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Aliases for OR2A42 Gene

Aliases for OR2A42 Gene

  • Olfactory Receptor Family 2 Subfamily A Member 42 2 3 5
  • Olfactory Receptor, Family 2, Subfamily A, Member 42 2
  • Olfactory Receptor OR7-16 4
  • Olfactory Receptor OR7-19 4
  • OR2A1 OR2A42 4

External Ids for OR2A42 Gene

Previous GeneCards Identifiers for OR2A42 Gene

  • GC07M143320
  • GC07M143366
  • GC07M143559
  • GC07M143929

Summaries for OR2A42 Gene

Entrez Gene Summary for OR2A42 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A42 Gene

OR2A42 (Olfactory Receptor Family 2 Subfamily A Member 42) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A5.

UniProtKB/Swiss-Prot for OR2A42 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2A42 Gene

Genomics for OR2A42 Gene

Regulatory Elements for OR2A42 Gene

Enhancers for OR2A42 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR2A42 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2A42 Gene

144,231,911 bp from pter
144,232,843 bp from pter
933 bases
Minus strand

Genomic View for OR2A42 Gene

Genes around OR2A42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2A42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2A42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A42 Gene

Proteins for OR2A42 Gene

  • Protein details for OR2A42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2A1/2A42
    Protein Accession:
    Secondary Accessions:
    • Q6IF44
    • Q96R46

    Protein attributes for OR2A42 Gene

    310 amino acids
    Molecular mass:
    34714 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05915.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2A42 Gene

Proteomics data for OR2A42 Gene at MOPED

Post-translational modifications for OR2A42 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2A42 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2A42 Gene

Domains & Families for OR2A42 Gene

Gene Families for OR2A42 Gene

Protein Domains for OR2A42 Gene

Suggested Antigen Peptide Sequences for OR2A42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2A42: view

Function for OR2A42 Gene

Molecular function for OR2A42 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2A42 Gene

Localization for OR2A42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A42 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR2A42 Gene COMPARTMENTS Subcellular localization image for OR2A42 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2A42: view

Pathways & Interactions for OR2A42 Gene

genes like me logo Genes that share pathways with OR2A42: view

Pathways by source for OR2A42 Gene

Interacting Proteins for OR2A42 Gene

Gene Ontology (GO) - Biological Process for OR2A42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2A42: view

No data available for SIGNOR curated interactions for OR2A42 Gene

Drugs & Compounds for OR2A42 Gene

No Compound Related Data Available

Transcripts for OR2A42 Gene

mRNA/cDNA for OR2A42 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A42 Gene

No ASD Table

Relevant External Links for OR2A42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2A42 Gene

mRNA expression in normal human tissues for OR2A42 Gene

mRNA differential expression in normal tissues according to GTEx for OR2A42 Gene

This gene is overexpressed in Thyroid (x7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR2A42 Gene

genes like me logo Genes that share expression patterns with OR2A42: view

Protein tissue co-expression partners for OR2A42 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR2A42 Gene

Orthologs for OR2A42 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A42 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC504233 35
  • 84.14 (n)
  • 77.35 (a)
-- 36
  • 47 (a)
(Canis familiaris)
Mammalia OR08A11 35
  • 85.48 (n)
  • 83.55 (a)
-- 36
  • 80 (a)
OR08A11 36
  • 83 (a)
(Mus musculus)
Mammalia Olfr435 35
  • 79.46 (n)
  • 77.74 (a)
Olfr435 16
Olfr434 36
  • 77 (a)
Olfr435 36
  • 77 (a)
Olfr47 36
  • 76 (a)
(Pan troglodytes)
Mammalia LOC744895 35
  • 98.17 (n)
  • 97.1 (a)
-- 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Olr819 35
  • 77.53 (n)
  • 75.81 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
Species with no ortholog for OR2A42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A42 Gene

Gene Tree for OR2A42 (if available)
Gene Tree for OR2A42 (if available)

Paralogs for OR2A42 Gene

Paralogs for OR2A42 Gene

(455) SIMAP similar genes for OR2A42 Gene using alignment to 1 proteins: Pseudogenes for OR2A42 Gene

genes like me logo Genes that share paralogs with OR2A42: view

Variants for OR2A42 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2A42 Gene

Variant ID Type Subtype PubMed ID
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
nsv8227 CNV Gain+Loss 18304495
esv1682998 OTHER Inversion 17803354
dgv7520n71 CNV Gain 21882294
dgv2149e1 CNV Complex 17122850
dgv2150e1 CNV Complex 17122850
essv3984 CNV CNV 17122850
nsv7411 OTHER Inversion 18451855
dgv7522n71 CNV Gain 21882294
dgv7523n71 CNV Gain 21882294
dgv7524n71 CNV Gain+Loss 21882294
esv1003295 OTHER Inversion 20482838
dgv7525n71 CNV Loss 21882294
nsv821609 CNV Duplication 20802225
nsv824360 CNV Gain 20364138
dgv24n31 CNV Duplication 19718026
nsv819701 CNV Insertion 19587683
esv24292 CNV Gain+Loss 19812545
nsv831175 CNV Loss 17160897
esv33253 CNV Gain 17666407
nsv515040 CNV Complex 21397061
nsv433394 CNV Gain 18776910
nsv508489 CNV Loss 20534489
nsv469769 CNV Complex 16826518
nsv471646 CNV Gain+Loss 15918152
dgv7526n71 CNV Gain 21882294
dgv7527n71 CNV Loss 21882294
nsv889373 CNV Loss 21882294
nsv471455 CNV Duplication 19718026

Variation tolerance for OR2A42 Gene

Gene Damage Index Score: 2.72; 46.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for OR2A42 Gene

Disorders for OR2A42 Gene

Relevant External Links for OR2A42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR2A42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2A42 Gene

Publications for OR2A42 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3

Products for OR2A42 Gene

Sources for OR2A42 Gene