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OR2AG1 Gene

protein-coding   GIFtS: 50
GCID: GC11P006806

Olfactory Receptor, Family 2, Subfamily AG, Member 1


(Previous symbol: OR2AG3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily AG, Member 11 2     HT3 Olfactory Receptor2
OR2AG31 2 3     Olfactory Receptor 2AG12
Olfactory Receptor 2AG32 3     Olfactory Receptor, Family 2, Subfamily AG, Member 32
Olfactory Receptor OR11-792 3     HT33
OR11-792     

External Ids:    HGNC: 151421   Entrez Gene: 1441252   Ensembl: ENSG000001708037   UniProtKB: Q9H2053   

Export aliases for OR2AG1 gene to outside databases

Previous GC identifers: GC11U990571 GC11P006771 GC11P006762


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2AG1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2AG1 Gene:
OR2AG1 (olfactory receptor, family 2, subfamily AG, member 1) is a protein-coding gene. Diseases associated with OR2AG1 include telangiectasis, and hereditary hemorrhagic telangiectasia. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T35.

UniProtKB/Swiss-Prot: O2AG1_HUMAN, Q9H205
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2AG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2AG1 gene promoter:
         USF1   C/EBPbeta   GATA-3   SREBP-1c   NF-kappaB   Arnt   SREBP-1b   SREBP-1a   Sox9   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2AG1 promoter sequence
   Search Chromatin IP Primers for OR2AG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2AG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR2AG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2AG1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P006806:  view genomic region     (about GC identifiers)

Start:
6,806,269 bp from pter      End:
6,807,216 bp from pter
Size:
948 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: O2AG1_HUMAN, Q9H205 (See protein sequence)
Recommended Name: Olfactory receptor 2AG1  
Size: 316 amino acids; 35270 Da
Secondary accessions: B9EKV7 Q6IFG7 Q96R26

Explore the universe of human proteins at neXtProt for OR2AG1: NX_Q9H205

Explore proteomics data for OR2AG1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn19
  • HORDE protein sequence for OR2AG1

    See OR2AG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004489.1  
    ENSEMBL proteins: 
     ENSP00000307447  
    Reactome Protein details: Q9H205

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9H205

    ProtoNet protein and cluster: Q9H205

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O2AG1_HUMAN, Q9H205
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR2AG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O2AG1_HUMAN, Q9H205
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
    GO:0005515protein binding IPI19909339
         
    OR2AG1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR2AG1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O2AG1_HUMAN, Q9H205: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR2AG1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2AG1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR2AG1
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR2AG1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2AG1):
        Olfactory transduction


    OR2AG1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2AG1
    Interactions:

        Search GeneGlobe Interaction Network for OR2AG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR2AG1 (Q9H2051, 2, 3 ENSP000003074474) via UniProtKB, MINT, STRING, and/or I2D (see all 274)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPDZO759701, 2, 3, ENSP000003704104EBI-7590304,EBI-821405 MINT-7289933 MINT-7290250 MINT-7289999 MINT-7289954 MINT-7290110 MINT-7289978 MINT-7290063 MINT-7290305 I2D: score=1 STRING: ENSP00000370410
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR14A16ENSP000003502484STRING: ENSP00000350248
    OR1D2ENSP000003275854STRING: ENSP00000327585
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR2AG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2AG1 (O2AG1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR2AG1 gene: 
    NM_001004489.2  

    Unigene Cluster for OR2AG1:

    Olfactory receptor, family 2, subfamily AG, member 1
    Hs.553608
    Unigene Representative Sequence: NM_001004489
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000307401(uc001mer.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR2AG1

    Additional mRNA sequence: BC151143.1 

    1 AceView cDNA sequence:

    NM_001004489 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2AG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCAGCAC
    OR2AG1 Expression
    About this image

    OR2AG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2AG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553608
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2AG1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr7051 , 5 olfactory receptor 7051, 5 83.12(n)1
    82.59(a)1
      7 (56.10 cM)5
    2590341  NM_147032.21  NP_667243.21 
     1068732935 


