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Aliases for OR2A25 Gene

Aliases for OR2A25 Gene

  • Olfactory Receptor Family 2 Subfamily A Member 25 2 3 5
  • Olfactory Receptor 2A27 3 4
  • OR2A25P 3 4
  • OR2A27 3 4
  • Olfactory Receptor, Family 2, Subfamily A, Member 24 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 25 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 25 2
  • Olfactory Receptor, Family 2, Subfamily A, Member 27 3
  • Olfactory Receptor 2A25 3
  • OR2A24P 3

External Ids for OR2A25 Gene

Previous HGNC Symbols for OR2A25 Gene

  • OR2A25P
  • OR2A27

Previous GeneCards Identifiers for OR2A25 Gene

  • GC07P143163
  • GC07P143208
  • GC07P143402
  • GC07P143771

Summaries for OR2A25 Gene

Entrez Gene Summary for OR2A25 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A25 Gene

OR2A25 (Olfactory Receptor Family 2 Subfamily A Member 25) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is OR2A4.

UniProtKB/Swiss-Prot for OR2A25 Gene

  • Odorant receptor.

Additional gene information for OR2A25 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2A25 Gene

Genomics for OR2A25 Gene

Regulatory Elements for OR2A25 Gene

Enhancers for OR2A25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H143978 0.7 ENCODE 10.9 -90.3 -90340 2.1 ATF1 TAL1 JUN TCF12 CTBP1 GATA2 NCOR1 FOS TRIM24 ATF7 OR2F1 OR2A25 OR2A41P LOC154761 LOC100422324 OR2F2
GH07H144031 0.5 ENCODE 10.9 -38.1 -38069 1.3 NFIC NFIB ZSCAN4 NR2F2 ARHGEF35 OR2A25 OR2A41P OR2A5 OR6B1
GH07H143893 0.8 FANTOM5 5.4 -177.3 -177277 0 HDAC1 CTCF ATF1 ZNF175 RFX5 CHAMP1 FOSL1 ATF7 IKZF2 ZNF362 OR2A2 OR2A25 OR2A12 TCAF1 OR2F1 TAS2R60 LOC105375549
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2A25 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR2A25 Gene

Genomic Locations for OR2A25 Gene
6,060 bases
Plus strand

Genomic View for OR2A25 Gene

Genes around OR2A25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2A25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2A25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A25 Gene

Proteins for OR2A25 Gene

  • Protein details for OR2A25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2A25
    Protein Accession:
    Secondary Accessions:
    • B2RNC9

    Protein attributes for OR2A25 Gene

    310 amino acids
    Molecular mass:
    34606 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2A25 Gene

Post-translational modifications for OR2A25 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2A25 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2A25 Gene

Domains & Families for OR2A25 Gene

Gene Families for OR2A25 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2A25 Gene

Suggested Antigen Peptide Sequences for OR2A25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2A25: view

Function for OR2A25 Gene

Molecular function for OR2A25 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR2A25: view

Phenotypes for OR2A25 Gene

GenomeRNAi human phenotypes for OR2A25:
genes like me logo Genes that share phenotypes with OR2A25: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2A25 Gene

Localization for OR2A25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A25 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2A25 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2A25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2A25 Gene

Pathways & Interactions for OR2A25 Gene

genes like me logo Genes that share pathways with OR2A25: view

Pathways by source for OR2A25 Gene

Interacting Proteins for OR2A25 Gene

Gene Ontology (GO) - Biological Process for OR2A25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR2A25: view

No data available for SIGNOR curated interactions for OR2A25 Gene

Drugs & Compounds for OR2A25 Gene

No Compound Related Data Available

Transcripts for OR2A25 Gene

mRNA/cDNA for OR2A25 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A25 Gene

No ASD Table

Relevant External Links for OR2A25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2A25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2A25 Gene

Protein differential expression in normal tissues from HIPED for OR2A25 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2A25 Gene

Protein tissue co-expression partners for OR2A25 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2A25 Gene:


SOURCE GeneReport for Unigene cluster for OR2A25 Gene:

genes like me logo Genes that share expression patterns with OR2A25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2A25 Gene

Orthologs for OR2A25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC472573 33
  • 99.25 (n)
OR2A25 34
  • 99 (a)
(Canis familiaris)
Mammalia OR2A25 33 34
  • 85.48 (n)
(Mus musculus)
Mammalia Or2a25 52 Olfr447 33 16 34
  • 81.72 (n)
(Rattus norvegicus)
Mammalia Olr813 33
  • 81.4 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 45 (a)
(Bos Taurus)
Mammalia -- 34
  • 44 (a)
Species where no ortholog for OR2A25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A25 Gene

Gene Tree for OR2A25 (if available)
Gene Tree for OR2A25 (if available)

Paralogs for OR2A25 Gene

Paralogs for OR2A25 Gene

(460) SIMAP similar genes for OR2A25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2A25: view

Variants for OR2A25 Gene

Sequence variations from dbSNP and Humsavar for OR2A25 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000053555 -- 144,073,764(+) CTGAT(A/G)GCAGG intron-variant, upstream-variant-2KB
rs1000971728 -- 144,074,892(+) CCATT(C/T)TAAAG intron-variant, reference, synonymous-codon
rs1002429418 -- 144,075,355(+) AAATA(A/T)GTTTA intron-variant, downstream-variant-500B
rs1004836626 -- 144,072,396(+) TATTT(A/G)TTTGT intron-variant, upstream-variant-2KB
rs1007242098 -- 144,075,052(+) TCACA(C/G)CCTCT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR2A25 Gene

Variant ID Type Subtype PubMed ID
nsv471453 CNV gain 19718026
nsv522225 CNV gain 19592680
nsv608682 CNV gain 21841781
nsv608699 CNV gain 21841781
nsv8227 CNV gain+loss 18304495
nsv831173 CNV gain 17160897
nsv831174 CNV loss 17160897
nsv428188 CNV gain+loss 18775914
nsv1016831 CNV gain 25217958
esv3891223 CNV loss 25118596
esv2759570 CNV gain+loss 17122850
esv2752147 CNV gain 17911159
esv1682998 OTHER inversion 17803354
esv1006326 CNV gain 20482838
dgv842n27 CNV gain 19166990
dgv6725n100 CNV gain 25217958
dgv11664n54 CNV gain 21841781

Variation tolerance for OR2A25 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.15; 75.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2A25 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2A25 Gene

Disorders for OR2A25 Gene

Relevant External Links for OR2A25

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR2A25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2A25 Gene

Publications for OR2A25 Gene

  1. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 45 60
  2. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 4 60
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4 60

Products for OR2A25 Gene

Sources for OR2A25 Gene

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