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Aliases for OR2AG1 Gene

Aliases for OR2AG1 Gene

  • Olfactory Receptor Family 2 Subfamily AG Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR11-79 3 4
  • Olfactory Receptor 2AG3 3 4
  • OR2AG3 3 4
  • Olfactory Receptor, Family 2, Subfamily AG, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 2, Subfamily AG, Member 1 3
  • Olfactory Receptor, Family 2, Subfamily AG, Member 3 3
  • Olfactory Receptor 2AG1 3
  • HT3 Olfactory Receptor 3
  • OR11-79 3
  • HT3 4

External Ids for OR2AG1 Gene

Previous HGNC Symbols for OR2AG1 Gene

  • OR2AG3

Previous GeneCards Identifiers for OR2AG1 Gene

  • GC11U990571
  • GC11P006771
  • GC11P006762

Summaries for OR2AG1 Gene

Entrez Gene Summary for OR2AG1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]

GeneCards Summary for OR2AG1 Gene

OR2AG1 (Olfactory Receptor Family 2 Subfamily AG Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2AG2.

UniProtKB/Swiss-Prot for OR2AG1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2AG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2AG1 Gene

Genomics for OR2AG1 Gene

Regulatory Elements for OR2AG1 Gene

Enhancers for OR2AG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F006742 1.2 FANTOM5 ENCODE 7.9 -39.8 -39785 6.5 TBP HDAC1 PKNOX1 CBX3 NFRKB YBX1 GATA2 CBX5 SMAD5 CEBPB OR2AG2 ILK RRP8 ENSG00000254641 TAF10 OR10A4 APBB1 SMPD1 OR2AG1 GVINP1
GH11F006812 0.7 ENCODE 10.7 +27.6 27568 0.2 CTCF PKNOX1 ZNF654 L3MBTL2 MAX TRIM22 RAD21 KLF16 PBX2 ZNF143 OR2AG1 OR6A2 GC11P006840
GH11F006468 1.4 FANTOM5 Ensembl ENCODE 5.2 -315.6 -315646 1.5 HDGF PKNOX1 WRNIP1 GLIS2 ZBTB48 POLR2A PATZ1 CREM ZNF263 SP3 OR56A1 OR10A4 OR2AG2 OR10A2 OR56A4 OR52W1 OR2AG1 OR56B4 OR10A5 OR6A2
GH11F006817 0.5 ENCODE 10.5 +32.8 32828 0.1 CTCF SMARCA4 POLR2A TEAD4 OR2AG1 OR6A2 GC11P006840
GH11F006719 0.4 ENCODE 9.7 -65.3 -65270 0.6 MNT RPL21P94 MRPL17 DCHS1 ENSG00000255390 TPP1 OR2AG2 OR2AG1 PIR51504 GC11P006733
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2AG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2AG1 Gene

Chromosome:
11
Start:
6,785,017 bp from pter
End:
6,786,014 bp from pter
Size:
998 bases
Orientation:
Plus strand

Genomic View for OR2AG1 Gene

Genes around OR2AG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2AG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2AG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AG1 Gene

Proteins for OR2AG1 Gene

  • Protein details for OR2AG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H205-O2AG1_HUMAN
    Recommended name:
    Olfactory receptor 2AG1
    Protein Accession:
    Q9H205
    Secondary Accessions:
    • B9EKV7
    • Q6IFG7
    • Q96R26

    Protein attributes for OR2AG1 Gene

    Size:
    316 amino acids
    Molecular mass:
    35270 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AG1 Gene

Post-translational modifications for OR2AG1 Gene

  • Glycosylation at Asn 5 and Asn 19

Other Protein References for OR2AG1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AG1 Gene

Domains & Families for OR2AG1 Gene

Gene Families for OR2AG1 Gene

Protein Domains for OR2AG1 Gene

Suggested Antigen Peptide Sequences for OR2AG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H205

UniProtKB/Swiss-Prot:

O2AG1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AG1: view

Function for OR2AG1 Gene

Molecular function for OR2AG1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2AG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005515 protein binding IPI 19909339
genes like me logo Genes that share ontologies with OR2AG1: view
genes like me logo Genes that share phenotypes with OR2AG1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2AG1 Gene

Localization for OR2AG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AG1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2AG1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2AG1: view

