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Aliases for OR2A7 Gene

Aliases for OR2A7 Gene

  • Olfactory Receptor Family 2 Subfamily A Member 7 2 3 5
  • Olfactory Receptor OR7-18 3 4
  • Olfactory Receptor, Family 2, Subfamily A, Member 21 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 7 2
  • Olfactory Receptor OR7-20 3
  • Olfactory Receptor 2A7 3
  • HSDJ0798C17 3
  • OR2A21 3

External Ids for OR2A7 Gene

Previous GeneCards Identifiers for OR2A7 Gene

  • GC07U990172
  • GC07M143393
  • GC07M143587
  • GC07M143588
  • GC07M143589
  • GC07M143590
  • GC07M143591
  • GC07M143955

Summaries for OR2A7 Gene

Entrez Gene Summary for OR2A7 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A7 Gene

OR2A7 (Olfactory Receptor Family 2 Subfamily A Member 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is OR2A4.

UniProtKB/Swiss-Prot for OR2A7 Gene

  • Odorant receptor.

Additional gene information for OR2A7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2A7 Gene

Genomics for OR2A7 Gene

GeneHancer (GH) Regulatory Elements for OR2A7 Gene

Promoters and enhancers for OR2A7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I143933 Enhancer 0.7 ENCODE 5.1 +329.4 329387 2.9 FOXA2 RFX1 HLF MAFG CEBPG ZFHX2 ATF4 MAFF JUND ZNF316 OR2F2 ARHGEF35 OR2F1 TCAF1 OR2A7 LOC100422324
GH07I144269 Promoter 0.5 EPDnew 0.8 -4.5 -4516 0.1 CTAGE8 OR2A7 ARHGEF34P ENSG00000244198 LOC101928605 ENSG00000284644 OR2A1-AS1
GH07I144256 Enhancer 0.6 ENCODE 0.4 +8.5 8509 0.2 ETV1 CEBPB MAFG MCM5 CEBPG ZNF148 FOSL1 JUND ATF4 IKZF1 OR2A20P CASP2 LOC154761 TCAF2 RN7SL535P OR2A9P OR2A7 ENSG00000244198 LOC101928605 ENSG00000284644
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR2A7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2A7 gene promoter:

Genomic Locations for OR2A7 Gene

Genomic Locations for OR2A7 Gene
7,130 bases
Minus strand

Genomic View for OR2A7 Gene

Genes around OR2A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A7 Gene

Proteins for OR2A7 Gene

  • Protein details for OR2A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2A7
    Protein Accession:
    Secondary Accessions:
    • B2RN57
    • Q6IFP4

    Protein attributes for OR2A7 Gene

    310 amino acids
    Molecular mass:
    34742 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2A7 Gene

Post-translational modifications for OR2A7 Gene

Other Protein References for OR2A7 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2A7 Gene

Domains & Families for OR2A7 Gene

Gene Families for OR2A7 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2A7 Gene

Suggested Antigen Peptide Sequences for OR2A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2A7: view

Function for OR2A7 Gene

Molecular function for OR2A7 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2A7: view

Phenotypes for OR2A7 Gene

GenomeRNAi human phenotypes for OR2A7:
genes like me logo Genes that share phenotypes with OR2A7: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2A7 Gene

Localization for OR2A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2A7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2A7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2A7 Gene

Pathways & Interactions for OR2A7 Gene

genes like me logo Genes that share pathways with OR2A7: view

Pathways by source for OR2A7 Gene

Interacting Proteins for OR2A7 Gene

Gene Ontology (GO) - Biological Process for OR2A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR2A7: view

No data available for SIGNOR curated interactions for OR2A7 Gene

Drugs & Compounds for OR2A7 Gene

No Compound Related Data Available

Transcripts for OR2A7 Gene

mRNA/cDNA for OR2A7 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(176) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2A7 Gene

Olfactory receptor, family 2, subfamily A, member 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A7 Gene

No ASD Table

Relevant External Links for OR2A7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2A7 Gene

mRNA differential expression in normal tissues according to GTEx for OR2A7 Gene

This gene is overexpressed in Thyroid (x4.3) and Skin - Sun Exposed (Lower leg) (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of OR2A7 Gene:


SOURCE GeneReport for Unigene cluster for OR2A7 Gene:


Evidence on tissue expression from TISSUES for OR2A7 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with OR2A7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2A7 Gene

