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Aliases for OR2A25 Gene

Aliases for OR2A25 Gene

  • Olfactory Receptor Family 2 Subfamily A Member 25 2 3 5
  • Olfactory Receptor 2A27 3 4
  • OR2A25P 3 4
  • OR2A27 3 4
  • Olfactory Receptor, Family 2, Subfamily A, Member 24 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 25 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 25 2
  • Olfactory Receptor, Family 2, Subfamily A, Member 27 3
  • Olfactory Receptor 2A25 3
  • OR2A24P 3

External Ids for OR2A25 Gene

Previous HGNC Symbols for OR2A25 Gene

  • OR2A25P
  • OR2A27

Previous GeneCards Identifiers for OR2A25 Gene

  • GC07P143163
  • GC07P143208
  • GC07P143402
  • GC07P143771

Summaries for OR2A25 Gene

Entrez Gene Summary for OR2A25 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A25 Gene

OR2A25 (Olfactory Receptor Family 2 Subfamily A Member 25) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is OR2A4.

UniProtKB/Swiss-Prot for OR2A25 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2A25 Gene

Genomics for OR2A25 Gene

Regulatory Elements for OR2A25 Gene

Enhancers for OR2A25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F144031 0.9 ENCODE 10.9 -42.4 -42440 1.3 HNF4G NR2F2 ARHGEF35 OR2A25 OR2A41P OR2A5 OR6B1
GH07F143978 0.5 ENCODE 10.8 -94.7 -94711 2.1 ATF1 TAL1 JUN CEBPB EP300 ARID1B JUND NCOR1 GATA2 FOS ENSG00000243583 OR2F1 OR2A25 OR2A41P LOC154761 LOC100422324
GH07F143893 0.4 FANTOM5 5.4 -181.6 -181648 0.0 ZNF362 ATF1 ZNF512 ZNF175 CHAMP1 OR2A2 OR2A25 OR2A12 TCAF1 OR2F1 TAS2R60 LOC105375549
GH07F143898 1.3 FANTOM5 Ensembl ENCODE 5 -171.0 -171026 9.0 HDGF CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ARHGEF35 OR2A13P TCAF1 OR2A25 OR2A12 ARHGEF34P OR2A2 OR2F1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR2A25 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2A25 Gene

Chromosome:
7
Start:
144,074,182 bp from pter
End:
144,075,195 bp from pter
Size:
1,014 bases
Orientation:
Plus strand

Genomic View for OR2A25 Gene

Genes around OR2A25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2A25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2A25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A25 Gene

Proteins for OR2A25 Gene

  • Protein details for OR2A25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D2G3-O2A25_HUMAN
    Recommended name:
    Olfactory receptor 2A25
    Protein Accession:
    A4D2G3
    Secondary Accessions:
    • B2RNC9

    Protein attributes for OR2A25 Gene

    Size:
    310 amino acids
    Molecular mass:
    34606 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2A25 Gene

Post-translational modifications for OR2A25 Gene

  • Glycosylation at Asn 4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2A25 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2A25 Gene

Domains & Families for OR2A25 Gene

Gene Families for OR2A25 Gene

Protein Domains for OR2A25 Gene

Suggested Antigen Peptide Sequences for OR2A25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A4D2G3

UniProtKB/Swiss-Prot:

O2A25_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2A25: view

Function for OR2A25 Gene

Molecular function for OR2A25 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2A25: view

Phenotypes for OR2A25 Gene

GenomeRNAi human phenotypes for OR2A25:
genes like me logo Genes that share phenotypes with OR2A25: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2A25 Gene

Localization for OR2A25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A25 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2A25 Gene COMPARTMENTS Subcellular localization image for OR2A25 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2A25: view

Pathways & Interactions for OR2A25 Gene

genes like me logo Genes that share pathways with OR2A25: view

Pathways by source for OR2A25 Gene

Gene Ontology (GO) - Biological Process for OR2A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR2A25: view

No data available for SIGNOR curated interactions for OR2A25 Gene

Transcripts for OR2A25 Gene

mRNA/cDNA for OR2A25 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A25 Gene

No ASD Table

Relevant External Links for OR2A25 Gene

GeneLoc Exon Structure for
OR2A25
ECgene alternative splicing isoforms for
OR2A25

Expression for OR2A25 Gene

mRNA expression in normal human tissues for OR2A25 Gene

Protein differential expression in normal tissues from HIPED for OR2A25 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2A25 Gene



Protein tissue co-expression partners for OR2A25 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2A25 Gene:

OR2A25

SOURCE GeneReport for Unigene cluster for OR2A25 Gene:

Hs.553787
genes like me logo Genes that share expression patterns with OR2A25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR2A25 Gene

Orthologs for OR2A25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC472573 34
  • 99.25 (n)
OR2A25 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR2A25 34 35
  • 85.48 (n)
mouse
(Mus musculus)
Mammalia Or2a25 55 Olfr447 34 16 35
  • 81.72 (n)
rat
(Rattus norvegicus)
Mammalia Olr813 34
  • 81.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 45 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 44 (a)
ManyToMany
Species where no ortholog for OR2A25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A25 Gene

ENSEMBL:
Gene Tree for OR2A25 (if available)
TreeFam:
Gene Tree for OR2A25 (if available)

Paralogs for OR2A25 Gene

Paralogs for OR2A25 Gene

(460) SIMAP similar genes for OR2A25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2A25: view

Variants for OR2A25 Gene

Sequence variations from dbSNP and Humsavar for OR2A25 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs111255131 -- 144,074,646(+) TCACT(C/T)TGGCA intron-variant, reference, synonymous-codon
rs112737914 -- 144,075,593(+) GGGAG(A/G)CCGAG intron-variant, downstream-variant-500B
rs115524880 -- 144,073,863(+) TGCAA(C/T)GAAGG intron-variant, upstream-variant-2KB
rs117311917 -- 144,075,322(+) CAGCA(C/T)TGAAG intron-variant, downstream-variant-500B
rs11769576 -- 144,075,612(+) atcac(A/C/G)cggtc intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR2A25 Gene

Variant ID Type Subtype PubMed ID
dgv11664n54 CNV gain 21841781
dgv6725n100 CNV gain 25217958
dgv842n27 CNV gain 19166990
esv1006326 CNV gain 20482838
esv1682998 OTHER inversion 17803354
esv2752147 CNV gain 17911159
esv2759570 CNV gain+loss 17122850
esv3891223 CNV loss 25118596
nsv1016831 CNV gain 25217958
nsv428188 CNV gain+loss 18775914
nsv471453 CNV gain 19718026
nsv522225 CNV gain 19592680
nsv608682 CNV gain 21841781
nsv608699 CNV gain 21841781
nsv8227 CNV gain+loss 18304495
nsv831173 CNV gain 17160897
nsv831174 CNV loss 17160897

Variation tolerance for OR2A25 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.15; 75.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2A25 Gene

Human Gene Mutation Database (HGMD)
OR2A25
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2A25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2A25 Gene

Disorders for OR2A25 Gene

Relevant External Links for OR2A25

Genetic Association Database (GAD)
OR2A25
Human Genome Epidemiology (HuGE) Navigator
OR2A25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2A25

No disorders were found for OR2A25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2A25 Gene

Publications for OR2A25 Gene

  1. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 46 64
  2. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4 64

Products for OR2A25 Gene

Sources for OR2A25 Gene

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