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Aliases for OR2AG2 Gene

Aliases for OR2AG2 Gene

  • Olfactory Receptor Family 2 Subfamily AG Member 2 2 3 5
  • OR2AG2P 3 4
  • Olfactory Receptor, Family 2, Subfamily AG, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily AG, Member 2 2
  • Olfactory Receptor OR11-76 Pseudogene 3
  • Olfactory Receptor 2AG2 3
  • OR11-76 3

External Ids for OR2AG2 Gene

Previous HGNC Symbols for OR2AG2 Gene

  • OR2AG2P

Previous GeneCards Identifiers for OR2AG2 Gene

  • GC11M006754
  • GC11M006745
  • GC11M006790

Summaries for OR2AG2 Gene

Entrez Gene Summary for OR2AG2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AG2 Gene

OR2AG2 (Olfactory Receptor Family 2 Subfamily AG Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2AG1.

UniProtKB/Swiss-Prot for OR2AG2 Gene

  • Odorant receptor.

Additional gene information for OR2AG2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2AG2 Gene

Genomics for OR2AG2 Gene

Regulatory Elements for OR2AG2 Gene

Enhancers for OR2AG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H006742 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.2 +181.2 181194 6 HDAC1 PKNOX1 RB1 NFRKB SIN3A YBX1 BATF TCF12 ZNF766 GATA2 ILK OR2AG2 CAVIN3 RRP8 ENSG00000254641 TAF10 OR10A4 APBB1 SMPD1 OR2AG1
GH11H006693 1.4 Ensembl ENCODE dbSUPER 10.5 +231.4 231427 3 HDAC1 PKNOX1 TCF12 ZNF121 ATF7 CAVIN1 ZBTB11 HDAC8 NR2F2 ZNF592 RRP8 OLFML1 GVINP2 OR2AG2 ILK LOC644169 ENSG00000254400 TIMM10B ENSG00000254641 TAF10
GH11H006468 1.4 FANTOM5 Ensembl ENCODE 9.8 +457.1 457055 1 HDGF PKNOX1 GLIS2 POLR2A ZBTB48 PATZ1 ATF7 CREM MAZ SP3 OR56A1 OR10A4 OR2AG2 OR10A2 OR56A4 OR52W1 OR2AG1 OR56B4 OR10A5 OR6A2
GH11H006737 0.9 ENCODE dbSUPER 10.3 +188.4 188352 0 CTCF ZNF654 TRIM22 REST RAD21 ZNF143 SMC3 RUNX3 OR2AG2 GC11P006733 PIR50704
GH11H006733 0.6 ENCODE dbSUPER 11.2 +191.9 191859 2 JUN OR2AG2 GVINP1 GC11P006733 PIR50704
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2AG2 on UCSC Golden Path with GeneCards custom track

Promoters for OR2AG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036337 -374 1601 HDGF PKNOX1 ATF1 ARNT ZNF2 ETS1 GLIS2 GATA2 ELK1 ATF7

Genomic Location for OR2AG2 Gene

Chromosome:
11
Start:
6,765,626 bp from pter
End:
6,926,426 bp from pter
Size:
160,801 bases
Orientation:
Minus strand

Genomic View for OR2AG2 Gene

Genes around OR2AG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2AG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2AG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AG2 Gene

Proteins for OR2AG2 Gene

  • Protein details for OR2AG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NM03-O2AG2_HUMAN
    Recommended name:
    Olfactory receptor 2AG2
    Protein Accession:
    A6NM03

    Protein attributes for OR2AG2 Gene

    Size:
    316 amino acids
    Molecular mass:
    35270 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AG2 Gene

Post-translational modifications for OR2AG2 Gene

  • Glycosylation at Asn5 and Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2AG2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AG2 Gene

Domains & Families for OR2AG2 Gene

Gene Families for OR2AG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2AG2 Gene

Suggested Antigen Peptide Sequences for OR2AG2 Gene

Graphical View of Domain Structure for InterPro Entry

A6NM03

UniProtKB/Swiss-Prot:

O2AG2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AG2: view

Function for OR2AG2 Gene

Molecular function for OR2AG2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2AG2 Gene

Gene Ontology (GO) - Molecular Function for OR2AG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2AG2: view

Phenotypes for OR2AG2 Gene

genes like me logo Genes that share phenotypes with OR2AG2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2AG2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2AG2 Gene

Localization for OR2AG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AG2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2AG2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2AG2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2AG2 Gene

