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Aliases for OR2AE1 Gene

Aliases for OR2AE1 Gene

  • Olfactory Receptor Family 2 Subfamily AE Member 1 2 3 5
  • Olfactory Receptor, Family 2, Subfamily AE, Member 2 2 3
  • Olfactory Receptor 2AE2 3 4
  • OR2AE2 3 4
  • Olfactory Receptor, Family 2, Subfamily AE, Member 1 2
  • Olfactory Receptor 2AE1 3

External Ids for OR2AE1 Gene

Previous HGNC Symbols for OR2AE1 Gene

  • OR2AE2

Previous GeneCards Identifiers for OR2AE1 Gene

  • GC07U990316
  • GC07M099119
  • GC07M099120
  • GC07M099311
  • GC07M099473

Summaries for OR2AE1 Gene

Entrez Gene Summary for OR2AE1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2AE1 Gene

OR2AE1 (Olfactory Receptor Family 2 Subfamily AE Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2M4.

UniProtKB/Swiss-Prot for OR2AE1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2AE1 Gene

Additional gene information for OR2AE1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2AE1 Gene

Genomics for OR2AE1 Gene

Regulatory Elements for OR2AE1 Gene

Enhancers for OR2AE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H099826 1 ENCODE 11.8 +48.3 48318 5 PKNOX1 FOXA2 MLX ARID4B YY1 REST PPARG NFIL3 ZNF184 RCOR2 OR2AE1 PILRB ATP5J2 CNPY4 GATS TRIM4 CYP3A43 ENSG00000260445
GH07H099272 1.2 Ensembl ENCODE 5.1 +603.2 603181 2 ZNF121 ZNF207 FOS ATF7 REST KAT8 SNIP1 SMARCA4 SP7 CTCF ZSCAN25 ZNF655 TRIM4 PTCD1 LOC101927550 ZNF3 TRRAP LOC100419643 ZNF394 AP4M1
GH07H099223 1.5 Ensembl ENCODE dbSUPER 3.9 +652.1 652113 1 PKNOX1 ATF1 ARNT YBX1 TCF12 GTF3C2 CBX5 ATF7 FOS TSHZ1 ZSCAN25 TRIM4 ZNF655 SMURF1 ZNF3 PTCD1 TRRAP LOC100419643 LOC101927550 ENSG00000242798
GH07H100343 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -468.0 -467975 2 HDGF PKNOX1 ATF1 ARNT SIN3A FEZF1 GLI4 ZNF2 TCF12 GLIS2 PILRA C7orf43 MBLAC1 ZCWPW1 MEPCE FAM200A LAMTOR4 ENSG00000241357 GPC2 GAL3ST4
GH07H100364 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.2 -493.9 -493912 12 HDGF PKNOX1 ATF1 YBX1 ZBTB7B ZNF121 ZNF143 ZNF207 ATF7 RUNX3 PILRA ZCWPW1 MEPCE MOSPD3 LAMTOR4 C7orf43 PVRIG ENSG00000241357 STAG3 GIGYF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2AE1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the OR2AE1 gene promoter:

Genomic Location for OR2AE1 Gene

Chromosome:
7
Start:
99,875,987 bp from pter
End:
99,877,057 bp from pter
Size:
1,071 bases
Orientation:
Minus strand

Genomic View for OR2AE1 Gene

Genes around OR2AE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2AE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2AE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AE1 Gene

Proteins for OR2AE1 Gene

  • Protein details for OR2AE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHA4-O2AE1_HUMAN
    Recommended name:
    Olfactory receptor 2AE1
    Protein Accession:
    Q8NHA4
    Secondary Accessions:
    • B2RPD2

    Protein attributes for OR2AE1 Gene

    Size:
    323 amino acids
    Molecular mass:
    36588 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AE1 Gene

Post-translational modifications for OR2AE1 Gene

Other Protein References for OR2AE1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AE1 Gene

Domains & Families for OR2AE1 Gene

Gene Families for OR2AE1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2AE1 Gene

Suggested Antigen Peptide Sequences for OR2AE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHA4

UniProtKB/Swiss-Prot:

O2AE1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AE1: view

Function for OR2AE1 Gene

Molecular function for OR2AE1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2AE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2AE1: view
genes like me logo Genes that share phenotypes with OR2AE1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2AE1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2AE1 Gene

Localization for OR2AE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AE1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2AE1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2AE1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2AE1 Gene

Pathways & Interactions for OR2AE1 Gene

genes like me logo Genes that share pathways with OR2AE1: view

Pathways by source for OR2AE1 Gene

Interacting Proteins for OR2AE1 Gene

Gene Ontology (GO) - Biological Process for OR2AE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AE1: view

No data available for SIGNOR curated interactions for OR2AE1 Gene

Drugs & Compounds for OR2AE1 Gene

No Compound Related Data Available

Transcripts for OR2AE1 Gene

mRNA/cDNA for OR2AE1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2AE1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AE1 Gene

No ASD Table

Relevant External Links for OR2AE1 Gene

GeneLoc Exon Structure for
OR2AE1
ECgene alternative splicing isoforms for
OR2AE1

Expression for OR2AE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2AE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2AE1 Gene:

OR2AE1

SOURCE GeneReport for Unigene cluster for OR2AE1 Gene:

Hs.647523
genes like me logo Genes that share expression patterns with OR2AE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2AE1 Gene

Orthologs for OR2AE1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2AE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR2AE1 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR2AE1 33 34
  • 87.37 (n)
dog
(Canis familiaris)
Mammalia LOC100686764 33
  • 87.21 (n)
OR2AE1 34
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 48 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr332 34
  • 45 (a)
ManyToMany
Species where no ortholog for OR2AE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2AE1 Gene

ENSEMBL:
Gene Tree for OR2AE1 (if available)
TreeFam:
Gene Tree for OR2AE1 (if available)

Paralogs for OR2AE1 Gene

(427) SIMAP similar genes for OR2AE1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2AE1: view

Variants for OR2AE1 Gene

Sequence variations from dbSNP and Humsavar for OR2AE1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1002023206 -- 99,877,699(+) CCTTT(A/G)TGTCT upstream-variant-2KB
rs1002055692 -- 99,878,025(+) GCCTC(C/T)GTAGT upstream-variant-2KB
rs1002805866 -- 99,877,039(+) TGTCC(C/G)CTTTC upstream-variant-2KB
rs1004668201 -- 99,875,681(+) ACTTC(C/T)CATGC downstream-variant-500B
rs1004768571 -- 99,877,564(+) GAGAG(-/AC)AGTTT upstream-variant-2KB

Variation tolerance for OR2AE1 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.64; 72.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2AE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2AE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR2AE1 Gene

Disorders for OR2AE1 Gene

Relevant External Links for OR2AE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2AE1

No disorders were found for OR2AE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2AE1 Gene

Publications for OR2AE1 Gene

  1. Sequence diversity and haplotype structure at the human CYP3A cluster. (PMID: 16314882) Thompson EE … Di Rienzo A (The pharmacogenomics journal 2006) 3 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60
  4. Toward a complete human genome sequence. (PMID: 9847074) Sanger Center … Genome Sequencing Center (Genome research 1998) 3 60

Products for OR2AE1 Gene

Sources for OR2AE1 Gene

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