H SMARCA4 PBX2 THRAP3 IKZF1 OR2AJ1 TRIM58 OR2T8 OR2T12 OR2W3
GH01F247858 1 Ensembl ENCODE 10.6 -74.7 -74682 0.6 BCOR HDAC1 PKNOX1 TAL1 ZNF316 FOXK2 NCOR1 TRIM24 ZSCAN29 NFE2 TRIM58 OR2AJ1 OR2T8 CLK3P2 OR2L13 OR2X1P PIR41167
GH01F247852 0.6 Ensembl 11.2 -81.0 -80966 0.8 MAFG MAFF ZNF316 HMBOX1 NFE2 MAFK EMSY SPI1 TRIM58 OR2AJ1 OR11L1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2AJ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2AJ1 Gene

Chromosome:
1
Start:
247,933,766 bp from pter
End:
247,934,819 bp from pter
Size:
1,054 bases
Orientation:
Plus strand

Genomic View for OR2AJ1 Gene

Genes around OR2AJ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2AJ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2AJ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AJ1 Gene

Proteins for OR2AJ1 Gene

  • Protein details for OR2AJ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGZ0-O2AJ1_HUMAN
    Recommended name:
    Olfactory receptor 2AJ1
    Protein Accession:
    Q8NGZ0

    Protein attributes for OR2AJ1 Gene

    Size:
    328 amino acids
    Molecular mass:
    37063 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AJ1 Gene

Post-translational modifications for OR2AJ1 Gene

Other Protein References for OR2AJ1 Gene

ENSEMBL proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AJ1 Gene

Domains & Families for OR2AJ1 Gene

Gene Families for OR2AJ1 Gene

Protein Domains for OR2AJ1 Gene

Suggested Antigen Peptide Sequences for OR2AJ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGZ0

UniProtKB/Swiss-Prot:

O2AJ1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AJ1: view

Function for OR2AJ1 Gene

Molecular function for OR2AJ1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2AJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2AJ1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2AJ1 Gene

Localization for OR2AJ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AJ1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2AJ1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2AJ1: view

Pathways & Interactions for OR2AJ1 Gene

genes like me logo Genes that share pathways with OR2AJ1: view

Pathways by source for OR2AJ1 Gene

Interacting Proteins for OR2AJ1 Gene

Gene Ontology (GO) - Biological Process for OR2AJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AJ1: view

No data available for SIGNOR curated interactions for OR2AJ1 Gene

Transcripts for OR2AJ1 Gene

mRNA/cDNA for OR2AJ1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AJ1 Gene

No ASD Table

Relevant External Links for OR2AJ1 Gene

GeneLoc Exon Structure for
OR2AJ1
ECgene alternative splicing isoforms for
OR2AJ1

Expression for OR2AJ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2AJ1 Gene

mRNA differential expression in normal tissues according to GTEx for OR2AJ1 Gene

This gene is overexpressed in Spleen (x9.0), Brain - Frontal Cortex (BA9) (x5.8), Brain - Hippocampus (x5.4), Brain - Hypothalamus (x4.6), Brain - Anterior cingulate cortex (BA24) (x4.5), and Brain - Spinal cord (cervical c-1) (x4.4).

Protein differential expression in normal tissues from HIPED for OR2AJ1 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2AJ1 Gene



Protein tissue co-expression partners for OR2AJ1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2AJ1 Gene:

OR2AJ1
genes like me logo Genes that share expression patterns with OR2AJ1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR2AJ1 Gene

Orthologs for OR2AJ1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2AJ1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Or2aj4 55 Olfr169 35
  • 79 (a)
OneToMany
Or2aj6 55 Olfr171 35
  • 78 (a)
OneToMany
Or2aj5 55 Olfr170 35
  • 77 (a)
OneToMany
cow
(Bos Taurus)
Mammalia OR2AJ1 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR2AJ1 35
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 50 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
Species where no ortholog for OR2AJ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2AJ1 Gene

ENSEMBL:
Gene Tree for OR2AJ1 (if available)
TreeFam:
Gene Tree for OR2AJ1 (if available)

Paralogs for OR2AJ1 Gene

Paralogs for OR2AJ1 Gene

(436) SIMAP similar genes for OR2AJ1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR2AJ1 Gene

genes like me logo Genes that share paralogs with OR2AJ1: view

Variants for OR2AJ1 Gene

Variation tolerance for OR2AJ1 Gene

Gene Damage Index Score: 2.36; 41.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2AJ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2AJ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for OR2AJ1 Gene

Disorders for OR2AJ1 Gene

No disorders were found for OR2AJ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for OR2AJ1 Gene

Publications for OR2AJ1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 64

Products for OR2AJ1 Gene

Sources for OR2AJ1 Gene

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