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Aliases for OR2A5 Gene

Aliases for OR2A5 Gene

  • Olfactory Receptor Family 2 Subfamily A Member 5 2 3 5
  • Olfactory Receptor, Family 2, Subfamily A, Member 5 2 3
  • Olfactory Receptor 7-138/7-141 3 4
  • Olfactory Receptor 2A26 3 4
  • Olfactory Receptor 2A8 3 4
  • OR7-138 3 4
  • OR7-141 3 4
  • OR2A26 3 4
  • OR2A8 3 4
  • Olfactory Receptor, Family 2, Subfamily A, Member 11 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 26 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 8 3
  • OR2A11P 3

External Ids for OR2A5 Gene

Previous HGNC Symbols for OR2A5 Gene

  • OR2A8
  • OR2A26

Previous GeneCards Identifiers for OR2A5 Gene

  • GC07U990161
  • GC07M141994
  • GC07P143207
  • GC07P143406
  • GC07Ph42714
  • GC07Ph43185
  • GC07P143378
  • GC07P143747

Summaries for OR2A5 Gene

Entrez Gene Summary for OR2A5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A5 Gene

OR2A5 (Olfactory Receptor Family 2 Subfamily A Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A42.

UniProtKB/Swiss-Prot for OR2A5 Gene

  • Odorant receptor.

Gene Wiki entry for OR2A5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2A5 Gene

Genomics for OR2A5 Gene

Regulatory Elements for OR2A5 Gene

Enhancers for OR2A5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR2A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2A5 Gene

144,050,368 bp from pter
144,051,380 bp from pter
1,013 bases
Plus strand

Genomic View for OR2A5 Gene

Genes around OR2A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A5 Gene

Proteins for OR2A5 Gene

  • Protein details for OR2A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2A5
    Protein Accession:
    Secondary Accessions:
    • B9EGX2
    • O43885
    • O43888

    Protein attributes for OR2A5 Gene

    311 amino acids
    Molecular mass:
    35207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2A5 Gene

Proteomics data for OR2A5 Gene at MOPED

Post-translational modifications for OR2A5 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2A5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2A5 Gene

Domains & Families for OR2A5 Gene

Gene Families for OR2A5 Gene

Protein Domains for OR2A5 Gene

Suggested Antigen Peptide Sequences for OR2A5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2A5: view

Function for OR2A5 Gene

Molecular function for OR2A5 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily A,member 5,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR2A5 Gene

genes like me logo Genes that share phenotypes with OR2A5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2A5 Gene

Localization for OR2A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR2A5 Gene COMPARTMENTS Subcellular localization image for OR2A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2A5: view

Pathways & Interactions for OR2A5 Gene

genes like me logo Genes that share pathways with OR2A5: view

Pathways by source for OR2A5 Gene

1 BioSystems pathway for OR2A5 Gene
1 KEGG pathway for OR2A5 Gene

Interacting Proteins for OR2A5 Gene

Gene Ontology (GO) - Biological Process for OR2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2A5: view

No data available for SIGNOR curated interactions for OR2A5 Gene

Drugs & Compounds for OR2A5 Gene

No Compound Related Data Available

Transcripts for OR2A5 Gene

mRNA/cDNA for OR2A5 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A5 Gene

No ASD Table

Relevant External Links for OR2A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2A5 Gene

mRNA expression in normal human tissues for OR2A5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2A5 Gene

SOURCE GeneReport for Unigene cluster for OR2A5 Gene Hs.553793

genes like me logo Genes that share expression patterns with OR2A5: view

Protein tissue co-expression partners for OR2A5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR2A5 Gene

Orthologs for OR2A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR2A5 35
  • 88.42 (n)
  • 88.31 (a)
OR2A5 36
  • 88 (a)
(Canis familiaris)
Mammalia OR2A5 35
  • 89 (n)
  • 89.32 (a)
OR2A5 36
  • 89 (a)
(Mus musculus)
Mammalia Olfr448 35
  • 83.66 (n)
  • 86.77 (a)
Olfr448 16
Olfr448 36
  • 87 (a)
(Pan troglodytes)
Mammalia LOC472572 35
  • 98.82 (n)
  • 99.04 (a)
OR2A5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Olr812 35
  • 84.41 (n)
  • 86.13 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
Species with no ortholog for OR2A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A5 Gene

Gene Tree for OR2A5 (if available)
Gene Tree for OR2A5 (if available)

Paralogs for OR2A5 Gene

Paralogs for OR2A5 Gene

(458) SIMAP similar genes for OR2A5 Gene using alignment to 2 proteins: Pseudogenes for OR2A5 Gene

genes like me logo Genes that share paralogs with OR2A5: view

Variants for OR2A5 Gene

Sequence variations from dbSNP and Humsavar for OR2A5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2961144 - 144,050,777(+) TGGCT(A/G)TCTGC reference, missense
rs6464573 - 144,051,005(+) TTGCT(C/G/T)CTTCA reference, missense
rs6464574 - 144,051,164(+) GCAGC(A/G)CCATT reference, missense
rs13226728 -- 144,049,485(+) CCTAA(C/T)GTAAT upstream-variant-2KB
rs13229266 -- 144,049,998(+) GCAAA(C/G)TAAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2A5 Gene

Variant ID Type Subtype PubMed ID
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
nsv8227 CNV Gain+Loss 18304495
nsv522225 CNV Gain 19592680
esv1682998 OTHER Inversion 17803354
dgv842n27 CNV Gain 19166990
nsv889336 CNV Gain 21882294
dgv7520n71 CNV Gain 21882294
esv2752147 CNV Gain 17911159
dgv2149e1 CNV Complex 17122850
nsv831173 CNV Gain 17160897
dgv2150e1 CNV Complex 17122850
nsv831174 CNV Loss 17160897
nsv507424 CNV Insertion 20534489

Variation tolerance for OR2A5 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.13; 98.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR2A5 Gene

Disorders for OR2A5 Gene

Relevant External Links for OR2A5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR2A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2A5 Gene

Publications for OR2A5 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3 4 67
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2A5 Gene

Sources for OR2A5 Gene