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Aliases for OR2A14 Gene

Aliases for OR2A14 Gene

  • Olfactory Receptor, Family 2, Subfamily A, Member 14 2 3
  • Olfactory Receptor OR7-12 3 4
  • Olfactory Receptor 2A6 3 4
  • OR2A14P 3 4
  • OST182 3 4
  • OR2A6 3 4
  • Olfactory Receptor, Family 2, Subfamily A, Member 14 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 6 3
  • Olfactory Receptor 2A14 3

External Ids for OR2A14 Gene

Previous HGNC Symbols for OR2A14 Gene

  • OR2A14P
  • OR2A6

Previous GeneCards Identifiers for OR2A14 Gene

  • GC07P143218
  • GC07P143263
  • GC07P143457
  • GC07P143826

Summaries for OR2A14 Gene

Entrez Gene Summary for OR2A14 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A14 Gene

OR2A14 (Olfactory Receptor, Family 2, Subfamily A, Member 14) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A42.

UniProtKB/Swiss-Prot for OR2A14 Gene

  • Odorant receptor.

Gene Wiki entry for OR2A14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2A14 Gene

Genomics for OR2A14 Gene

Regulatory Elements for OR2A14 Gene

Genomic Location for OR2A14 Gene

Start:
144,129,058 bp from pter
End:
144,130,069 bp from pter
Size:
1,012 bases
Orientation:
Plus strand

Genomic View for OR2A14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A14 Gene

Proteins for OR2A14 Gene

  • Protein details for OR2A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R47-O2A14_HUMAN
    Recommended name:
    Olfactory receptor 2A14
    Protein Accession:
    Q96R47
    Secondary Accessions:
    • Q6IF41
    • Q8NGT8

    Protein attributes for OR2A14 Gene

    Size:
    310 amino acids
    Molecular mass:
    34993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2A14 Gene

Proteomics data for OR2A14 Gene at MOPED

Post-translational modifications for OR2A14 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2A14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2A14 Gene

Domains for OR2A14 Gene

Gene Families for OR2A14 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2A14 Gene

Suggested Antigen Peptide Sequences for OR2A14 Gene

Graphical View of Domain Structure for InterPro Entry

Q96R47

UniProtKB/Swiss-Prot:

O2A14_HUMAN :
  • Q96R47
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2A14: view

Function for OR2A14 Gene

Molecular function for OR2A14 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2A14: view

Phenotypes for OR2A14 Gene

GenomeRNAi human phenotypes for OR2A14:
genes like me logo Genes that share phenotypes with OR2A14: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2A14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2A14 Gene

Localization for OR2A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A14 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2A14 Gene COMPARTMENTS Subcellular localization image for OR2A14 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2A14: view

Pathways for OR2A14 Gene

genes like me logo Genes that share pathways with OR2A14: view

Pathways by source for OR2A14 Gene

Interacting Proteins for OR2A14 Gene

Gene Ontology (GO) - Biological Process for OR2A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2A14: view

Transcripts for OR2A14 Gene

mRNA/cDNA for OR2A14 Gene

(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR2A14

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A14 Gene

No ASD Table

Relevant External Links for OR2A14 Gene

GeneLoc Exon Structure for
OR2A14
ECgene alternative splicing isoforms for
OR2A14

Expression for OR2A14 Gene

mRNA expression in normal human tissues for OR2A14 Gene

Protein differential expression in normal tissues for OR2A14 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR2A14 Gene

SOURCE GeneReport for Unigene cluster for OR2A14 Gene Hs.534547

genes like me logo Genes that share expressions with OR2A14: view

Expression partners for OR2A14 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR2A14 Gene

Orthologs for OR2A14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR2A14 35
  • 84.69 (n)
  • 84.35 (a)
-- 36
  • 80 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR2A14 35
  • 83.85 (n)
  • 83.62 (a)
OR2A14 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr237-ps1 35
  • 83.12 (n)
  • 82.79 (a)
Olfr434 16
Olfr237-ps1 36
  • 82 (a)
OneToMany
Olfr441 36
  • 79 (a)
OneToMany
Olfr444 36
  • 79 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC472615 35
  • 97.53 (n)
  • 94.52 (a)
OR2A14 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr816 35
  • 83.23 (n)
  • 82.79 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
Species with no ortholog for OR2A14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A14 Gene

ENSEMBL:
Gene Tree for OR2A14 (if available)
TreeFam:
Gene Tree for OR2A14 (if available)

Paralogs for OR2A14 Gene

Paralogs for OR2A14 Gene

Selected SIMAP similar genes for OR2A14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR2A14: view

Variants for OR2A14 Gene

Sequence variations from dbSNP and Humsavar for OR2A14 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1881902 -- 144,128,335(-) AATAC(A/G)TGTAT upstream-variant-2KB
rs1881903 -- 144,128,002(-) GAGCA(G/T)GTGAT upstream-variant-2KB
rs2951335 -- 144,130,223(-) TCCAG(G/T)ATTAT downstream-variant-500B
rs2951336 -- 144,128,501(-) ACGCT(C/G)CTTTT upstream-variant-2KB
rs2961159 -- 144,128,909(+) ATACA(C/G)ATATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2A14 Gene

Variant ID Type Subtype PubMed ID
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
nsv8227 CNV Gain+Loss 18304495
nsv522225 CNV Gain 19592680
esv1682998 OTHER Inversion 17803354
dgv842n27 CNV Gain 19166990
dgv7520n71 CNV Gain 21882294
esv2752147 CNV Gain 17911159
dgv2149e1 CNV Complex 17122850
nsv831173 CNV Gain 17160897
dgv2150e1 CNV Complex 17122850
nsv831174 CNV Loss 17160897
dgv7521n71 CNV Gain 21882294

Relevant External Links for OR2A14 Gene

HapMap Linkage Disequilibrium report
OR2A14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2A14 Gene

Disorders for OR2A14 Gene

No disorders were found for OR2A14 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR2A14 Gene

Publications for OR2A14 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR2A14 Gene

Sources for OR2A14 Gene

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