Pathways & Interactions for OR2AG1 Gene

genes like me logo Genes that share pathways with OR2AG1: view

Pathways by source for OR2AG1 Gene

1 BioSystems pathway for OR2AG1 Gene
1 KEGG pathway for OR2AG1 Gene

Gene Ontology (GO) - Biological Process for OR2AG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AG1: view

No data available for SIGNOR curated interactions for OR2AG1 Gene

Transcripts for OR2AG1 Gene

mRNA/cDNA for OR2AG1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AG1 Gene

No ASD Table

Relevant External Links for OR2AG1 Gene

GeneLoc Exon Structure for
OR2AG1
ECgene alternative splicing isoforms for
OR2AG1

Expression for OR2AG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR2AG1 Gene

Protein differential expression in normal tissues from HIPED for OR2AG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2AG1 Gene



Protein tissue co-expression partners for OR2AG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2AG1 Gene:

OR2AG1

SOURCE GeneReport for Unigene cluster for OR2AG1 Gene:

Hs.553608
genes like me logo Genes that share expression patterns with OR2AG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR2AG1 Gene

Orthologs for OR2AG1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2AG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466417 34
  • 98.73 (n)
cow
(Bos Taurus)
Mammalia LOC100125776 34
  • 86.09 (n)
mouse
(Mus musculus)
Mammalia Or2ag1 55 Olfr705 34 16
  • 83.12 (n)
Or2ag12 55 Olfr693
  • chr7:106,677,537-106,678,484
Or2ag13 55 Olfr695
  • chr7:106,713,735-106,714,679
Or2ag16 55 Olfr698
  • chr7:106,752,454-106,753,386
Or2ag17 55 Olfr699
  • chr7:106,790,052-106,790,999
Or2ag18 55 Olfr700
  • chr7:106,805,513-106,806,460
Or2ag1b 55 Olfr694
  • chr7:106,688,788-106,689,729
Or2ag20 55 Olfr704
  • chr7:106,864,982-106,865,926
rat
(Rattus norvegicus)
Mammalia Olr217 34
  • 82.59 (n)
Species where no ortholog for OR2AG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2AG1 Gene

ENSEMBL:
Gene Tree for OR2AG1 (if available)
TreeFam:
Gene Tree for OR2AG1 (if available)

Paralogs for OR2AG1 Gene

(445) SIMAP similar genes for OR2AG1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR2AG1 Gene

genes like me logo Genes that share paralogs with OR2AG1: view

Variants for OR2AG1 Gene

Sequence variations from dbSNP and Humsavar for OR2AG1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10839621 -- 6,783,266(+) TGCAG(A/G)TAAGT upstream-variant-2KB
rs11041021 -- 6,784,669(+) CTAAC(G/T)GGATA upstream-variant-2KB
rs11041022 -- 6,785,265(+) TCTGT(C/T)GTCAC reference, synonymous-codon
rs11041023 -- 6,786,099(+) TTTAA(C/T)AGAAA downstream-variant-500B
rs111527093 -- 6,785,347(+) TCCTG(A/G)CACTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR2AG1 Gene

Variant ID Type Subtype PubMed ID
nsv982979 CNV duplication 23825009
nsv832060 CNV gain 17160897
nsv467701 CNV loss 19166990
nsv1046129 CNV loss 25217958
nsv1043006 CNV loss 25217958
nsv1035138 CNV gain 25217958
esv3579329 CNV loss 25503493
dgv1626n54 CNV loss 21841781
dgv1625n54 CNV loss 21841781
dgv1056n100 CNV loss 25217958
dgv1055n100 CNV loss 25217958

Variation tolerance for OR2AG1 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2AG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2AG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2AG1 Gene

Disorders for OR2AG1 Gene

Relevant External Links for OR2AG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2AG1

No disorders were found for OR2AG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2AG1 Gene

Publications for OR2AG1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. Genomic analysis of orthologous mouse and human olfactory receptor loci. (PMID: 11416212) Lane R.P. … Trask B.J. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 64
  4. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3 64
  5. Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1. (PMID: 19909339) Dooley R. … Neuhaus E.M. (FEBS J. 2009) 3 64

Products for OR2AG1 Gene

Sources for OR2AG1 Gene

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