    ENSEMBL Gene Tree for OR2AG1 (if available)
    TreeFam Gene Tree for OR2AG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2AG1 gene
    OR2T352  OR2V22  OR2V12  OR2M32  OR2T72  OR2M72  OR2T82  OR2M42  
    OR2T22  OR2T122  OR2T272  OR2M52  OR2Z12  OR2T332  OR2T52  OR2T102  
    OR2M22  OR2T42  OR2T342  OR2T112  OR2T292  OR2T62  OR2T12  OR2AG22  
    OR2T32  
    Selected SIMAP similar genes for OR2AG1 using alignment to 1 protein entry:     O2AG1_HUMAN(see all similar genes):
    OR2AG2    OR2T2    OR2T35    OR2T6    OR2T11    OR2M2
    OR2M3    OR2T1    OR2T10    OR2T27    OR2T29    OR2T7
    OR2Z1    OR2AK2    OR2M5    OR2M7    OR2T4    OR2T5

    OR2AG1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for OR2AG1
    PGOHUM00000244546 PGOHUM00000245308


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2AG1 (see all 129)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs14639541,2
    C,F--6804267(-) CTGGGG/TTCAGG 1 -- us2k111Minor allele frequency- T:0.28MN NA WA CSA EA 556
    rs1879352211,2
    --6804276(+) AGCAAC/GAATGA 1 -- us2k10--------
    rs1494925571,2
    --6804290(+) AAAGTC/GTGAGT 1 -- us2k10--------
    rs1439643721,2
    --6804386(+) TAGTTC/TTTCAC 1 -- us2k10--------
    rs6597841,2
    C,H--6804395(-) CTCACA/GCCTGT 1 -- us2k114Minor allele frequency- G:0.01NA WA CSA EA 377
    rs122868121,2
    C,F,A--6804461(+) GTCTGC/TCTGCA 1 -- us2k110Minor allele frequency- T:0.22NA WA CSA EA 372
    rs1164020921,2
    C,F--6804468(+) TGCATC/TCACTG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs122868191,2
    C,F--6804491(+) TAGACC/TTGCAG 1 -- us2k110Minor allele frequency- T:0.23NA WA CSA EA 372
    rs108396211,2
    C,F,A,H--6804497(+) TGCAGA/GTAAGT 1 -- us2k110Minor allele frequency- G:0.19NA WA CSA EA 374
    rs79327811,2
    C,F,H--6804645(+) GAACTT/CCAAAC 1 -- us2k14Minor allele frequency- C:0.00NS EA 398

    HapMap Linkage Disequilibrium report for OR2AG1 ( 6806269 - 6807216 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR2AG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv467701CNV Loss19166990
    nsv832060CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for OR2AG1:    
    About MalaCards
    telangiectasis    hereditary hemorrhagic telangiectasia    cervical cancer    neuronitis
    cervicitis

    1 disease from the University of Copenhagen DISEASES database for OR2AG1:
    Cervical cancer

    OR2AG1 for disorders           About GeneDecksing


    Export disorders for OR2AG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2AG1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2AG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. Genomic analysis of orthologous mouse and human olfactory receptor loci. (PubMed id 11416212)1, 2 Lane R.P.... Trask B.J. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    4. Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1. (PubMed id 19909339)1 Dooley R....Neuhaus E.M. (FEBS J. 2009)
    5. A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins. (PubMed id 16565291)1 Neuhaus E.M....Hatt H. (Chem. Senses 2006)
    6. Beta-arrestin2-mediated internalization of mammalian odorant receptors. (PubMed id 17005854)1 Mashukova A....Neuhaus E.M. (J. Neurosci. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 144125 HGNC: 15142 AceView: OR2AG1 Ensembl:ENSG00000170803 euGenes: HUgn144125
    ECgene: OR2AG1 Kegg: 144125 H-InvDB: OR2AG1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2AG1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2AG1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2AG1 gene:
    Search GeneIP for patents involving OR2AG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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