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OR2A42 Gene

protein-coding   GIFtS: 37
GCID: GC07M143929

Olfactory Receptor, Family 2, Subfamily A, Member 42

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily A, Member 421 2
Olfactory Receptor OR7-162 3
Olfactory Receptor OR7-192 3
Olfactory Receptor 2A1/2A422

External Ids:    HGNC: 312301   Entrez Gene: 4023172   Ensembl: ENSG000002128077   UniProtKB: Q8NGT93   

Export aliases for OR2A42 gene to outside databases

Previous GC identifers: GC07M143320 GC07M143366 GC07M143559


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2A42 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2A42 Gene:
OR2A42 (olfactory receptor, family 2, subfamily A, member 42) is a protein-coding gene. Diseases associated with OR2A42 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A25.

UniProtKB/Swiss-Prot: OR2A1_HUMAN, Q8NGT9
Function: Odorant receptor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the OR2A42 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   E47   GATA-1   Max   Nkx3-1 v2   deltaCREB   Nkx3-1 v3   c-Myc   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2A42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q35

OR2A42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2A42 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M143929:  view genomic region     (about GC identifiers)

Start:
143,929,007 bp from pter      End:
143,929,936 bp from pter
Size:
930 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 143,267,262-143,268,194     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR2A1_HUMAN, Q8NGT9 (See protein sequence)
Recommended Name: Olfactory receptor 2A1/2A42  
Size: 310 amino acids; 34714 Da
Sequence caution: Sequence=BAC05915.1; Type=Erroneous initiation;
Secondary accessions: Q6IF44 Q96R46

Explore the universe of human proteins at neXtProt for OR2A42: NX_Q8NGT9

Explore proteomics data for OR2A42 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4
  • HORDE protein sequence for OR2A42

    See OR2A42 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001001802.2  
    ENSEMBL proteins: 
     ENSP00000375334  
    Reactome Protein details: Q8NGT9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGT9

    ProtoNet protein and cluster: Q8NGT9

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR2A1_HUMAN, Q8NGT9
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR2A42 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR2A1_HUMAN, Q8NGT9
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR2A42 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR2A1_HUMAN, Q8NGT9: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR2A42 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2A42 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR2A42
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2A42):
        Olfactory transduction


    OR2A42 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2A42
    Interactions:

        Search GeneGlobe Interaction Network for OR2A42

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR2A42 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2A42 (OR2A1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR2A42 gene: 
    NM_001001802.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000391496(uc011kub.2)
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      QuantiFast Probe-based Assays in human, mouse, rat OR2A42

    3 AceView cDNA sequences:

    BF116115 BV189121 BX280997 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2A42 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR2A42 Expression
    About this image

    OR2A42 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2A42 Protein Expression
        Custom PCR Arrays for OR2A42
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2A42 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr4351 olfactory receptor 435 79.46(n)
    77.74(a)
      258647  NM_146653.1  NP_666864.1 


    ENSEMBL Gene Tree for OR2A42 (if available)
    TreeFam Gene Tree for OR2A42 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2A42 gene
    OR2A11 2  OR2A252  OR2A42  OR2A122  OR2A52  OR2F22  OR2A22  OR2A72  
    OR2D22  OR2F12  OR2D32  OR2A142  
    Selected SIMAP similar genes for OR2A42 using alignment to 1 protein entry:     OR2A1_HUMAN(see all similar genes):
    OR2A1    FKSG35    OR2A5    OR2A14    OR2A2    OR2A25
    OR2A7    OR2A12    OR2A4    OR2D3    OR10A7    OR2AG2
    OR2B2    OR2C1    OR2D2    OR2G3    OR2G6    OR2K2

    OR2A42 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for OR2A42
    PGOHUM00000242282 PGOHUM00000250917 PGOHUM00000250975


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2A42 (see all 15)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012156381,2
    C--143929720(+) GCGGGC/TGTAGG 2 T A mis10--------
    rs2020910771,2
    C,F--143929772(+) GGGGTG/ATGGAG 2 /H syn11Minor allele frequency- A:0.11EU 411
    rs2004483351,2
    C--143931930(+) ATTCTA/GTTAAA 1 -- us2k10--------
    rs2008843501,2
    C--143931933(+) CTATT-/AAAAAA 1 -- us2k10--------
    rs2011732341,2
    ----143931933(+) CTATTA/TAAAAA 1 -- us2k10--------
    rs3776193781,2
    ----143931202(+) CTCTG-/AAAGAA 1 -- us2k10--------
    rs2020532251,2
    ----143929434(+) GCCCAC/GAGAAG 2 S C mis10--------
    rs2001488531,2
    ----143929717(+) GTTGCA/GGGTGT 2 R C mis10--------
    rs1997469281,2
    ----143929710(+) GCACCG/ATGTTG 2 /T /M mis11Minor allele frequency- A:0.00EU 483
    rs2015924781,2
    ----143929537(+) CATGAT/CGACGG 2 /I /V mis11Minor allele frequency- C:0.00EU 457

    HapMap Linkage Disequilibrium report for OR2A42 ( 143929007 - 143929936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR2A42 (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471455CNV Duplication19718026
    dgv24n31CNV Duplication19718026
    nsv821609CNV Duplication20802225
    nsv819701CNV Insertion19587683
    nsv889373CNV Loss21882294
    dgv7527n71CNV Loss21882294
    nsv831175CNV Loss17160897
    nsv508489CNV Loss20534489
    dgv7525n71CNV Loss21882294
    dgv7526n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR2A42:    
    About MalaCards
    neuronitis


    OR2A42 for disorders           About GeneDecksing


    Export disorders for OR2A42 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2A42 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2A42)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 402317 HGNC: 31230 AceView: OR2A42 Ensembl:ENSG00000212807 euGenes: HUgn402317
    ECgene: OR2A42 Kegg: 402317 H-InvDB: OR2A42

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2A42 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2A42 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2A42 gene:
    Search GeneIP for patents involving OR2A42

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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