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Aliases for OR2A4 Gene

Aliases for OR2A4 Gene

  • Olfactory Receptor Family 2 Subfamily A Member 4 2 3 5
  • Olfactory Receptor, Family 2, Subfamily A, Member 10 2 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 4 2 3
  • Olfactory Receptor OR6-37 3 4
  • Olfactory Receptor 2A10 3 4
  • OR2A10 3 4

External Ids for OR2A4 Gene

Previous HGNC Symbols for OR2A4 Gene

  • OR2A10

Previous GeneCards Identifiers for OR2A4 Gene

  • GC07M142202
  • GC06M131868
  • GC06M132002
  • GC06M132063
  • GC06M132021
  • GC07M143295

Summaries for OR2A4 Gene

Entrez Gene Summary for OR2A4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A4 Gene

OR2A4 (Olfactory Receptor Family 2 Subfamily A Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is OR2A42.

UniProtKB/Swiss-Prot for OR2A4 Gene

  • Odorant receptor.

Gene Wiki entry for OR2A4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2A4 Gene

Genomics for OR2A4 Gene

Regulatory Elements for OR2A4 Gene

Genomic Location for OR2A4 Gene

Chromosome:
6
Start:
131,699,644 bp from pter
End:
131,701,401 bp from pter
Size:
1,758 bases
Orientation:
Minus strand

Genomic View for OR2A4 Gene

Genes around OR2A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A4 Gene

Proteins for OR2A4 Gene

  • Protein details for OR2A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95047-OR2A4_HUMAN
    Recommended name:
    Olfactory receptor 2A4
    Protein Accession:
    O95047
    Secondary Accessions:
    • Q0VAR3
    • Q6IF18
    • Q9NQN0

    Protein attributes for OR2A4 Gene

    Size:
    310 amino acids
    Molecular mass:
    34802 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB99212.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2A4 Gene

Proteomics data for OR2A4 Gene at MOPED

Post-translational modifications for OR2A4 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2A4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

No data available for DME Specific Peptides for OR2A4 Gene

Domains & Families for OR2A4 Gene

Gene Families for OR2A4 Gene

Protein Domains for OR2A4 Gene

Suggested Antigen Peptide Sequences for OR2A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95047

UniProtKB/Swiss-Prot:

OR2A4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2A4: view

Function for OR2A4 Gene

Molecular function for OR2A4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR2A4: view

Phenotypes for OR2A4 Gene

GenomeRNAi human phenotypes for OR2A4:
genes like me logo Genes that share phenotypes with OR2A4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR2A4 Gene

Localization for OR2A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2A4 Gene COMPARTMENTS Subcellular localization image for OR2A4 gene
Compartment Confidence
cytoskeleton 5
endosome 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055037 recycling endosome IDA 22888021
GO:0090543 Flemming body IDA 22888021
GO:0097431 mitotic spindle pole IDA 22888021
genes like me logo Genes that share ontologies with OR2A4: view

Pathways & Interactions for OR2A4 Gene

genes like me logo Genes that share pathways with OR2A4: view

Pathways by source for OR2A4 Gene

1 KEGG pathway for OR2A4 Gene

Interacting Proteins for OR2A4 Gene

Gene Ontology (GO) - Biological Process for OR2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0032467 positive regulation of cytokinesis IMP 22888021
genes like me logo Genes that share ontologies with OR2A4: view

No data available for SIGNOR curated interactions for OR2A4 Gene

Drugs & Compounds for OR2A4 Gene

No Compound Related Data Available

Transcripts for OR2A4 Gene

mRNA/cDNA for OR2A4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2A4 Gene

Olfactory receptor, family 2, subfamily A, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A4 Gene

No ASD Table

Relevant External Links for OR2A4 Gene

GeneLoc Exon Structure for
OR2A4
ECgene alternative splicing isoforms for
OR2A4

Expression for OR2A4 Gene

mRNA expression in normal human tissues for OR2A4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2A4 Gene



SOURCE GeneReport for Unigene cluster for OR2A4 Gene Hs.734368

genes like me logo Genes that share expression patterns with OR2A4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR2A4 Gene

Orthologs for OR2A4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC507423 35
  • 84.47 (n)
  • 77.85 (a)
-- 36
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC608585 35
  • 86.88 (n)
  • 83.87 (a)
-- 36
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr13 35
  • 80.43 (n)
  • 81.29 (a)
Olfr13 36
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr818 35
  • 80.32 (n)
  • 80 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 42 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
Species with no ortholog for OR2A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A4 Gene

ENSEMBL:
Gene Tree for OR2A4 (if available)
TreeFam:
Gene Tree for OR2A4 (if available)

Paralogs for OR2A4 Gene

Paralogs for OR2A4 Gene

(448) SIMAP similar genes for OR2A4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2A4: view

Variants for OR2A4 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2A4 Gene

Variant ID Type Subtype PubMed ID
nsv7968 CNV Loss 18304495
dgv88n68 CNV Loss 17160897
nsv886669 CNV Gain 21882294
esv24430 CNV Gain+Loss 19812545
nsv821228 CNV Duplication 20802225
nsv471444 CNV Duplication 19718026

Variation tolerance for OR2A4 Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2A4 Gene

HapMap Linkage Disequilibrium report
OR2A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for OR2A4 Gene

Disorders for OR2A4 Gene

Relevant External Links for OR2A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2A4

No disorders were found for OR2A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2A4 Gene

Publications for OR2A4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. G protein-coupled receptors participate in cytokinesis. (PMID: 22888021) Zhang X. … Eggert U.S. (Cytoskeleton (Hoboken) 2012) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2A4 Gene

Sources for OR2A4 Gene

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