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Aliases for OR2A25 Gene

Aliases for OR2A25 Gene

  • Olfactory Receptor, Family 2, Subfamily A, Member 25 2 3
  • Olfactory Receptor 2A27 3 4
  • OR2A25P 3 4
  • OR2A27 3 4
  • Olfactory Receptor, Family 2, Subfamily A, Member 24 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 25 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 27 3
  • Olfactory Receptor 2A25 3
  • OR2A24P 3

External Ids for OR2A25 Gene

Previous Symbols for OR2A25 Gene

  • OR2A25P
  • OR2A27

Summaries for OR2A25 Gene

Entrez Gene Summary for OR2A25 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A25 Gene

OR2A25 (Olfactory Receptor, Family 2, Subfamily A, Member 25) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A42.

UniProtKB/Swiss-Prot for OR2A25 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2A25 Gene

Genomics for OR2A25 Gene

Genomic Location for OR2A25 Gene

Start:
144,074,182 bp from pter
End:
144,075,195 bp from pter
Size:
1,014 bases
Orientation:
Plus strand

Genomic View for OR2A25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2A25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A25 Gene

Regulatory Elements for OR2A25 Gene

Proteins for OR2A25 Gene

  • Protein details for OR2A25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D2G3-O2A25_HUMAN
    Recommended name:
    Olfactory receptor 2A25
    Protein Accession:
    A4D2G3
    Secondary Accessions:
    • B2RNC9

    Protein attributes for OR2A25 Gene

    Size:
    310 amino acids
    Molecular mass:
    34606 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2A25 Gene

Proteomics data for OR2A25 Gene at MOPED

Post-translational modifications for OR2A25 Gene

Other Protein References for OR2A25 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2A25 Gene

Domains for OR2A25 Gene

Gene Families for OR2A25 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2A25 Gene

UniProtKB/Swiss-Prot:

O2A25_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • A4D2G3
genes like me logo Genes that share domains with OR2A25: view

Function for OR2A25 Gene

Molecular function for OR2A25 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004984 olfactory receptor activity IEA --
GO:0008527 taste receptor activity IBA --
genes like me logo Genes that share ontologies with OR2A25: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2A25 Gene

Localization for OR2A25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A25 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2A25 Gene COMPARTMENTS Subcellular localization image for OR2A25 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2A25: view

Pathways for OR2A25 Gene

genes like me logo Genes that share pathways with OR2A25: view

Pathways by source for OR2A25 Gene

Interacting Proteins for OR2A25 Gene

Gene Ontology (GO) - Biological Process for OR2A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
GO:0050912 detection of chemical stimulus involved in sensory perception of taste IBA --
genes like me logo Genes that share ontologies with OR2A25: view

Transcripts for OR2A25 Gene

mRNA/cDNA for OR2A25 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A25 Gene

No ASD Table

Relevant External Links for OR2A25 Gene

GeneLoc Exon Structure for
OR2A25
ECgene alternative splicing isoforms for
OR2A25

Expression for OR2A25 Gene

mRNA expression in normal human tissues for OR2A25 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR2A25 Gene

SOURCE GeneReport for Unigene cluster for OR2A25 Gene Hs.553787

genes like me logo Genes that share expressions with OR2A25: view

Orthologs for OR2A25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC472573 36
  • 99.25 (n)
  • 99.03 (a)
OR2A25 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 44 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia OR2A25 36
  • 85.48 (n)
  • 83.87 (a)
OR2A25 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr447 36
  • 81.72 (n)
  • 81.94 (a)
Olfr447 16
Olfr447 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 45 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 64 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr813 36
  • 81.4 (n)
  • 81.94 (a)
Species with no ortholog for OR2A25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A25 Gene

ENSEMBL:
Gene Tree for OR2A25 (if available)
TreeFam:
Gene Tree for OR2A25 (if available)

Paralogs for OR2A25 Gene

Paralogs for OR2A25 Gene

Selected SIMAP similar genes for OR2A25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2A25: view

Variants for OR2A25 Gene

Sequence variations from dbSNP and Humsavar for OR2A25 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2951309 -- 144,074,018(+) TAACA(C/T)TGAAT upstream-variant-2KB
rs2961133 -- 144,073,482(+) ATATA(C/G)AGTAG upstream-variant-2KB
rs2961134 -- 144,073,969(+) ACGAA(A/T)GTAGA upstream-variant-2KB
rs2961135 - 144,074,844(+) TGGGA(C/G)CCTTC missense, reference
rs2961136 -- 144,075,362(+) TTTAT(A/G)CTAGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR2A25 Gene

Variant ID Type Subtype PubMed ID
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
nsv8227 CNV Gain+Loss 18304495
nsv522225 CNV Gain 19592680
esv1682998 OTHER Inversion 17803354
dgv842n27 CNV Gain 19166990
nsv889336 CNV Gain 21882294
dgv7520n71 CNV Gain 21882294
esv2752147 CNV Gain 17911159
dgv2149e1 CNV Complex 17122850
nsv831173 CNV Gain 17160897
dgv2150e1 CNV Complex 17122850
nsv831174 CNV Loss 17160897
dgv7521n71 CNV Gain 21882294
esv1006326 CNV Gain 20482838
nsv471453 CNV Duplication 19718026

Relevant External Links for OR2A25 Gene

HapMap Linkage Disequilibrium report
OR2A25
Human Gene Mutation Database (HGMD)
OR2A25

Disorders for OR2A25 Gene

Relevant External Links for OR2A25

Genetic Association Database (GAD)
OR2A25
Human Genome Epidemiology (HuGE) Navigator
OR2A25
genes like me logo Genes that share disorders with OR2A25: view

No data available for UniProtKB/Swiss-Prot for OR2A25 Gene

Publications for OR2A25 Gene

  1. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 49
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 49
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for OR2A25 Gene

Sources for OR2A25 Gene

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