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Aliases for OR2A5 Gene

Aliases for OR2A5 Gene

  • Olfactory Receptor, Family 2, Subfamily A, Member 5 2 3
  • Olfactory Receptor 7-138/7-141 3 4
  • Olfactory Receptor 2A26 3 4
  • Olfactory Receptor 2A8 3 4
  • OR7-138 3 4
  • OR7-141 3 4
  • OR2A26 3 4
  • OR2A8 3 4
  • Olfactory Receptor, Family 2, Subfamily A, Member 11 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 26 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 8 3
  • Olfactory Receptor 2A5 3
  • OR2A11P 3

External Ids for OR2A5 Gene

Previous Symbols for OR2A5 Gene

  • OR2A8
  • OR2A26

Summaries for OR2A5 Gene

Entrez Gene Summary for OR2A5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A5 Gene

OR2A5 (Olfactory Receptor, Family 2, Subfamily A, Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A42.

UniProtKB/Swiss-Prot for OR2A5 Gene

  • Odorant receptor.

Gene Wiki entry for OR2A5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2A5 Gene

Genomics for OR2A5 Gene

Genomic Location for OR2A5 Gene

Start:
144,050,368 bp from pter
End:
144,051,380 bp from pter
Size:
1,013 bases
Orientation:
Plus strand

Genomic View for OR2A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A5 Gene

Regulatory Elements for OR2A5 Gene

Proteins for OR2A5 Gene

  • Protein details for OR2A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R48-OR2A5_HUMAN
    Recommended name:
    Olfactory receptor 2A5
    Protein Accession:
    Q96R48
    Secondary Accessions:
    • B9EGX2
    • O43885
    • O43888

    Protein attributes for OR2A5 Gene

    Size:
    311 amino acids
    Molecular mass:
    35207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2A5 Gene

Proteomics data for OR2A5 Gene at MOPED

Post-translational modifications for OR2A5 Gene

Other Protein References for OR2A5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2A5 Gene

Domains for OR2A5 Gene

Gene Families for OR2A5 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2A5 Gene

Suggested Antigen Peptide Sequences for OR2A5 Gene

Graphical View of Domain Structure for InterPro Entry

Q96R48

UniProtKB/Swiss-Prot:

OR2A5_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q96R48
genes like me logo Genes that share domains with OR2A5: view

Function for OR2A5 Gene

Molecular function for OR2A5 Gene

GENATLAS Biochemistry: olfactory receptor,family 2,subfamily A,member 5,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2A5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2A5 Gene

Localization for OR2A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2A5 Gene COMPARTMENTS Subcellular localization image for OR2A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2A5: view

Pathways for OR2A5 Gene

genes like me logo Genes that share pathways with OR2A5: view

Pathways by source for OR2A5 Gene

1 BioSystems pathway for OR2A5 Gene
1 KEGG pathway for OR2A5 Gene

Interacting Proteins for OR2A5 Gene

Gene Ontology (GO) - Biological Process for OR2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2A5: view

Transcripts for OR2A5 Gene

mRNA/cDNA for OR2A5 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A5 Gene

No ASD Table

Relevant External Links for OR2A5 Gene

GeneLoc Exon Structure for
OR2A5
ECgene alternative splicing isoforms for
OR2A5

Expression for OR2A5 Gene

mRNA expression in normal human tissues for OR2A5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR2A5 Gene

SOURCE GeneReport for Unigene cluster for OR2A5 Gene Hs.553793

genes like me logo Genes that share expressions with OR2A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR2A5 Gene

Orthologs for OR2A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC472572 35
  • 98.82 (n)
  • 99.04 (a)
OR2A5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR2A5 35
  • 88.42 (n)
  • 88.31 (a)
OR2A5 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR2A5 35
  • 89 (n)
  • 89.32 (a)
OR2A5 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr448 35
  • 83.66 (n)
  • 86.77 (a)
Olfr448 16
Olfr448 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr812 35
  • 84.41 (n)
  • 86.13 (a)
Species with no ortholog for OR2A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A5 Gene

ENSEMBL:
Gene Tree for OR2A5 (if available)
TreeFam:
Gene Tree for OR2A5 (if available)

Paralogs for OR2A5 Gene

Selected SIMAP similar genes for OR2A5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR2A5 Gene

genes like me logo Genes that share paralogs with OR2A5: view

Variants for OR2A5 Gene

Sequence variations from dbSNP and Humsavar for OR2A5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1919969 -- 144,051,427(-) ATCTA(A/C/G)GAGAT downstream-variant-500B
rs2961144 - 144,050,777(+) TGGCT(A/G)TCTGC reference, missense
rs2961148 -- 144,051,791(+) GAGTA(G/T)AGAAA downstream-variant-500B
rs4407791 -- 144,051,271(+) ATCTA(C/T)AGCCT synonymous-codon, reference
rs6464573 - 144,051,005(+) TTGCT(G/T)CTTCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR2A5 Gene

Variant ID Type Subtype PubMed ID
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
nsv8227 CNV Gain+Loss 18304495
nsv522225 CNV Gain 19592680
esv1682998 OTHER Inversion 17803354
dgv842n27 CNV Gain 19166990
nsv889336 CNV Gain 21882294
dgv7520n71 CNV Gain 21882294
esv2752147 CNV Gain 17911159
dgv2149e1 CNV Complex 17122850
nsv831173 CNV Gain 17160897
dgv2150e1 CNV Complex 17122850
nsv831174 CNV Loss 17160897
nsv507424 CNV Insertion 20534489

Relevant External Links for OR2A5 Gene

HapMap Linkage Disequilibrium report
OR2A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2A5 Gene

Disorders for OR2A5 Gene

Relevant External Links for OR2A5

Genetic Association Database (GAD)
OR2A5
genes like me logo Genes that share disorders with OR2A5: view

No data available for UniProtKB/Swiss-Prot for OR2A5 Gene

Publications for OR2A5 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S. … Cupples L.A. (BMC Med. Genet. 2007) 48

Products for OR2A5 Gene

Sources for OR2A5 Gene

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