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Aliases for OR2AG2 Gene

Aliases for OR2AG2 Gene

  • Olfactory Receptor, Family 2, Subfamily AG, Member 2 2 3
  • OR2AG2P 3 4
  • Olfactory Receptor, Family 2, Subfamily AG, Member 2 Pseudogene 3
  • Olfactory Receptor OR11-76 Pseudogene 3
  • Olfactory Receptor 2AG2 3
  • OR11-76 3

External Ids for OR2AG2 Gene

Previous HGNC Symbols for OR2AG2 Gene

  • OR2AG2P

Previous GeneCards Identifiers for OR2AG2 Gene

  • GC11M006754
  • GC11M006745
  • GC11M006790

Summaries for OR2AG2 Gene

Entrez Gene Summary for OR2AG2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AG2 Gene

OR2AG2 (Olfactory Receptor, Family 2, Subfamily AG, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2AG2 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2AG2 Gene

Genomics for OR2AG2 Gene

Regulatory Elements for OR2AG2 Gene

Genomic Location for OR2AG2 Gene

Start:
6,767,987 bp from pter
End:
6,769,055 bp from pter
Size:
1,069 bases
Orientation:
Minus strand

Genomic View for OR2AG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2AG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AG2 Gene

Proteins for OR2AG2 Gene

  • Protein details for OR2AG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NM03-O2AG2_HUMAN
    Recommended name:
    Olfactory receptor 2AG2
    Protein Accession:
    A6NM03
    Secondary Accessions:

    Protein attributes for OR2AG2 Gene

    Size:
    316 amino acids
    Molecular mass:
    35270 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AG2 Gene

Proteomics data for OR2AG2 Gene at MOPED

Post-translational modifications for OR2AG2 Gene

  • Glycosylation at Asn5 and Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2AG2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AG2 Gene

Domains for OR2AG2 Gene

Gene Families for OR2AG2 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2AG2 Gene

Suggested Antigen Peptide Sequences for OR2AG2 Gene

Graphical View of Domain Structure for InterPro Entry

A6NM03

UniProtKB/Swiss-Prot:

O2AG2_HUMAN :
  • A6NM03
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AG2: view

Function for OR2AG2 Gene

Molecular function for OR2AG2 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2AG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2AG2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2AG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2AG2 Gene

Localization for OR2AG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AG2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2AG2 Gene COMPARTMENTS Subcellular localization image for OR2AG2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2AG2: view

Pathways for OR2AG2 Gene

genes like me logo Genes that share pathways with OR2AG2: view

Pathways by source for OR2AG2 Gene

Interacting Proteins for OR2AG2 Gene

Gene Ontology (GO) - Biological Process for OR2AG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AG2: view

Transcripts for OR2AG2 Gene

mRNA/cDNA for OR2AG2 Gene

(1) Selected AceView cDNA sequences:
(6) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2AG2 Gene

Olfactory receptor, family 2, subfamily AG, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2AG2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR2AG2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AG2 Gene

No ASD Table

Relevant External Links for OR2AG2 Gene

GeneLoc Exon Structure for
OR2AG2
ECgene alternative splicing isoforms for
OR2AG2

Expression for OR2AG2 Gene

mRNA expression in normal human tissues for OR2AG2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2AG2 Gene

This gene is overexpressed in Testis (4.5), Brain - Nucleus accumbens (basal ganglia) (4.1), and Brain - Frontal Cortex (BA9) (4.0).

SOURCE GeneReport for Unigene cluster for OR2AG2 Gene Hs.534614

genes like me logo Genes that share expressions with OR2AG2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for OR2AG2 Gene

Orthologs for OR2AG2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2AG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466416 35
  • 98.63 (n)
  • 98.1 (a)
OR2AG2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 81 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
OR2AG1 35
  • 83.76 (n)
  • 82.48 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 82 (a)
OneToMany
cOR2AG1 35
  • 84.23 (n)
  • 81.9 (a)
mouse
(Mus musculus)
Mammalia Olfr693 36
  • 73 (a)
ManyToMany
Olfr694 36
  • 77 (a)
ManyToMany
Olfr695 36
  • 75 (a)
ManyToMany
Olfr697 36
  • 73 (a)
ManyToMany
Olfr698 36
  • 77 (a)
ManyToMany
Olfr699 36
  • 72 (a)
ManyToMany
Olfr700 36
  • 78 (a)
ManyToMany
Olfr701 35
  • 81.75 (n)
  • 80.38 (a)
Olfr701 36
  • 80 (a)
ManyToMany
Olfr703 36
  • 74 (a)
ManyToMany
Olfr704 36
  • 75 (a)
ManyToMany
Olfr705 36
  • 80 (a)
ManyToMany
Olfr706 16
Olfr706 36
  • 82 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr210 35
  • 80.59 (n)
  • 79.75 (a)
Species with no ortholog for OR2AG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2AG2 Gene

ENSEMBL:
Gene Tree for OR2AG2 (if available)
TreeFam:
Gene Tree for OR2AG2 (if available)

Paralogs for OR2AG2 Gene

Selected SIMAP similar genes for OR2AG2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR2AG2: view

Variants for OR2AG2 Gene

Sequence variations from dbSNP and Humsavar for OR2AG2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs530667 -- 6,770,663(-) TTTGG(A/G)CTTGT upstream-variant-2KB
rs670151 -- 6,769,920(-) AAAGC(A/G)AGCCA upstream-variant-2KB
rs7102536 - 6,768,875(+) TAGCA(C/T)AGAGC reference, missense
rs7103980 -- 6,770,162(+) tcaat(A/C)aatat upstream-variant-2KB
rs7924459 - 6,768,063(+) GGCCC(C/G)CATGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR2AG2 Gene

Variant ID Type Subtype PubMed ID
nsv832060 CNV Gain 17160897
nsv467701 CNV Loss 19166990

Relevant External Links for OR2AG2 Gene

HapMap Linkage Disequilibrium report
OR2AG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2AG2 Gene

Disorders for OR2AG2 Gene

No disorders were found for OR2AG2 Gene.

No data available for UniProtKB/Swiss-Prot for OR2AG2 Gene

Publications for OR2AG2 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for OR2AG2 Gene

  • antibodies-online peptides for OR2AG2
  • antibodies-online antibodies for OR2AG2
  • antibodies-online kits for OR2AG2

Sources for OR2AG2 Gene

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