OR2A25 Gene
protein-coding GIFtS: 43
GCID: GC07P143771
|
|
olfactory receptor, family 2, subfamily A, member 25
(Previous symbols: OR2A25P, OR2A27)
| |
Aliases
for OR2A25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 2, Subfamily A, Member 251 2 | | Olfactory Receptor 2A252 | | OR2A25P1 2 3 | | Olfactory Receptor, Family 2, Subfamily A, Member 24 Pseudogene2 | | OR2A271 2 3 | | Olfactory Receptor, Family 2, Subfamily A, Member 25 Pseudogene2 | | Olfactory Receptor 2A272 3 | | Olfactory Receptor, Family 2, Subfamily A, Member 272 | | OR2A24P2 | | |
Export aliases for OR2A25 gene to outside databasesPrevious GC identifers: GC07P143163 GC07P143208 GC07P143402 |
Summaries
for OR2A25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR2A25:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: O2A25_HUMAN, A4D2G3Function: Odorant receptor (Potential)
|
Genomic Views
for OR2A25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR2A25 gene promoter:
AREB6 CREB PPAR-gamma1 Nkx6-1 POU2F1 deltaCREB POU2F1a POU2F1b PPAR-gamma2 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR2A25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR2A25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q35 Ensembl cytogenetic band: 7q35 HGNC cytogenetic band: 7q35OR2A25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P143771: view genomic region
(about GC identifiers)
Start:
|
143,771,313 bp from pter |
End:
|
143,772,242 bp from pter |
Size:
|
930 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 143,109,535-143,110,467 |
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Proteins
for OR2A25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: O2A25_HUMAN, A4D2G3 (See
protein sequence)Recommended Name: Olfactory receptor 2A25 Size: 310 amino acids; 34606 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2RNC9Explore the universe of human proteins at neXtProt for OR2A25: NX_A4D2G3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A4D2G3
HORDE protein sequence for OR2A25
OR2A25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001004488.1
ENSEMBL proteins: ENSP00000386167 Reactome Protein details: A4D2G3
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR2A25 for ontologies About GeneDecksing
OR2A25 Antibody Products:
Assay Products for OR2A25: |
Protein
Domains /
Families
for OR2A25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR2A25 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A4D2G3ProtoNet protein and cluster: A4D2G3 UniProtKB/Swiss-Prot: O2A25_HUMAN, A4D2G3Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR2A25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: O2A25_HUMAN, A4D2G3Function: Odorant receptor (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2A25 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2A25
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: OR2A25 (NM_001004488) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR2A25 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2A25 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR2A25 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR2A25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR2A25
1 
Kegg Pathway (Kegg details for OR2A25):
OR2A25 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2A25
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/273 Interacting proteins for OR2A25 (ENSP000003861674) via UniProtKB, MINT, STRING, and/or I2D (see all 273)About this table
|
Drugs & Compounds
for OR2A25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR2A25
Search CenterWatch for drugs/clinical trials and news about OR2A25 / O2A25
|
Transcripts
for OR2A25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR2A25 gene: NM_001004488.1 Unigene Cluster for OR2A25: Olfactory receptor, family 2, subfamily A, member 25 Hs.553787 Unigene Representative Sequence: BC1368141 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000408898(uc011ktx.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2A25 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2A25
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR2A25 (NM_001004488) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR2A25 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2A25 |
Additional cDNA sequence: BC136814.1 BC136829.1 1 AceView cDNA sequence: NM_001004488
GeneLoc Exon Structure
|
Expression
for OR2A25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR2A25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGCCTGAA
About this image
See OR2A25 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.553787
SABiosciences Custom PCR Arrays for OR2A25
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2A25
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR2A25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR2A25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR2A25 |
Orthologs
for OR2A25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR2A25 gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
F1NLN2_CHICK6 |
Uncharacterized protein |
44(a) |
1 → many |
17(871607-872557) |
ENSEMBL Gene Tree for OR2A25 (if available)
TreeFam Gene Tree for OR2A25 (if available) |
Paralogs
for OR2A25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR2A25 gene
- OR2A42 OR2A422 OR2A12 OR2A122 OR2A52 OR2A22 OR2A72 OR2A142
18/460 SIMAP similar genes for OR2A25 using alignment to 1 protein entry: O2A25_HUMAN(see all similar genes):FKSG35 OR2A1 OR2A4 OR2A7 OR2A42 OR2A5
OR2A12 OR2A14 OR2A2 OR10A7 OR2C1 OR4K2
OR4Q3 OR13F1 OR10R3P OR2B8P OR2G6 OR2Y1
OR2A25 for paralogs About GeneDecksing
|
Genomic Variants
for OR2A25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR2A25 ( 143771313 - 143772242 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for OR2A25
5 CNVs: 8581 4570 32962 53583 3708 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR2A25 |
|
Disorders
/ Diseases
for OR2A25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR2A25 for disorders About GeneDecksing
1  disease for OR2A25: About MalaCardsneuronitis
Human Genome Epidemiology (HuGE) Navigator: OR2A25 (2 documents)
Export disorders for OR2A25 gene to outside databases
|
Publications
for OR2A25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR2A25 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR2A25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1 Luke M.M....Psaty B.M. (2009)
- Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1 Shiffman D....Psaty B.M. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for OR2A25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR2A25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR2A25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR2A25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR2A25 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR2A25 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
|
| | |
About This Section
| Patent Information for OR2A25 gene:
Search GeneIP for patents involving OR2A25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR2A25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR2A25 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR2A25 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR2A25 | | | OriGene Protein Over-expression Lysate for OR2A25 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR2A25 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR2A25 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR2A25 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | OR2A25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for OR2A25 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR2A25 |
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