Orthologs for OR2A7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR2A7 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC608585 33
  • 87.1 (n)
-- 34
  • 85 (a)
(Bos Taurus)
Mammalia LOC507423 33
  • 84.69 (n)
-- 34
  • 77 (a)
(Mus musculus)
Mammalia Or2a7 51 Olfr13 33 16 34
  • 80.65 (n)
(Rattus norvegicus)
Mammalia Olr818 33
  • 80.54 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 65 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 44 (a)
(Gallus gallus)
Aves -- 34
  • 38 (a)
Species where no ortholog for OR2A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A7 Gene

Gene Tree for OR2A7 (if available)
Gene Tree for OR2A7 (if available)

Paralogs for OR2A7 Gene

Paralogs for OR2A7 Gene

(457) SIMAP similar genes for OR2A7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2A7: view

Variants for OR2A7 Gene

Sequence variations from dbSNP and Humsavar for OR2A7 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1010420170 -- 144,260,414(-) C/T upstream_transcript_variant
rs1024453141 -- 144,260,454(-) C/A upstream_transcript_variant
rs10275843 -- 144,259,464(-) G/A coding_sequence_variant, synonymous_variant
rs1033796944 -- 144,260,630(-) GAC/GACGAC upstream_transcript_variant
rs1036791382 -- 144,258,921(-) G/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2A7 Gene

Variant ID Type Subtype PubMed ID
dgv11668n54 CNV gain 21841781
dgv11669n54 CNV loss 21841781
dgv11682n54 CNV loss 21841781
dgv11683n54 CNV loss 21841781
dgv152e203 CNV gain+loss 21179565
dgv24n31 CNV gain 19718026
dgv253n111 CNV duplication 26073780
dgv254n111 CNV duplication 26073780
dgv255n111 CNV deletion 26073780
dgv3972e59 CNV duplication 20981092
dgv6726n100 CNV gain 25217958
dgv6727n100 CNV loss 25217958
dgv6728n100 CNV gain+loss 25217958
dgv6729n100 CNV gain 25217958
dgv6730n100 CNV loss 25217958
dgv6731n100 CNV gain+loss 25217958
dgv6732n100 CNV gain+loss 25217958
dgv6733n100 CNV gain+loss 25217958
dgv6734n100 CNV gain+loss 25217958
dgv6735n100 CNV gain 25217958
dgv6736n100 CNV gain 25217958
dgv6737n100 CNV gain 25217958
dgv6738n100 CNV gain+loss 25217958
dgv6739n100 CNV gain+loss 25217958
dgv6740n100 CNV loss 25217958
dgv6741n100 CNV loss 25217958
dgv6742n100 CNV loss 25217958
dgv6743n100 CNV gain+loss 25217958
dgv6744n100 CNV loss 25217958
esv1003295 OTHER inversion 20482838
esv1682998 OTHER inversion 17803354
esv24292 CNV gain+loss 19812545
esv2759570 CNV gain+loss 17122850
esv3380478 CNV duplication 20981092
esv3409556 CNV duplication 20981092
esv3412618 CNV duplication 20981092
esv3432947 CNV duplication 20981092
esv3584873 CNV loss 24956385
esv3891225 CNV gain 25118596
esv8347 OTHER inversion 19470904
nsv1016831 CNV gain 25217958
nsv1119235 CNV duplication 24896259
nsv1133019 OTHER inversion 24896259
nsv1141559 CNV duplication 24896259
nsv1153905 CNV duplication 26484159
nsv428188 CNV gain+loss 18775914
nsv433394 CNV gain 18776910
nsv469769 CNV gain+loss 16826518
nsv471646 CNV gain+loss 15918152
nsv508489 CNV deletion 20534489
nsv510970 OTHER inversion 20534489
nsv515041 CNV gain 21397061
nsv608699 CNV gain 21841781
nsv608829 CNV loss 21841781
nsv608830 CNV loss 21841781
nsv608831 CNV loss 21841781
nsv608840 CNV loss 21841781
nsv608841 CNV loss 21841781
nsv608845 CNV loss 21841781
nsv7411 OTHER inversion 18451855
nsv819701 CNV insertion 19587683
nsv821609 CNV duplication 20802225
nsv8227 CNV gain+loss 18304495
nsv824360 CNV gain 20364138
nsv831175 CNV loss 17160897
nsv970598 CNV duplication 23825009

Variation tolerance for OR2A7 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.96; 74.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2A7 Gene

Disorders for OR2A7 Gene

Additional Disease Information for OR2A7

No disorders were found for OR2A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2A7 Gene

Publications for OR2A7 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR2A7 Gene

Sources for OR2A7 Gene

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