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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR2AE1 Gene

protein-coding   GIFtS: 42
GCID: GC07M099473

Olfactory Receptor, Family 2, Subfamily AE, Member 1

(Previous names: olfactory receptor, family 2, subfamily AE, member 2)
(Previous symbol: OR2AE2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 2, Subfamily AE, Member 11 2
OR2AE21 2 3
Olfactory Receptor, Family 2, Subfamily AE, Member 21 2
Olfactory Receptor 2AE22 3
Olfactory Receptor 2AE12

External Ids:    HGNC: 150871   Entrez Gene: 813922   Ensembl: ENSG000002446237   UniProtKB: Q8NHA43   

Export aliases for OR2AE1 gene to outside databases

Previous GC identifers: GC07U990316 GC07M099119 GC07M099120 GC07M099311


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR2AE1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2AE1 Gene: 
OR2AE1 (olfactory receptor, family 2, subfamily AE, member 1) is a protein-coding gene. Diseases associated with OR2AE1 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T35.

UniProtKB/Swiss-Prot: O2AE1_HUMAN, Q8NHA4
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2AE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR2AE1 gene promoter:
         CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2AE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR2AE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2AE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

OR2AE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2AE1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099473:  view genomic region     (about GC identifiers)

Start:
99,473,688 bp from pter      End:
99,474,656 bp from pter
Size:
969 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 98,833,506-98,834,477     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: O2AE1_HUMAN, Q8NHA4 (See protein sequence)
Recommended Name: Olfactory receptor 2AE1  
Size: 323 amino acids; 36588 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2RPD2

Explore the universe of human proteins at neXtProt for OR2AE1: NX_Q8NHA4

Explore proteomics data for OR2AE1 at MOPED 

HORDE protein sequence for OR2AE1
OR2AE1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

OR2AE1 Protein Expression

REFSEQ proteins: NP_001005276.1  
ENSEMBL proteins: 
 ENSP00000313936  
Reactome Protein details: Q8NHA4
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

OR2AE1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
OR2: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NHA4

ProtoNet protein and cluster: Q8NHA4

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O2AE1_HUMAN, Q8NHA4
Similarity: Belongs to the G-protein coupled receptor 1 family


OR2AE1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: O2AE1_HUMAN, Q8NHA4
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR2AE1 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for OR2AE1:
 Large cells 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR2AE1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory transduction
Olfactory Signaling Pathway0.81
Olfactory transduction0.81
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4        Reactome Pathways for OR2AE1
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR2AE1):
    Olfactory transduction


OR2AE1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2AE1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/273 Interacting proteins for OR2AE1 (ENSP000003139364) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR56B4ENSP000003211964STRING: ENSP00000321196
OR9G1ENSP000003090124STRING: ENSP00000309012
GNALENSP000003340514STRING: ENSP00000334051
GNGT1ENSP000002485724STRING: ENSP00000248572
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR2AE1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR2AE1 (O2AE1)

Search CenterWatch for drugs/clinical trials and news about OR2AE1 / O2AE1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR2AE1 gene: 
NM_001005276.1  

Unigene Cluster for OR2AE1:

Olfactory receptor, family 2, subfamily AE, member 1
Hs.647523
Unigene Representative Sequence: BC137375
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000316368(uc003usc.1)
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Additional mRNA sequence: 

BC137375.1 BC137376.1 

1 DOTS entry:

DT.121107628 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR2AE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGACCCAGGT
OR2AE1 Expression
About this image


See OR2AE1 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.647523
    SABiosciences Custom PCR Arrays for OR2AE1
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR2AE1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for OR2AE1 gene from 1/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr1715 olfactory receptor 171   --   16 (12.15 cM) 19624157 


ENSEMBL Gene Tree for OR2AE1 (if available)
TreeFam Gene Tree for OR2AE1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR2AE1 gene
OR2T352  OR2V22  OR2V12  OR2M32  OR2T72  OR2M72  OR2T82  OR2M42  
OR2T22  OR2T122  OR2T272  OR2M52  OR2Z12  OR2T332  OR2AG12  OR2T52  
OR2T102  OR2M22  OR2T42  OR2T342  OR2T112  OR2T292  OR2T62  OR2T12  
OR2AG22  OR2T32  
18/429 SIMAP similar genes for OR2AE1 using alignment to 1 protein entry:     O2AE1_HUMAN(see all similar genes):
OR2T7    OR2M5    OR2T27    OR2T33    OR2V2    OR2M2
OR2M3    OR2M7    OR2T1    OR2T11    OR2T12    OR2AJ1
OR2B3    OR2F2    OR2M4    OR2T3    OR2T6    OR2T8

OR2AE1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/129 SNPs in OR2AE1 are shown (see all 129)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs774222301,2
C,F--94112428(+) ATTCAG/TTCACT 1 -- us2k11Minor allele frequency- T:0.21WA 118
rs1463911041,2
--94112438(+) TACTAC/TACAGT 1 -- us2k10--------
rs1880114881,2
--94112457(+) GGAGAA/GTTATG 1 -- us2k10--------
rs1926641171,2
--99473186(+) AGATCA/GTGCCA 1 -- ds50010--------
rs25720241,2
C--99473229(-) TTTTGC/TGACGG 1 -- ds50019Minor allele frequency- T:0.43NA WA CSA EA 369
rs584404151,2
C,F--99473355(+) AATACT/ACTCTG 1 -- ds50011Minor allele frequency- A:0.22WA 118
rs776501571,2
F--99473407(+) GATAAG/CGGCCC 1 -- ds50011Minor allele frequency- C:0.05NA 120
rs10255771,2
C,F,O,H--99473473(-) CCTTTG/CAAAGA 1 -- ds50018Minor allele frequency- C:0.01NS EA NA 782
rs795835491,2
F--99473486(+) CTTTTT/AAAAAA 1 -- ds50012Minor allele frequency- A:0.05WA NA 238
rs10255761,2
C,F,O,A,H--99473624(-) GGGAGC/ATAGCT 1 -- ds500127Minor allele frequency- A:0.39MN NS EA NA WA CSA 2714

HapMap Linkage Disequilibrium report for OR2AE1 ( 99473688 - 99474656 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for OR2AE1: --
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing OR2AE1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for OR2AE1:    About MalaCards
neuronitis    


OR2AE1 for disorders           About GeneDecksing


Export disorders for OR2AE1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR2AE1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR2AE1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Sequence diversity and haplotype structure at the human CYP3A cluster. (PubMed id 16314882)1 Thompson E.E....Di Rienzo A. (2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  4. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
  5. Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 81392 HGNC: 15087 Ensembl:ENSG00000244623 euGenes: HUgn81392 ECgene: OR2AE1 Kegg: 81392
H-InvDB: OR2AE1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR2AE1 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR2AE1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR2AE1 gene:
Search GeneIP for patents involving OR2AE1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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