Pathways & Interactions for OR2AG2 Gene

genes like me logo Genes that share pathways with OR2AG2: view

Pathways by source for OR2AG2 Gene

Interacting Proteins for OR2AG2 Gene

Gene Ontology (GO) - Biological Process for OR2AG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AG2: view

No data available for SIGNOR curated interactions for OR2AG2 Gene

Drugs & Compounds for OR2AG2 Gene

No Compound Related Data Available

Transcripts for OR2AG2 Gene

mRNA/cDNA for OR2AG2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2AG2 Gene

Olfactory receptor, family 2, subfamily AG, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2AG2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AG2 Gene

No ASD Table

Relevant External Links for OR2AG2 Gene

GeneLoc Exon Structure for
OR2AG2
ECgene alternative splicing isoforms for
OR2AG2

Expression for OR2AG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2AG2 Gene

mRNA differential expression in normal tissues according to GTEx for OR2AG2 Gene

This gene is overexpressed in Testis (x4.5), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Frontal Cortex (BA9) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of OR2AG2 Gene:

OR2AG2

SOURCE GeneReport for Unigene cluster for OR2AG2 Gene:

Hs.534614
genes like me logo Genes that share expression patterns with OR2AG2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2AG2 Gene

Orthologs for OR2AG2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2AG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466416 33
  • 98.63 (n)
OR2AG2 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cOR2AG1 33
  • 84.23 (n)
-- 34
  • 82 (a)
OneToMany
cow
(Bos Taurus)
Mammalia OR2AG1 33
  • 83.76 (n)
-- 34
  • 83 (a)
ManyToMany
-- 34
  • 82 (a)
ManyToMany
-- 34
  • 81 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Or2ag2 52 Olfr706 34
  • 82 (a)
ManyToMany
Or2ag2b 52 Olfr701 33 16 34
  • 81.75 (n)
Olfr705 34
  • 80 (a)
ManyToMany
Olfr700 34
  • 78 (a)
ManyToMany
Olfr694 34
  • 77 (a)
ManyToMany
Olfr698 34
  • 77 (a)
ManyToMany
Olfr695 34
  • 75 (a)
ManyToMany
Olfr704 34
  • 75 (a)
ManyToMany
Or2ag19 52 Olfr703 34
  • 74 (a)
ManyToMany
Olfr693 34
  • 73 (a)
ManyToMany
Or2ag15 52 Olfr697 34
  • 73 (a)
ManyToMany
Olfr699 34
  • 72 (a)
ManyToMany
Or2ag14-ps 52 Olfr696-ps1
  • chr7:106,728,914-106,729,819
rat
(Rattus norvegicus)
Mammalia Olr210 33
  • 80.59 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
ManyToMany
-- 34
  • 70 (a)
ManyToMany
-- 34
  • 67 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 49 (a)
OneToMany
Species where no ortholog for OR2AG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2AG2 Gene

ENSEMBL:
Gene Tree for OR2AG2 (if available)
TreeFam:
Gene Tree for OR2AG2 (if available)

Paralogs for OR2AG2 Gene

Paralogs for OR2AG2 Gene

(451) SIMAP similar genes for OR2AG2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR2AG2: view

Variants for OR2AG2 Gene

Sequence variations from dbSNP and Humsavar for OR2AG2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000426883 -- 6,770,001(+) GATCA(A/G)ATTAT upstream-variant-2KB
rs1001211548 -- 6,770,616(+) CTGAC(C/G)CACTG upstream-variant-2KB
rs1004108249 -- 6,769,272(+) TTTCT(G/T)CACAA upstream-variant-2KB
rs1004836875 -- 6,767,718(+) GCCTA(C/G)CACAG downstream-variant-500B
rs1008403628 -- 6,767,865(+) TAAAA(A/G)TAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR2AG2 Gene

Variant ID Type Subtype PubMed ID
dgv1055n100 CNV loss 25217958
dgv1056n100 CNV loss 25217958
dgv1625n54 CNV loss 21841781
dgv1626n54 CNV loss 21841781
esv3579329 CNV loss 25503493
nsv1035138 CNV gain 25217958
nsv1043006 CNV loss 25217958
nsv1046129 CNV loss 25217958
nsv467701 CNV loss 19166990
nsv832060 CNV gain 17160897
nsv971984 CNV duplication 23825009

Variation tolerance for OR2AG2 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.09; 87.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2AG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2AG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2AG2 Gene

Disorders for OR2AG2 Gene

Relevant External Links for OR2AG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2AG2

No disorders were found for OR2AG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2AG2 Gene

Publications for OR2AG2 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 60
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 60
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR2AG2 Gene

Sources for OR2AG2 Gene

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